ADGRE4P homology model

PROTEIN CLASS

Class B2 (Adhesion)

RECEPTOR

ADGRE4P

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-02-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

GLP-1 receptor (sequence similarity: 36%) PDB: 6X19
Align

TEMPLATES

5UZ7 (CT receptor)
6NIY (CT receptor)
6X19 (GLP-1 receptor)
6X1A (GLP-1 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 81.7 4.2 14.1
Side-chains 18.0 25.4 56.7

Number of backbone templates: 4
Number of rotamer templates: 14

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 173 L - - - -
N-term 174 S - - - -
N-term 175 S - - - -
N-term 176 F - - - -
N-term 177 A - - - -
TM1 178 V 1.27x27 CT receptor 5UZ7 - -
TM1 179 L 1.28x28 CT receptor 5UZ7 VPAC1 receptor 6VN7
TM1 180 V 1.29x29 CT receptor 5UZ7 - -
TM1 181 A 1.30x30 CT receptor 5UZ7 GHRH receptor 7CZ5
TM1 182 L 1.31x31 CT receptor 5UZ7 - -
TM1 183 A 1.32x32 CT receptor 5UZ7 - -
TM1 184 P 1.33x33 CT receptor 5UZ7 - -
TM1 185 K 1.34x34 CT receptor 5UZ7 CT receptor 5UZ7
TM1 186 E 1.35x35 CT receptor 5UZ7 - -
TM1 187 D 1.36x36 GLP-1 receptor 6X19 - -
TM1 188 P 1.37x37 GLP-1 receptor 6X19 - -
TM1 189 V 1.38x38 GLP-1 receptor 6X19 CT receptor 6NIY
TM1 190 L 1.39x39 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM1 191 T 1.40x40 GLP-1 receptor 6X19 - -
TM1 192 V 1.41x41 GLP-1 receptor 6X19 secretin receptor 6WZG
TM1 193 I 1.42x42 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM1 194 T 1.43x43 GLP-1 receptor 6X19 calcitonin receptor-like receptor 6UUS
TM1 195 Q 1.44x44 GLP-1 receptor 6X19 - -
TM1 196 V 1.45x45 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM1 197 G 1.46x46 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM1 198 L 1.47x47 GLP-1 receptor 6X19 - -
TM1 199 T 1.48x48 GLP-1 receptor 6X19 - -
TM1 200 I 1.49x49 GLP-1 receptor 6X19 CRF1 receptor 6P9X
TM1 201 S 1.50x50 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM1 202 L 1.51x51 GLP-1 receptor 6X19 secretin receptor 6WZG
TM1 203 L 1.52x52 GLP-1 receptor 6X19 - -
TM1 204 C 1.53x53 GLP-1 receptor 6X19 - -
TM1 205 L 1.54x54 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM1 206 F 1.55x55 GLP-1 receptor 6X19 GHRH receptor 7CZ5
TM1 207 L 1.56x56 GLP-1 receptor 6X19 glucagon receptor 6WPW
TM1 208 A 1.57x57 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM1 209 I 1.58x58 GLP-1 receptor 6X19 GHRH receptor 7CZ5
TM1 210 L 1.59x59 GLP-1 receptor 6X19 CRF2 receptor 6PB1
TM1 211 T 1.60x60 GLP-1 receptor 6X19 - -
TM1 212 F 1.61x61 GLP-1 receptor 6X19 CT receptor 6NIY
TM1 213 L 1.62x62 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM1 214 L 1.63x63 GLP-1 receptor 6X19 VPAC1 receptor 6VN7
TM1 215 C 1.64x64 GLP-1 receptor 6X19 - -
ICL1 216 R 12.48x48 GLP-1 receptor 6X19 GLP-1 receptor 6X19
ICL1 217 P 12.49x49 GLP-1 receptor 6X19 - -
ICL1 218 I 12.50x50 GLP-1 receptor 6X19 CRF1 receptor 6P9X
