Gs - GPR65 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 87.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 R 112 3x50 G.H5 L 393 G.H5.25
Hydrophobic ICL3 K 214 - G.S6 Y 360 G.S6.02
Hydrophobic C-term M 331 - G.h4s6 R 356 G.h4s6.12
Polar ICL3 K 214 - G.H5 D 381 G.H5.13
Hydrophobic ICL3 K 214 - G.H5 D 381 G.H5.13
Van-der-waals ICL3 K 214 - G.H5 D 381 G.H5.13
Hydrophobic TM2 L 49 2x39 G.H5 E 392 G.H5.24
Polar TM2 E 48 2x38 G.H5 Y 391 G.H5.23
Hydrophobic TM2 E 48 2x38 G.H5 Y 391 G.H5.23
Van-der-waals TM2 E 48 2x38 G.H5 Y 391 G.H5.23
Hydrophobic C-term D 329 - G.h3s5 T 284 G.h3s5.02
Hydrophobic TM3 V 116 3x54 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 119 34x50 G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 119 34x50 G.H5 H 387 G.H5.19
Polar ICL3 N 213 - G.H5 D 381 G.H5.13
Hydrophobic ICL3 N 213 - G.H5 D 381 G.H5.13
Van-der-waals ICL3 N 213 - G.H5 D 381 G.H5.13
Polar ICL3 K 214 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 K 214 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 P 119 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 119 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM6 I 224 6x33 G.H5 L 388 G.H5.20
Polar TM1 Q 42 1x60 G.H5 E 392 G.H5.24
Hydrophobic TM1 Q 42 1x60 G.H5 E 392 G.H5.24
Van-der-waals TM1 Q 42 1x60 G.H5 E 392 G.H5.24
Hydrophobic TM6 I 224 6x33 G.H5 L 394 G.H5.26
Hydrophobic TM6 E 220 6x29 G.H5 L 394 G.H5.26
Polar TM3 V 116 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 116 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 116 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM7 Y 290 7x53 G.H5 E 392 G.H5.24
Ionic C-term E 332 - G.h4s6 R 356 G.h4s6.12
Polar C-term E 332 - G.h4s6 R 356 G.h4s6.12
Hydrophobic C-term V 325 - G.H5 R 389 G.H5.21
Ionic ICL1 E 46 - G.hns1 R 38 G.hns1.02
Polar ICL1 E 46 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL1 E 46 - G.hns1 R 38 G.hns1.02
Polar TM3 R 112 3x50 G.H5 E 392 G.H5.24
Van-der-waals TM3 R 112 3x50 G.H5 E 392 G.H5.24
Polar ICL3 A 215 - G.H5 R 385 G.H5.17
Hydrophobic ICL3 A 215 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 A 215 - G.H5 R 385 G.H5.17
Hydrophobic TM6 I 224 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 I 224 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 119 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 119 34x50 G.H5 R 380 G.H5.12
Hydrophobic ICL2 L 120 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 120 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 L 120 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM3 V 116 3x54 G.H5 L 388 G.H5.20
Van-der-waals ICL3 T 216 - G.H5 R 385 G.H5.17
Ionic C-term K 328 - G.h2s4 D 240 G.h2s4.03
Polar C-term K 328 - G.h2s4 D 240 G.h2s4.03
Hydrophobic C-term K 328 - G.h2s4 D 240 G.h2s4.03
Van-der-waals C-term K 328 - G.h2s4 D 240 G.h2s4.03
Hydrophobic TM6 L 228 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL3 A 215 - G.S6 Y 360 G.S6.02
Van-der-waals ICL3 A 215 - G.S6 Y 360 G.S6.02
Hydrophobic ICL3 A 215 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 A 215 - G.h4s6 Y 358 G.h4s6.20
Polar ICL2 R 126 34x57 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 R 126 34x57 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 R 126 34x57 G.H5 Y 391 G.H5.23
Polar H8 T 294 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 T 294 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 T 294 8x47 G.H5 E 392 G.H5.24
Polar TM3 R 112 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 112 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 112 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM5 V 206 5x61 G.H5 L 393 G.H5.25
Polar ICL2 R 126 34x57 G.H5 H 387 G.H5.19
Hydrophobic ICL2 R 126 34x57 G.H5 H 387 G.H5.19
Van-der-waals ICL2 R 126 34x57 G.H5 H 387 G.H5.19
Ionic TM6 E 220 6x29 G.H5 R 385 G.H5.17
Polar TM6 E 220 6x29 G.H5 R 385 G.H5.17
Hydrophobic TM6 E 220 6x29 G.H5 R 385 G.H5.17
Van-der-waals TM6 E 220 6x29 G.H5 R 385 G.H5.17
Hydrophobic TM5 A 209 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 A 209 5x64 G.H5 Q 384 G.H5.16
Ionic C-term D 329 - G.H5 R 389 G.H5.21
Polar C-term D 329 - G.H5 R 389 G.H5.21
Hydrophobic C-term D 329 - G.H5 R 389 G.H5.21
Van-der-waals C-term D 329 - G.H5 R 389 G.H5.21
Hydrophobic TM2 L 53 2x43 G.H5 E 392 G.H5.24
Van-der-waals TM2 L 53 2x43 G.H5 E 392 G.H5.24
Hydrophobic ICL2 F 123 34x54 G.S1 H 41 G.S1.02
Polar TM3 A 115 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 115 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 115 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 120 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 120 34x51 G.H5 I 383 G.H5.15
Ionic ICL1 E 46 - G.HN K 34 G.HN.51
Polar ICL1 E 46 - G.HN K 34 G.HN.51
Van-der-waals ICL1 E 46 - G.HN K 34 G.HN.51
Hydrophobic TM6 L 227 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM3 A 115 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 115 3x53 G.H5 Y 391 G.H5.23
Hydrophobic C-term K 328 - G.h2s4 N 239 G.h2s4.02
Van-der-waals C-term K 328 - G.h2s4 N 239 G.h2s4.02
Hydrophobic ICL2 L 120 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 120 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM2 L 49 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 L 49 2x39 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 119 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM5 V 210 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 V 210 5x65 G.H5 L 388 G.H5.20
Polar ICL3 N 213 - G.H5 Q 384 G.H5.16
Hydrophobic ICL3 N 213 - G.H5 Q 384 G.H5.16
Van-der-waals ICL3 N 213 - G.H5 Q 384 G.H5.16
Ionic ICL2 K 121 34x52 G.s2s3 D 215 G.s2s3.01
Polar ICL2 K 121 34x52 G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL2 K 121 34x52 G.s2s3 D 215 G.s2s3.01
Polar ICL3 A 215 - G.H5 D 381 G.H5.13
Van-der-waals ICL3 A 215 - G.H5 D 381 G.H5.13
Hydrophobic ICL3 T 216 - G.H5 L 394 G.H5.26
Hydrophobic ICL2 L 120 34x51 G.S3 V 217 G.S3.01
Hydrophobic TM3 D 111 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 111 3x49 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 123 34x54 G.hns1 A 39 G.hns1.03