ADGRE3 homology model

PROTEIN CLASS

Class B2 (Adhesion)

RECEPTOR

ADGRE3

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-01-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

NGL is a WebGL based 3D viewer powered by MMTF.

MAIN TEMPLATE

secretin receptor (sequence similarity: 37%) PDB: 6WZG
Align

TEMPLATES

6VN7 (VPAC1 receptor)
6WZG (secretin receptor)
7D3S (secretin receptor)
6M1H (PAC1 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 81.3 3.2 15.5
Side-chains 20.8 22.5 56.7

Number of backbone templates: 4
Number of rotamer templates: 15

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 339 S - - - -
N-term 340 S - - - -
N-term 341 F - - - -
N-term 342 A - - - -
N-term 343 V - - - -
TM1 344 L 1.27x27 VPAC1 receptor 6VN7 - -
TM1 345 M 1.28x28 VPAC1 receptor 6VN7 - -
TM1 346 A 1.29x29 secretin receptor 6WZG - -
TM1 347 L 1.30x30 secretin receptor 6WZG - -
TM1 348 T 1.31x31 secretin receptor 6WZG - -
TM1 349 S 1.32x32 secretin receptor 6WZG CRF1 receptor 6PB0
TM1 350 Q 1.33x33 secretin receptor 6WZG - -
TM1 351 E 1.34x34 secretin receptor 6WZG GLP-1 receptor 5VAI
TM1 352 E 1.35x35 secretin receptor 6WZG - -
TM1 353 D 1.36x36 secretin receptor 6WZG - -
TM1 354 P 1.37x37 secretin receptor 6WZG - -
TM1 355 V 1.38x38 secretin receptor 6WZG CRF1 receptor 6P9X
TM1 356 L 1.39x39 secretin receptor 6WZG secretin receptor 6WZG
TM1 357 T 1.40x40 secretin receptor 6WZG - -
TM1 358 V 1.41x41 secretin receptor 6WZG secretin receptor 6WZG
TM1 359 I 1.42x42 secretin receptor 6WZG CRF1 receptor 6P9X
TM1 360 T 1.43x43 secretin receptor 6WZG calcitonin receptor-like receptor 6UUS
TM1 361 Y 1.44x44 secretin receptor 6WZG CRF1 receptor 6P9X
TM1 362 V 1.45x45 secretin receptor 6WZG secretin receptor 6WZG
TM1 363 G 1.46x46 secretin receptor 6WZG secretin receptor 6WZG
TM1 364 L 1.47x47 secretin receptor 6WZG - -
TM1 365 S 1.48x48 secretin receptor 6WZG secretin receptor 6WZG
TM1 366 V 1.49x49 secretin receptor 6WZG CRF2 receptor 6PB1
TM1 367 S 1.50x50 secretin receptor 6WZG secretin receptor 6WZG
TM1 368 L 1.51x51 secretin receptor 6WZG secretin receptor 6WZG
TM1 369 L 1.52x52 secretin receptor 6WZG - -
TM1 370 C 1.53x53 secretin receptor 6WZG - -
TM1 371 L 1.54x54 secretin receptor 6WZG secretin receptor 6WZG
TM1 372 L 1.55x55 secretin receptor 6WZG secretin receptor 6WZG
TM1 373 L 1.56x56 secretin receptor 6WZG PAC1 receptor 6M1I
TM1 374 A 1.57x57 secretin receptor 6WZG secretin receptor 6WZG
TM1 375 A 1.58x58 secretin receptor 6WZG - -
TM1 376 L 1.59x59 secretin receptor 6WZG CRF2 receptor 6PB1
TM1 377 T 1.60x60 secretin receptor 6WZG - -
TM1 378 F 1.61x61 secretin receptor 6WZG CRF1 receptor 6P9X
TM1 379 L 1.62x62 secretin receptor 6WZG CRF1 receptor 6P9X
TM1 380 L 1.63x63 secretin receptor 6WZG VPAC1 receptor 6VN7
TM1 381 C 1.64x64 secretin receptor 6WZG - -
ICL1 382 K 12.48x48 secretin receptor 6WZG calcitonin receptor-like receptor 6UUS