ICL1 219 Q 12.51x51 GLP-1 receptor 6X19 - -
TM2 220 N 2.44x44 GLP-1 receptor 6X19 - -
TM2 221 T 2.45x45 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM2 222 S 2.46x46 GLP-1 receptor 6X19 - -
TM2 223 T 2.47x47 GLP-1 receptor 6X19 - -
TM2 224 S 2.48x48 GLP-1 receptor 6X19 - -
TM2 225 L 2.49x49 GLP-1 receptor 6X19 CT receptor 6NIY
TM2 226 H 2.50x50 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM2 227 L 2.51x51 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM2 228 E 2.52x52 GLP-1 receptor 6X19 - -
TM2 229 L 2.53x53 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM2 230 S 2.54x54 GLP-1 receptor 6X19 - -
TM2 231 L 2.55x55 GLP-1 receptor 6X19 CT receptor 6NIY
TM2 232 C 2.56x56 GLP-1 receptor 6X19 - -
TM2 233 L 2.57x57 GLP-1 receptor 6X19 - -
TM2 234 F 2.58x58 GLP-1 receptor 6X19 - -
TM2 235 L 2.59x59 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM2 236 A 2.60x60 GLP-1 receptor 6X19 - -
TM2 237 H 2.61x61 GLP-1 receptor 6X19 - -
TM2 238 L 2.62x62 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM2 239 L 2.63x63 GLP-1 receptor 6X19 - -
TM2 240 F 2.64x64 GLP-1 receptor 6X19 - -
TM2 241 L 2.65x65 GLP-1 receptor 6X19 glucagon receptor 6WPW
TM2 242 T 2.66x66 GLP-1 receptor 6X19 - -
TM2 243 G 2.67x67 GLP-1 receptor 6X19 - -
TM2 244 I 2.68x68 GLP-1 receptor 6X19 - -
TM2 245 N 2.69x69 GLP-1 receptor 6X19 - -
TM2 246 R 2.70x70 GLP-1 receptor 6X19 - -
ECL1 247 T - - - -
ECL1 248 E - - - -
ECL1 249 P - - - -
ECL1 250 E - - - -
TM3 251 V 3.27x27 GLP-1 receptor 6X19 CT receptor 6NIY
TM3 252 L 3.28x28 GLP-1 receptor 6X19 GHRH receptor 7CZ5
TM3 253 C 3.29x29 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM3 254 S 3.30x30 GLP-1 receptor 6X19 - -
TM3 255 I 3.31x31 GLP-1 receptor 6X19 CT receptor 6NIY
TM3 256 I 3.32x32 GLP-1 receptor 6X19 CRF2 receptor 6PB1
TM3 257 A 3.33x33 GLP-1 receptor 6X19 glucagon receptor 6WPW
TM3 258 G 3.34x34 GLP-1 receptor 6X19 - -
TM3 259 L 3.35x35 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM3 260 L 3.36x36 GLP-1 receptor 6X19 - -
TM3 261 H 3.37x37 GLP-1 receptor 6X19 GHRH receptor 7CZ5
TM3 262 F 3.38x38 GLP-1 receptor 6X19 GHRH receptor 7CZ5
TM3 263 L 3.39x39 GLP-1 receptor 6X19 calcitonin receptor-like receptor 6UUS
TM3 264 Y 3.40x40 GLP-1 receptor 6X19 - -
TM3 265 L 3.41x41 GLP-1 receptor 6X19 - -
TM3 266 A 3.42x42 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM3 267 C 3.43x43 GLP-1 receptor 6X19 - -
TM3 268 F 3.44x44 GLP-1 receptor 6X19 CRF1 receptor 6P9X
TM3 269 T 3.45x45 GLP-1 receptor 6X19 - -
TM3 270 W 3.46x46 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM3 271 M 3.47x47 GLP-1 receptor 6X19 CT receptor 6NIY
TM3 272 L 3.48x48 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM3 273 L 3.49x49 GLP-1 receptor 6X19 - -
