ACKR4 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive

VERSION

2020-09-02

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

CCR7 (sequence similarity: 59%) PDB: 6QZH

TEMPLATES

5LWE (CCR9)
6QZH (CCR7)
5ZBH (Y1 receptor)
5UIW (CCR5)
6RNK (succinate receptor)
6J21 (NK1 receptor)
6WWZ (CCR6)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 74.5 19.2 6.3
Side-chains 35.1 45.7 19.2

Number of backbone templates: 7
Number of rotamer templates: 39

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 31 C CCR9 5LWE CCR9 5LWE
N-term 32 I CCR9 5LWE CCR9 5LWE
N-term 33 K CCR9 5LWE CCR9 5LWE
N-term 34 E CCR9 5LWE CCR9 5LWE
N-term 35 D CCR9 5LWE CCR9 5LWE
TM1 36 V 1.27x27 CCR9 5LWE CCR9 5LWE
TM1 37 R 1.28x28 CCR9 5LWE CCR9 5LWE
TM1 38 E 1.29x29 CCR9 5LWE OT receptor 6TPK
TM1 39 F 1.30x30 CCR7 6QZH CCR7 6QZH
TM1 40 A 1.31x31 CCR7 6QZH CCR9 5LWE
TM1 41 K 1.32x32 CCR7 6QZH CXCR4 3ODU
TM1 42 V 1.33x33 CCR7 6QZH AT1 receptor 4ZUD
TM1 43 F 1.34x34 CCR7 6QZH CCR7 6QZH
TM1 44 L 1.35x35 CCR7 6QZH CCR7 6QZH
TM1 45 P 1.36x36 CCR7 6QZH CCR7 6QZH
TM1 46 V 1.37x37 CCR7 6QZH C5a1 receptor 5O9H
TM1 47 F 1.38x38 CCR7 6QZH succinate receptor 6RNK
TM1 48 L 1.39x39 CCR7 6QZH BLT1 receptor 5X33
TM1 49 T 1.40x40 CCR7 6QZH NK1 receptor 6HLP
TM1 50 I 1.41x41 CCR7 6QZH CCR7 6QZH
TM1 51 V 1.42x42 CCR7 6QZH CCR9 5LWE
TM1 52 F 1.43x43 CCR7 6QZH CCR9 5LWE
TM1 53 V 1.44x44 CCR7 6QZH AT1 receptor 4ZUD
TM1 54 I 1.45x45 CCR7 6QZH M5 receptor 6OL9
TM1 55 G 1.46x46 CCR7 6QZH CCR7 6QZH
TM1 56 L 1.47x47 CCR7 6QZH CCR7 6QZH
TM1 57 A 1.48x48 CCR7 6QZH 5-HT2A receptor 6A94
TM1 58 G 1.49x49 CCR7 6QZH CCR7 6QZH
TM1 59 N 1.50x50 CCR7 6QZH CCR7 6QZH
TM1 60 S 1.51x51 CCR7 6QZH CCR9 5LWE
TM1 61 M 1.52x52 CCR7 6QZH PAR2 5NDD
TM1 62 V 1.53x53 CCR7 6QZH CCR7 6QZH
TM1 63 V 1.54x54 CCR7 6QZH CCR7 6QZH
TM1 64 A 1.55x55 CCR7 6QZH 5-HT1B receptor 4IAQ
TM1 65 I 1.56x56 CCR7 6QZH CCR5 5UIW
TM1 66 Y 1.57x57 CCR7 6QZH CCR7 6QZH
TM1 67 A 1.58x58 CCR7 6QZH C5a1 receptor 5O9H
TM1 68 Y 1.59x59 CCR7 6QZH CCR7 6QZH
