ADGRB3 homology model

PROTEIN CLASS

Class B2 (Adhesion)

RECEPTOR

ADGRB3

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-11-02

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

CRF1 receptor (sequence similarity: 9%) PDB: 6PB0
Align

TEMPLATES

6PB0 (CRF1 receptor)
4Z9G (CRF1 receptor)
6P9Y (PAC1 receptor)
7D77 (ADGRG3)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 79.2 4.7 16.1
Side-chains 22.6 30.3 47.1

Number of backbone templates: 4
Number of rotamer templates: 17

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 867 R - CRF1 receptor 6PB0 CRF1 receptor 6PB0
N-term 868 E - CRF1 receptor 6PB0 CRF1 receptor 6PB0
N-term 869 I - CRF1 receptor 6PB0 CRF1 receptor 6PB0
N-term 870 I - CRF1 receptor 6PB0 CRF1 receptor 6PB0
N-term 871 M - CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM1 872 E 1.34x34 CRF1 receptor 6PB0 GLP-1 receptor 5VAI
TM1 873 S 1.35x35 CRF1 receptor 6PB0 - -
TM1 874 S 1.36x36 CRF1 receptor 6PB0 - -
TM1 875 G 1.37x37 CRF1 receptor 6PB0 VPAC1 receptor 6VN7
TM1 876 T 1.38x38 CRF1 receptor 6PB0 GLP-2 receptor 7D68
TM1 877 P 1.39x39 CRF1 receptor 6PB0 - -
TM1 878 S 1.40x40 CRF1 receptor 6PB0 - -
TM1 879 V 1.41x41 CRF1 receptor 6PB0 CRF2 receptor 6PB1
TM1 880 T 1.42x42 CRF1 receptor 6PB0 - -
TM1 881 L 1.43x43 CRF1 receptor 6PB0 - -
TM1 882 I 1.44x44 CRF1 receptor 6PB0 calcitonin receptor-like receptor 6UVA
TM1 883 V 1.45x45 CRF1 receptor 6PB0 CT receptor 6NIY
TM1 884 G 1.46x46 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM1 885 S 1.47x47 CRF1 receptor 6PB0 - -
TM1 886 G 1.48x48 CRF1 receptor 6PB0 calcitonin receptor-like receptor 6UVA
TM1 887 L 1.49x49 CRF1 receptor 6PB0 calcitonin receptor-like receptor 6UVA
TM1 888 S 1.50x50 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM1 889 C 1.51x51 CRF1 receptor 6PB0 - -
TM1 890 L 1.52x52 CRF1 receptor 6PB0 - -
TM1 891 A 1.53x53 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM1 892 L 1.54x54 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM1 893 I 1.55x55 CRF1 receptor 6PB0 - -
TM1 894 T 1.56x56 CRF1 receptor 6PB0 PAC1 receptor 6P9Y
TM1 895 L 1.57x57 CRF1 receptor 6PB0 - -
TM1 896 A 1.58x58 CRF1 receptor 6PB0 - -
TM1 897 V 1.59x59 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM1 898 V 1.60x60 CRF1 receptor 6PB0 - -
TM1 899 Y 1.61x61 CRF1 receptor 6PB0 ADGRG3 7D77
TM1 900 A 1.62x62 CRF1 receptor 6PB0 ADGRG3 7D77
TM1 901 A 1.63x63 CRF1 receptor 6PB0 CRF2 receptor 6PB1
TM1 902 L 1.64x64 CRF1 receptor 6PB0 CRF1 receptor 6PB0
ICL1 903 W - - - - -
ICL1 904 R 12.48x48 CRF1 receptor 4Z9G CRF1 receptor 4Z9G
ICL1 905 Y 12.49x49 CRF1 receptor 4Z9G - -
ICL1 906 I 12.50x50 CRF1 receptor 4Z9G CRF1 receptor 4Z9G
ICL1 907 R 12.51x51 - - - -
TM2 908 S 2.44x44 CRF1 receptor 6PB0 - -
TM2 909 E 2.45x45 CRF1 receptor 6PB0 - -