TM3 274 E 3.50x50 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM3 275 G 3.51x51 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM3 276 L 3.52x52 GLP-1 receptor 6X19 secretin receptor 6WZG
TM3 277 H 3.53x53 GLP-1 receptor 6X19 - -
TM3 278 L 3.54x54 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM3 279 F 3.55x55 GLP-1 receptor 6X19 PAC1 receptor 6P9Y
TM3 280 L 3.56x56 GLP-1 receptor 6X19 - -
TM3 281 T 3.57x57 GLP-1 receptor 6X19 - -
TM3 282 V 3.58x58 GLP-1 receptor 6X19 - -
TM3 283 R 3.59x59 GLP-1 receptor 6X19 - -
TM3 284 N 3.60x60 GLP-1 receptor 6X19 - -
ICL2 285 L - - - -
ICL2 286 K - - - -
ICL2 287 V - - - -
ICL2 288 A - - - -
ICL2 289 N - - - -
ICL2 290 Y - - - -
ICL2 291 T - - - -
ICL2 292 S - - - -
ICL2 293 T - - - -
TM4 294 G 4.38x39 GLP-1 receptor 6X19 - -
TM4 295 R 4.39x40 GLP-1 receptor 6X19 secretin receptor 7D3S
TM4 296 F 4.40x41 GLP-1 receptor 6X19 - -
TM4 297 K 4.41x42 GLP-1 receptor 6X19 - -
TM4 298 K 4.42x43 GLP-1 receptor 6X19 CRF1 receptor 6P9X
TM4 299 R 4.43x44 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM4 300 F 4.44x45 GLP-1 receptor 6X19 - -
TM4 301 M 4.45x46 GLP-1 receptor 6X19 - -
TM4 302 Y 4.46x47 GLP-1 receptor 6X19 CT receptor 6NIY
TM4 303 P 4.47x48 GLP-1 receptor 6X19 - -
TM4 304 V 4.48x49 GLP-1 receptor 6X19 - -
TM4 305 G 4.49x491 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM4 306 Y 4.50x50 GLP-1 receptor 6X19 - -
TM4 307 G 4.51x51 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM4 308 I 4.52x52 GLP-1 receptor 6X19 CRF2 receptor 6PB1
TM4 309 P 4.53x53 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM4 310 A 4.54x54 GLP-1 receptor 6X19 secretin receptor 6WZG
TM4 311 V 4.55x55 GLP-1 receptor 6X19 CT receptor 6NIY
TM4 312 I 4.56x56 GLP-1 receptor 6X19 CRF1 receptor 6P9X
TM4 313 I 4.57x57 GLP-1 receptor 6X19 CRF1 receptor 6P9X
TM4 314 A 4.58x58 GLP-1 receptor 6X19 secretin receptor 6WZG
TM4 315 V 4.59x59 GLP-1 receptor 6X19 PAC1 receptor 6P9Y
TM4 316 S 4.60x60 GLP-1 receptor 6X19 - -
TM4 317 A 4.61x61 GLP-1 receptor 6X19 secretin receptor 6WZG
TM4 318 I 4.62x62 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM4 319 V 4.63x63 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM4 320 G 4.64x64 GLP-1 receptor 6X19 - -
TM4 321 P 4.65x65 GLP-1 receptor 6X19 - -
TM4 322 Q 4.66x66 GLP-1 receptor 6X19 - -
TM4 323 N 4.67x67 GLP-1 receptor 6X19 - -
TM4 324 Y 4.68x68 GLP-1 receptor 6X19 calcitonin receptor-like receptor 6UUS
ECL2 325 G GLP-1 receptor 6X19 - -
ECL2 326 T GLP-1 receptor 6X19 - -
ECL2 327 F GLP-1 receptor 6X19 - -
ECL2 328 T - - - -
ECL2 329 C 45.50x50 GLP-1 receptor 6X19 GLP-1 receptor 6X19
ECL2 330 W 45.51x51 GLP-1 receptor 6X19 GLP-1 receptor 6X19
ECL2 331 L 45.52x52 GLP-1 receptor 6X19 CT receptor 6NIY
ECL2 332 K - - - -
ECL2 333 L - - - -
TM5 334 D 5.32x32 - - - -
TM5 335 K 5.33x33 - - - -
TM5 336 G 5.34x34 - - - -
TM5 337 F 5.35x35 GLP-1 receptor 6X19 - -