TM1 69 Y 1.60x60 CCR9 5LWE CCR5 5UIW
ICL1 70 K 12.48x48 CCR7 6QZH 5-HT2A receptor 6A94
ICL1 71 K 12.49x49 CCR7 6QZH AT1 receptor 4YAY
ICL1 72 Q 12.50x50 CCR7 6QZH - -
ICL1 73 R 12.51x51 CCR7 6QZH Y1 receptor 5ZBH
TM2 74 T 2.37x37 CCR7 6QZH CCR7 6QZH
TM2 75 K 2.38x38 CCR7 6QZH - -
TM2 76 T 2.39x39 CCR7 6QZH CCR7 6QZH
TM2 77 D 2.40x40 CCR7 6QZH CCR7 6QZH
TM2 78 V 2.41x41 CCR7 6QZH AT1 receptor 4ZUD
TM2 79 Y 2.42x42 CCR7 6QZH CCR7 6QZH
TM2 80 I 2.43x43 CCR7 6QZH apelin receptor 5VBL
TM2 81 L 2.44x44 CCR7 6QZH CCR7 6QZH
TM2 82 N 2.45x45 CCR7 6QZH CCR7 6QZH
TM2 83 L 2.46x46 CCR7 6QZH CCR7 6QZH
TM2 84 A 2.47x47 CCR7 6QZH CCR7 6QZH
TM2 85 V 2.48x48 CCR7 6QZH CCR7 6QZH
TM2 86 A 2.49x49 CCR7 6QZH CCR7 6QZH
TM2 87 D 2.50x50 CCR7 6QZH CCR7 6QZH
TM2 88 L 2.51x51 CCR7 6QZH CCR9 5LWE
TM2 89 L 2.52x52 CCR7 6QZH CCR7 6QZH
TM2 90 L 2.53x53 CCR7 6QZH 5-HT2A receptor 6A94
TM2 91 L 2.54x54 CCR7 6QZH CCR7 6QZH
TM2 92 F 2.55x55 CCR7 6QZH 5-HT2A receptor 6A94
TM2 93 T 2.56x56 CCR7 6QZH CCR7 6QZH
TM2 94 L 2.57x57 CCR7 6QZH CCR7 6QZH
TM2 95 P 2.58x58 CCR7 6QZH CCR7 6QZH
TM2 96 F 2.59x59 CCR7 6QZH CCR7 6QZH
TM2 97 W 2.60x60 CCR7 6QZH CCR7 6QZH
TM2 98 A 2.61x61 CCR7 6QZH CCR7 6QZH
TM2 99 V 2.62x62 CCR7 6QZH CXCR4 3ODU
TM2 100 N 2.63x63 CCR7 6QZH μ receptor 4DKL
TM2 101 A 2.64x64 CCR7 6QZH CCR7 6QZH
TM2 102 V 2.65x65 CCR7 6QZH CXCR4 3ODU
TM2 103 H 2.66x66 CCR7 6QZH Rhodopsin 1GZM
ECL1 104 G 23.49x49 CCR7 6QZH MT1 receptor 6ME2
ECL1 105 W 23.50x50 CCR7 6QZH CCR7 6QZH
ECL1 106 V 23.51x51 CCR7 6QZH CCR7 6QZH
ECL1 107 L 23.52x52 CCR7 6QZH DP2 receptor 6D27
TM3 108 G 3.21x21 CCR7 6QZH CCR7 6QZH
TM3 109 K 3.22x22 CCR7 6QZH α2A-adrenoceptor 6KUX
TM3 110 I 3.23x23 CCR7 6QZH μ receptor 4DKL
TM3 111 M 3.24x24 CCR7 6QZH CCR5 5UIW
TM3 112 C 3.25x25 CCR7 6QZH CCR7 6QZH
TM3 113 K 3.26x26 CCR7 6QZH CCR7 6QZH
TM3 114 I 3.27x27 CCR7 6QZH AT1 receptor 4ZUD
TM3 115 T 3.28x28 CCR7 6QZH P2Y12 receptor 4NTJ
TM3 116 S 3.29x29 CCR7 6QZH AT1 receptor 4ZUD
TM3 117 A 3.30x30 CCR7 6QZH CCR7 6QZH
TM3 118 L 3.31x31 CCR7 6QZH CCR5 5UIW
