ACKR2 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active

VERSION

2020-10-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

CCR6 (sequence similarity: 59%) PDB: 6WWZ

TEMPLATES

6WWZ (CCR6)
5UIW (CCR5)
5T1A (CCR2)
4ZUD (AT1 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 87.2 7.7 5.1
Side-chains 34.3 50.5 15.2

Number of backbone templates: 4
Number of rotamer templates: 43

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 36 C CCR6 6WWZ CCR6 6WWZ
N-term 37 R CCR6 6WWZ CCR6 6WWZ
N-term 38 K CCR6 6WWZ CCR6 6WWZ
N-term 39 D CCR6 6WWZ CCR6 6WWZ
N-term 40 A CCR6 6WWZ CCR6 6WWZ
TM1 41 V 1.27x27 CCR6 6WWZ CCR6 6WWZ
TM1 42 V 1.28x28 CCR6 6WWZ - -
TM1 43 S 1.29x29 CCR6 6WWZ PAR1 3VW7
TM1 44 F 1.30x30 CCR6 6WWZ CCR6 6WWZ
TM1 45 G 1.31x31 CCR6 6WWZ A2A receptor 5WF5
TM1 46 K 1.32x32 CCR6 6WWZ CXCR2 6LFO
TM1 47 V 1.33x33 CCR6 6WWZ AT1 receptor 6OS2
TM1 48 F 1.34x34 CCR6 6WWZ CCR6 6WWZ
TM1 49 L 1.35x35 CCR6 6WWZ Rhodopsin 4ZWJ
TM1 50 P 1.36x36 CCR6 6WWZ CCR6 6WWZ
TM1 51 V 1.37x37 CCR6 6WWZ FPR2/ALX 6LW5
TM1 52 F 1.38x38 CCR6 6WWZ EP3 receptor 6M9T
TM1 53 Y 1.39x39 CCR6 6WWZ CCR6 6WWZ
TM1 54 S 1.40x40 CCR6 6WWZ CCR6 6WWZ
TM1 55 L 1.41x41 CCR6 6WWZ CCR6 6WWZ
TM1 56 I 1.42x42 CCR6 6WWZ CCR6 6WWZ
TM1 57 F 1.43x43 CCR6 6WWZ CXCR2 6LFO
TM1 58 V 1.44x44 CCR6 6WWZ CCR6 6WWZ
TM1 59 L 1.45x45 CCR6 6WWZ CXCR2 6LFO
TM1 60 G 1.46x46 CCR6 6WWZ CCR6 6WWZ
TM1 61 L 1.47x47 CCR6 6WWZ CCR6 6WWZ
TM1 62 S 1.48x48 CCR6 6WWZ Y1 receptor 5ZBH
TM1 63 G 1.49x49 CCR6 6WWZ CCR6 6WWZ
TM1 64 N 1.50x50 CCR6 6WWZ CCR6 6WWZ
TM1 65 L 1.51x51 CCR6 6WWZ M1 receptor 6OIJ
TM1 66 L 1.52x52 CCR6 6WWZ CCR6 6WWZ
TM1 67 L 1.53x53 CCR6 6WWZ GPBA receptor 7CFN
TM1 68 L 1.54x54 CCR6 6WWZ NTS1 receptor 6OSA
TM1 69 M 1.55x55 CCR6 6WWZ 5-HT2C receptor 6BQG
TM1 70 V 1.56x56 CCR6 6WWZ CXCR2 6LFO
TM1 71 L 1.57x57 CCR6 6WWZ NTS1 receptor 6OSA
TM1 72 L 1.58x58 CCR6 6WWZ CXCR2 6LFO
TM1 73 R 1.59x59 CCR6 6WWZ μ receptor 5C1M
TM1 74 Y 1.60x60 CCR6 6WWZ CCR6 6WWZ
ICL1 75 V 12.48x48 CCR6 6WWZ - -