ICL1 383 A 12.49x49 secretin receptor 6WZG - -
ICL1 384 I 12.50x50 secretin receptor 6WZG CRF1 receptor 6P9X
ICL1 385 R 12.51x51 secretin receptor 6WZG CRF1 receptor 6P9X
TM2 386 N 2.44x44 secretin receptor 6WZG - -
TM2 387 T 2.45x45 secretin receptor 6WZG secretin receptor 6WZG
TM2 388 S 2.46x46 secretin receptor 6WZG - -
TM2 389 T 2.47x47 secretin receptor 6WZG - -
TM2 390 S 2.48x48 secretin receptor 6WZG - -
TM2 391 L 2.49x49 secretin receptor 6WZG CT receptor 6NIY
TM2 392 H 2.50x50 secretin receptor 6WZG secretin receptor 6WZG
TM2 393 L 2.51x51 secretin receptor 6WZG GLP-1 receptor 5VAI
TM2 394 Q 2.52x52 secretin receptor 6WZG GHRH receptor 7CZ5
TM2 395 L 2.53x53 secretin receptor 6WZG secretin receptor 6WZG
TM2 396 S 2.54x54 secretin receptor 6WZG - -
TM2 397 L 2.55x55 secretin receptor 6WZG CT receptor 6NIY
TM2 398 C 2.56x56 secretin receptor 6WZG - -
TM2 399 L 2.57x57 secretin receptor 6WZG - -
TM2 400 F 2.58x58 secretin receptor 6WZG - -
TM2 401 L 2.59x59 secretin receptor 6WZG secretin receptor 6WZG
TM2 402 A 2.60x60 secretin receptor 6WZG - -
TM2 403 H 2.61x61 secretin receptor 6WZG - -
TM2 404 L 2.62x62 secretin receptor 6WZG secretin receptor 6WZG
TM2 405 L 2.63x63 secretin receptor 6WZG - -
TM2 406 F 2.64x64 secretin receptor 6WZG - -
TM2 407 L 2.65x65 secretin receptor 6WZG glucagon receptor 6WPW
TM2 408 V 2.66x66 secretin receptor 6WZG CRF1 receptor 6P9X
TM2 409 G 2.67x67 secretin receptor 6WZG - -
TM2 410 I 2.68x68 secretin receptor 6WZG - -
TM2 411 D 2.69x69 secretin receptor 6WZG - -
TM2 412 R 2.70x70 secretin receptor 6WZG - -
ECL1 413 T - - - -
ECL1 414 E - - - -
ECL1 415 P - - - -
ECL1 416 K - - - -
TM3 417 V 3.27x27 secretin receptor 6WZG GHRH receptor 7CZ5
TM3 418 L 3.28x28 secretin receptor 6WZG GHRH receptor 7CZ5
TM3 419 C 3.29x29 secretin receptor 6WZG secretin receptor 6WZG
TM3 420 S 3.30x30 secretin receptor 6WZG - -
TM3 421 I 3.31x31 secretin receptor 6WZG CT receptor 6NIY
TM3 422 I 3.32x32 secretin receptor 6WZG CRF2 receptor 6PB1
TM3 423 A 3.33x33 secretin receptor 6WZG glucagon receptor 6WPW
TM3 424 G 3.34x34 secretin receptor 6WZG - -
TM3 425 A 3.35x35 secretin receptor 6WZG CRF1 receptor 6P9X
TM3 426 L 3.36x36 secretin receptor 6WZG - -
TM3 427 H 3.37x37 secretin receptor 6WZG GHRH receptor 7CZ5
TM3 428 Y 3.38x38 secretin receptor 6WZG secretin receptor 6WZG
TM3 429 L 3.39x39 secretin receptor 6WZG calcitonin receptor-like receptor 6UUS
TM3 430 Y 3.40x40 secretin receptor 6WZG - -
TM3 431 L 3.41x41 secretin receptor 6WZG - -
TM3 432 A 3.42x42 secretin receptor 6WZG secretin receptor 6WZG
TM3 433 A 3.43x43 secretin receptor 6WZG - -
TM3 434 F 3.44x44 secretin receptor 6WZG CRF1 receptor 6P9X
TM3 435 T 3.45x45 secretin receptor 6WZG - -
TM3 436 W 3.46x46 secretin receptor 6WZG secretin receptor 6WZG
TM3 437 M 3.47x47 secretin receptor 6WZG CRF1 receptor 6P9X
TM3 438 L 3.48x48 secretin receptor 6WZG secretin receptor 6WZG
