Gi3 - SST5 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 A 140 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 144 34x50 G.H5 I 344 G.H5.16
Hydrophobic H8 S 308 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM7 L 307 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM3 V 141 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 141 3x54 G.H5 L 348 G.H5.20
Ionic TM5 R 234 5x71 G.H5 D 337 G.H5.09
Polar TM5 R 234 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 R 234 5x71 G.H5 D 337 G.H5.09
Van-der-waals TM5 R 234 5x71 G.H5 D 337 G.H5.09
Polar TM3 R 137 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 137 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 137 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 73 2x37 G.H5 E 350 G.H5.22
Van-der-waals TM2 T 73 2x37 G.H5 E 350 G.H5.22
Hydrophobic TM5 V 228 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM5 V 235 5x72 G.H5 D 341 G.H5.13
Ionic ICL2 R 149 34x55 G.s2s3 D 193 G.s2s3.02
Polar ICL2 R 149 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 149 34x55 G.s2s3 D 193 G.s2s3.02
Polar ICL2 R 151 34x57 G.H5 C 351 G.H5.23
Ionic ICL3 R 239 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 239 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 239 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 239 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 V 235 5x72 G.S6 Y 320 G.S6.02
Ionic TM6 R 241 6x28 G.h4s6 D 315 G.h4s6.09
Polar TM6 R 241 6x28 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 R 241 6x28 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 R 241 6x28 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 M 249 6x36 G.H5 Y 354 G.H5.26
Van-der-waals TM6 M 249 6x36 G.H5 Y 354 G.H5.26
Polar TM2 T 75 2x39 G.H5 E 350 G.H5.22
Van-der-waals TM2 T 75 2x39 G.H5 E 350 G.H5.22
Hydrophobic TM5 A 231 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 A 231 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 Y 221 5x58 G.H5 L 353 G.H5.25
Ionic ICL2 R 151 34x57 G.H5 E 350 G.H5.22
Polar ICL2 R 151 34x57 G.H5 E 350 G.H5.22
Hydrophobic ICL2 R 151 34x57 G.H5 E 350 G.H5.22
Van-der-waals ICL2 R 151 34x57 G.H5 E 350 G.H5.22
Hydrophobic TM5 V 235 5x72 G.H5 D 337 G.H5.09
Van-der-waals TM5 V 235 5x72 G.H5 D 337 G.H5.09
Polar TM6 K 245 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM6 K 245 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 245 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM5 V 228 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 144 34x50 G.H5 T 340 G.H5.12
Polar TM3 A 140 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 140 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 140 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM2 T 75 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM5 A 231 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM6 V 246 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL3 R 239 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 R 239 - G.H5 K 345 G.H5.17
Hydrophobic ICL2 R 149 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 L 145 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM6 M 249 6x36 G.H5 G 352 G.H5.24
Hydrophobic ICL2 P 144 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 144 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 A 148 34x54 G.hns1 K 32 G.hns1.03
Ionic ICL3 R 239 - G.H5 D 341 G.H5.13
Polar ICL3 R 239 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 239 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 239 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 L 145 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 L 145 34x51 G.S3 L 194 G.S3.01
Polar ICL3 R 239 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 R 239 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 R 239 - G.S6 Y 320 G.S6.02
Hydrophobic TM6 M 249 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 249 6x36 G.H5 L 353 G.H5.25
Polar TM3 R 137 3x50 G.H5 G 352 G.H5.24
Van-der-waals TM3 R 137 3x50 G.H5 G 352 G.H5.24
Hydrophobic TM3 V 141 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 141 3x54 G.H5 I 344 G.H5.16
Polar ICL3 C 237 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 C 237 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 C 237 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 I 224 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM5 V 235 5x72 G.H5 A 338 G.H5.10
Ionic TM4 R 152 4x38 G.HN E 28 G.HN.52
Polar TM4 R 152 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 R 152 4x38 G.HN E 28 G.HN.52
Hydrophobic TM5 K 227 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 K 227 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM3 R 137 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 137 3x50 G.H5 L 353 G.H5.25