G12 - OX2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 N 90 2x40 G.H5 L 380 G.H5.25
Hydrophobic TM5 I 255 5x70 G.S6 F 347 G.S6.02
Van-der-waals TM5 I 255 5x70 G.S6 F 347 G.S6.02
Polar C-term R 404 - G.H2 Q 240 G.H2.09
Hydrophobic C-term R 404 - G.H2 Q 240 G.H2.09
Van-der-waals C-term R 404 - G.H2 Q 240 G.H2.09
Polar ICL3 S 284 - G.H4 Q 333 G.H4.13
Polar ICL3 S 287 - G.H4 D 336 G.H4.16
Van-der-waals ICL3 S 287 - G.H4 D 336 G.H4.16
Hydrophobic TM6 L 306 6x37 G.H5 M 379 G.H5.24
Polar C-term S 403 - G.H2 Q 240 G.H2.09
Hydrophobic C-term S 403 - G.H2 Q 240 G.H2.09
Van-der-waals C-term S 403 - G.H2 Q 240 G.H2.09
Polar H8 G 369 8x48 G.H5 L 380 G.H5.25
Hydrophobic ICL3 S 284 - G.H4 R 329 G.H4.09
Polar TM3 R 152 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 152 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 152 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL3 M 286 - G.H4 V 332 G.H4.12
Polar TM6 Q 295 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 Q 295 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 Q 295 6x26 G.H5 Q 372 G.H5.17
Polar ICL3 T 282 - G.H4 R 329 G.H4.09
Hydrophobic ICL2 L 160 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 160 34x51 G.H5 F 363 G.H5.08
Hydrophobic C-term T 427 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term T 427 - G.s4h3 R 265 G.s4h3.12
Polar TM3 A 155 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 155 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 155 3x53 G.H5 N 374 G.H5.19
Polar H8 S 368 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 S 368 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 S 368 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL3 M 286 - G.H4 Q 333 G.H4.13
Van-der-waals ICL3 M 286 - G.H4 Q 333 G.H4.13
Polar H8 F 371 8x50 G.H5 L 380 G.H5.25
Hydrophobic H8 F 371 8x50 G.H5 L 380 G.H5.25
Hydrophobic C-term D 415 - G.H2 R 232 G.H2.01
Van-der-waals C-term D 415 - G.H2 R 232 G.H2.01
Polar C-term L 407 - G.H2 Q 236 G.H2.05
Hydrophobic C-term L 407 - G.H2 Q 236 G.H2.05
Van-der-waals C-term L 407 - G.H2 Q 236 G.H2.05
Polar TM2 T 89 2x39 G.H5 D 377 G.H5.22
Hydrophobic C-term S 403 - G.H3 L 285 G.H3.17
Van-der-waals C-term S 403 - G.H3 L 285 G.H3.17
Hydrophobic ICL2 F 162 34x53 G.H5 I 370 G.H5.15
Hydrophobic TM5 P 256 5x71 G.H5 H 364 G.H5.09
Van-der-waals TM5 P 256 5x71 G.H5 H 364 G.H5.09
Hydrophobic TM5 P 256 5x71 G.H5 A 365 G.H5.10
Hydrophobic ICL2 F 162 34x53 G.hns1 R 56 G.hns1.03
Hydrophobic TM2 I 93 2x43 G.H5 L 380 G.H5.25
Hydrophobic TM4 T 165 4x38 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 T 165 4x38 G.hns1 R 55 G.hns1.02
Hydrophobic TM6 M 305 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 M 305 6x36 G.H5 M 379 G.H5.24
Polar H8 K 370 8x49 G.H5 L 380 G.H5.25
Hydrophobic H8 K 370 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 K 370 8x49 G.H5 L 380 G.H5.25
Hydrophobic C-term I 429 - G.s4h3 V 260 G.s4h3.07
Polar C-term T 408 - G.H2 Q 236 G.H2.05
Hydrophobic C-term T 408 - G.H2 Q 236 G.H2.05
Ionic TM6 R 299 6x30 G.H5 D 368 G.H5.13
Polar TM6 R 299 6x30 G.H5 D 368 G.H5.13
Hydrophobic TM6 R 299 6x30 G.H5 D 368 G.H5.13
Van-der-waals TM6 R 299 6x30 G.H5 D 368 G.H5.13
Hydrophobic TM5 P 256 5x71 G.H5 D 368 G.H5.13
Hydrophobic ICL2 L 160 34x51 G.H5 K 367 G.H5.12
Hydrophobic H8 K 370 8x49 G.H5 Q 381 G.H5.26
Hydrophobic TM3 R 152 3x50 G.H5 M 379 G.H5.24
Polar ICL2 S 164 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 S 164 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 S 164 - G.hns1 R 55 G.hns1.02
Polar C-term T 427 - H.HD S 171 H.HD.11
Hydrophobic ICL2 P 159 34x50 G.H5 L 371 G.H5.16
Polar TM6 T 302 6x33 G.H5 Q 381 G.H5.26
Hydrophobic ICL3 M 286 - G.H4 R 329 G.H4.09
Polar C-term R 404 - G.H2 K 237 G.H2.06
Van-der-waals C-term R 404 - G.H2 K 237 G.H2.06
Polar ICL3 A 288 - G.H4 D 336 G.H4.16
Hydrophobic ICL3 A 288 - G.H4 D 336 G.H4.16
Van-der-waals ICL3 A 288 - G.H4 D 336 G.H4.16
Hydrophobic C-term I 417 - G.s4h3 E 263 G.s4h3.10
Van-der-waals C-term I 417 - G.s4h3 E 263 G.s4h3.10
Polar ICL3 S 287 - G.h4s6 R 342 G.h4s6.11
Hydrophobic ICL3 S 287 - G.h4s6 R 342 G.h4s6.11
Van-der-waals ICL3 S 287 - G.h4s6 R 342 G.h4s6.11