TM3 439 L 3.49x49 secretin receptor 6WZG - -
TM3 440 E 3.50x50 secretin receptor 6WZG secretin receptor 6WZG
TM3 441 G 3.51x51 secretin receptor 6WZG secretin receptor 6WZG
TM3 442 V 3.52x52 secretin receptor 6WZG GHRH receptor 7CZ5
TM3 443 H 3.53x53 secretin receptor 6WZG - -
TM3 444 L 3.54x54 secretin receptor 6WZG secretin receptor 6WZG
TM3 445 F 3.55x55 secretin receptor 6WZG PAC1 receptor 6P9Y
TM3 446 L 3.56x56 secretin receptor 6WZG - -
TM3 447 T 3.57x57 secretin receptor 6WZG - -
TM3 448 A 3.58x58 secretin receptor 6WZG - -
TM3 449 R 3.59x59 secretin receptor 6WZG - -
TM3 450 N 3.60x60 secretin receptor 6WZG - -
ICL2 451 L - - - -
ICL2 452 T - - - -
ICL2 453 V - - - -
ICL2 454 V - - - -
ICL2 455 N - - - -
ICL2 456 Y - - - -
ICL2 457 S - - - -
ICL2 458 S - - - -
TM4 459 I 4.37x38 secretin receptor 7D3S - -
TM4 460 N 4.38x39 secretin receptor 7D3S - -
TM4 461 R 4.39x40 secretin receptor 7D3S secretin receptor 7D3S
TM4 462 L 4.40x41 secretin receptor 7D3S - -
TM4 463 M 4.41x42 secretin receptor 6WZG - -
TM4 464 K 4.42x43 secretin receptor 6WZG CRF1 receptor 6P9X
TM4 465 W 4.43x44 secretin receptor 6WZG CRF1 receptor 6P9X
TM4 466 I 4.44x45 secretin receptor 6WZG - -
TM4 467 M 4.45x46 secretin receptor 6WZG - -
TM4 468 F 4.46x47 secretin receptor 6WZG - -
TM4 469 P 4.47x48 secretin receptor 6WZG - -
TM4 470 V 4.48x49 secretin receptor 6WZG - -
TM4 471 G 4.49x491 secretin receptor 6WZG secretin receptor 6WZG
TM4 472 Y 4.50x50 secretin receptor 6WZG - -
TM4 473 G 4.51x51 secretin receptor 6WZG secretin receptor 6WZG
TM4 474 V 4.52x52 secretin receptor 6WZG CRF1 receptor 6P9X
TM4 475 P 4.53x53 secretin receptor 6WZG secretin receptor 6WZG
TM4 476 A 4.54x54 secretin receptor 6WZG secretin receptor 6WZG
TM4 477 V 4.55x55 secretin receptor 6WZG PAC1 receptor 6P9Y
TM4 478 T 4.56x56 secretin receptor 6WZG - -
TM4 479 V 4.57x57 secretin receptor 6WZG secretin receptor 6WZG
TM4 480 A 4.58x58 secretin receptor 6WZG secretin receptor 6WZG
TM4 481 I 4.59x59 secretin receptor 6WZG CT receptor 6NIY
TM4 482 S 4.60x60 secretin receptor 6WZG - -
TM4 483 A 4.61x61 secretin receptor 6WZG secretin receptor 6WZG
TM4 484 A 4.62x62 secretin receptor 6WZG - -
TM4 485 S 4.63x63 secretin receptor 6WZG - -
TM4 486 W 4.64x64 secretin receptor 6WZG - -
TM4 487 P 4.65x65 secretin receptor 6WZG - -
TM4 488 H 4.66x66 secretin receptor 6WZG VPAC1 receptor 6VN7
TM4 489 L 4.67x67 secretin receptor 6WZG secretin receptor 6WZG
TM4 490 Y 4.68x68 secretin receptor 7D3S calcitonin receptor-like receptor 6UUS
ECL2 491 G - - - -
ECL2 492 T - - - -
ECL2 493 A - - - -
ECL2 494 D - - - -
ECL2 495 R - - - -
ECL2 496 C 45.50x50 secretin receptor 6WZG secretin receptor 6WZG
ECL2 497 W 45.51x51 secretin receptor 6WZG secretin receptor 6WZG
ECL2 498 L 45.52x52 secretin receptor 6WZG CT receptor 6NIY
ECL2 499 H - - - -
ECL2 500 L - - - -
TM5 501 D 5.32x32 - - - -
TM5 502 Q 5.33x33 secretin receptor 6WZG - -
