ADGRA2 homology model

PROTEIN CLASS

Class B2 (Adhesion)

RECEPTOR

ADGRA2

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-09-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

CRF2 receptor (sequence similarity: 7%) PDB: 6PB1
Align

TEMPLATES

6PB1 (CRF2 receptor)
6PB0 (CRF1 receptor)
4Z9G (CRF1 receptor)
7D77 (ADGRG3)
6WZG (secretin receptor)
7JHJ (BILF1)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 77.6 5.2 17.1
Side-chains 16.8 26.9 56.3

Number of backbone templates: 6
Number of rotamer templates: 18

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 762 V - CRF2 receptor 6PB1 CRF2 receptor 6PB1
N-term 763 G - CRF2 receptor 6PB1 CRF2 receptor 6PB1
N-term 764 G - CRF2 receptor 6PB1 CRF2 receptor 6PB1
N-term 765 A - CRF2 receptor 6PB1 CRF2 receptor 6PB1
N-term 766 G - CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM1 767 A 1.34x34 CRF2 receptor 6PB1 GLP-2 receptor 7D68
TM1 768 G 1.35x35 CRF2 receptor 6PB1 - -
TM1 769 L 1.36x36 CRF2 receptor 6PB1 secretin receptor 6WZG
TM1 770 H 1.37x37 CRF2 receptor 6PB1 CRF1 receptor 6PB0
TM1 771 P 1.38x38 CRF2 receptor 6PB1 - -
TM1 772 V 1.39x39 CRF2 receptor 6PB1 GHRH receptor 7CZ5
TM1 773 V 1.40x40 CRF2 receptor 6PB1 CRF1 receptor 6PB0
TM1 774 Y 1.41x41 CRF2 receptor 6PB1 CT receptor 6NIY
TM1 775 P 1.42x42 CRF2 receptor 6PB1 - -
TM1 776 C 1.43x43 CRF2 receptor 6PB1 PTH1 receptor 6FJ3
TM1 777 T 1.44x44 CRF2 receptor 6PB1 secretin receptor 6WZG
TM1 778 A 1.45x45 CRF2 receptor 6PB1 ADGRG3 7D77
TM1 779 L 1.46x46 CRF2 receptor 6PB1 BILF1 7JHJ
TM1 780 L 1.47x47 CRF2 receptor 6PB1 BILF1 7JHJ
TM1 781 L 1.48x48 CRF2 receptor 6PB1 - -
TM1 782 L 1.49x49 CRF2 receptor 6PB1 PAC1 receptor 6M1I
TM1 783 C 1.50x50 CRF2 receptor 6PB1 - -
TM1 784 L 1.51x51 CRF2 receptor 6PB1 CRF1 receptor 6PB0
TM1 785 F 1.52x52 CRF2 receptor 6PB1 CT receptor 6NIY
TM1 786 A 1.53x53 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM1 787 T 1.54x54 CRF2 receptor 6PB1 BILF1 7JHJ
TM1 788 I 1.55x55 CRF2 receptor 6PB1 - -
TM1 789 I 1.56x56 CRF2 receptor 6PB1 GLP-1 receptor 5VAI
TM1 790 T 1.57x57 CRF2 receptor 6PB1 ADGRG3 7D77
TM1 791 Y 1.58x58 CRF2 receptor 6PB1 - -
TM1 792 I 1.59x59 CRF2 receptor 6PB1 ADGRG3 7D77
TM1 793 L 1.60x60 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM1 794 N 1.61x61 CRF2 receptor 6PB1 - -
TM1 795 H 1.62x62 CRF2 receptor 6PB1 - -
TM1 796 S 1.63x63 CRF2 receptor 6PB1 - -
TM1 797 S 1.64x64 CRF2 receptor 6PB1 - -
ICL1 798 I - - - - -
ICL1 799 R - - - - -
TM2 800 V 2.44x44 CRF2 receptor 6PB1 - -
TM2 801 S 2.45x45 CRF2 receptor 6PB1 - -
TM2 802 R 2.46x46 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM2 803 K 2.47x47 CRF2 receptor 6PB1 - -
TM2 804 G 2.48x48 CRF2 receptor 6PB1 - -
