ADGRE4P homology model
PROTEIN CLASS
Class B2 (Adhesion)
RECEPTOR
SPECIES
Homo sapiens
STATE
Inactive
VERSION
2020-09-02
MODEL
MAIN TEMPLATE
TEMPLATES
5UZ7 (CT receptor)
4Z9G (CRF1 receptor)
6P9X (CRF1 receptor)
6WZG (secretin receptor)
6M1H (PAC1 receptor)
None
4Z9G (CRF1 receptor)
6P9X (CRF1 receptor)
6WZG (secretin receptor)
6M1H (PAC1 receptor)
None
| Main template (%) | Additional templates (%) | No template - freely modelled (%) | |
|---|---|---|---|
| Backbone | 73.2 | 10.6 | 16.2 |
| Side-chains | 18.3 | 21.5 | 60.2 |
Number of backbone templates: 5
Number of rotamer templates: 12
| Segment | Seq.num. | AA | GPCRdb# | Backbone | PDB | Rotamer | PDB |
|---|---|---|---|---|---|---|---|
| N-term | 173 | L | - | - | - | - | |
| N-term | 174 | S | - | - | - | - | |
| N-term | 175 | S | - | - | - | - | |
| N-term | 176 | F | - | - | - | - | |
| N-term | 177 | A | - | - | - | - | |
| TM1 | 178 | V | 1.27x27 | CT receptor | 5UZ7 | - | - |
| TM1 | 179 | L | 1.28x28 | CT receptor | 5UZ7 | - | - |
| TM1 | 180 | V | 1.29x29 | CT receptor | 5UZ7 | - | - |
| TM1 | 181 | A | 1.30x30 | CT receptor | 5UZ7 | - | - |
| TM1 | 182 | L | 1.31x31 | CT receptor | 5UZ7 | - | - |
| TM1 | 183 | A | 1.32x32 | CRF1 receptor | 4Z9G | - | - |
| TM1 | 184 | P | 1.33x33 | CRF1 receptor | 4Z9G | - | - |
| TM1 | 185 | K | 1.34x34 | CRF1 receptor | 4Z9G | glucagon receptor | 5XEZ |
| TM1 | 186 | E | 1.35x35 | CRF1 receptor | 4Z9G | - | - |
| TM1 | 187 | D | 1.36x36 | CRF1 receptor | 4Z9G | - | - |
| TM1 | 188 | P | 1.37x37 | CRF1 receptor | 4Z9G | - | - |
| TM1 | 189 | V | 1.38x38 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM1 | 190 | L | 1.39x39 | CRF1 receptor | 4Z9G | GLP-1 receptor | 5VEW |
| TM1 | 191 | T | 1.40x40 | CRF1 receptor | 4Z9G | - | - |
| TM1 | 192 | V | 1.41x41 | CRF1 receptor | 4Z9G | glucagon receptor | 5XEZ |
| TM1 | 193 | I | 1.42x42 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM1 | 194 | T | 1.43x43 | CRF1 receptor | 4Z9G | calcitonin receptor-like receptor | 6UUS |
| TM1 | 195 | Q | 1.44x44 | CRF1 receptor | 4Z9G | - | - |
| TM1 | 196 | V | 1.45x45 | CRF1 receptor | 4Z9G | GLP-1 receptor | 5VEW |
| TM1 | 197 | G | 1.46x46 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM1 | 198 | L | 1.47x47 | CRF1 receptor | 4Z9G | - | - |
| TM1 | 199 | T | 1.48x48 | CRF1 receptor | 4Z9G | - | - |
| TM1 | 200 | I | 1.49x49 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM1 | 201 | S | 1.50x50 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM1 | 202 | L | 1.51x51 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM1 | 203 | L | 1.52x52 | CRF1 receptor | 4Z9G | - | - |
| TM1 | 204 | C | 1.53x53 | CRF1 receptor | 4Z9G | - | - |
