ADGRE2 homology model

PROTEIN CLASS

Class B2 (Adhesion)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active

VERSION

2022-06-19

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

ADGRL3 (sequence similarity: 17%) PDB: 7SF7

TEMPLATES

7WU2 (ADGRD1)
7SF7 (ADGRL3)
7WU3 (ADGRF1)
6WZG (secretin receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 80.6 7.2 12.2
Side-chains 31.9 18.3 49.8

Number of backbone templates: 4
Number of rotamer templates: 11

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 525 A - ADGRD1 7WU2 ADGRD1 7WU2
N-term 526 H - ADGRD1 7WU2 ADGRD1 7WU2
N-term 527 Y - ADGRD1 7WU2 ADGRD1 7WU2
N-term 528 D - ADGRD1 7WU2 ADGRD1 7WU2
N-term 529 V - ADGRD1 7WU2 ADGRD1 7WU2
TM1 530 Q 1.33x33 ADGRD1 7WU2 - -
TM1 531 E 1.34x34 ADGRD1 7WU2 GLP-1 receptor 5NX2
TM1 532 E 1.35x35 ADGRL3 7SF7 - -
TM1 533 D 1.36x36 ADGRL3 7SF7 ADGRL3 7SF7
TM1 534 P 1.37x37 ADGRL3 7SF7 - -
TM1 535 V 1.38x38 ADGRL3 7SF7 CRF1 receptor 4Z9G
TM1 536 L 1.39x39 ADGRL3 7SF7 ADGRL3 7SF7
TM1 537 T 1.40x40 ADGRL3 7SF7 - -
TM1 538 V 1.41x41 ADGRL3 7SF7 ADGRL3 7SF7
TM1 539 I 1.42x42 ADGRL3 7SF7 ADGRL3 7SF7
TM1 540 T 1.43x43 ADGRL3 7SF7 ADGRL3 7SF7
TM1 541 Y 1.44x44 ADGRL3 7SF7 CRF1 receptor 4Z9G
TM1 542 M 1.45x45 ADGRL3 7SF7 - -
TM1 543 G 1.46x46 ADGRL3 7SF7 ADGRL3 7SF7
TM1 544 L 1.47x47 ADGRL3 7SF7 - -
TM1 545 S 1.48x48 ADGRL3 7SF7 glucagon receptor 5YQZ
TM1 546 V 1.49x49 ADGRL3 7SF7 PTH1 receptor 6FJ3
TM1 547 S 1.50x50 ADGRL3 7SF7 ADGRL3 7SF7
TM1 548 L 1.51x51 ADGRL3 7SF7 ADGRL3 7SF7
TM1 549 L 1.52x52 ADGRL3 7SF7 - -
TM1 550 C 1.53x53 ADGRL3 7SF7 ADGRL3 7SF7
TM1 551 L 1.54x54 ADGRL3 7SF7 ADGRL3 7SF7
TM1 552 L 1.55x55 ADGRL3 7SF7 ADGRL3 7SF7
TM1 553 L 1.56x56 ADGRL3 7SF7 glucagon receptor 5YQZ
TM1 554 A 1.57x57 ADGRL3 7SF7 CRF1 receptor 4Z9G
TM1 555 A 1.58x58 ADGRL3 7SF7 - -
TM1 556 L 1.59x59 ADGRL3 7SF7 PTH1 receptor 6FJ3
TM1 557 T 1.60x60 ADGRL3 7SF7 ADGRL3 7SF7
TM1 558 F 1.61x61 ADGRL3 7SF7 ADGRL3 7SF7
TM1 559 L 1.62x62 ADGRL3 7SF7 CRF1 receptor 4Z9G
TM1 560 L 1.63x63 ADGRL3 7SF7 - -
TM1 561 C 1.64x64 ADGRD1 7WU2 - -
ICL1 562 K 12.48x48 - - - -
ICL1 563 A 12.49x49 ADGRF1 7WU3 - -
ICL1 564 I 12.50x50 ADGRF1 7WU3 ADGRF1 7WU3
ICL1 565 Q 12.51x51 - - - -
TM2 566 N 2.44x44 ADGRF1 7WU3 - -
