Gi2 - EP1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic TM5 R 236 5x70 G.h4s6 E 319 G.h4s6.12
Polar TM5 R 236 5x70 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM5 R 236 5x70 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM5 R 236 5x70 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM3 V 139 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 V 139 3x54 G.H5 L 349 G.H5.20
Polar ICL2 P 142 34x50 G.H5 N 348 G.H5.19
Hydrophobic TM5 L 229 5x63 G.H5 L 349 G.H5.20
Van-der-waals TM5 L 229 5x63 G.H5 L 349 G.H5.20
Hydrophobic C-term S 394 - G.H2 E 208 G.H2.03
Van-der-waals C-term S 394 - G.H2 E 208 G.H2.03
Hydrophobic C-term F 402 - G.s1h1 G 40 G.s1h1.01
Van-der-waals C-term F 402 - G.s1h1 G 40 G.s1h1.01
Ionic TM2 R 68 2x34 G.HN E 28 G.HN.52
Polar TM2 R 68 2x34 G.HN E 28 G.HN.52
Hydrophobic TM2 R 68 2x34 G.HN E 28 G.HN.52
Van-der-waals TM2 R 68 2x34 G.HN E 28 G.HN.52
Hydrophobic C-term F 402 - G.H3 L 250 G.H3.08
Van-der-waals C-term F 402 - G.H3 L 250 G.H3.08
Polar C-term S 397 - G.H2 E 208 G.H2.03
Polar TM2 R 68 2x34 G.HN R 24 G.HN.48
Van-der-waals C-term F 402 - G.H1 K 46 G.H1.01
Hydrophobic ICL2 L 143 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 143 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM3 R 135 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 135 3x50 G.H5 L 354 G.H5.25
Polar TM2 S 69 2x35 G.H5 D 351 G.H5.22
Hydrophobic TM2 S 69 2x35 G.H5 D 351 G.H5.22
Van-der-waals TM2 S 69 2x35 G.H5 D 351 G.H5.22
Hydrophobic ICL2 L 143 34x51 G.H5 I 344 G.H5.15
Hydrophobic ICL2 P 142 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 142 34x50 G.H5 I 345 G.H5.16
Hydrophobic C-term F 402 - G.H2 R 209 G.H2.04
Van-der-waals C-term F 402 - G.H2 R 209 G.H2.04
Hydrophobic TM6 M 295 6x33 G.H5 F 355 G.H5.26
Van-der-waals TM6 M 295 6x33 G.H5 F 355 G.H5.26
Ionic TM2 R 67 2x33 G.h3s5 D 262 G.h3s5.02
Polar TM2 R 67 2x33 G.h3s5 D 262 G.h3s5.02
Van-der-waals TM2 R 67 2x33 G.h3s5 D 262 G.h3s5.02
Hydrophobic C-term F 402 - G.s1h1 G 42 G.s1h1.03
Van-der-waals C-term F 402 - G.s1h1 G 42 G.s1h1.03
Ionic C-term H 401 - G.s4h3 E 237 G.s4h3.10
Polar C-term H 401 - G.s4h3 E 237 G.s4h3.10
Hydrophobic C-term H 401 - G.s4h3 E 237 G.s4h3.10
Van-der-waals C-term H 401 - G.s4h3 E 237 G.s4h3.10
Hydrophobic TM6 L 299 6x37 G.H5 L 354 G.H5.25
Van-der-waals H8 R 355 8x47 G.H5 G 353 G.H5.24
Polar H8 R 355 8x47 G.H5 G 353 G.H5.24
Hydrophobic H8 R 355 8x47 G.H5 G 353 G.H5.24
Hydrophobic C-term F 402 - G.S1 L 39 G.S1.07
Hydrophobic TM2 F 73 2x39 G.H5 C 352 G.H5.23
Van-der-waals TM2 F 73 2x39 G.H5 C 352 G.H5.23
Polar TM3 G 138 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 G 138 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 G 138 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM2 R 68 2x34 G.hns1 A 31 G.hns1.02
Polar C-term S 400 - G.H2 R 209 G.H2.04