ICL1 76 P 12.49x49 CCR6 6WWZ - -
ICL1 77 R 12.50x50 CCR6 6WWZ - -
ICL1 78 R 12.51x51 CCR6 6WWZ CCR6 6WWZ
TM2 79 R 2.37x37 CCR6 6WWZ CB1 receptor 6KPG
TM2 80 M 2.38x38 CCR6 6WWZ CCR6 6WWZ
TM2 81 V 2.39x39 CCR6 6WWZ NTS1 receptor 6OSA
TM2 82 E 2.40x40 CCR6 6WWZ - -
TM2 83 I 2.41x41 CCR6 6WWZ AT2 receptor 6JOD
TM2 84 Y 2.42x42 CCR6 6WWZ CCR6 6WWZ
TM2 85 L 2.43x43 CCR6 6WWZ CCR6 6WWZ
TM2 86 L 2.44x44 CCR6 6WWZ CCR6 6WWZ
TM2 87 N 2.45x45 CCR6 6WWZ CCR6 6WWZ
TM2 88 L 2.46x46 CCR6 6WWZ CXCR2 6LFO
TM2 89 A 2.47x47 CCR6 6WWZ CCR6 6WWZ
TM2 90 I 2.48x48 CCR6 6WWZ CCR6 6WWZ
TM2 91 S 2.49x49 CCR6 6WWZ NTS1 receptor 6OSA
TM2 92 N 2.50x50 CCR6 6WWZ A2A receptor 5WF5
TM2 93 L 2.51x51 CCR6 6WWZ CXCR2 6LFO
TM2 94 L 2.52x52 CCR6 6WWZ CCR6 6WWZ
TM2 95 F 2.53x53 CCR6 6WWZ CCR6 6WWZ
TM2 96 L 2.54x54 CCR6 6WWZ AT1 receptor 6OS2
TM2 97 V 2.55x55 CCR6 6WWZ M2 receptor 4MQT
TM2 98 T 2.56x56 CCR6 6WWZ CCR6 6WWZ
TM2 99 L 2.57x57 CCR6 6WWZ CCR6 6WWZ
TM2 100 P 2.58x58 CCR6 6WWZ CCR6 6WWZ
TM2 101 F 2.59x59 CCR6 6WWZ CCR6 6WWZ
TM2 102 W 2.60x60 CCR6 6WWZ CCR6 6WWZ
TM2 103 G 2.61x61 CCR6 6WWZ NOP receptor 5DHG
TM2 104 I 2.62x62 CCR6 6WWZ CB1 receptor 6N4B
TM2 105 S 2.63x63 CCR6 6WWZ CCR6 6WWZ
TM2 106 V 2.64x64 CCR6 6WWZ - -
TM2 107 A 2.65x65 CCR6 6WWZ CCR6 6WWZ
TM2 108 W 2.66x66 CCR6 6WWZ NTS1 receptor 6OSA
ECL1 109 H 23.49x49 - - - -
ECL1 110 W 23.50x50 CCR5 5UIW CCR5 5UIW
ECL1 111 V 23.51x51 CCR5 5UIW CCR6 6WWZ
ECL1 112 F 23.52x52 - - - -
TM3 113 G 3.21x21 CCR6 6WWZ AT1 receptor 6OS2
TM3 114 S 3.22x22 CCR6 6WWZ US28 5WB1
TM3 115 F 3.23x23 CCR6 6WWZ CXCR2 6LFO
TM3 116 L 3.24x24 CCR6 6WWZ CXCR2 6LFO
TM3 117 C 3.25x25 CCR6 6WWZ CCR6 6WWZ
TM3 118 K 3.26x26 CCR6 6WWZ CCR6 6WWZ
TM3 119 M 3.27x27 CCR6 6WWZ A1 receptor 6D9H
TM3 120 V 3.28x28 CCR6 6WWZ CXCR2 6LFO
TM3 121 S 3.29x29 CCR6 6WWZ CXCR2 6LFO
TM3 122 T 3.30x30 CCR6 6WWZ D2 receptor 6VMS
TM3 123 L 3.31x31 CCR6 6WWZ CXCR2 6LFO
TM3 124 Y 3.32x32 CCR6 6WWZ CCR6 6WWZ
TM3 125 T 3.33x33 CCR6 6WWZ AT2 receptor 6JOD
TM3 126 I 3.34x34 CCR6 6WWZ CCR6 6WWZ