TM2 567 T 2.45x45 ADGRF1 7WU3 ADGRF1 7WU3
TM2 568 S 2.46x46 ADGRL3 7SF7 - -
TM2 569 T 2.47x47 ADGRL3 7SF7 - -
TM2 570 S 2.48x48 ADGRL3 7SF7 - -
TM2 571 L 2.49x49 ADGRL3 7SF7 calcitonin receptor-like receptor 7KNU
TM2 572 H 2.50x50 ADGRL3 7SF7 ADGRL3 7SF7
TM2 573 L 2.51x51 ADGRL3 7SF7 GLP-1 receptor 6LN2
TM2 574 Q 2.52x52 ADGRL3 7SF7 - -
TM2 575 L 2.53x53 ADGRL3 7SF7 ADGRL3 7SF7
TM2 576 S 2.54x54 ADGRL3 7SF7 - -
TM2 577 L 2.55x55 ADGRL3 7SF7 glucagon receptor 5EE7
TM2 578 C 2.56x56 ADGRL3 7SF7 - -
TM2 579 L 2.57x57 ADGRL3 7SF7 ADGRL3 7SF7
TM2 580 F 2.58x58 ADGRL3 7SF7 ADGRL3 7SF7
TM2 581 L 2.59x59 ADGRL3 7SF7 CRF1 receptor 4Z9G
TM2 582 A 2.60x60 ADGRL3 7SF7 ADGRL3 7SF7
TM2 583 H 2.61x61 ADGRL3 7SF7 - -
TM2 584 L 2.62x62 ADGRL3 7SF7 ADGRL3 7SF7
TM2 585 L 2.63x63 ADGRL3 7SF7 ADGRL3 7SF7
TM2 586 F 2.64x64 ADGRL3 7SF7 ADGRL3 7SF7
TM2 587 L 2.65x65 ADGRL3 7SF7 ADGRL3 7SF7
TM2 588 V 2.66x66 ADGRL3 7SF7 CRF1 receptor 4Z9G
TM2 589 A 2.67x67 ADGRL3 7SF7 - -
ECL1 590 I - - - - -
ECL1 591 D - - - - -
ECL1 592 Q - - - - -
ECL1 593 T - - - - -
ECL1 594 G - - - - -
ECL1 595 H - - - - -
ECL1 596 K - - - - -
TM3 597 V 3.27x27 ADGRL3 7SF7 calcitonin receptor-like receptor 7KNU
TM3 598 L 3.28x28 ADGRL3 7SF7 - -
TM3 599 C 3.29x29 ADGRL3 7SF7 ADGRL3 7SF7
TM3 600 S 3.30x30 ADGRL3 7SF7 - -
TM3 601 I 3.31x31 ADGRL3 7SF7 - -
TM3 602 I 3.32x32 ADGRL3 7SF7 - -
TM3 603 A 3.33x33 ADGRL3 7SF7 ADGRL3 7SF7
TM3 604 G 3.34x34 ADGRL3 7SF7 - -
TM3 605 T 3.35x35 ADGRL3 7SF7 - -
TM3 606 L 3.36x36 ADGRL3 7SF7 ADGRL3 7SF7
TM3 607 H 3.37x37 ADGRL3 7SF7 ADGRL3 7SF7
TM3 608 Y 3.38x38 ADGRL3 7SF7 CRF1 receptor 4Z9G
TM3 609 L 3.39x39 ADGRL3 7SF7 calcitonin receptor-like receptor 7KNU
TM3 610 Y 3.40x40 ADGRL3 7SF7 - -
TM3 611 L 3.41x41 ADGRL3 7SF7 ADGRL3 7SF7
TM3 612 A 3.42x42 ADGRL3 7SF7 ADGRL3 7SF7
TM3 613 T 3.43x43 ADGRL3 7SF7 - -
TM3 614 L 3.44x44 ADGRL3 7SF7 - -
TM3 615 T 3.45x45 ADGRL3 7SF7 ADGRL3 7SF7
TM3 616 W 3.46x46 ADGRL3 7SF7 ADGRL3 7SF7
TM3 617 M 3.47x47 ADGRL3 7SF7 ADGRL3 7SF7
TM3 618 L 3.48x48 ADGRL3 7SF7 GLP-1 receptor 6LN2
TM3 619 L 3.49x49 ADGRL3 7SF7 ADGRL3 7SF7
TM3 620 E 3.50x50 ADGRL3 7SF7 ADGRL3 7SF7
TM3 621 A 3.51x51 ADGRL3 7SF7 - -
TM3 622 L 3.52x52 ADGRL3 7SF7 glucagon receptor 5YQZ
TM3 623 Y 3.53x53 ADGRL3 7SF7 CRF1 receptor 4Z9G