TM3 119 Y 3.32x32 CCR7 6QZH CCR7 6QZH
TM3 120 T 3.33x33 CCR7 6QZH CXCR4 3ODU
TM3 121 L 3.34x34 CCR7 6QZH C5a1 receptor 5O9H
TM3 122 N 3.35x35 CCR7 6QZH CCR9 5LWE
TM3 123 F 3.36x36 CCR7 6QZH CCR7 6QZH
TM3 124 V 3.37x37 CCR7 6QZH - -
TM3 125 S 3.38x38 CCR7 6QZH CCR7 6QZH
TM3 126 G 3.39x39 CCR7 6QZH CCR7 6QZH
TM3 127 M 3.40x40 CCR7 6QZH CCR7 6QZH
TM3 128 Q 3.41x41 CCR7 6QZH - -
TM3 129 F 3.42x42 CCR7 6QZH CCR5 5UIW
TM3 130 L 3.43x43 CCR7 6QZH CCR7 6QZH
TM3 131 A 3.44x44 CCR7 6QZH CXCR4 3ODU
TM3 132 C 3.45x45 CCR7 6QZH CCR7 6QZH
TM3 133 I 3.46x46 CCR7 6QZH CCR7 6QZH
TM3 134 S 3.47x47 CCR7 6QZH CCR7 6QZH
TM3 135 I 3.48x48 CCR7 6QZH CCR7 6QZH
TM3 136 D 3.49x49 CCR7 6QZH CCR7 6QZH
TM3 137 R 3.50x50 CCR7 6QZH CCR7 6QZH
TM3 138 Y 3.51x51 CCR7 6QZH CCR7 6QZH
TM3 139 V 3.52x52 CCR7 6QZH CCR7 6QZH
TM3 140 A 3.53x53 CCR7 6QZH CCR7 6QZH
TM3 141 V 3.54x54 CCR7 6QZH CCR5 5UIW
TM3 142 T 3.55x55 CCR7 6QZH β2-adrenoceptor 3P0G
TM3 143 K 3.56x56 CCR9 5LWE C5a1 receptor 5O9H
ICL2 144 V - - - -
ICL2 145 P Y1 receptor 5ZBH - -
ICL2 146 S Y1 receptor 5ZBH - -
ICL2 147 Q Y1 receptor 5ZBH - -
ICL2 148 S Y1 receptor 5ZBH - -
ICL2 149 G - - - -
TM4 150 V 4.38x38 CCR7 6QZH CCR7 6QZH
TM4 151 G 4.39x39 CCR7 6QZH A2A receptor 3VG9
TM4 152 K 4.40x40 CCR7 6QZH OX2 receptor 5WS3
TM4 153 P 4.41x41 CCR7 6QZH - -
TM4 154 C 4.42x42 CCR7 6QZH - -
TM4 155 W 4.43x43 CCR7 6QZH C5a1 receptor 5O9H
TM4 156 I 4.44x44 CCR7 6QZH μ receptor 4DKL
TM4 157 I 4.45x45 CCR7 6QZH κ receptor 6VI4
TM4 158 C 4.46x46 CCR7 6QZH CCR7 6QZH
TM4 159 F 4.47x47 CCR7 6QZH CCR9 5LWE
TM4 160 C 4.48x48 CCR7 6QZH μ receptor 4DKL
TM4 161 V 4.49x49 CCR7 6QZH CXCR4 3ODU
TM4 162 W 4.50x50 CCR7 6QZH CCR7 6QZH
TM4 163 M 4.51x51 CCR7 6QZH - -
TM4 164 A 4.52x52 CCR7 6QZH BLT1 receptor 5X33
TM4 165 A 4.53x53 CCR7 6QZH CCR7 6QZH
TM4 166 I 4.54x54 CCR7 6QZH 5-HT2C receptor 6BQH
TM4 167 L 4.55x55 CCR7 6QZH CXCR4 3ODU
TM4 168 L 4.56x56 CCR7 6QZH CCR7 6QZH
TM4 169 S 4.57x57 CCR7 6QZH CCR7 6QZH
TM4 170 I 4.58x59 CCR7 6QZH CCR7 6QZH
