Gs - PAR4 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar N-term M 1 - G.h1ha G 72 G.h1ha.08
Hydrophobic N-term M 1 - G.h1ha G 72 G.h1ha.08
Van-der-waals N-term M 1 - G.h1ha G 72 G.h1ha.08
Polar ICL2 R 183 34x52 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 R 183 34x52 G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL2 L 182 34x51 G.H5 C 379 G.H5.11
Hydrophobic ICL2 A 186 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic TM6 Y 278 6x31 G.H5 L 388 G.H5.20
Van-der-waals TM6 Y 278 6x31 G.H5 L 388 G.H5.20
Polar H8 S 344 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 S 344 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 S 344 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM3 L 178 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM2 L 109 2x37 G.H5 Q 390 G.H5.22
Hydrophobic TM5 L 271 5x65 G.H5 L 388 G.H5.20
Polar H8 F 347 8x50 G.H5 E 392 G.H5.24
Hydrophobic H8 F 347 8x50 G.H5 E 392 G.H5.24
Van-der-waals H8 F 347 8x50 G.H5 E 392 G.H5.24
Polar N-term W 2 - G.h1ha E 71 G.h1ha.07
Hydrophobic N-term W 2 - G.h1ha E 71 G.h1ha.07
Van-der-waals N-term W 2 - G.h1ha E 71 G.h1ha.07
Polar TM3 L 178 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 178 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 178 3x54 G.H5 Q 384 G.H5.16
Polar TM3 D 173 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 D 173 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 173 3x49 G.H5 Y 391 G.H5.23
Polar TM3 R 174 3x50 G.H5 Y 391 G.H5.23
Aromatic TM3 R 174 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 174 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 174 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 178 3x54 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 182 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL2 L 182 34x51 G.H5 R 380 G.H5.12
Hydrophobic ICL2 P 181 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 181 34x50 G.H5 R 380 G.H5.12
Hydrophobic ICL2 P 181 34x50 G.H5 H 387 G.H5.19
Polar TM4 R 191 4x40 G.HN Q 31 G.HN.48
Hydrophobic TM4 R 191 4x40 G.HN Q 31 G.HN.48
Van-der-waals TM4 R 191 4x40 G.HN Q 31 G.HN.48
Polar TM6 Y 278 6x31 G.H5 R 385 G.H5.17
Hydrophobic TM6 Y 278 6x31 G.H5 R 385 G.H5.17
Van-der-waals TM6 Y 278 6x31 G.H5 R 385 G.H5.17
Polar ICL2 R 188 34x57 G.H5 Q 390 G.H5.22
Polar TM6 Y 278 6x31 G.H5 D 381 G.H5.13
Van-der-waals TM6 Y 278 6x31 G.H5 D 381 G.H5.13
Ionic H8 E 346 8x49 G.H5 R 389 G.H5.21
Polar TM3 A 177 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 177 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 177 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 178 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 178 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 P 181 34x50 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 182 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 182 34x51 G.H5 F 376 G.H5.08
Polar ICL2 R 185 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL2 R 185 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 R 185 34x54 G.S1 H 41 G.S1.02
Polar TM6 A 281 6x34 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 281 6x34 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 281 6x34 G.H5 L 393 G.H5.25
Hydrophobic ICL3 R 277 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 R 277 - G.H5 R 385 G.H5.17
Polar ICL2 L 182 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 182 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 182 34x51 G.S1 H 41 G.S1.02
Polar N-term M 1 - G.h1ha E 71 G.h1ha.07
Hydrophobic N-term M 1 - G.h1ha E 71 G.h1ha.07
Van-der-waals N-term M 1 - G.h1ha E 71 G.h1ha.07
Ionic H8 K 350 8x53 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 182 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 182 34x51 G.H5 I 383 G.H5.15
Hydrophobic ICL2 L 182 34x51 G.S3 F 219 G.S3.03
Hydrophobic ICL2 A 184 34x53 G.H5 H 387 G.H5.19
Van-der-waals ICL2 A 184 34x53 G.H5 H 387 G.H5.19
Hydrophobic TM6 H 280 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 H 280 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 281 6x34 G.H5 L 388 G.H5.20
Van-der-waals TM6 A 281 6x34 G.H5 L 388 G.H5.20
Hydrophobic TM3 A 177 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 177 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 R 185 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 R 185 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 P 181 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 181 34x50 G.H5 I 383 G.H5.15
Polar ICL2 R 185 34x54 G.h2s4 T 242 G.h2s4.05
Hydrophobic ICL2 R 185 34x54 G.h2s4 T 242 G.h2s4.05
Van-der-waals ICL2 R 185 34x54 G.h2s4 T 242 G.h2s4.05
Hydrophobic TM3 R 174 3x50 G.H5 L 393 G.H5.25
Polar ICL2 R 188 34x57 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 R 188 34x57 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 R 188 34x57 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 R 183 34x52 G.S3 V 217 G.S3.01
Hydrophobic TM2 S 111 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 S 111 2x39 G.H5 Y 391 G.H5.23
Polar ICL2 R 188 34x57 G.H5 H 387 G.H5.19
Aromatic ICL2 R 188 34x57 G.H5 H 387 G.H5.19
Van-der-waals ICL2 R 188 34x57 G.H5 H 387 G.H5.19
Hydrophobic TM6 L 284 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 284 6x37 G.H5 L 393 G.H5.25