TM3 127 N 3.35x35 CCR6 6WWZ CCR6 6WWZ
TM3 128 F 3.36x36 CCR6 6WWZ CCR6 6WWZ
TM3 129 Y 3.37x37 CCR6 6WWZ CXCR2 6LFO
TM3 130 S 3.38x38 CCR6 6WWZ CXCR2 6LFO
TM3 131 G 3.39x39 CCR6 6WWZ CCR6 6WWZ
TM3 132 I 3.40x40 CCR6 6WWZ CXCR2 6LFO
TM3 133 F 3.41x41 CCR6 6WWZ AT1 receptor 6OS2
TM3 134 F 3.42x42 CCR6 6WWZ AT2 receptor 6JOD
TM3 135 I 3.43x43 CCR6 6WWZ AT2 receptor 6JOD
TM3 136 S 3.44x44 CCR6 6WWZ EP3 receptor 6M9T
TM3 137 C 3.45x45 CCR6 6WWZ CCR6 6WWZ
TM3 138 M 3.46x46 CCR6 6WWZ AT2 receptor 6JOD
TM3 139 S 3.47x47 CCR6 6WWZ CCR6 6WWZ
TM3 140 L 3.48x48 CCR6 6WWZ US28 5WB1
TM3 141 D 3.49x49 CCR6 6WWZ CCR6 6WWZ
TM3 142 K 3.50x50 CCR6 6WWZ - -
TM3 143 Y 3.51x51 CCR6 6WWZ CCR6 6WWZ
TM3 144 L 3.52x52 CCR6 6WWZ CXCR2 6LFO
TM3 145 E 3.53x53 CCR6 6WWZ PAR2 5NDD
TM3 146 I 3.54x54 CCR6 6WWZ CCR6 6WWZ
TM3 147 V 3.55x55 CCR6 6WWZ CCR6 6WWZ
TM3 148 H 3.56x56 CCR5 5UIW CCR5 5UIW
ICL2 149 A 34.50x50 - - - -
ICL2 150 Q 34.51x51 CCR5 5UIW - -
ICL2 151 P 34.52x52 CCR5 5UIW - -
ICL2 152 Y 34.53x53 CCR5 5UIW β2-adrenoceptor 3SN6
ICL2 153 H 34.54x54 CCR5 5UIW CCR9 5LWE
ICL2 154 R 34.55x55 CCR5 5UIW CCR6 6WWZ
ICL2 155 L 34.56x56 CCR5 5UIW CCR6 6WWZ
ICL2 156 R 34.57x57 - - - -
TM4 157 T 4.38x38 CCR5 5UIW CCR5 5UIW
TM4 158 R 4.39x39 CCR6 6WWZ 5-HT2C receptor 6BQG
TM4 159 A 4.40x40 CCR6 6WWZ δ receptor 6PT2
TM4 160 K 4.41x41 CCR6 6WWZ κ receptor 6B73
TM4 161 S 4.42x42 CCR6 6WWZ CCR6 6WWZ
TM4 162 L 4.43x43 CCR6 6WWZ CB2 receptor 6PT0
TM4 163 L 4.44x44 CCR6 6WWZ US28 5WB1
TM4 164 L 4.45x45 CCR6 6WWZ CysLT2 receptor 6RZ6
TM4 165 A 4.46x46 CCR6 6WWZ - -
TM4 166 T 4.47x47 CCR6 6WWZ 5-HT2B receptor 4IB4
TM4 167 I 4.48x48 CCR6 6WWZ AT1 receptor 6OS2
TM4 168 V 4.49x49 CCR6 6WWZ CCR6 6WWZ
TM4 169 W 4.50x50 CCR6 6WWZ CCR6 6WWZ
TM4 170 A 4.51x51 CCR6 6WWZ 5-HT2C receptor 6BQG
TM4 171 V 4.52x52 CCR6 6WWZ β2-adrenoceptor 3SN6
TM4 172 S 4.53x53 CCR6 6WWZ CCR6 6WWZ
TM4 173 L 4.54x54 CCR6 6WWZ CXCR2 6LFO
TM4 174 A 4.55x55 CCR6 6WWZ μ receptor 5C1M
TM4 175 V 4.56x56 CCR6 6WWZ κ receptor 6B73
