Gq -
EP1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 86.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 10.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM3 | G | 138 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | TM3 | G | 138 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | ICL3 | G | 278 | - | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | ICL3 | S | 279 | - | G.H4 | V | 314 | G.H4.16 |
Van-der-waals | ICL3 | S | 279 | - | G.H4 | V | 314 | G.H4.16 |
Polar | ICL3 | S | 284 | - | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | C-term | L | 391 | - | G.H2 | I | 217 | G.H2.08 |
Hydrophobic | TM6 | M | 295 | 6x33 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM6 | M | 295 | 6x33 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM2 | F | 73 | 2x39 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL2 | A | 147 | 34x55 | G.hns1 | R | 38 | G.hns1.03 |
Hydrophobic | TM6 | H | 291 | 6x29 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | ICL3 | S | 245 | - | G.S6 | S | 326 | G.S6.03 |
Hydrophobic | H8 | R | 355 | 8x47 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | H8 | R | 355 | 8x47 | G.H5 | L | 358 | G.H5.25 |
Polar | TM2 | R | 67 | 2x33 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM2 | R | 67 | 2x33 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | ICL3 | S | 279 | - | G.H4 | L | 310 | G.H4.12 |
Polar | ICL3 | S | 279 | - | G.S6 | I | 324 | G.S6.01 |
Polar | ICL3 | S | 279 | - | G.S6 | S | 326 | G.S6.03 |
Van-der-waals | ICL3 | S | 279 | - | G.S6 | S | 326 | G.S6.03 |
Hydrophobic | C-term | W | 386 | - | G.H3 | Y | 261 | G.H3.15 |
Polar | ICL3 | S | 284 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Hydrophobic | ICL3 | S | 284 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Van-der-waals | ICL3 | S | 284 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Hydrophobic | ICL3 | A | 244 | - | G.H4 | R | 306 | G.H4.08 |
Hydrophobic | TM3 | V | 139 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | TM3 | V | 139 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | ICL2 | L | 143 | 34x51 | G.S3 | V | 199 | G.S3.01 |
Hydrophobic | H8 | V | 358 | 8x50 | G.H5 | L | 358 | G.H5.25 |
Polar | TM3 | R | 135 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Aromatic | TM3 | R | 135 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | R | 135 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | R | 135 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | L | 143 | 34x51 | G.S1 | L | 40 | G.S1.02 |
Van-der-waals | ICL2 | L | 143 | 34x51 | G.S1 | L | 40 | G.S1.02 |
Polar | TM6 | H | 291 | 6x29 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM6 | H | 291 | 6x29 | G.H5 | N | 357 | G.H5.24 |
Polar | TM6 | E | 294 | 6x32 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM6 | E | 294 | 6x32 | G.H5 | N | 357 | G.H5.24 |
Polar | TM2 | A | 70 | 2x36 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM2 | A | 70 | 2x36 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | TM2 | A | 70 | 2x36 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM7 | I | 352 | 7x54 | G.H5 | L | 358 | G.H5.25 |
Polar | ICL3 | S | 284 | - | G.h4s6 | K | 322 | G.h4s6.13 |
Hydrophobic | ICL2 | P | 142 | 34x50 | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | ICL2 | P | 142 | 34x50 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | C-term | F | 402 | - | G.H3 | R | 256 | G.H3.10 |
Van-der-waals | C-term | F | 402 | - | G.H3 | R | 256 | G.H3.10 |
Hydrophobic | TM6 | H | 291 | 6x29 | G.H5 | K | 354 | G.H5.21 |
Polar | ICL3 | G | 246 | - | G.S6 | S | 326 | G.S6.03 |
Van-der-waals | ICL3 | G | 246 | - | G.S6 | S | 326 | G.S6.03 |
Polar | ICL2 | H | 145 | 34x53 | G.H5 | Y | 356 | G.H5.23 |
Aromatic | TM2 | F | 73 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM2 | F | 73 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM2 | F | 73 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM2 | R | 67 | 2x33 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | TM2 | R | 67 | 2x33 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ICL3 | P | 243 | - | G.H4 | E | 307 | G.H4.09 |