TM4 171 P 4.59x60 CCR7 6QZH CCR7 6QZH
TM4 172 Q 4.60x61 CCR7 6QZH OX2 receptor 5WS3
TM4 173 L 4.61x62 CCR7 6QZH CCR7 6QZH
TM4 174 V 4.62x63 CCR7 6QZH apelin receptor 5VBL
TM4 175 F 4.63x64 CCR7 6QZH CCR5 5UIW
TM4 176 Y 4.64x65 CCR5 5UIW - -
ECL2 177 T - - - -
ECL2 178 V succinate receptor 6RNK - -
ECL2 179 N succinate receptor 6RNK - -
ECL2 180 D succinate receptor 6RNK - -
ECL2 181 N succinate receptor 6RNK - -
ECL2 182 A succinate receptor 6RNK - -
ECL2 183 R - - - -
ECL2 184 C 45.50x50 CCR7 6QZH CCR7 6QZH
ECL2 185 I 45.51x51 CCR7 6QZH AT2 receptor 6JOD
ECL2 186 P 45.52x52 CCR7 6QZH CCR2 5T1A
ECL2 187 I - - - -
ECL2 188 F NK1 receptor 6J21 - -
ECL2 189 P NK1 receptor 6J21 NK1 receptor 6J21
ECL2 190 R NK1 receptor 6J21 - -
ECL2 191 Y NK1 receptor 6J21 - -
ECL2 192 L NK1 receptor 6J21 - -
ECL2 193 G NK1 receptor 6J21 - -
ECL2 194 T - - - -
TM5 195 S 5.33x34 CCR6 6WWZ Y1 receptor 5ZBH
TM5 196 M 5.34x35 CCR6 6WWZ FPR2/ALX 6LW5
TM5 197 K 5.35x36 CCR7 6QZH CCR5 5UIW
TM5 198 A 5.36x37 CCR7 6QZH BLT1 receptor 5X33
TM5 199 L 5.37x38 CCR7 6QZH μ receptor 4DKL
TM5 200 I 5.38x39 CCR7 6QZH CCR7 6QZH
TM5 201 Q 5.39x40 CCR7 6QZH CCR7 6QZH
TM5 202 M 5.40x41 CCR7 6QZH CB1 receptor 5TGZ
TM5 203 L 5.41x42 CCR7 6QZH Y1 receptor 5ZBH
TM5 204 E 5.42x43 CCR7 6QZH BLT1 receptor 5X33
TM5 205 I 5.43x44 CCR7 6QZH CXCR4 3ODU
TM5 206 C 5.44x45 CCR7 6QZH - -
TM5 207 I 5.45x46 CCR7 6QZH CCR7 6QZH
TM5 208 G 5.46x461 CCR7 6QZH CCR7 6QZH
TM5 209 F 5.47x47 CCR7 6QZH CCR7 6QZH
TM5 210 V 5.48x48 CCR7 6QZH CCR5 5UIW
TM5 211 V 5.49x49 CCR7 6QZH CCR7 6QZH
TM5 212 P 5.50x50 CCR7 6QZH CCR7 6QZH
TM5 213 F 5.51x51 CCR7 6QZH AT1 receptor 4ZUD
TM5 214 L 5.52x52 CCR7 6QZH CCR7 6QZH
TM5 215 I 5.53x53 CCR7 6QZH CCR2 5T1A
TM5 216 M 5.54x54 CCR7 6QZH CCR7 6QZH
TM5 217 G 5.55x55 CCR7 6QZH NK1 receptor 6HLP
TM5 218 V 5.56x56 CCR7 6QZH μ receptor 4DKL
TM5 219 C 5.57x57 CCR7 6QZH CCR7 6QZH
TM5 220 Y 5.58x58 CCR7 6QZH CCR7 6QZH
TM5 221 F 5.59x59 CCR7 6QZH apelin receptor 5VBL
TM5 222 I 5.60x60 CCR7 6QZH CXCR4 3ODU