TM4 176 S 4.57x57 CCR5 5UIW CCR5 5UIW
TM4 177 I 4.58x59 CCR5 5UIW US28 5WB1
TM4 178 P 4.59x60 CCR6 6WWZ CXCR2 6LFO
TM4 179 D 4.60x61 CCR6 6WWZ CXCR4 3ODU
TM4 180 M 4.61x62 CCR6 6WWZ CB2 receptor 6PT0
TM4 181 V 4.62x63 CCR6 6WWZ 5-HT2A receptor 6WHA
TM4 182 F 4.63x64 CCR6 6WWZ - -
TM4 183 V 4.64x65 CCR5 5UIW ghrelin receptor 6KO5
ECL2 184 Q CCR6 6WWZ CCR6 6WWZ
ECL2 185 T CCR6 6WWZ - -
ECL2 186 H CCR6 6WWZ - -
ECL2 187 E CCR6 6WWZ - -
ECL2 188 N CCR6 6WWZ - -
ECL2 189 P CCR6 6WWZ - -
ECL2 190 K CCR6 6WWZ - -
ECL2 191 G CCR6 6WWZ - -
ECL2 192 V CCR6 6WWZ - -
ECL2 193 W CCR6 6WWZ - -
ECL2 194 N - - - -
ECL2 195 C 45.50x50 CCR6 6WWZ CCR6 6WWZ
ECL2 196 H 45.51x51 CCR6 6WWZ - -
ECL2 197 A 45.52x52 CCR6 6WWZ BLT1 receptor 5X33
ECL2 198 D - - - -
ECL2 199 F CCR5 5UIW - -
ECL2 200 G CCR5 5UIW - -
ECL2 201 G CCR5 5UIW CCR5 5UIW
ECL2 202 H - - - -
TM5 203 G 5.31x32 CCR6 6WWZ P2Y12 receptor 4NTJ
TM5 204 T 5.32x33 CCR6 6WWZ NTS1 receptor 6OSA
TM5 205 I 5.33x34 CCR6 6WWZ OX2 receptor 5WS3
TM5 206 W 5.34x35 CCR6 6WWZ CCR6 6WWZ
TM5 207 K 5.35x36 CCR6 6WWZ CCR6 6WWZ
TM5 208 L 5.36x37 CCR6 6WWZ CCR6 6WWZ
TM5 209 F 5.37x38 CCR6 6WWZ κ receptor 6B73
TM5 210 L 5.38x39 CCR6 6WWZ CXCR2 6LFO
TM5 211 R 5.39x40 CCR6 6WWZ CXCR2 6LFO
TM5 212 F 5.40x41 CCR6 6WWZ M1 receptor 6OIJ
TM5 213 Q 5.41x42 CCR6 6WWZ CXCR4 3ODU
TM5 214 Q 5.42x43 CCR6 6WWZ CCR7 6QZH
TM5 215 N 5.43x44 CCR6 6WWZ AT1 receptor 6OS2
TM5 216 L 5.44x45 CCR6 6WWZ CCR6 6WWZ
TM5 217 L 5.45x46 CCR6 6WWZ AT1 receptor 6OS2
TM5 218 G 5.46x461 CCR6 6WWZ CCR6 6WWZ
TM5 219 F 5.47x47 CCR6 6WWZ CCR6 6WWZ
TM5 220 L 5.48x48 CCR6 6WWZ AT1 receptor 6OS2
TM5 221 L 5.49x49 CCR6 6WWZ FPR2/ALX 6LW5
TM5 222 P 5.50x50 CCR6 6WWZ CCR6 6WWZ
TM5 223 L 5.51x51 CCR6 6WWZ CCR6 6WWZ
TM5 224 L 5.52x52 CCR6 6WWZ CXCR2 6LFO
TM5 225 A 5.53x53 CCR6 6WWZ CCR7 6QZH
TM5 226 M 5.54x54 CCR6 6WWZ CCR6 6WWZ
TM5 227 I 5.55x55 CCR6 6WWZ CCR6 6WWZ
TM5 228 F 5.56x56 CCR6 6WWZ CCR6 6WWZ
TM5 229 F 5.57x57 CCR6 6WWZ GPR52 6LI3
TM5 230 Y 5.58x58 CCR6 6WWZ CCR6 6WWZ