TM2 805 W 2.49x49 CRF2 receptor 6PB1 BILF1 7JHJ
TM2 806 H 2.50x50 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM2 807 M 2.51x51 CRF2 receptor 6PB1 secretin receptor 6WZG
TM2 808 L 2.52x52 CRF2 receptor 6PB1 - -
TM2 809 L 2.53x53 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM2 810 N 2.54x54 CRF2 receptor 6PB1 - -
TM2 811 L 2.55x55 CRF2 receptor 6PB1 CT receptor 6NIY
TM2 812 C 2.56x56 CRF2 receptor 6PB1 - -
TM2 813 F 2.57x57 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM2 814 H 2.58x58 CRF2 receptor 6PB1 - -
TM2 815 I 2.59x59 CRF2 receptor 6PB1 - -
TM2 816 A 2.60x60 CRF2 receptor 6PB1 - -
TM2 817 M 2.61x61 CRF2 receptor 6PB1 - -
TM2 818 T 2.62x62 CRF2 receptor 6PB1 - -
TM2 819 S 2.63x63 CRF2 receptor 6PB1 secretin receptor 6WZG
TM2 820 A 2.64x64 CRF2 receptor 6PB1 - -
TM2 821 V 2.65x65 CRF2 receptor 6PB1 - -
TM2 822 F 2.66x66 CRF2 receptor 6PB1 glucagon receptor 5EE7
TM2 823 A 2.67x67 CRF2 receptor 6PB1 - -
TM2 824 G 2.68x68 CRF2 receptor 6PB1 - -
TM2 825 G 2.69x69 CRF1 receptor 6PB0 ADGRG3 7D77
TM2 826 I 2.70x70 CRF1 receptor 6PB0 PAC1 receptor 6P9Y
ECL1 827 T - - - - -
ECL1 828 L - ADGRG3 7D77 - -
ECL1 829 T - ADGRG3 7D77 - -
ECL1 830 N - - - - -
TM3 831 Y 3.25x25 ADGRG3 7D77 - -
TM3 832 Q 3.26x26 ADGRG3 7D77 - -
TM3 833 M 3.27x27 CRF2 receptor 6PB1 - -
TM3 834 V 3.28x28 CRF2 receptor 6PB1 - -
TM3 835 C 3.29x29 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM3 836 Q 3.30x30 CRF2 receptor 6PB1 - -
TM3 837 A 3.31x31 CRF2 receptor 6PB1 ADGRG3 7D77
TM3 838 V 3.32x32 CRF2 receptor 6PB1 CRF1 receptor 6PB0
TM3 839 G 3.33x33 CRF2 receptor 6PB1 ADGRG3 7D77
TM3 840 I 3.34x34 CRF2 receptor 6PB1 GIP receptor 7DTY
TM3 841 T 3.35x35 CRF2 receptor 6PB1 - -
TM3 842 L 3.36x36 CRF2 receptor 6PB1 GLP-2 receptor 7D68
TM3 843 H 3.37x37 CRF2 receptor 6PB1 GHRH receptor 7CZ5
TM3 844 Y 3.38x38 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM3 845 S 3.39x39 CRF2 receptor 6PB1 - -
TM3 846 S 3.40x40 CRF2 receptor 6PB1 - -
TM3 847 L 3.41x41 CRF2 receptor 6PB1 ADGRG3 7D77
TM3 848 S 3.42x42 CRF2 receptor 6PB1 PAC1 receptor 6P9Y
TM3 849 T 3.43x43 CRF2 receptor 6PB1 - -
TM3 850 L 3.44x44 CRF2 receptor 6PB1 - -
TM3 851 L 3.45x45 CRF2 receptor 6PB1 GLP-2 receptor 7D68
TM3 852 W 3.46x46 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM3 853 M 3.47x47 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM3 854 G 3.48x48 CRF2 receptor 6PB1 ADGRG3 7D77
TM3 855 V 3.49x49 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM3 856 K 3.50x50 CRF2 receptor 6PB1 - -
TM3 857 A 3.51x51 CRF2 receptor 6PB1 GHRH receptor 7CZ5
TM3 858 R 3.52x52 CRF2 receptor 6PB1 - -
TM3 859 V 3.53x53 CRF2 receptor 6PB1 - -