TM5 223 T 5.61x61 CCR7 6QZH 5-HT2A receptor 6A94
TM5 224 A 5.62x62 CCR7 6QZH apelin receptor 5VBL
TM5 225 R 5.63x63 CCR6 6WWZ BLT1 receptor 5X33
TM5 226 T 5.64x64 CCR6 6WWZ CCR6 6WWZ
TM5 227 L 5.65x65 CCR6 6WWZ CCR6 6WWZ
TM5 228 M 5.66x66 CCR6 6WWZ - -
TM5 229 K 5.67x67 CCR6 6WWZ 5-HT2A receptor 6A94
TM5 230 M 5.68x68 CCR6 6WWZ - -
ICL3 231 P - - - -
ICL3 232 N - - - -
ICL3 233 I - - - -
ICL3 234 K - - - -
TM6 235 I 6.30x30 CCR9 5LWE - -
TM6 236 S 6.31x31 CCR9 5LWE FPR2/ALX 6OMM
TM6 237 R 6.32x32 CCR9 5LWE CCR5 5UIW
TM6 238 P 6.33x33 CCR9 5LWE FPR2/ALX 6OMM
TM6 239 L 6.34x34 CCR9 5LWE CCR9 5LWE
TM6 240 K 6.35x35 CCR7 6QZH CCR7 6QZH
TM6 241 V 6.36x36 CCR7 6QZH CCR7 6QZH
TM6 242 L 6.37x37 CCR7 6QZH Y1 receptor 5ZBH
TM6 243 L 6.38x38 CCR7 6QZH μ receptor 4DKL
TM6 244 T 6.39x39 CCR7 6QZH CCR9 5LWE
TM6 245 V 6.40x40 CCR7 6QZH CCR7 6QZH
TM6 246 V 6.41x41 CCR7 6QZH CCR7 6QZH
TM6 247 I 6.42x42 CCR7 6QZH CCR5 5UIW
TM6 248 V 6.43x43 CCR7 6QZH CCR7 6QZH
TM6 249 F 6.44x44 CCR7 6QZH CCR7 6QZH
TM6 250 I 6.45x45 CCR7 6QZH CCR7 6QZH
TM6 251 V 6.46x46 CCR7 6QZH CCR7 6QZH
TM6 252 T 6.47x47 CCR7 6QZH M2 receptor 5ZKC
TM6 253 Q 6.48x48 CCR7 6QZH CCR7 6QZH
TM6 254 L 6.49x49 CCR7 6QZH CCR7 6QZH
TM6 255 P 6.50x50 CCR7 6QZH CCR7 6QZH
TM6 256 Y 6.51x51 CCR7 6QZH CCR7 6QZH
TM6 257 N 6.52x52 CCR7 6QZH CCR7 6QZH
TM6 258 I 6.53x53 CCR7 6QZH CCR5 5UIW
TM6 259 V 6.54x54 CCR7 6QZH CCR7 6QZH
TM6 260 K 6.55x55 CCR7 6QZH apelin receptor 5VBL
TM6 261 F 6.56x56 CCR7 6QZH AT1 receptor 4ZUD
TM6 262 C 6.57x57 CCR7 6QZH - -
TM6 263 R 6.58x58 CCR7 6QZH succinate receptor 6RNK
TM6 264 A 6.59x59 CCR9 5LWE μ receptor 4DKL
TM6 265 I 6.60x60 CCR9 5LWE CCR9 5LWE
TM6 266 D 6.61x61 CCR9 5LWE CCR9 5LWE
TM6 267 I 6.62x62 CCR9 5LWE PAR2 5NDD
TM6 268 I 6.63x63 CCR9 5LWE - -
TM6 269 Y 6.64x64 CCR9 5LWE - -
ECL3 270 S - - - -
ECL3 271 L - - - -
ECL3 272 I - - - -
ECL3 273 T - - - -
TM7 274 S 7.24x23 CCR9 5LWE CCR6 6WWZ
TM7 275 C 7.25x24 CCR7 6QZH CCR7 6QZH
TM7 276 N 7.26x25 CCR7 6QZH - -
TM7 277 M 7.27x26 CCR7 6QZH - -
TM7 278 S 7.28x27 CCR7 6QZH CCR7 6QZH