TM5 338 I 5.36x36 GLP-1 receptor 6X19 secretin receptor 6WZG
TM5 339 W 5.37x37 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM5 340 S 5.38x38 GLP-1 receptor 6X19 - -
TM5 341 F 5.39x39 GLP-1 receptor 6X19 - -
TM5 342 M 5.40x40 GLP-1 receptor 6X19 - -
TM5 343 G 5.41x41 GLP-1 receptor 6X19 secretin receptor 6WZG
TM5 344 P 5.42x42 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM5 345 V 5.43x43 GLP-1 receptor 6X19 secretin receptor 6WZG
TM5 346 A 5.44x44 GLP-1 receptor 6X19 CRF1 receptor 4Z9G
TM5 347 V 5.45x45 GLP-1 receptor 6X19 - -
TM5 348 I 5.46x46 GLP-1 receptor 6X19 - -
TM5 349 I 5.47x47 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM5 350 L 5.48x48 GLP-1 receptor 6X19 secretin receptor 6WZG
TM5 351 I 5.49x49 GLP-1 receptor 6X19 secretin receptor 6WZG
TM5 352 N 5.50x50 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM5 353 L 5.51x51 GLP-1 receptor 6X19 calcitonin receptor-like receptor 6UUS
TM5 354 V 5.52x52 GLP-1 receptor 6X19 CRF2 receptor 6PB1
TM5 355 F 5.53x53 GLP-1 receptor 6X19 CT receptor 6NIY
TM5 356 Y 5.54x54 GLP-1 receptor 6X19 - -
TM5 357 F 5.55x55 GLP-1 receptor 6X19 CRF1 receptor 6P9X
TM5 358 Q 5.56x56 GLP-1 receptor 6X19 - -
TM5 359 V 5.57x57 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM5 360 L 5.58x58 GLP-1 receptor 6X19 secretin receptor 6WZG
TM5 361 W 5.59x59 GLP-1 receptor 6X19 - -
TM5 362 I 5.60x60 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM5 363 L 5.61x61 GLP-1 receptor 6X19 secretin receptor 6WZG
TM5 364 R 5.62x62 GLP-1 receptor 6X19 - -
TM5 365 S 5.63x63 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM5 366 K 5.64x64 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM5 367 L 5.65x65 GLP-1 receptor 6X19 GLP-1 receptor 6X19
ICL3 368 S - - - -
ICL3 369 S - - - -
ICL3 370 L - - - -
ICL3 371 N - - - -
ICL3 372 K - - - -
ICL3 374 V - - - -
ICL3 375 S - - - -
ICL3 376 T - - - -
ICL3 377 I - - - -
ICL3 378 Q - - - -
TM6 379 D 6.34x34 GLP-1 receptor 6X19 - -
TM6 380 T 6.35x35 GLP-1 receptor 6X19 - -
TM6 381 R 6.36x36 GLP-1 receptor 6X19 CRF1 receptor 6P9X
TM6 382 V 6.37x37 GLP-1 receptor 6X19 - -
TM6 383 M 6.38x38 GLP-1 receptor 6X19 - -
TM6 384 T 6.39x39 GLP-1 receptor 6X19 - -
TM6 385 F 6.40x40 GLP-1 receptor 6X19 - -
TM6 386 K 6.41x41 GLP-1 receptor 6X19 - -
TM6 387 A 6.42x42 GLP-1 receptor 6X19 - -
TM6 388 I 6.43x43 GLP-1 receptor 6X19 - -
TM6 389 S 6.44x44 GLP-1 receptor 6X19 - -
TM6 390 Q 6.45x45 GLP-1 receptor 6X19 - -
TM6 391 L 6.46x46 GLP-1 receptor 6X19 CRF1 receptor 6P9X
TM6 392 F 6.47x47 GLP-1 receptor 6X19 - -
TM6 393 I 6.48x48 GLP-1 receptor 6X19 - -
TM6 394 L 6.49x49 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM6 395 G 6.50x50 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM6 396 C 6.51x51 GLP-1 receptor 6X19 - -
TM6 397 S 6.52x52 GLP-1 receptor 6X19 - -
TM6 398 W 6.53x53 GLP-1 receptor 6X19 - -