TM2 910 R 2.46x46 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM2 911 S 2.47x47 CRF1 receptor 6PB0 - -
TM2 912 I 2.48x48 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM2 913 I 2.49x49 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM2 914 L 2.50x50 CRF1 receptor 6PB0 - -
TM2 915 I 2.51x51 CRF1 receptor 6PB0 GIP receptor 7DTY
TM2 916 N 2.52x52 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM2 917 F 2.53x53 CRF1 receptor 6PB0 - -
TM2 918 C 2.54x54 CRF1 receptor 6PB0 - -
TM2 919 L 2.55x55 CRF1 receptor 6PB0 CT receptor 6NIY
TM2 920 S 2.56x56 CRF1 receptor 6PB0 calcitonin receptor-like receptor 6UVA
TM2 921 I 2.57x57 CRF1 receptor 6PB0 - -
TM2 922 I 2.58x58 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM2 923 S 2.59x59 CRF1 receptor 6PB0 - -
TM2 924 S 2.60x60 CRF1 receptor 6PB0 - -
TM2 925 N 2.61x61 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM2 926 I 2.62x62 CRF1 receptor 6PB0 PAC1 receptor 6P9Y
TM2 927 L 2.63x63 CRF1 receptor 6PB0 - -
TM2 928 I 2.64x64 CRF1 receptor 6PB0 CT receptor 6NIY
TM2 929 L 2.65x65 CRF1 receptor 6PB0 ADGRG3 7D77
TM2 930 V 2.66x66 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM2 931 G 2.67x67 CRF1 receptor 6PB0 - -
TM2 932 Q 2.68x68 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM2 933 T 2.69x69 CRF1 receptor 6PB0 calcitonin receptor-like receptor 6UVA
TM2 934 Q 2.70x70 CRF1 receptor 6PB0 - -
ECL1 935 T - - - - -
ECL1 936 H - - - - -
ECL1 937 N - - - - -
ECL1 938 K - - - - -
TM3 939 S 3.27x27 CRF1 receptor 6PB0 - -
TM3 940 I 3.28x28 CRF1 receptor 6PB0 - -
TM3 941 C 3.29x29 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM3 942 T 3.30x30 CRF1 receptor 6PB0 - -
TM3 943 T 3.31x31 CRF1 receptor 6PB0 GIP receptor 7DTY
TM3 944 T 3.32x32 CRF1 receptor 6PB0 - -
TM3 945 T 3.33x33 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM3 946 A 3.34x34 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM3 947 F 3.35x35 CRF1 receptor 6PB0 CT receptor 6NIY
TM3 948 L 3.36x36 CRF1 receptor 6PB0 GLP-2 receptor 7D68
TM3 949 H 3.37x37 CRF1 receptor 6PB0 ADGRG3 7D77
TM3 950 F 3.38x38 CRF1 receptor 6PB0 GHRH receptor 7CZ5
TM3 951 F 3.39x39 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM3 952 F 3.40x40 CRF1 receptor 6PB0 - -
TM3 953 L 3.41x41 CRF1 receptor 6PB0 ADGRG3 7D77
TM3 954 A 3.42x42 CRF1 receptor 6PB0 VPAC1 receptor 6VN7
TM3 955 S 3.43x43 CRF1 receptor 6PB0 - -
TM3 956 F 3.44x44 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM3 957 C 3.45x45 CRF1 receptor 6PB0 glucagon receptor 6WPW
TM3 958 W 3.46x46 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM3 959 V 3.47x47 CRF1 receptor 6PB0 - -
TM3 960 L 3.48x48 CRF1 receptor 6PB0 calcitonin receptor-like receptor 6UVA
TM3 961 T 3.49x49 CRF1 receptor 6PB0 - -
TM3 962 E 3.50x50 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM3 963 A 3.51x51 CRF1 receptor 6PB0 ADGRG3 7D77