TM5 503 G 5.34x34 secretin receptor 6WZG PTH1 receptor 6NBI
TM5 504 F 5.35x35 secretin receptor 6WZG - -
TM5 505 M 5.36x36 secretin receptor 6WZG - -
TM5 506 W 5.37x37 secretin receptor 6WZG secretin receptor 6WZG
TM5 507 S 5.38x38 secretin receptor 6WZG - -
TM5 508 F 5.39x39 secretin receptor 6WZG - -
TM5 509 L 5.40x40 secretin receptor 6WZG - -
TM5 510 G 5.41x41 secretin receptor 6WZG secretin receptor 6WZG
TM5 511 P 5.42x42 secretin receptor 6WZG secretin receptor 6WZG
TM5 512 V 5.43x43 secretin receptor 6WZG secretin receptor 6WZG
TM5 513 C 5.44x44 secretin receptor 6WZG calcitonin receptor-like receptor 6UUS
TM5 514 A 5.45x45 secretin receptor 6WZG CT receptor 6NIY
TM5 515 I 5.46x46 secretin receptor 6WZG - -
TM5 516 F 5.47x47 secretin receptor 6WZG - -
TM5 517 S 5.48x48 secretin receptor 6WZG - -
TM5 518 A 5.49x49 secretin receptor 6WZG - -
TM5 519 N 5.50x50 secretin receptor 6WZG secretin receptor 6WZG
TM5 520 L 5.51x51 secretin receptor 6WZG calcitonin receptor-like receptor 6UUS
TM5 521 V 5.52x52 secretin receptor 6WZG CRF2 receptor 6PB1
TM5 522 L 5.53x53 secretin receptor 6WZG secretin receptor 6WZG
TM5 523 F 5.54x54 secretin receptor 6WZG secretin receptor 6WZG
TM5 524 I 5.55x55 secretin receptor 6WZG secretin receptor 6WZG
TM5 525 L 5.56x56 secretin receptor 6WZG - -
TM5 526 V 5.57x57 secretin receptor 6WZG GLP-1 receptor 5VAI
TM5 527 F 5.58x58 secretin receptor 6WZG - -
TM5 528 W 5.59x59 secretin receptor 6WZG - -
TM5 529 I 5.60x60 secretin receptor 6WZG secretin receptor 6WZG
TM5 530 L 5.61x61 secretin receptor 6WZG secretin receptor 6WZG
TM5 531 K 5.62x62 secretin receptor 6WZG - -
TM5 532 R 5.63x63 secretin receptor 6WZG secretin receptor 6WZG
TM5 533 K 5.64x64 secretin receptor 6WZG secretin receptor 6WZG
TM5 534 L 5.65x65 secretin receptor 6WZG secretin receptor 6WZG
ICL3 535 S - - - -
ICL3 536 S - - - -
ICL3 537 L - - - -
ICL3 538 N - - - -
ICL3 539 S - - - -
ICL3 541 V - - - -
ICL3 542 S - - - -
ICL3 543 T - - - -
ICL3 544 I - - - -
ICL3 545 Q - - - -
TM6 546 N 6.34x34 secretin receptor 6WZG - -
TM6 547 T 6.35x35 secretin receptor 6WZG - -
TM6 548 R 6.36x36 secretin receptor 6WZG CRF1 receptor 6P9X
TM6 549 M 6.37x37 secretin receptor 6WZG - -
TM6 550 L 6.38x38 secretin receptor 6WZG secretin receptor 6WZG
TM6 551 A 6.39x39 secretin receptor 6WZG secretin receptor 6WZG
TM6 552 F 6.40x40 secretin receptor 6WZG - -
TM6 553 K 6.41x41 secretin receptor 6WZG - -
TM6 554 A 6.42x42 secretin receptor 6WZG - -
TM6 555 T 6.43x43 secretin receptor 6WZG - -
TM6 556 A 6.44x44 secretin receptor 6WZG - -
TM6 557 Q 6.45x45 secretin receptor 6WZG - -
TM6 558 L 6.46x46 secretin receptor 6WZG CRF1 receptor 6P9X
TM6 559 F 6.47x47 secretin receptor 6WZG - -
TM6 560 I 6.48x48 secretin receptor 6WZG - -
TM6 561 L 6.49x49 secretin receptor 6WZG CRF1 receptor 6P9X
TM6 562 G 6.50x50 secretin receptor 6WZG secretin receptor 6WZG