Hydrophobic C-term V 424 - H.HA A 111 H.HA.25
Hydrophobic C-term L 426 - H.HA K 114 H.HA.28
Van-der-waals C-term L 426 - H.HA K 114 H.HA.28
Hydrophobic TM6 T 302 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM6 A 291 6x22 G.h4s6 P 345 G.h4s6.20
Hydrophobic C-term F 414 - G.s4h3 D 264 G.s4h3.11
Hydrophobic TM6 T 302 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 302 6x33 G.H5 M 379 G.H5.24
Polar C-term D 415 - G.H2 S 233 G.H2.02
Hydrophobic C-term D 415 - G.H2 S 233 G.H2.02
Van-der-waals C-term D 415 - G.H2 S 233 G.H2.02
Hydrophobic TM5 P 256 5x71 G.H5 F 361 G.H5.06
Hydrophobic TM3 A 155 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 155 3x53 G.H5 I 378 G.H5.23
Hydrophobic ICL2 L 160 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 160 34x51 G.H5 I 370 G.H5.15
Ionic H8 K 370 8x49 G.H5 D 377 G.H5.22
Polar H8 K 370 8x49 G.H5 D 377 G.H5.22
Hydrophobic TM6 A 291 6x22 G.h4s6 K 344 G.h4s6.19
Ionic C-term E 422 - H.HA R 106 H.HA.20
Polar C-term E 422 - H.HA R 106 H.HA.20
Van-der-waals C-term E 422 - H.HA R 106 H.HA.20
Hydrophobic TM6 Q 295 6x26 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 Q 295 6x26 G.h4s6 P 345 G.h4s6.20
Ionic C-term E 422 - H.HA K 103 H.HA.17
Hydrophobic C-term E 422 - H.HA K 103 H.HA.17
Van-der-waals C-term E 422 - H.HA K 103 H.HA.17
Hydrophobic ICL2 P 159 34x50 G.H5 I 370 G.H5.15
Hydrophobic C-term S 406 - G.H2 K 237 G.H2.06
Ionic C-term E 402 - G.H3 K 284 G.H3.16
Hydrophobic ICL3 G 257 - G.H5 F 361 G.H5.06
Van-der-waals ICL3 G 257 - G.H5 F 361 G.H5.06
Polar C-term S 406 - G.H2 Q 236 G.H2.05
Van-der-waals C-term S 406 - G.H2 Q 236 G.H2.05
Hydrophobic ICL2 L 160 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 160 34x51 G.S3 I 221 G.S3.01
Polar C-term V 425 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term V 425 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term V 425 - G.s4h3 R 265 G.s4h3.12
Polar C-term V 424 - H.HA D 110 H.HA.24
Hydrophobic C-term V 424 - H.HA D 110 H.HA.24
Van-der-waals C-term V 424 - H.HA D 110 H.HA.24
Hydrophobic ICL2 P 159 34x50 G.H5 K 367 G.H5.12
Hydrophobic TM6 A 291 6x22 G.h4s6 R 342 G.h4s6.11
Van-der-waals TM6 A 291 6x22 G.h4s6 R 342 G.h4s6.11
Hydrophobic TM5 K 249 5x64 G.H5 L 371 G.H5.16
Hydrophobic C-term V 424 - H.hdhe F 173 H.hdhe.01
Van-der-waals C-term V 424 - H.hdhe F 173 H.hdhe.01
Hydrophobic C-term T 427 - G.s4h3 V 260 G.s4h3.07
Van-der-waals C-term T 427 - G.s4h3 V 260 G.s4h3.07
Polar C-term T 399 - G.H3 K 284 G.H3.16
Hydrophobic C-term T 399 - G.H3 K 284 G.H3.16
Van-der-waals C-term T 399 - G.H3 K 284 G.H3.16
Polar C-term T 427 - H.hdhe F 173 H.hdhe.01
Polar TM6 R 299 6x30 G.H5 Q 372 G.H5.17
Van-der-waals TM6 R 299 6x30 G.H5 Q 372 G.H5.17
Hydrophobic C-term L 426 - H.HA L 115 H.HA.29
Van-der-waals C-term L 426 - H.HA L 115 H.HA.29
Hydrophobic ICL3 M 286 - G.H4 D 336 G.H4.16
Hydrophobic TM3 I 156 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM3 I 156 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 156 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL3 A 288 - G.S6 L 346 G.S6.01
Polar C-term V 424 - H.HA K 114 H.HA.28
Hydrophobic C-term V 424 - H.HA K 114 H.HA.28
Van-der-waals C-term V 424 - H.HA K 114 H.HA.28
Hydrophobic TM5 L 250 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 250 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM2 T 89 2x39 G.H5 I 378 G.H5.23
Hydrophobic H8 S 368 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 S 368 8x47 G.H5 M 379 G.H5.24
Polar C-term Q 423 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term Q 423 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term V 424 - H.HA V 107 H.HA.21
Van-der-waals C-term V 424 - H.HA V 107 H.HA.21
Hydrophobic TM6 A 291 6x22 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM5 P 256 5x71 G.S6 F 347 G.S6.02
Van-der-waals TM5 P 256 5x71 G.S6 F 347 G.S6.02
Polar C-term S 400 - G.H2 Q 240 G.H2.09
Van-der-waals C-term S 400 - G.H2 Q 240 G.H2.09
Van-der-waals C-term T 427 - H.HD E 172 H.HD.12
Polar C-term T 427 - H.HD E 172 H.HD.12
Hydrophobic C-term T 427 - H.HD E 172 H.HD.12
Hydrophobic TM6 R 299 6x30 G.H5 L 375 G.H5.20