Gq -
EP2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 86.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 10.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM7 | F | 315 | 7x53 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM7 | F | 315 | 7x53 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM2 | S | 65 | 2x37 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | TM2 | S | 65 | 2x37 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ICL2 | Y | 142 | 34x51 | G.S3 | V | 199 | G.S3.01 |
Van-der-waals | ICL2 | Y | 142 | 34x51 | G.S3 | V | 199 | G.S3.01 |
Hydrophobic | H8 | P | 321 | 8x49 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | H8 | R | 319 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | R | 319 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | ICL2 | Y | 142 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | Y | 142 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | ICL2 | P | 141 | 34x50 | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | P | 141 | 34x50 | G.H5 | I | 348 | G.H5.15 |
Aromatic | TM2 | F | 67 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM2 | F | 67 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM2 | F | 67 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Polar | TM1 | R | 49 | 1x60 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM1 | R | 49 | 1x60 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM1 | R | 49 | 1x60 | G.H5 | V | 359 | G.H5.26 |
Polar | TM6 | H | 262 | 6x33 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM6 | H | 262 | 6x33 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM6 | H | 262 | 6x33 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM6 | E | 258 | 6x29 | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | TM6 | E | 258 | 6x29 | G.H5 | K | 354 | G.H5.21 |
Polar | ICL2 | Y | 142 | 34x51 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | ICL2 | Y | 142 | 34x51 | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | ICL2 | Y | 142 | 34x51 | G.H5 | K | 345 | G.H5.12 |
Polar | TM1 | R | 49 | 1x60 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM1 | R | 49 | 1x60 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM1 | R | 49 | 1x60 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM5 | M | 225 | 5x66 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM5 | M | 225 | 5x66 | G.H5 | L | 353 | G.H5.20 |
Polar | TM3 | E | 133 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | E | 133 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | E | 133 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM7 | A | 316 | 7x54 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM2 | H | 68 | 2x40 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM2 | H | 68 | 2x40 | G.H5 | L | 358 | G.H5.25 |
Polar | TM6 | E | 259 | 6x30 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | ICL2 | Y | 142 | 34x51 | G.s2s3 | S | 198 | G.s2s3.02 |
Polar | TM6 | H | 262 | 6x33 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM6 | H | 262 | 6x33 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM6 | H | 262 | 6x33 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM3 | I | 138 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM3 | I | 138 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | TM3 | I | 138 | 3x54 | G.H5 | Y | 356 | G.H5.23 |
Polar | TM3 | S | 137 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | S | 137 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | S | 137 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | Y | 142 | 34x51 | G.H5 | V | 344 | G.H5.11 |
Van-der-waals | ICL2 | Y | 142 | 34x51 | G.H5 | V | 344 | G.H5.11 |
Polar | ICL1 | R | 60 | - | G.h3s5 | N | 266 | G.h3s5.02 |
Hydrophobic | ICL1 | R | 60 | - | G.h3s5 | N | 266 | G.h3s5.02 |
Van-der-waals | ICL1 | R | 60 | - | G.h3s5 | N | 266 | G.h3s5.02 |
Polar | ICL2 | R | 146 | 34x55 | G.hns1 | R | 38 | G.hns1.03 |
Hydrophobic | ICL2 | R | 146 | 34x55 | G.hns1 | R | 38 | G.hns1.03 |
Van-der-waals | ICL2 | R | 146 | 34x55 | G.hns1 | R | 38 | G.hns1.03 |
Polar | ICL1 | R | 60 | - | G.H3 | P | 262 | G.H3.16 |
Hydrophobic | TM2 | F | 67 | 2x39 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM2 | F | 67 | 2x39 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL2 | Y | 142 | 34x51 | G.S1 | L | 40 | G.S1.02 |
Hydrophobic | TM6 | E | 259 | 6x30 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | ICL2 | P | 141 | 34x50 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | ICL2 | P | 141 | 34x50 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL2 | Q | 145 | 34x54 | G.S1 | L | 40 | G.S1.02 |
Hydrophobic | ICL2 | Y | 142 | 34x51 | G.S3 | F | 201 | G.S3.03 |
Polar | ICL2 | R | 146 | 34x55 | G.s2s3 | Q | 197 | G.s2s3.01 |
Van-der-waals | ICL2 | R | 146 | 34x55 | G.s2s3 | Q | 197 | G.s2s3.01 |
Polar | TM3 | R | 134 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | R | 134 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | R | 134 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | I | 138 | 3x54 | G.H5 | N | 352 | G.H5.19 |
Polar | ICL2 | Y | 142 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Aromatic | ICL2 | Y | 142 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Hydrophobic | ICL2 | Y | 142 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Van-der-waals | ICL2 | Y | 142 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Hydrophobic | TM6 | H | 262 | 6x33 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM5 | L | 222 | 5x63 | G.H5 | L | 353 | G.H5.20 |
Polar | ICL1 | R | 60 | - | G.h3s5 | Q | 265 | G.h3s5.01 |
Hydrophobic | ICL1 | R | 60 | - | G.h3s5 | Q | 265 | G.h3s5.01 |
Van-der-waals | ICL1 | R | 60 | - | G.h3s5 | Q | 265 | G.h3s5.01 |
Ionic | ICL3 | R | 248 | - | G.H4 | D | 315 | G.H4.17 |
Hydrophobic | H8 | P | 320 | 8x48 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | P | 320 | 8x48 | G.H5 | N | 357 | G.H5.24 |
Polar | ICL2 | R | 146 | 34x55 | G.s2s3 | S | 198 | G.s2s3.02 |
Hydrophobic | H8 | P | 321 | 8x49 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | H8 | P | 321 | 8x49 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | ICL2 | P | 141 | 34x50 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | TM5 | M | 225 | 5x66 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM3 | S | 137 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Polar | TM3 | S | 137 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Polar | H8 | R | 319 | 8x47 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | H8 | R | 319 | 8x47 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | H8 | R | 319 | 8x47 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM3 | I | 138 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM5 | M | 225 | 5x66 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM5 | M | 225 | 5x66 | G.H5 | Q | 350 | G.H5.17 |