| TM1 | 205 | L | 1.54x54 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM1 | 206 | F | 1.55x55 | CRF1 receptor | 4Z9G | - | - |
| TM1 | 207 | L | 1.56x56 | CRF1 receptor | 4Z9G | glucagon receptor | 5XEZ |
| TM1 | 208 | A | 1.57x57 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM1 | 209 | I | 1.58x58 | CRF1 receptor | 4Z9G | - | - |
| TM1 | 210 | L | 1.59x59 | CRF1 receptor | 4Z9G | PTH1 receptor | 6FJ3 |
| TM1 | 211 | T | 1.60x60 | CRF1 receptor | 4Z9G | - | - |
| TM1 | 212 | F | 1.61x61 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM1 | 213 | L | 1.62x62 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM1 | 214 | L | 1.63x63 | CRF1 receptor | 4Z9G | - | - |
| TM1 | 215 | C | 1.64x64 | CRF1 receptor | 4Z9G | - | - |
| ICL1 | 216 | R | 12.48x48 | - | - | - | - |
| ICL1 | 217 | P | 12.49x49 | secretin receptor | 6WZG | - | - |
| ICL1 | 218 | I | 12.50x50 | secretin receptor | 6WZG | CRF1 receptor | 4Z9G |
| ICL1 | 219 | Q | 12.51x51 | - | - | - | - |
| TM2 | 220 | N | 2.44x44 | CRF1 receptor | 4Z9G | - | - |
| TM2 | 221 | T | 2.45x45 | CRF1 receptor | 4Z9G | GLP-1 receptor | 5VEW |
| TM2 | 222 | S | 2.46x46 | CRF1 receptor | 4Z9G | - | - |
| TM2 | 223 | T | 2.47x47 | CRF1 receptor | 4Z9G | - | - |
| TM2 | 224 | S | 2.48x48 | CRF1 receptor | 4Z9G | - | - |
| TM2 | 225 | L | 2.49x49 | CRF1 receptor | 4Z9G | calcitonin receptor-like receptor | 6UUS |
| TM2 | 226 | H | 2.50x50 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM2 | 227 | L | 2.51x51 | CRF1 receptor | 4Z9G | GLP-1 receptor | 5VEW |
| TM2 | 228 | E | 2.52x52 | CRF1 receptor | 4Z9G | - | - |
| TM2 | 229 | L | 2.53x53 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM2 | 230 | S | 2.54x54 | CRF1 receptor | 4Z9G | - | - |
| TM2 | 231 | L | 2.55x55 | CRF1 receptor | 4Z9G | glucagon receptor | 5EE7 |
| TM2 | 232 | C | 2.56x56 | CRF1 receptor | 4Z9G | - | - |
| TM2 | 233 | L | 2.57x57 | CRF1 receptor | 4Z9G | - | - |
| TM2 | 234 | F | 2.58x58 | CRF1 receptor | 4Z9G | - | - |
| TM2 | 235 | L | 2.59x59 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM2 | 236 | A | 2.60x60 | CRF1 receptor | 4Z9G | - | - |
| TM2 | 237 | H | 2.61x61 | CRF1 receptor | 4Z9G | - | - |
| TM2 | 238 | L | 2.62x62 | CRF1 receptor | 4Z9G | GLP-1 receptor | 5VEW |
| TM2 | 239 | L | 2.63x63 | CRF1 receptor | 4Z9G | - | - |
| TM2 | 240 | F | 2.64x64 | CRF1 receptor | 4Z9G | - | - |
| TM2 | 241 | L | 2.65x65 | CRF1 receptor | 4Z9G | glucagon receptor | 5XEZ |
| TM2 | 242 | T | 2.66x66 | CRF1 receptor | 4Z9G | - | - |
| TM2 | 243 | G | 2.67x67 | CRF1 receptor | 4Z9G | - | - |
| TM2 | 244 | I | 2.68x68 | CRF1 receptor | 4Z9G | - | - |
| TM2 | 245 | N | 2.69x69 | CRF1 receptor | 4Z9G | - | - |
| TM2 | 246 | R | 2.70x70 | CRF1 receptor | 4Z9G | - | - |
| ECL1 | 247 | T | - | - | - | - | |
