G12 - MT1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 15.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 Y 128 3x53 G.H5 D 377 G.H5.22
Hydrophobic TM3 Y 128 3x53 G.H5 D 377 G.H5.22
Van-der-waals TM3 Y 128 3x53 G.H5 D 377 G.H5.22
Hydrophobic ICL2 S 132 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 S 132 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM5 L 213 5x64 G.H5 L 371 G.H5.16
Van-der-waals TM5 L 213 5x64 G.H5 L 371 G.H5.16
Polar TM6 N 236 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM6 N 236 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 N 236 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM6 F 237 6x34 G.H5 I 378 G.H5.23
Polar TM2 N 60 2x37 G.H5 Q 381 G.H5.26
Hydrophobic TM2 N 60 2x37 G.H5 Q 381 G.H5.26
Van-der-waals TM2 N 60 2x37 G.H5 Q 381 G.H5.26
Hydrophobic TM5 V 214 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 V 214 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL2 L 133 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 133 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM5 V 217 5x68 G.H5 D 368 G.H5.13
Hydrophobic ICL2 L 133 34x51 G.H5 K 367 G.H5.12
Hydrophobic ICL2 L 133 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 133 34x51 G.H5 I 370 G.H5.15
Polar TM3 R 125 3x50 G.H5 Q 381 G.H5.26
Hydrophobic TM3 R 125 3x50 G.H5 Q 381 G.H5.26
Van-der-waals TM3 R 125 3x50 G.H5 Q 381 G.H5.26
Hydrophobic TM6 N 236 6x33 G.H5 L 380 G.H5.25
Van-der-waals TM6 N 236 6x33 G.H5 L 380 G.H5.25
Hydrophobic TM6 F 237 6x34 G.H5 M 379 G.H5.24
Van-der-waals TM6 F 237 6x34 G.H5 M 379 G.H5.24
Hydrophobic TM6 P 227 6x24 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM6 P 227 6x24 G.h4s6 S 343 G.h4s6.12
Polar TM3 Y 128 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 Y 128 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 Y 128 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 D 136 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 I 129 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM3 I 129 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 129 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM6 D 233 6x30 G.H5 M 379 G.H5.24
Van-der-waals TM6 D 233 6x30 G.H5 M 379 G.H5.24
Polar TM3 C 130 3x55 G.H5 K 367 G.H5.12
Polar C-term P 337 - G.H3 K 284 G.H3.16
Hydrophobic C-term P 337 - G.H3 K 284 G.H3.16
Van-der-waals C-term P 337 - G.H3 K 284 G.H3.16
Hydrophobic C-term V 350 - G.s4h3 R 266 G.s4h3.13
Van-der-waals C-term V 350 - G.s4h3 R 266 G.s4h3.13
Hydrophobic ICL2 L 133 34x51 G.S1 V 58 G.S1.02
Polar H8 N 299 8x47 G.H5 Q 381 G.H5.26
Hydrophobic H8 N 299 8x47 G.H5 Q 381 G.H5.26
Van-der-waals H8 N 299 8x47 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 K 137 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 K 137 34x55 G.hns1 R 56 G.hns1.03
Polar ICL2 D 136 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 D 136 34x54 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 D 136 34x54 G.hns1 R 56 G.hns1.03
Polar H8 N 301 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 N 301 8x49 G.H5 L 380 G.H5.25
Hydrophobic TM6 F 237 6x34 G.H5 L 375 G.H5.20
Hydrophobic TM3 R 125 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 125 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM5 V 217 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 V 217 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM5 V 221 5x72 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM5 V 221 5x72 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM5 V 217 5x68 G.H5 Q 372 G.H5.17
Van-der-waals TM5 V 217 5x68 G.H5 Q 372 G.H5.17
Ionic TM5 R 220 5x71 G.H5 D 368 G.H5.13
Polar TM5 R 220 5x71 G.H5 D 368 G.H5.13
Hydrophobic TM5 R 220 5x71 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 220 5x71 G.H5 D 368 G.H5.13
Hydrophobic TM6 L 229 6x26 G.H5 M 379 G.H5.24
Van-der-waals TM6 L 229 6x26 G.H5 M 379 G.H5.24
Hydrophobic TM5 V 221 5x72 G.H5 Q 372 G.H5.17
Van-der-waals TM5 V 221 5x72 G.H5 Q 372 G.H5.17
Hydrophobic TM3 I 129 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 129 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM3 I 129 3x54 G.H5 N 374 G.H5.19
Van-der-waals TM3 I 129 3x54 G.H5 N 374 G.H5.19
Hydrophobic ICL2 L 133 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 133 34x51 G.S3 I 221 G.S3.01
Ionic ICL3 D 224 - G.h4s6 R 342 G.h4s6.11
Polar ICL3 D 224 - G.h4s6 R 342 G.h4s6.11
Van-der-waals ICL3 D 224 - G.h4s6 R 342 G.h4s6.11
Hydrophobic TM3 Y 128 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 Y 128 3x53 G.H5 I 378 G.H5.23
Hydrophobic ICL2 S 132 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 S 132 34x50 G.H5 N 374 G.H5.19