TM6 399 G 6.54x54 GLP-1 receptor 6X19 - -
TM6 400 L 6.55x55 GLP-1 receptor 6X19 CRF1 receptor 6P9X
TM6 401 G 6.56x56 GLP-1 receptor 6X19 - -
TM6 402 F 6.57x57 GLP-1 receptor 6X19 CRF1 receptor 4Z9G
TM6 403 F 6.58x58 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM6 404 M 6.59x59 GLP-1 receptor 6X1A - -
TM6 405 V 6.60x60 GLP-1 receptor 6X1A - -
ECL3 406 E - - - -
ECL3 407 E - - - -
ECL3 408 V - - - -
ECL3 409 G - - - -
TM7 410 K 7.32x31 CT receptor 6NIY CT receptor 6NIY
TM7 411 T 7.33x32 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM7 412 I 7.34x33 GLP-1 receptor 6X19 - -
TM7 413 G 7.35x34 GLP-1 receptor 6X19 CT receptor 6NIY
TM7 414 S 7.36x35 GLP-1 receptor 6X19 glucagon receptor 6WPW
TM7 415 I 7.37x36 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM7 416 I 7.38x37 GLP-1 receptor 6X19 - -
TM7 417 A 7.39x38 GLP-1 receptor 6X19 - -
TM7 418 Y 7.40x39 GLP-1 receptor 6X19 CT receptor 6NIY
TM7 419 S 7.41x40 GLP-1 receptor 6X19 - -
TM7 420 F 7.42x41 GLP-1 receptor 6X19 - -
TM7 421 T 7.43x42 GLP-1 receptor 6X19 - -
TM7 422 I 7.44x43 GLP-1 receptor 6X19 calcitonin receptor-like receptor 6UUS
TM7 423 I 7.45x44 GLP-1 receptor 6X19 - -
TM7 424 N 7.46x45 GLP-1 receptor 6X19 PTH1 receptor 6NBI
TM7 425 T 7.47x46 GLP-1 receptor 6X19 - -
TM7 426 L 7.48x47 GLP-1 receptor 6X19 - -
TM7 427 Q 7.49x49 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM7 428 G 7.50x50 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM7 429 V 7.51x51 GLP-1 receptor 6X19 - -
TM7 430 L 7.52x52 GLP-1 receptor 6X19 calcitonin receptor-like receptor 6UUS
TM7 431 L 7.53x53 GLP-1 receptor 6X19 - -
TM7 432 F 7.54x54 GLP-1 receptor 6X19 - -
TM7 433 V 7.55x55 GLP-1 receptor 6X19 secretin receptor 6WZG
TM7 434 V 7.56x56 GLP-1 receptor 6X19 - -
TM7 435 H 7.57x57 GLP-1 receptor 6X19 - -
TM7 436 C 7.58x58 GLP-1 receptor 6X19 GLP-1 receptor 6X19
TM7 437 L 7.59x59 GLP-1 receptor 6X19 - -
TM7 438 L 7.60x60 GLP-1 receptor 6X19 secretin receptor 6WZG
H8 439 N 8.47x47 GLP-1 receptor 6X19 GLP-1 receptor 6X19
H8 440 R 8.48x48 GLP-1 receptor 6X19 - -
H8 441 Q 8.49x49 GLP-1 receptor 6X19 - -
H8 442 V 8.50x50 GLP-1 receptor 6X19 GLP-1 receptor 6X19
H8 443 R 8.51x51 GLP-1 receptor 6X19 CRF1 receptor 6P9X
H8 444 L 8.52x52 GLP-1 receptor 6X19 GLP-1 receptor 6X19
H8 445 I 8.53x53 GLP-1 receptor 6X19 calcitonin receptor-like receptor 6UUS
H8 446 I 8.54x54 GLP-1 receptor 6X19 CRF1 receptor 6P9X
H8 447 L 8.55x55 GLP-1 receptor 6X19 - -
H8 448 S 8.56x56 GLP-1 receptor 6X19 - -
H8 449 V 8.57x57 GLP-1 receptor 6X19 - -
H8 450 I 8.58x58 GLP-1 receptor 6X19 - -
H8 451 S 8.59x59 GLP-1 receptor 6X19 PTH1 receptor 6NBI
H8 452 L 8.60x60 GLP-1 receptor 6X19 - -
H8 453 V 8.61x61 GLP-1 receptor 6X19 - -
H8 454 P 8.62x62 GLP-1 receptor 6X19 - -
H8 455 K 8.63x63 GLP-1 receptor 6X19 - -
C-term 456 S - - - -
C-term 457 N - - - -