TM3 964 W 3.52x52 CRF1 receptor 6PB0 - -
TM3 965 Q 3.53x53 CRF1 receptor 6PB0 - -
TM3 966 S 3.54x54 CRF1 receptor 6PB0 - -
TM3 967 Y 3.55x55 CRF1 receptor 6PB0 ADGRG3 7D77
TM3 968 M 3.56x56 CRF1 receptor 6PB0 - -
TM3 969 A 3.57x57 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM3 970 V 3.58x58 CRF1 receptor 6PB0 - -
TM3 971 T 3.59x59 CRF1 receptor 6PB0 - -
TM3 972 G 3.60x60 CRF1 receptor 6PB0 - -
ICL2 973 K - - - - -
ICL2 974 I - - - - -
ICL2 975 R - - - - -
ICL2 976 T - - - - -
ICL2 977 R - - - - -
TM4 978 L 4.40x41 CRF1 receptor 4Z9G CRF1 receptor 4Z9G
TM4 979 I 4.41x42 CRF1 receptor 4Z9G - -
TM4 980 R 4.42x43 CRF1 receptor 6PB0 - -
TM4 981 K 4.43x44 CRF1 receptor 6PB0 GLP-1 receptor 5VAI
TM4 982 R 4.44x45 CRF1 receptor 6PB0 GLP-2 receptor 7D68
TM4 983 F 4.45x46 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM4 984 L 4.46x47 CRF1 receptor 6PB0 CRF2 receptor 6PB1
TM4 985 C 4.47x48 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM4 986 L 4.48x49 CRF1 receptor 6PB0 calcitonin receptor-like receptor 6UVA
TM4 987 G 4.49x491 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM4 988 W 4.50x50 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM4 989 G 4.51x51 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM4 990 L 4.52x52 CRF1 receptor 6PB0 ADGRG3 7D77
TM4 991 P 4.53x53 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM4 992 A 4.54x54 CRF1 receptor 6PB0 ADGRG3 7D77
TM4 993 L 4.55x55 CRF1 receptor 6PB0 ADGRG3 7D77
TM4 994 V 4.56x56 CRF1 receptor 6PB0 - -
TM4 995 V 4.57x57 CRF1 receptor 6PB0 ADGRG3 7D77
TM4 996 A 4.58x58 CRF1 receptor 6PB0 secretin receptor 6WZG
TM4 997 T 4.59x59 CRF1 receptor 6PB0 GHRH receptor 7CZ5
TM4 998 S 4.60x60 CRF1 receptor 6PB0 - -
TM4 999 V 4.61x61 CRF1 receptor 6PB0 GIP receptor 7DTY
TM4 1000 G 4.62x62 CRF1 receptor 6PB0 - -
TM4 1001 F 4.63x63 CRF1 receptor 6PB0 - -
TM4 1002 T 4.64x64 CRF1 receptor 6PB0 - -
ECL2 1003 R - - - - -
ECL2 1004 T - - - - -
ECL2 1005 K - - - - -
ECL2 1006 G - - - - -
ECL2 1007 Y - - - - -
ECL2 1008 G - - - - -
ECL2 1009 T - - - - -
ECL2 1010 D - - - - -
ECL2 1011 H - - - - -
ECL2 1012 Y - - - - -
ECL2 1013 C 45.50x50 CRF1 receptor 6PB0 CRF1 receptor 6PB0
ECL2 1014 W 45.51x51 CRF1 receptor 6PB0 CRF1 receptor 6PB0
ECL2 1015 L 45.52x52 CRF1 receptor 6PB0 CT receptor 6NIY
ECL2 1016 S - - - - -
ECL2 1017 L - PAC1 receptor 6P9Y - -
ECL2 1018 E - - - - -
TM5 1019 G 5.33x33 PAC1 receptor 6P9Y - -
TM5 1020 G 5.34x34 PAC1 receptor 6P9Y PTH2 receptor 7F16
TM5 1021 L 5.35x35 PAC1 receptor 6P9Y - -
TM5 1022 L 5.36x36 CRF1 receptor 6PB0 calcitonin receptor-like receptor 6UVA
TM5 1023 Y 5.37x37 CRF1 receptor 6PB0 ADGRG3 7D77
TM5 1024 A 5.38x38 CRF1 receptor 6PB0 - -
TM5 1025 F 5.39x39 CRF1 receptor 6PB0 - -