Van-der-waals | ICL3 | P | 243 | - | G.H4 | E | 307 | G.H4.09 |
Hydrophobic | ICL2 | P | 142 | 34x50 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL2 | P | 142 | 34x50 | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | ICL3 | R | 280 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Van-der-waals | ICL3 | R | 280 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Polar | ICL3 | R | 280 | - | G.S6 | Y | 325 | G.S6.02 |
Polar | TM3 | E | 134 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | E | 134 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | E | 134 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL1 | L | 64 | 12x50 | G.H5 | L | 358 | G.H5.25 |
Polar | TM6 | R | 287 | 6x25 | G.h4s6 | S | 320 | G.h4s6.11 |
Polar | H8 | R | 355 | 8x47 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | H8 | R | 355 | 8x47 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | H8 | R | 355 | 8x47 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM6 | D | 292 | 6x30 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM6 | D | 292 | 6x30 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM4 | S | 150 | 4x38 | G.hns1 | R | 37 | G.hns1.02 |
Ionic | TM5 | R | 236 | 5x70 | G.H5 | D | 346 | G.H5.13 |
Polar | TM5 | R | 236 | 5x70 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | TM5 | R | 236 | 5x70 | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | TM5 | R | 236 | 5x70 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | ICL3 | S | 245 | - | G.S6 | H | 327 | G.S6.04 |
Hydrophobic | TM6 | M | 295 | 6x33 | G.H5 | L | 353 | G.H5.20 |
Polar | H8 | R | 355 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | H8 | R | 355 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | R | 355 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Polar | TM2 | R | 67 | 2x33 | G.h3s5 | N | 266 | G.h3s5.02 |
Van-der-waals | TM2 | R | 67 | 2x33 | G.h3s5 | N | 266 | G.h3s5.02 |
Hydrophobic | TM2 | L | 74 | 2x40 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM2 | L | 74 | 2x40 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL2 | L | 143 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Van-der-waals | ICL2 | L | 143 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Van-der-waals | C-term | L | 391 | - | G.H3 | Y | 261 | G.H3.15 |
Ionic | ICL3 | R | 280 | - | G.H5 | D | 346 | G.H5.13 |
Polar | ICL3 | R | 280 | - | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | ICL3 | R | 280 | - | G.H5 | D | 346 | G.H5.13 |
Polar | TM6 | D | 292 | 6x30 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | C-term | W | 386 | - | G.H3 | P | 262 | G.H3.16 |
Van-der-waals | C-term | W | 386 | - | G.H3 | P | 262 | G.H3.16 |
Hydrophobic | ICL3 | A | 244 | - | G.S6 | F | 328 | G.S6.05 |
Van-der-waals | ICL3 | A | 244 | - | G.S6 | F | 328 | G.S6.05 |
Ionic | TM6 | R | 287 | 6x25 | G.h4s6 | D | 321 | G.h4s6.12 |
Polar | TM6 | R | 287 | 6x25 | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | TM6 | R | 287 | 6x25 | G.h4s6 | D | 321 | G.h4s6.12 |
Van-der-waals | TM6 | R | 287 | 6x25 | G.h4s6 | D | 321 | G.h4s6.12 |
Polar | ICL3 | S | 284 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | ICL3 | S | 284 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Van-der-waals | ICL3 | S | 284 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | TM5 | L | 229 | 5x63 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | ICL2 | L | 143 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | L | 143 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Polar | ICL2 | H | 145 | 34x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM1 | A | 60 | 1x60 | G.H5 | L | 358 | G.H5.25 |
Polar | TM2 | S | 69 | 2x35 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM2 | S | 69 | 2x35 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | TM2 | S | 69 | 2x35 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | H8 | A | 357 | 8x49 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM6 | A | 288 | 6x26 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM6 | A | 288 | 6x26 | G.H5 | Q | 350 | G.H5.17 |