TM3 860 L 3.54x54 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM3 861 H 3.55x55 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM3 862 K 3.56x56 CRF2 receptor 6PB1 - -
TM3 863 E 3.57x57 CRF2 receptor 6PB1 - -
TM3 864 L 3.58x58 CRF2 receptor 6PB1 secretin receptor 6WZG
TM3 865 T 3.59x59 CRF2 receptor 6PB1 - -
TM3 866 W 3.60x60 CRF2 receptor 6PB1 - -
ICL2 867 R - - - - -
ICL2 868 A - - - - -
ICL2 869 P - - - - -
ICL2 870 P - - - - -
ICL2 871 P - - - - -
ICL2 872 Q - - - - -
ICL2 873 E - - - - -
ICL2 874 G - - - - -
ICL2 875 D - - - - -
ICL2 876 P - - - - -
ICL2 877 A - - - - -
ICL2 878 L - - - - -
ICL2 879 P - - - - -
ICL2 880 T - - - - -
ICL2 881 P - - - - -
ICL2 882 S - - - - -
TM4 883 P 4.41x42 CRF2 receptor 6PB1 - -
TM4 884 M 4.42x43 CRF2 receptor 6PB1 - -
TM4 885 L 4.43x44 CRF2 receptor 6PB1 ADGRG3 7D77
TM4 886 R 4.44x45 CRF2 receptor 6PB1 GLP-2 receptor 7D68
TM4 887 F 4.45x46 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM4 888 Y 4.46x47 CRF2 receptor 6PB1 CT receptor 6NIY
TM4 889 L 4.47x48 CRF2 receptor 6PB1 GHRH receptor 7CZ5
TM4 890 I 4.48x49 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM4 891 A 4.49x491 CRF2 receptor 6PB1 - -
TM4 892 G 4.50x50 CRF2 receptor 6PB1 - -
TM4 893 G 4.51x51 CRF2 receptor 6PB1 CRF1 receptor 6PB0
TM4 894 I 4.52x52 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM4 895 P 4.53x53 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM4 896 L 4.54x54 CRF2 receptor 6PB1 PAC1 receptor 6M1I
TM4 897 I 4.55x55 CRF2 receptor 6PB1 secretin receptor 6WZG
TM4 898 I 4.56x56 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM4 899 C 4.57x57 CRF2 receptor 6PB1 - -
TM4 900 G 4.58x58 CRF2 receptor 6PB1 GHRH receptor 7CZ5
TM4 901 I 4.59x59 CRF2 receptor 6PB1 BILF1 7JHJ
TM4 902 T 4.60x60 CRF2 receptor 6PB1 ADGRG3 7D77
TM4 903 A 4.61x61 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM4 904 A 4.62x62 CRF2 receptor 6PB1 - -
TM4 905 V 4.63x63 CRF2 receptor 6PB1 GLP-1 receptor 5VAI
TM4 906 N 4.64x64 CRF2 receptor 6PB1 ADGRG3 7D76
ECL2 907 I - - - - -
ECL2 908 H - - - - -
ECL2 909 N - - - - -
ECL2 910 Y - - - - -
ECL2 911 R - - - - -
ECL2 912 D - - - - -
ECL2 913 H - - - - -
ECL2 914 S - - - - -
ECL2 915 P - - - - -
ECL2 916 Y - - - - -
ECL2 917 C 45.50x50 CRF2 receptor 6PB1 CRF2 receptor 6PB1
ECL2 918 W 45.51x51 CRF2 receptor 6PB1 CRF2 receptor 6PB1
ECL2 919 L 45.52x52 CRF2 receptor 6PB1 CT receptor 6NIY
ECL2 920 V - - - - -
ECL2 921 W - - - - -
TM5 922 R 5.33x33 secretin receptor 6WZG - -
TM5 923 P 5.34x34 secretin receptor 6WZG - -
TM5 924 S 5.35x35 secretin receptor 6WZG secretin receptor 6WZG
TM5 925 L 5.36x36 CRF2 receptor 6PB1 ADGRG3 7D77
TM5 926 G 5.37x37 CRF2 receptor 6PB1 BILF1 7JHJ
TM5 927 A 5.38x38 BILF1 7JHJ - -
TM5 928 F 5.39x39 BILF1 7JHJ - -
TM5 929 Y 5.40x40 CRF2 receptor 6PB1 - -