TM6 563 C 6.51x51 secretin receptor 6WZG - -
TM6 564 T 6.52x52 secretin receptor 6WZG CRF1 receptor 6P9X
TM6 565 W 6.53x53 secretin receptor 6WZG - -
TM6 566 C 6.54x54 secretin receptor 6WZG - -
TM6 567 L 6.55x55 secretin receptor 6WZG CRF1 receptor 6P9X
TM6 568 G 6.56x56 secretin receptor 6WZG - -
TM6 569 L 6.57x57 secretin receptor 6WZG - -
TM6 570 L 6.58x58 PAC1 receptor 6M1H PTH1 receptor 6FJ3
TM6 571 Q 6.59x59 PAC1 receptor 6M1H - -
ECL3 572 V - - - -
ECL3 573 G - - - -
ECL3 574 P - - - -
ECL3 575 A - - - -
TM7 576 A 7.35x34 secretin receptor 6WZG - -
TM7 577 Q 7.36x35 secretin receptor 6WZG PTH1 receptor 6NBI
TM7 578 V 7.37x36 secretin receptor 6WZG CRF1 receptor 6P9X
TM7 579 M 7.38x37 secretin receptor 6WZG - -
TM7 580 A 7.39x38 secretin receptor 6WZG - -
TM7 581 Y 7.40x39 secretin receptor 6WZG CRF1 receptor 6P9X
TM7 582 L 7.41x40 secretin receptor 6WZG GHRH receptor 7CZ5
TM7 583 F 7.42x41 secretin receptor 6WZG - -
TM7 584 T 7.43x42 secretin receptor 6WZG - -
TM7 585 I 7.44x43 secretin receptor 6WZG calcitonin receptor-like receptor 6UUS
TM7 586 I 7.45x44 secretin receptor 6WZG - -
TM7 587 N 7.46x45 secretin receptor 6WZG PTH1 receptor 6NBI
TM7 588 S 7.47x46 secretin receptor 6WZG secretin receptor 6WZG
TM7 589 L 7.48x47 secretin receptor 6WZG - -
TM7 590 Q 7.49x49 secretin receptor 6WZG secretin receptor 6WZG
TM7 591 G 7.50x50 secretin receptor 6WZG secretin receptor 6WZG
TM7 592 F 7.51x51 secretin receptor 6WZG CRF1 receptor 6P9X
TM7 593 F 7.52x52 secretin receptor 6WZG CRF1 receptor 6P9X
TM7 594 I 7.53x53 secretin receptor 6WZG - -
TM7 595 F 7.54x54 secretin receptor 6WZG - -
TM7 596 L 7.55x55 secretin receptor 6WZG - -
TM7 597 V 7.56x56 secretin receptor 6WZG - -
TM7 598 Y 7.57x57 secretin receptor 6WZG secretin receptor 6WZG
TM7 599 C 7.58x58 secretin receptor 6WZG secretin receptor 6WZG
TM7 600 L 7.59x59 secretin receptor 6WZG - -
TM7 601 L 7.60x60 secretin receptor 6WZG secretin receptor 6WZG
H8 602 S 8.47x47 secretin receptor 6WZG - -
H8 603 Q 8.48x48 secretin receptor 6WZG GHRH receptor 7CZ5
H8 604 Q 8.49x49 secretin receptor 6WZG - -
H8 605 V 8.50x50 secretin receptor 6WZG secretin receptor 6WZG
H8 606 Q 8.51x51 secretin receptor 6WZG secretin receptor 6WZG
H8 607 K 8.52x52 secretin receptor 6WZG - -
H8 608 Q 8.53x53 secretin receptor 6WZG - -
H8 609 Y 8.54x54 secretin receptor 6WZG - -
H8 610 Q 8.55x55 secretin receptor 6WZG secretin receptor 6WZG
H8 611 K 8.56x56 secretin receptor 6WZG secretin receptor 6WZG
H8 612 W 8.57x57 secretin receptor 6WZG - -
H8 613 F 8.58x58 secretin receptor 6WZG - -
H8 614 R 8.59x59 secretin receptor 6WZG VPAC1 receptor 6VN7
H8 615 E 8.60x60 secretin receptor 6WZG - -
H8 616 I 8.61x61 secretin receptor 6WZG - -
H8 617 V 8.62x62 secretin receptor 6WZG - -
H8 618 K 8.63x63 secretin receptor 6WZG - -
C-term 619 S - - - -
C-term 620 K - - - -
C-term 621 S - - - -
C-term 622 E - - - -
C-term 623 S - - - -