TM3 624 L 3.54x54 ADGRL3 7SF7 ADGRL3 7SF7
TM3 625 F 3.55x55 ADGRL3 7SF7 - -
TM3 626 L 3.56x56 ADGRL3 7SF7 - -
TM3 627 T 3.57x57 ADGRL3 7SF7 - -
TM3 628 A 3.58x58 ADGRL3 7SF7 - -
TM3 629 R 3.59x59 ADGRL3 7SF7 - -
TM3 630 N 3.60x60 ADGRD1 7WU2 - -
ICL2 631 L - - - - -
ICL2 632 T - - - - -
ICL2 633 V - - - - -
ICL2 634 V - - - - -
ICL2 635 N - - - - -
ICL2 636 Y - - - - -
ICL2 637 S - - - - -
ICL2 638 S - - - - -
ICL2 639 I - - - - -
ICL2 640 N - - - - -
ICL2 641 R - - - - -
ICL2 642 F - - - - -
TM4 643 M 4.41x42 ADGRL3 7SF7 - -
TM4 644 K 4.42x43 ADGRL3 7SF7 - -
TM4 645 K 4.43x44 ADGRL3 7SF7 ADGRL3 7SF7
TM4 646 L 4.44x45 ADGRL3 7SF7 GLP-1 receptor 6LN2
TM4 647 M 4.45x46 ADGRL3 7SF7 - -
TM4 648 F 4.46x47 ADGRL3 7SF7 - -
TM4 649 P 4.47x48 ADGRL3 7SF7 - -
TM4 650 V 4.48x49 ADGRL3 7SF7 ADGRL3 7SF7
TM4 651 G 4.49x491 ADGRL3 7SF7 ADGRL3 7SF7
TM4 652 Y 4.50x50 ADGRL3 7SF7 ADGRL3 7SF7
TM4 653 G 4.51x51 ADGRL3 7SF7 ADGRL3 7SF7
TM4 654 V 4.52x52 ADGRL3 7SF7 CRF1 receptor 4Z9G
TM4 655 P 4.53x53 ADGRL3 7SF7 ADGRL3 7SF7
TM4 656 A 4.54x54 ADGRL3 7SF7 ADGRL3 7SF7
TM4 657 V 4.55x55 ADGRL3 7SF7 - -
TM4 658 T 4.56x56 ADGRL3 7SF7 - -
TM4 659 V 4.57x57 ADGRL3 7SF7 ADGRL3 7SF7
TM4 660 A 4.58x58 ADGRL3 7SF7 ADGRL3 7SF7
TM4 661 I 4.59x59 ADGRL3 7SF7 calcitonin receptor-like receptor 7KNU
TM4 662 S 4.60x60 ADGRL3 7SF7 ADGRL3 7SF7
TM4 663 A 4.61x61 ADGRL3 7SF7 ADGRL3 7SF7
TM4 664 A 4.62x62 ADGRL3 7SF7 ADGRL3 7SF7
TM4 665 S 4.63x63 ADGRL3 7SF7 - -
TM4 666 R 4.64x64 ADGRL3 7SF7 - -
ECL2 667 P - ADGRL3 7SF7 - -
ECL2 668 H - ADGRL3 7SF7 - -
ECL2 669 L - ADGRL3 7SF7 - -
ECL2 670 Y - ADGRL3 7SF7 ADGRL3 7SF7
ECL2 671 G - ADGRL3 7SF7 ADGRL3 7SF7
ECL2 672 T - ADGRL3 7SF7 ADGRL3 7SF7
ECL2 673 P - ADGRL3 7SF7 - -
ECL2 674 S - ADGRL3 7SF7 - -
ECL2 675 R - ADGRL3 7SF7 - -
ECL2 676 C 45.50x50 ADGRL3 7SF7 ADGRL3 7SF7
ECL2 677 W 45.51x51 ADGRL3 7SF7 ADGRL3 7SF7
ECL2 678 L 45.52x52 ADGRL3 7SF7 ADGRL3 7SF7
ECL2 679 Q - ADGRL3 7SF7 - -
ECL2 680 P - ADGRL3 7SF7 - -
ECL2 681 E - ADGRL3 7SF7 - -
ECL2 682 K - ADGRL3 7SF7 - -
TM5 683 G 5.34x34 ADGRD1 7WU2 ADGRD1 7WU2
TM5 684 F 5.35x35 ADGRD1 7WU2 - -
TM5 685 I 5.36x36 ADGRL3 7SF7 ADGRL3 7SF7
TM5 686 W 5.37x37 ADGRL3 7SF7 ADGRL3 7SF7
TM5 687 G 5.38x38 ADGRL3 7SF7 - -