| ECL1 | 248 | E | - | - | - | - | |
| ECL1 | 249 | P | - | - | - | - | |
| ECL1 | 250 | E | - | - | - | - | |
| TM3 | 251 | V | 3.27x27 | CRF1 receptor | 4Z9G | calcitonin receptor-like receptor | 6UUS |
| TM3 | 252 | L | 3.28x28 | CRF1 receptor | 4Z9G | - | - |
| TM3 | 253 | C | 3.29x29 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM3 | 254 | S | 3.30x30 | CRF1 receptor | 4Z9G | - | - |
| TM3 | 255 | I | 3.31x31 | CRF1 receptor | 4Z9G | CT receptor | 6NIY |
| TM3 | 256 | I | 3.32x32 | CRF1 receptor | 4Z9G | CRF2 receptor | 6PB1 |
| TM3 | 257 | A | 3.33x33 | CRF1 receptor | 4Z9G | glucagon receptor | 5XEZ |
| TM3 | 258 | G | 3.34x34 | CRF1 receptor | 4Z9G | - | - |
| TM3 | 259 | L | 3.35x35 | CRF1 receptor | 4Z9G | GLP-1 receptor | 5VEW |
| TM3 | 260 | L | 3.36x36 | CRF1 receptor | 4Z9G | - | - |
| TM3 | 261 | H | 3.37x37 | CRF1 receptor | 4Z9G | PAC1 receptor | 6P9Y |
| TM3 | 262 | F | 3.38x38 | CRF1 receptor | 4Z9G | - | - |
| TM3 | 263 | L | 3.39x39 | CRF1 receptor | 4Z9G | calcitonin receptor-like receptor | 6UUS |
| TM3 | 264 | Y | 3.40x40 | CRF1 receptor | 4Z9G | - | - |
| TM3 | 265 | L | 3.41x41 | CRF1 receptor | 4Z9G | - | - |
| TM3 | 266 | A | 3.42x42 | CRF1 receptor | 4Z9G | GLP-1 receptor | 5VEW |
| TM3 | 267 | C | 3.43x43 | CRF1 receptor | 4Z9G | - | - |
| TM3 | 268 | F | 3.44x44 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM3 | 269 | T | 3.45x45 | CRF1 receptor | 4Z9G | - | - |
| TM3 | 270 | W | 3.46x46 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM3 | 271 | M | 3.47x47 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM3 | 272 | L | 3.48x48 | CRF1 receptor | 4Z9G | GLP-1 receptor | 5VEW |
| TM3 | 273 | L | 3.49x49 | CRF1 receptor | 4Z9G | - | - |
| TM3 | 274 | E | 3.50x50 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM3 | 275 | G | 3.51x51 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM3 | 276 | L | 3.52x52 | CRF1 receptor | 4Z9G | glucagon receptor | 5XEZ |
| TM3 | 277 | H | 3.53x53 | CRF1 receptor | 4Z9G | - | - |
| TM3 | 278 | L | 3.54x54 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM3 | 279 | F | 3.55x55 | CRF1 receptor | 4Z9G | PAC1 receptor | 6P9Y |
| TM3 | 280 | L | 3.56x56 | CRF1 receptor | 4Z9G | - | - |
| TM3 | 281 | T | 3.57x57 | CRF1 receptor | 4Z9G | - | - |
| TM3 | 282 | V | 3.58x58 | CRF1 receptor | 4Z9G | - | - |
| TM3 | 283 | R | 3.59x59 | CRF1 receptor | 4Z9G | - | - |
| TM3 | 284 | N | 3.60x60 | CRF1 receptor | 4Z9G | - | - |
| ICL2 | 285 | L | - | - | - | - | |
| ICL2 | 286 | K | - | - | - | - | |
| ICL2 | 287 | V | - | - | - | - | |
| ICL2 | 288 | A | - | - | - | - | |
| ICL2 | 289 | N | - | - | - | - | |
| ICL2 | 290 | Y | - | - | - | - | |
| ICL2 | 291 | T | - | - | - | - | |
| ICL2 | 292 | S | - | - | - | - | |