TM5 1026 V 5.40x40 CRF1 receptor 6PB0 - -
TM5 1027 G 5.41x41 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM5 1028 P 5.42x42 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM5 1029 A 5.43x43 CRF1 receptor 6PB0 - -
TM5 1030 A 5.44x44 CRF1 receptor 6PB0 CRF1 receptor 4Z9G
TM5 1031 A 5.45x45 CRF1 receptor 6PB0 calcitonin receptor-like receptor 6UVA
TM5 1032 V 5.46x46 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM5 1033 V 5.47x47 CRF1 receptor 6PB0 GLP-2 receptor 7D68
TM5 1034 L 5.48x48 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM5 1035 V 5.49x49 CRF1 receptor 6PB0 calcitonin receptor-like receptor 6UVA
TM5 1036 N 5.50x50 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM5 1037 M 5.51x51 CRF1 receptor 6PB0 ADGRG3 7D77
TM5 1038 V 5.52x52 CRF1 receptor 6PB0 CRF2 receptor 6PB1
TM5 1039 I 5.53x53 CRF1 receptor 6PB0 GLP-1 receptor 5VAI
TM5 1040 G 5.54x54 CRF1 receptor 6PB0 - -
TM5 1041 I 5.55x55 CRF1 receptor 6PB0 PAC1 receptor 6P9Y
TM5 1042 L 5.56x56 CRF1 receptor 6PB0 ADGRG3 7D77
TM5 1043 V 5.57x57 CRF1 receptor 6PB0 ADGRG3 7D77
TM5 1044 F 5.58x58 CRF1 receptor 6PB0 - -
TM5 1045 N 5.59x59 CRF1 receptor 6PB0 - -
TM5 1046 K 5.60x60 CRF1 receptor 6PB0 ADGRG3 7D77
TM5 1047 L 5.61x61 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM5 1048 V 5.62x62 CRF1 receptor 6PB0 CT receptor 6NIY
TM5 1049 S 5.63x63 CRF1 receptor 6PB0 GLP-1 receptor 5VAI
TM5 1050 R 5.64x64 CRF1 receptor 6PB0 - -
TM5 1051 D 5.65x65 CRF1 receptor 6PB0 - -
ICL3 1052 G - - - - -
ICL3 1053 I - - - - -
ICL3 1054 L - - - - -
ICL3 1055 D - - - - -
ICL3 1056 K - - - - -
ICL3 1089 A - - - - -
ICL3 1090 T - - - - -
ICL3 1091 T - - - - -
ICL3 1092 A - - - - -
ICL3 1093 S - - - - -
TM6 1094 N 6.34x34 CRF1 receptor 6PB0 - -
TM6 1095 A 6.35x35 CRF1 receptor 6PB0 CRF1 receptor 4Z9G
TM6 1096 M 6.36x36 CRF1 receptor 6PB0 calcitonin receptor-like receptor 6UVA
TM6 1097 A 6.37x37 CRF1 receptor 6PB0 - -
TM6 1098 S 6.38x38 CRF1 receptor 6PB0 - -
TM6 1099 L 6.39x39 CRF1 receptor 6PB0 PTH1 receptor 6NBI
TM6 1100 W 6.40x40 CRF1 receptor 6PB0 - -
TM6 1101 S 6.41x41 CRF1 receptor 6PB0 PAC1 receptor 6P9Y
TM6 1102 S 6.42x42 CRF1 receptor 6PB0 - -
TM6 1103 C 6.43x43 CRF1 receptor 6PB0 - -
TM6 1104 V 6.44x44 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM6 1105 V 6.45x45 CRF1 receptor 6PB0 - -
TM6 1106 L 6.46x46 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM6 1107 P 6.47x47 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM6 1108 L 6.48x48 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM6 1109 L 6.49x49 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM6 1110 A 6.50x50 CRF1 receptor 6PB0 GLP-1 receptor 5NX2
TM6 1111 L 6.51x51 CRF1 receptor 6PB0 - -
TM6 1112 T 6.52x52 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM6 1113 W 6.53x53 CRF1 receptor 6PB0 ADGRG3 7D77