TM5 688 F 5.39x39 ADGRL3 7SF7 ADGRL3 7SF7
TM5 689 L 5.40x40 ADGRL3 7SF7 - -
TM5 690 G 5.41x41 ADGRL3 7SF7 ADGRL3 7SF7
TM5 691 P 5.42x42 ADGRL3 7SF7 ADGRL3 7SF7
TM5 692 V 5.43x43 ADGRL3 7SF7 glucagon receptor 5YQZ
TM5 693 C 5.44x44 ADGRL3 7SF7 calcitonin receptor-like receptor 7KNU
TM5 694 A 5.45x45 ADGRL3 7SF7 calcitonin receptor-like receptor 7KNU
TM5 695 I 5.46x46 ADGRL3 7SF7 ADGRL3 7SF7
TM5 696 F 5.47x47 ADGRL3 7SF7 - -
TM5 697 S 5.48x48 ADGRL3 7SF7 - -
TM5 698 V 5.49x49 ADGRL3 7SF7 GLP-1 receptor 6LN2
TM5 699 N 5.50x50 ADGRL3 7SF7 ADGRL3 7SF7
TM5 700 L 5.51x51 ADGRL3 7SF7 calcitonin receptor-like receptor 7KNU
TM5 701 V 5.52x52 ADGRL3 7SF7 - -
TM5 702 L 5.53x53 ADGRL3 7SF7 PTH1 receptor 6FJ3
TM5 703 F 5.54x54 ADGRL3 7SF7 GLP-1 receptor 6LN2
TM5 704 L 5.55x55 ADGRL3 7SF7 calcitonin receptor-like receptor 7KNU
TM5 705 V 5.56x56 ADGRL3 7SF7 - -
TM5 706 T 5.57x57 ADGRL3 7SF7 - -
TM5 707 L 5.58x58 ADGRL3 7SF7 ADGRL3 7SF7
TM5 708 W 5.59x59 ADGRL3 7SF7 - -
TM5 709 I 5.60x60 ADGRL3 7SF7 CRF1 receptor 4Z9G
TM5 710 L 5.61x61 ADGRL3 7SF7 CRF1 receptor 4Z9G
TM5 711 K 5.62x62 ADGRL3 7SF7 - -
TM5 712 N 5.63x63 ADGRL3 7SF7 - -
TM5 713 R 5.64x64 ADGRL3 7SF7 - -
TM5 714 L 5.65x65 ADGRL3 7SF7 CRF1 receptor 4Z9G
TM5 715 S 5.66x66 ADGRL3 7SF7 - -
TM5 716 S 5.67x67 ADGRL3 7SF7 - -
TM5 717 L 5.68x68 ADGRL3 7SF7 - -
ICL3 718 N - - - - -
ICL3 719 S - - - - -
ICL3 720 E - - - - -
ICL3 721 V - - - - -
ICL3 722 S - - - - -
ICL3 723 T - - - - -
ICL3 724 L - - - - -
ICL3 725 R - - - - -
TM6 726 N 6.34x34 ADGRL3 7SF7 ADGRL3 7SF7
TM6 727 T 6.35x35 ADGRL3 7SF7 - -
TM6 728 R 6.36x36 ADGRL3 7SF7 CRF1 receptor 4Z9G
TM6 729 M 6.37x37 ADGRL3 7SF7 - -
TM6 730 L 6.38x38 ADGRL3 7SF7 GLP-1 receptor 6LN2
TM6 731 A 6.39x39 ADGRL3 7SF7 GLP-1 receptor 6LN2
TM6 732 F 6.40x40 ADGRL3 7SF7 - -
TM6 733 K 6.41x41 ADGRL3 7SF7 - -
TM6 734 A 6.42x42 ADGRL3 7SF7 ADGRL3 7SF7
TM6 735 T 6.43x43 ADGRL3 7SF7 - -
TM6 736 A 6.44x44 ADGRL3 7SF7 ADGRL3 7SF7
TM6 737 Q 6.45x45 ADGRL3 7SF7 - -
TM6 738 L 6.46x46 ADGRL3 7SF7 ADGRL3 7SF7
TM6 739 F 6.47x47 ADGRL3 7SF7 - -
TM6 740 I 6.48x48 ADGRL3 7SF7 - -
TM6 741 L 6.49x49 ADGRL3 7SF7 ADGRL3 7SF7
TM6 742 G 6.50x50 ADGRL3 7SF7 ADGRL3 7SF7
TM6 743 C 6.51x51 ADGRL3 7SF7 - -
TM6 744 T 6.52x52 ADGRL3 7SF7 ADGRL3 7SF7
