Gz - LH receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM2 V 393 2x38 G.H5 Y 351 G.H5.22
Hydrophobic TM6 M 571 6x37 G.H5 L 354 G.H5.25
Hydrophobic C-term T 682 - G.H3 R 249 G.H3.07
Hydrophobic ICL3 L 558 - G.H5 A 339 G.H5.10
Hydrophobic ICL2 A 471 - G.H5 I 345 G.H5.16
Polar TM3 T 467 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 T 467 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 T 467 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 T 467 3x53 G.H5 I 352 G.H5.23
Hydrophobic ICL2 I 472 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 I 472 - G.S3 L 195 G.S3.01
Hydrophobic TM2 P 394 2x39 G.H5 I 352 G.H5.23
Ionic ICL2 D 475 - G.hns1 R 32 G.hns1.03
Polar ICL2 D 475 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 D 475 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 D 475 - G.hns1 R 32 G.hns1.03
Hydrophobic TM3 I 468 3x54 G.H5 I 352 G.H5.23
Van-der-waals TM3 I 468 3x54 G.H5 I 352 G.H5.23
Hydrophobic ICL3 L 558 - G.H5 D 338 G.H5.09
Van-der-waals ICL3 L 558 - G.H5 D 338 G.H5.09
Hydrophobic TM6 A 560 6x26 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 A 560 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM5 V 553 5x65 G.H5 I 345 G.H5.16
Hydrophobic ICL2 L 474 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 L 474 - G.hns1 R 31 G.hns1.02
Hydrophobic TM5 Y 546 5x58 G.H5 L 354 G.H5.25
Hydrophobic TM3 I 468 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 468 3x54 G.H5 L 349 G.H5.20
Polar TM3 R 464 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM3 R 464 3x50 G.H5 I 352 G.H5.23
Van-der-waals TM3 R 464 3x50 G.H5 I 352 G.H5.23
Hydrophobic ICL2 I 472 - G.H5 F 337 G.H5.08
Aromatic ICL2 K 477 - G.H5 Y 351 G.H5.22
Hydrophobic ICL2 K 477 - G.H5 Y 351 G.H5.22
Van-der-waals ICL2 K 477 - G.H5 Y 351 G.H5.22
Hydrophobic TM2 P 394 2x39 G.H5 Y 351 G.H5.22
Van-der-waals TM2 P 394 2x39 G.H5 Y 351 G.H5.22
Polar ICL2 A 471 - G.H5 N 348 G.H5.19
Hydrophobic ICL2 A 471 - G.H5 N 348 G.H5.19
Van-der-waals ICL2 A 471 - G.H5 N 348 G.H5.19
Polar TM2 T 392 2x37 G.H5 Y 351 G.H5.22
Hydrophobic TM2 T 392 2x37 G.H5 Y 351 G.H5.22
Van-der-waals TM2 T 392 2x37 G.H5 Y 351 G.H5.22
Hydrophobic ICL2 I 472 - G.H5 T 341 G.H5.12
Van-der-waals ICL2 I 472 - G.H5 T 341 G.H5.12
Hydrophobic TM3 R 464 3x50 G.H5 L 354 G.H5.25
Ionic TM6 K 563 6x29 G.h4s6 E 319 G.h4s6.12
Polar TM6 K 563 6x29 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 K 563 6x29 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 K 563 6x29 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 I 567 6x33 G.H5 L 349 G.H5.20
Hydrophobic TM6 L 574 6x40 G.H5 L 354 G.H5.25
Van-der-waals TM6 L 574 6x40 G.H5 L 354 G.H5.25
Polar C-term S 681 - G.H3 R 249 G.H3.07
Hydrophobic C-term S 681 - G.H3 R 249 G.H3.07
Van-der-waals C-term S 681 - G.H3 R 249 G.H3.07
Hydrophobic C-term L 680 - G.H3 R 249 G.H3.07
Hydrophobic C-term L 680 - G.H3 S 253 G.H3.11
Van-der-waals C-term L 680 - G.H3 S 253 G.H3.11
Hydrophobic TM6 K 570 6x36 G.H5 L 354 G.H5.25
Hydrophobic H8 T 627 8x47 G.H5 G 353 G.H5.24
Hydrophobic ICL2 A 471 - G.H5 I 344 G.H5.15
Van-der-waals ICL2 A 471 - G.H5 I 344 G.H5.15
Hydrophobic TM3 I 468 3x54 G.H5 I 345 G.H5.16
Polar C-term L 683 - G.H3 R 249 G.H3.07
Van-der-waals C-term L 683 - G.H3 R 249 G.H3.07
Hydrophobic ICL3 L 558 - G.S6 Y 321 G.S6.02
Van-der-waals C-term N 662 - G.h2s4 E 217 G.h2s4.02
Ionic ICL2 H 473 - G.s2s3 E 194 G.s2s3.02
Polar TM4 R 479 4x38 G.HN Q 28 G.HN.52
Hydrophobic TM4 R 479 4x38 G.HN Q 28 G.HN.52
Van-der-waals TM4 R 479 4x38 G.HN Q 28 G.HN.52
Hydrophobic C-term S 661 - G.H3 W 259 G.H3.17
Hydrophobic TM5 V 553 5x65 G.H5 L 349 G.H5.20
Hydrophobic ICL3 L 558 - G.H5 F 335 G.H5.06
Van-der-waals ICL3 L 558 - G.H5 F 335 G.H5.06
Hydrophobic TM6 I 567 6x33 G.H5 C 355 G.H5.26
Van-der-waals TM6 I 567 6x33 G.H5 C 355 G.H5.26