TM5 231 S 5.59x59 CCR6 6WWZ β2-adrenoceptor 3SN6
TM5 232 R 5.60x60 CCR6 6WWZ US28 5WB1
TM5 233 I 5.61x61 CCR6 6WWZ CCR6 6WWZ
TM5 234 G 5.62x62 CCR6 6WWZ ghrelin receptor 6KO5
TM5 235 C 5.63x63 CCR6 6WWZ ETB receptor 5X93
TM5 236 V 5.64x64 CCR6 6WWZ 5-HT2C receptor 6BQG
TM5 237 L 5.65x65 CCR6 6WWZ CCR6 6WWZ
TM5 238 V 5.66x66 CCR6 6WWZ CCR6 6WWZ
TM5 239 R 5.67x67 CCR6 6WWZ β2-adrenoceptor 3SN6
TM5 240 L 5.68x68 CCR6 6WWZ - -
ICL3 241 R - - - -
ICL3 242 P - - - -
TM6 243 A 6.28x28 CCR5 5UIW 5-HT1B receptor 6G79
TM6 244 G 6.29x29 CCR5 5UIW - -
TM6 245 Q 6.30x30 CCR6 6WWZ - -
TM6 246 G 6.31x31 CCR6 6WWZ US28 5WB1
TM6 247 R 6.32x32 CCR6 6WWZ CXCR2 6LFO
TM6 248 A 6.33x33 CCR6 6WWZ CCR6 6WWZ
TM6 249 L 6.34x34 CCR6 6WWZ AT2 receptor 6JOD
TM6 250 K 6.35x35 CCR6 6WWZ AT1 receptor 6OS2
TM6 251 I 6.36x36 CCR6 6WWZ AT1 receptor 6OS2
TM6 252 A 6.37x37 CCR6 6WWZ AT2 receptor 6JOD
TM6 253 A 6.38x38 CCR6 6WWZ AT2 receptor 6JOD
TM6 254 A 6.39x39 CCR6 6WWZ CCR6 6WWZ
TM6 255 L 6.40x40 CCR6 6WWZ CXCR4 3ODU
TM6 256 V 6.41x41 CCR6 6WWZ CCR6 6WWZ
TM6 257 V 6.42x42 CCR6 6WWZ δ receptor 6PT2
TM6 258 A 6.43x43 CCR6 6WWZ AT2 receptor 6JOD
TM6 259 F 6.44x44 CCR6 6WWZ CCR6 6WWZ
TM6 260 F 6.45x45 CCR6 6WWZ AT1 receptor 6OS2
TM6 261 V 6.46x46 CCR6 6WWZ κ receptor 6B73
TM6 262 L 6.47x47 CCR6 6WWZ GPR52 6LI3
TM6 263 W 6.48x48 CCR6 6WWZ CXCR2 6LFO
TM6 264 F 6.49x49 CCR6 6WWZ FPR2/ALX 6LW5
TM6 265 P 6.50x50 CCR6 6WWZ CCR6 6WWZ
TM6 266 Y 6.51x51 CCR6 6WWZ CXCR2 6LFO
TM6 267 N 6.52x52 CCR6 6WWZ CCR6 6WWZ
TM6 268 L 6.53x53 CCR6 6WWZ CXCR2 6LFO
TM6 269 T 6.54x54 CCR6 6WWZ US28 5WB1
TM6 270 L 6.55x55 CCR6 6WWZ CCR6 6WWZ
TM6 271 F 6.56x56 CCR6 6WWZ AT1 receptor 6OS2
TM6 272 L 6.57x57 CCR6 6WWZ AT1 receptor 6OS2
TM6 273 H 6.58x58 CCR6 6WWZ β2-adrenoceptor 3SN6
TM6 274 T 6.59x59 CCR6 6WWZ CXCR2 6LFO
TM6 275 L 6.60x60 CCR6 6WWZ CXCR2 6LFO
TM6 276 L 6.61x61 CCR2 5T1A ETB receptor 5X93
TM6 277 D 6.62x62 CCR2 5T1A - -
TM6 278 L 6.63x63 CCR2 5T1A AT1 receptor 6OS2
TM6 279 Q 6.64x64 CCR2 5T1A - -