TM6 1114 M 6.54x54 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM6 1115 S 6.55x55 CRF1 receptor 6PB0 - -
TM6 1116 A 6.56x56 CRF1 receptor 4Z9G CRF1 receptor 4Z9G
TM6 1117 V 6.57x57 CRF1 receptor 4Z9G PTH2 receptor 7F16
TM6 1118 L 6.58x58 CRF1 receptor 4Z9G - -
ECL3 1119 A - - - - -
ECL3 1120 M - - - - -
ECL3 1121 T - - - - -
ECL3 1122 D - - - - -
ECL3 1123 K - - - - -
ECL3 1124 R - - - - -
TM7 1125 S 7.35x34 CRF1 receptor 6PB0 - -
TM7 1126 I 7.36x35 CRF1 receptor 6PB0 CRF2 receptor 6PB1
TM7 1127 L 7.37x36 CRF1 receptor 6PB0 - -
TM7 1128 F 7.38x37 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM7 1129 Q 7.39x38 CRF1 receptor 6PB0 - -
TM7 1130 I 7.40x39 CRF1 receptor 6PB0 - -
TM7 1131 L 7.41x40 CRF1 receptor 6PB0 GHRH receptor 7CZ5
TM7 1132 F 7.42x41 CRF1 receptor 6PB0 ADGRG3 7D77
TM7 1133 A 7.43x42 CRF1 receptor 6PB0 ADGRG3 7D77
TM7 1134 V 7.44x43 CRF1 receptor 6PB0 VPAC1 receptor 6VN7
TM7 1135 F 7.45x44 CRF1 receptor 6PB0 ADGRG3 7D77
TM7 1136 D 7.46x45 CRF1 receptor 6PB0 - -
TM7 1137 S 7.47x46 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM7 1138 L 7.48x47 CRF1 receptor 6PB0 ADGRG3 7D77
TM7 1139 Q 7.49x49 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM7 1140 G 7.50x50 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM7 1141 F 7.51x51 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM7 1142 V 7.52x52 CRF1 receptor 6PB0 PAC1 receptor 6P9Y
TM7 1143 I 7.53x53 CRF1 receptor 6PB0 ADGRG3 7D77
TM7 1144 V 7.54x54 CRF1 receptor 6PB0 - -
TM7 1145 M 7.55x55 CRF1 receptor 6PB0 - -
TM7 1146 V 7.56x56 CRF1 receptor 6PB0 - -
TM7 1147 H 7.57x57 CRF1 receptor 6PB0 - -
TM7 1148 C 7.58x58 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM7 1149 I 7.59x59 CRF1 receptor 6PB0 ADGRG3 7D77
TM7 1150 L 7.60x60 CRF1 receptor 6PB0 CRF1 receptor 6PB0
TM7 1151 R 7.61x61 ADGRG3 7D77 - -
H8 1152 R 8.48x48 CRF1 receptor 6PB0 - -
H8 1153 E 8.49x49 CRF1 receptor 6PB0 CRF1 receptor 6PB0
H8 1154 V 8.50x50 CRF1 receptor 6PB0 CRF1 receptor 6PB0
H8 1155 Q 8.51x51 CRF1 receptor 6PB0 calcitonin receptor-like receptor 6UVA
H8 1156 D 8.52x52 CRF1 receptor 6PB0 - -
H8 1157 A 8.53x53 CRF1 receptor 6PB0 CRF1 receptor 6PB0
H8 1158 F 8.54x54 CRF1 receptor 6PB0 GLP-1 receptor 5VAI
H8 1159 R 8.55x55 CRF1 receptor 6PB0 CRF1 receptor 6PB0
H8 1160 C 8.56x56 CRF1 receptor 6PB0 - -
H8 1161 R 8.57x57 CRF1 receptor 6PB0 CRF1 receptor 6PB0
H8 1162 L 8.58x58 CRF1 receptor 6PB0 - -
H8 1163 R 8.59x59 CRF1 receptor 6PB0 PAC1 receptor 6P9Y
H8 1164 N 8.60x60 CRF1 receptor 6PB0 - -
H8 1165 C 8.61x61 CRF1 receptor 6PB0 GIP receptor 7DTY
H8 1166 Q 8.62x62 CRF1 receptor 6PB0 CRF1 receptor 6PB0
H8 1167 D 8.63x63 CRF1 receptor 6PB0 CRF1 receptor 6PB0
C-term 1168 P - - - - -
C-term 1169 I - - - - -
C-term 1170 N - - - - -
C-term 1171 A - - - - -
C-term 1172 D - - - - -