TM5 930 I 5.41x41 CRF2 receptor 6PB1 - -
TM5 931 P 5.42x42 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM5 932 V 5.43x43 CRF2 receptor 6PB1 secretin receptor 6WZG
TM5 933 A 5.44x44 CRF2 receptor 6PB1 CRF1 receptor 4Z9G
TM5 934 L 5.45x45 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM5 935 I 5.46x46 CRF2 receptor 6PB1 - -
TM5 936 L 5.47x47 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM5 937 L 5.48x48 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM5 938 I 5.49x49 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM5 939 T 5.50x50 CRF2 receptor 6PB1 - -
TM5 940 W 5.51x51 CRF2 receptor 6PB1 - -
TM5 941 I 5.52x52 CRF2 receptor 6PB1 CRF1 receptor 6PB0
TM5 942 Y 5.53x53 CRF2 receptor 6PB1 - -
TM5 943 F 5.54x54 CRF2 receptor 6PB1 secretin receptor 6WZG
TM5 944 L 5.55x55 CRF2 receptor 6PB1 GHRH receptor 7CZ5
TM5 945 C 5.56x56 CRF2 receptor 6PB1 VPAC1 receptor 6VN7
TM5 946 A 5.57x57 CRF2 receptor 6PB1 - -
TM5 947 G 5.58x58 CRF2 receptor 6PB1 - -
TM5 948 L 5.59x59 CRF2 receptor 6PB1 - -
TM5 949 R 5.60x60 CRF2 receptor 6PB1 - -
TM5 950 L 5.61x61 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM5 951 R 5.62x62 CRF2 receptor 6PB1 - -
TM5 952 G 5.63x63 CRF2 receptor 6PB1 - -
TM5 953 P 5.64x64 CRF2 receptor 6PB1 - -
TM5 954 L 5.65x65 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM5 955 A 5.66x66 CRF2 receptor 6PB1 - -
TM5 956 Q 5.67x67 CRF2 receptor 6PB1 - -
ICL3 957 N - - - - -
ICL3 958 P - - - - -
ICL3 959 K - - - - -
ICL3 960 A - - - - -
ICL3 961 G - - - - -
ICL3 1009 G - - - - -
ICL3 1010 D - - - - -
ICL3 1011 S - - - - -
ICL3 1012 L - - - - -
ICL3 1013 Y - - - - -
TM6 1014 S 6.34x34 CRF2 receptor 6PB1 - -
TM6 1015 P 6.35x35 CRF2 receptor 6PB1 - -
TM6 1016 G 6.36x36 CRF2 receptor 6PB1 - -
TM6 1017 V 6.37x37 CRF2 receptor 6PB1 - -
TM6 1018 Q 6.38x38 CRF2 receptor 6PB1 - -
TM6 1019 L 6.39x39 CRF2 receptor 6PB1 PTH1 receptor 6NBI
TM6 1020 G 6.40x40 CRF2 receptor 6PB1 - -
TM6 1021 A 6.41x41 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM6 1022 L 6.42x42 CRF2 receptor 6PB1 ADGRG3 7D77
TM6 1023 V 6.43x43 CRF2 receptor 6PB1 - -
TM6 1024 T 6.44x44 CRF2 receptor 6PB1 GLP-1 receptor 5VAI
TM6 1025 T 6.45x45 CRF2 receptor 6PB1 BILF1 7JHJ
TM6 1026 H 6.46x46 CRF2 receptor 6PB1 - -
TM6 1027 F 6.47x47 CRF2 receptor 6PB1 - -
TM6 1028 L 6.48x48 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM6 1029 Y 6.49x49 CRF2 receptor 6PB1 - -
TM6 1030 L 6.50x50 CRF2 receptor 6PB1 - -
TM6 1031 A 6.51x51 CRF2 receptor 6PB1 - -
TM6 1032 M 6.52x52 CRF2 receptor 6PB1 - -
TM6 1033 W 6.53x53 CRF2 receptor 6PB1 ADGRG3 7D77
TM6 1034 A 6.54x54 CRF2 receptor 6PB1 - -
TM6 1035 C 6.55x55 CRF2 receptor 6PB1 - -
TM6 1036 G 6.56x56 CRF1 receptor 4Z9G - -