TM7 279 K 7.29x28 CCR7 6QZH CCR7 6QZH
TM7 280 R 7.30x29 CCR7 6QZH CCR5 5UIW
TM7 281 M 7.31x30 CCR7 6QZH 5-HT2C receptor 6BQH
TM7 282 D 7.32x31 CCR7 6QZH CCR9 5LWE
TM7 283 I 7.33x32 CCR7 6QZH CCR7 6QZH
TM7 284 A 7.34x33 CCR7 6QZH CCR7 6QZH
TM7 285 I 7.35x34 CCR7 6QZH CXCR4 3ODU
TM7 286 Q 7.36x35 CCR7 6QZH CCR9 5LWE
TM7 287 V 7.37x36 CCR7 6QZH CCR7 6QZH
TM7 288 T 7.38x37 CCR7 6QZH CCR7 6QZH
TM7 289 E 7.39x38 CCR7 6QZH CCR5 5UIW
TM7 290 S 7.40x39 CCR7 6QZH CCR7 6QZH
TM7 291 I 7.41x40 CCR7 6QZH CCR9 5LWE
TM7 292 A 7.42x41 CCR7 6QZH CCR7 6QZH
TM7 293 L 7.43x42 CCR7 6QZH CB1 receptor 5TGZ
TM7 294 F 7.44x43 CCR7 6QZH CCR9 5LWE
TM7 295 H 7.45x45 CCR7 6QZH CCR9 5LWE
TM7 296 S 7.46x46 CCR7 6QZH CCR9 5LWE
TM7 297 C 7.47x47 CCR7 6QZH CCR7 6QZH
TM7 298 L 7.48x48 CCR7 6QZH CCR9 5LWE
TM7 299 N 7.49x49 CCR7 6QZH CCR7 6QZH
TM7 300 P 7.50x50 CCR7 6QZH CCR7 6QZH
TM7 301 I 7.51x51 CCR7 6QZH CCR5 5UIW
TM7 302 L 7.52x52 CCR7 6QZH CCR7 6QZH
TM7 303 Y 7.53x53 CCR7 6QZH CCR7 6QZH
TM7 304 V 7.54x54 CCR7 6QZH CCR9 5LWE
TM7 305 F 7.55x55 CCR7 6QZH CCR7 6QZH
TM7 306 M 7.56x56 CCR9 5LWE ghrelin receptor 6KO5
H8 307 G 8.47x47 CCR9 5LWE CCR9 5LWE
H8 308 A 8.48x48 CCR9 5LWE D4 receptor 5WIV
H8 309 S 8.49x49 CCR7 6QZH P2Y12 receptor 4NTJ
H8 310 F 8.50x50 CCR7 6QZH CCR7 6QZH
H8 311 K 8.51x51 CCR7 6QZH μ receptor 4DKL
H8 312 N 8.52x52 CCR7 6QZH CCR7 6QZH
H8 313 Y 8.53x53 CCR7 6QZH CCR5 5UIW
H8 314 V 8.54x54 CCR7 6QZH ghrelin receptor 6KO5
H8 315 M 8.55x55 CCR7 6QZH - -
H8 316 K 8.56x56 CCR7 6QZH CCR9 5LWE
H8 317 V 8.57x57 CCR7 6QZH AT2 receptor 6JOD
H8 318 A 8.58x58 CCR7 6QZH - -
H8 319 K 8.59x59 CCR9 5LWE CCR9 5LWE
H8 320 K 8.60x60 CCR9 5LWE - -
H8 321 Y 8.61x61 CCR9 5LWE succinate receptor 6IBB
H8 322 G 8.62x62 CCR9 5LWE CCR9 5LWE
H8 323 S 8.63x63 CCR9 5LWE - -
H8 324 W 8.64x64 CCR9 5LWE - -
H8 325 R 8.65x65 CCR9 5LWE - -
H8 326 R 8.66x66 CCR9 5LWE - -
H8 327 Q 8.67x67 CCR9 5LWE - -
C-term 328 R - - - -
C-term 329 Q - - - -
C-term 330 S - - - -
C-term 331 V - - - -
C-term 332 E - - - -