TM6 745 W 6.53x53 ADGRL3 7SF7 ADGRL3 7SF7
TM6 746 C 6.54x54 ADGRL3 7SF7 - -
TM6 747 L 6.55x55 ADGRL3 7SF7 CRF1 receptor 4Z9G
TM6 748 G 6.56x56 ADGRL3 7SF7 ADGRL3 7SF7
TM6 749 I 6.57x57 ADGRL3 7SF7 - -
TM6 750 L 6.58x58 ADGRL3 7SF7 PTH1 receptor 6FJ3
ECL3 751 Q - ADGRL3 7SF7 - -
ECL3 752 V - ADGRL3 7SF7 - -
ECL3 753 G - ADGRL3 7SF7 - -
ECL3 754 P - ADGRL3 7SF7 - -
ECL3 755 A - ADGRL3 7SF7 - -
TM7 756 A 7.35x34 ADGRL3 7SF7 - -
TM7 757 R 7.36x35 ADGRL3 7SF7 - -
TM7 758 V 7.37x36 ADGRL3 7SF7 CRF1 receptor 4Z9G
TM7 759 M 7.38x37 ADGRL3 7SF7 - -
TM7 760 A 7.39x38 ADGRL3 7SF7 ADGRL3 7SF7
TM7 761 Y 7.40x39 ADGRL3 7SF7 ADGRL3 7SF7
TM7 762 L 7.41x40 ADGRL3 7SF7 ADGRL3 7SF7
TM7 763 F 7.42x41 ADGRL3 7SF7 ADGRL3 7SF7
TM7 764 T 7.43x42 ADGRL3 7SF7 ADGRL3 7SF7
TM7 765 I 7.44x43 ADGRL3 7SF7 ADGRL3 7SF7
TM7 766 I 7.45x44 ADGRL3 7SF7 - -
TM7 767 N 7.46x45 ADGRL3 7SF7 ADGRL3 7SF7
TM7 768 S 7.47x46 ADGRL3 7SF7 ADGRL3 7SF7
TM7 769 L 7.48x47 ADGRL3 7SF7 ADGRL3 7SF7
TM7 770 Q 7.49x49 ADGRL3 7SF7 ADGRL3 7SF7
TM7 771 G 7.50x50 ADGRL3 7SF7 ADGRL3 7SF7
TM7 772 V 7.51x51 ADGRL3 7SF7 - -
TM7 773 F 7.52x52 ADGRL3 7SF7 ADGRL3 7SF7
TM7 774 I 7.53x53 ADGRL3 7SF7 ADGRL3 7SF7
TM7 775 F 7.54x54 ADGRL3 7SF7 ADGRL3 7SF7
TM7 776 L 7.55x55 ADGRL3 7SF7 - -
TM7 777 V 7.56x56 ADGRL3 7SF7 - -
TM7 778 Y 7.57x57 ADGRL3 7SF7 GLP-1 receptor 6LN2
TM7 779 C 7.58x58 ADGRL3 7SF7 ADGRL3 7SF7
TM7 780 L 7.59x59 ADGRL3 7SF7 - -
TM7 781 L 7.60x60 ADGRL3 7SF7 ADGRL3 7SF7
H8 782 S 8.47x47 ADGRL3 7SF7 - -
H8 783 Q 8.48x48 ADGRL3 7SF7 - -
H8 784 Q 8.49x49 ADGRL3 7SF7 - -
H8 785 V 8.50x50 ADGRL3 7SF7 ADGRL3 7SF7
H8 786 R 8.51x51 ADGRL3 7SF7 ADGRL3 7SF7
H8 787 E 8.52x52 ADGRL3 7SF7 - -
H8 788 Q 8.53x53 ADGRL3 7SF7 - -
H8 789 Y 8.54x54 ADGRL3 7SF7 ADGRL3 7SF7
H8 790 G 8.55x55 ADGRL3 7SF7 ADGRL3 7SF7
H8 791 K 8.56x56 ADGRL3 7SF7 GLP-1 receptor 5NX2
H8 792 W 8.57x57 ADGRL3 7SF7 - -
H8 793 S 8.58x58 ADGRL3 7SF7 - -
H8 794 K 8.59x59 secretin receptor 6WZG - -
H8 795 G 8.60x60 secretin receptor 6WZG - -
H8 796 I 8.61x61 secretin receptor 6WZG - -
H8 797 R 8.62x62 secretin receptor 6WZG glucagon receptor 4L6R
H8 798 K 8.63x63 secretin receptor 6WZG - -
C-term 799 L - - - - -
C-term 800 K - - - - -
C-term 801 T - - - - -
C-term 802 E - - - - -
C-term 803 S - - - - -