TM6 1037 A 6.57x57 CRF1 receptor 4Z9G PAC1 receptor 6M1I
TM6 1038 L 6.58x58 CRF1 receptor 4Z9G - -
ECL3 1039 A - - - - -
ECL3 1040 V - - - - -
ECL3 1041 S - - - - -
ECL3 1042 Q - - - - -
ECL3 1043 R - - - - -
ECL3 1044 W - - - - -
TM7 1045 L 7.33x32 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM7 1046 P 7.34x33 CRF2 receptor 6PB1 - -
TM7 1047 R 7.35x34 CRF2 receptor 6PB1 CRF1 receptor 6PB0
TM7 1048 V 7.36x35 CRF2 receptor 6PB1 CRF1 receptor 6PB0
TM7 1049 V 7.37x36 CRF2 receptor 6PB1 CRF1 receptor 6PB0
TM7 1050 C 7.38x37 CRF2 receptor 6PB1 - -
TM7 1051 S 7.39x38 CRF2 receptor 6PB1 - -
TM7 1052 C 7.40x39 CRF2 receptor 6PB1 - -
TM7 1053 L 7.41x40 CRF2 receptor 6PB1 GHRH receptor 7CZ5
TM7 1054 Y 7.42x41 CRF2 receptor 6PB1 BILF1 7JHJ
TM7 1055 G 7.43x42 CRF2 receptor 6PB1 - -
TM7 1056 V 7.44x43 CRF2 receptor 6PB1 VPAC1 receptor 6VN7
TM7 1057 A 7.45x44 CRF2 receptor 6PB1 - -
TM7 1058 A 7.46x45 CRF2 receptor 6PB1 BILF1 7JHJ
TM7 1059 S 7.47x46 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM7 1060 A 7.48x47 CRF2 receptor 6PB1 - -
TM7 1061 L 7.49x49 CRF2 receptor 6PB1 BILF1 7JHJ
TM7 1062 G 7.50x50 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM7 1063 L 7.51x51 CRF2 receptor 6PB1 secretin receptor 6WZG
TM7 1064 F 7.52x52 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM7 1065 V 7.53x53 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM7 1066 F 7.54x54 CRF2 receptor 6PB1 - -
TM7 1067 T 7.55x55 CRF2 receptor 6PB1 CT receptor 6NIY
TM7 1068 H 7.56x56 CRF2 receptor 6PB1 - -
TM7 1069 H 7.57x57 CRF2 receptor 6PB1 - -
TM7 1070 C 7.58x58 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM7 1071 A 7.59x59 CRF2 receptor 6PB1 - -
TM7 1072 R 7.60x60 CRF2 receptor 6PB1 - -
TM7 1073 R 7.61x61 ADGRG3 7D77 - -
H8 1074 R 8.48x48 CRF2 receptor 6PB1 - -
H8 1075 D 8.49x49 CRF2 receptor 6PB1 - -
H8 1076 V 8.50x50 CRF2 receptor 6PB1 CRF2 receptor 6PB1
H8 1077 R 8.51x51 CRF2 receptor 6PB1 CRF2 receptor 6PB1
H8 1078 A 8.52x52 CRF2 receptor 6PB1 GLP-2 receptor 7D68
H8 1079 S 8.53x53 CRF2 receptor 6PB1 BILF1 7JHJ
H8 1080 W 8.54x54 CRF2 receptor 6PB1 - -
H8 1081 R 8.55x55 CRF2 receptor 6PB1 CRF2 receptor 6PB1
H8 1082 A 8.56x56 CRF2 receptor 6PB1 - -
H8 1083 C 8.57x57 CRF2 receptor 6PB1 - -
H8 1084 C 8.58x58 CRF2 receptor 6PB1 - -
H8 1085 P 8.59x59 CRF2 receptor 6PB1 - -
H8 1086 P 8.60x60 CRF2 receptor 6PB1 - -
H8 1087 A 8.61x61 CRF2 receptor 6PB1 - -
H8 1088 S 8.62x62 CRF2 receptor 6PB1 - -
H8 1089 P 8.63x63 CRF2 receptor 6PB1 - -
C-term 1090 A - CRF2 receptor 6PB1 CRF2 receptor 6PB1
C-term 1091 A - CRF2 receptor 6PB1 CRF2 receptor 6PB1
C-term 1092 P - CRF2 receptor 6PB1 CRF2 receptor 6PB1
C-term 1093 H - CRF2 receptor 6PB1 CRF2 receptor 6PB1
C-term 1094 A - - - - -