Van-der-waals C-term S 400 - G.H2 R 209 G.H2.04
Hydrophobic ICL2 P 142 34x50 G.H5 I 344 G.H5.15
Polar ICL2 H 145 34x53 G.H5 N 348 G.H5.19
Hydrophobic ICL2 H 145 34x53 G.H5 N 348 G.H5.19
Van-der-waals ICL2 H 145 34x53 G.H5 N 348 G.H5.19
Van-der-waals C-term L 399 - G.s4h3 E 237 G.s4h3.10
Hydrophobic TM2 F 73 2x39 G.H5 G 353 G.H5.24
Hydrophobic TM6 M 295 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 M 295 6x33 G.H5 L 354 G.H5.25
Polar ICL3 S 281 - G.h4s6 K 315 G.h4s6.08
Van-der-waals ICL3 S 281 - G.h4s6 K 315 G.h4s6.08
Aromatic C-term W 386 - G.H3 K 258 G.H3.16
Hydrophobic C-term W 386 - G.H3 K 258 G.H3.16
Van-der-waals C-term W 386 - G.H3 K 258 G.H3.16
Ionic TM5 R 236 5x70 G.H5 D 342 G.H5.13
Polar TM5 R 236 5x70 G.H5 D 342 G.H5.13
Van-der-waals TM5 R 236 5x70 G.H5 D 342 G.H5.13
Hydrophobic ICL2 L 143 34x51 G.H5 F 337 G.H5.08
Van-der-waals ICL2 L 143 34x51 G.H5 F 337 G.H5.08
Hydrophobic TM2 F 73 2x39 G.H5 D 351 G.H5.22
Van-der-waals TM2 F 73 2x39 G.H5 D 351 G.H5.22
Polar TM2 A 70 2x36 G.H5 D 351 G.H5.22
Hydrophobic TM2 A 70 2x36 G.H5 D 351 G.H5.22
Polar ICL3 S 284 - G.h4s6 K 315 G.h4s6.08
Hydrophobic ICL3 S 284 - G.h4s6 K 315 G.h4s6.08
Van-der-waals ICL3 S 284 - G.h4s6 K 315 G.h4s6.08
Hydrophobic ICL2 P 142 34x50 G.H5 T 341 G.H5.12
Van-der-waals ICL2 P 142 34x50 G.H5 T 341 G.H5.12
Hydrophobic C-term W 386 - G.H3 W 259 G.H3.17
Hydrophobic C-term S 400 - G.H3 E 246 G.H3.04
Van-der-waals C-term S 400 - G.H3 E 246 G.H3.04
Polar ICL3 S 281 - G.H4 D 310 G.H4.17
Ionic TM6 R 287 6x25 G.h4s6 D 316 G.h4s6.09
Polar TM6 R 287 6x25 G.h4s6 D 316 G.h4s6.09
Hydrophobic TM6 R 287 6x25 G.h4s6 D 316 G.h4s6.09
Van-der-waals TM6 R 287 6x25 G.h4s6 D 316 G.h4s6.09
Polar C-term H 401 - G.H2 R 206 G.H2.01
Aromatic C-term H 401 - G.H2 R 206 G.H2.01
Hydrophobic C-term H 401 - G.H2 R 206 G.H2.01
Van-der-waals C-term H 401 - G.H2 R 206 G.H2.01
Polar TM3 R 135 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 135 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 135 3x50 G.H5 C 352 G.H5.23
Polar C-term H 401 - G.s1h1 G 42 G.s1h1.03
Hydrophobic TM6 M 295 6x33 G.H5 L 349 G.H5.20
Polar ICL2 A 147 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 A 147 34x55 G.hns1 R 32 G.hns1.03
Polar TM5 R 236 5x70 G.S6 Y 321 G.S6.02
Polar C-term F 402 - G.s3h2 G 204 G.s3h2.02
Hydrophobic C-term F 402 - G.s3h2 G 204 G.s3h2.02
Van-der-waals C-term F 402 - G.s3h2 G 204 G.s3h2.02
Polar C-term S 390 - G.H3 K 258 G.H3.16
Hydrophobic TM2 R 67 2x33 G.H5 K 350 G.H5.21
Polar ICL3 S 284 - G.h4s6 D 316 G.h4s6.09
Aromatic TM6 H 291 6x29 G.H5 F 355 G.H5.26
Hydrophobic TM6 H 291 6x29 G.H5 F 355 G.H5.26
Van-der-waals TM6 H 291 6x29 G.H5 F 355 G.H5.26
Hydrophobic TM6 Q 298 6x36 G.H5 L 354 G.H5.25
Polar TM2 R 68 2x34 G.HN G 27 G.HN.51
Hydrophobic TM2 R 68 2x34 G.HN G 27 G.HN.51
Van-der-waals TM2 R 68 2x34 G.HN G 27 G.HN.51