ECL3 280 V - - - -
ECL3 281 F AT1 receptor 4ZUD - -
ECL3 282 G - - - -
TM7 283 N 7.24x23 CCR6 6WWZ CCR5 5UIW
TM7 284 C 7.25x24 CCR6 6WWZ CCR6 6WWZ
TM7 285 E 7.26x25 CCR6 6WWZ CXCR2 6LFO
TM7 286 V 7.27x26 CCR6 6WWZ AT2 receptor 6JOD
TM7 287 S 7.28x27 CCR6 6WWZ CCR5 5UIW
TM7 288 Q 7.29x28 CCR6 6WWZ PAF receptor 5ZKQ
TM7 289 H 7.30x29 CCR6 6WWZ CXCR2 6LFO
TM7 290 L 7.31x30 CCR6 6WWZ US28 5WB1
TM7 291 D 7.32x31 CCR6 6WWZ CXCR2 6LFO
TM7 292 Y 7.33x32 CCR6 6WWZ CCR6 6WWZ
TM7 293 A 7.34x33 CCR6 6WWZ CXCR2 6LFO
TM7 294 L 7.35x34 CCR6 6WWZ CXCR2 6LFO
TM7 295 Q 7.36x35 CCR6 6WWZ α2B-adrenoceptor 6K41
TM7 296 V 7.37x36 CCR6 6WWZ CCR6 6WWZ
TM7 297 T 7.38x37 CCR6 6WWZ CCR6 6WWZ
TM7 298 E 7.39x38 CCR6 6WWZ CCR6 6WWZ
TM7 299 S 7.40x39 CCR6 6WWZ US28 5WB1
TM7 300 I 7.41x40 CCR6 6WWZ AT1 receptor 6OS2
TM7 301 A 7.42x41 CCR6 6WWZ CCR6 6WWZ
TM7 302 F 7.43x42 CCR6 6WWZ CCR6 6WWZ
TM7 303 L 7.44x43 CCR6 6WWZ CCR6 6WWZ
TM7 304 H 7.45x45 CCR6 6WWZ CCR6 6WWZ
TM7 305 C 7.46x46 CCR6 6WWZ CCR6 6WWZ
TM7 306 C 7.47x47 CCR6 6WWZ CCR6 6WWZ
TM7 307 F 7.48x48 CCR6 6WWZ β2-adrenoceptor 3SN6
TM7 308 S 7.49x49 CCR6 6WWZ - -
TM7 309 P 7.50x50 CCR6 6WWZ CCR6 6WWZ
TM7 310 I 7.51x51 CCR6 6WWZ NTS1 receptor 6OSA
TM7 311 L 7.52x52 CCR6 6WWZ CCR6 6WWZ
TM7 312 Y 7.53x53 CCR6 6WWZ CCR6 6WWZ
TM7 313 A 7.54x54 CCR6 6WWZ CCR6 6WWZ
TM7 314 F 7.55x55 CCR6 6WWZ CCR6 6WWZ
TM7 315 S 7.56x56 CCR6 6WWZ 5-HT1B receptor 6G79
H8 316 S 8.47x47 CCR6 6WWZ β2-adrenoceptor 3SN6
H8 317 H 8.48x48 CCR6 6WWZ PAR2 5NDD
H8 318 R 8.49x49 CCR6 6WWZ AT2 receptor 6JOD
H8 319 F 8.50x50 CCR6 6WWZ CCR6 6WWZ
H8 320 R 8.51x51 CCR6 6WWZ CCR6 6WWZ
H8 321 Q 8.52x52 CCR6 6WWZ AT2 receptor 6JOD
H8 322 Y 8.53x53 CCR6 6WWZ CCR6 6WWZ
H8 323 L 8.54x54 CCR6 6WWZ CXCR2 6LFO
H8 324 K 8.55x55 CCR6 6WWZ M2 receptor 4MQT
H8 325 A 8.56x56 CCR6 6WWZ NTS1 receptor 6OSA
H8 326 F 8.57x57 CCR6 6WWZ CCR5 5UIW
H8 327 L 8.58x58 CCR6 6WWZ CCR6 6WWZ
C-term 328 A CCR6 6WWZ CCR6 6WWZ
C-term 329 A - - - -
C-term 330 V - - - -
C-term 331 L - - - -
C-term 332 G - - - -