| ICL2 | 293 | T | - | - | - | - | |
| ICL2 | 294 | G | - | - | - | - | |
| ICL2 | 295 | R | - | - | - | - | |
| TM4 | 296 | F | 4.40x41 | CRF1 receptor | 4Z9G | - | - |
| TM4 | 297 | K | 4.41x42 | CRF1 receptor | 4Z9G | - | - |
| TM4 | 298 | K | 4.42x43 | CRF1 receptor | 4Z9G | CRF1 receptor | 6P9X |
| TM4 | 299 | R | 4.43x44 | CRF1 receptor | 4Z9G | GLP-1 receptor | 5VEW |
| TM4 | 300 | F | 4.44x45 | CRF1 receptor | 4Z9G | - | - |
| TM4 | 301 | M | 4.45x46 | CRF1 receptor | 4Z9G | - | - |
| TM4 | 302 | Y | 4.46x47 | CRF1 receptor | 4Z9G | calcitonin receptor-like receptor | 6UUS |
| TM4 | 303 | P | 4.47x48 | CRF1 receptor | 4Z9G | - | - |
| TM4 | 304 | V | 4.48x49 | CRF1 receptor | 4Z9G | - | - |
| TM4 | 305 | G | 4.49x491 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM4 | 306 | Y | 4.50x50 | CRF1 receptor | 4Z9G | - | - |
| TM4 | 307 | G | 4.51x51 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM4 | 308 | I | 4.52x52 | CRF1 receptor | 4Z9G | CRF2 receptor | 6PB1 |
| TM4 | 309 | P | 4.53x53 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM4 | 310 | A | 4.54x54 | CRF1 receptor | 4Z9G | glucagon receptor | 5EE7 |
| TM4 | 311 | V | 4.55x55 | CRF1 receptor | 4Z9G | CT receptor | 6NIY |
| TM4 | 312 | I | 4.56x56 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM4 | 313 | I | 4.57x57 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM4 | 314 | A | 4.58x58 | CRF1 receptor | 4Z9G | PTH1 receptor | 6FJ3 |
| TM4 | 315 | V | 4.59x59 | CRF1 receptor | 4Z9G | PTH1 receptor | 6FJ3 |
| TM4 | 316 | S | 4.60x60 | CRF1 receptor | 4Z9G | - | - |
| TM4 | 317 | A | 4.61x61 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM4 | 318 | I | 4.62x62 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM4 | 319 | V | 4.63x63 | CRF1 receptor | 4Z9G | GLP-1 receptor | 5VEW |
| TM4 | 320 | G | 4.64x64 | CRF1 receptor | 4Z9G | - | - |
| TM4 | 321 | P | 4.65x65 | CRF1 receptor | 4Z9G | - | - |
| TM4 | 322 | Q | 4.66x66 | CRF1 receptor | 4Z9G | - | - |
| TM4 | 323 | N | 4.67x67 | CRF1 receptor | 4Z9G | - | - |
| TM4 | 324 | Y | 4.68x68 | CRF1 receptor | 4Z9G | calcitonin receptor-like receptor | 6UUS |
| ECL2 | 325 | G | CRF1 receptor | 4Z9G | - | - | |
| ECL2 | 326 | T | CRF1 receptor | 4Z9G | - | - | |
| ECL2 | 327 | F | CRF1 receptor | 4Z9G | - | - | |
| ECL2 | 328 | T | - | - | - | - | |
| ECL2 | 329 | C | 45.50x50 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| ECL2 | 330 | W | 45.51x51 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| ECL2 | 331 | L | 45.52x52 | CRF1 receptor | 4Z9G | CT receptor | 6NIY |
| ECL2 | 332 | K | - | - | - | - | |
| ECL2 | 333 | L | - | - | - | - | |
| TM5 | 334 | D | 5.32x32 | - | - | - | - |
| TM5 | 335 | K | 5.33x33 | - | - | - | - |
| TM5 | 336 | G | 5.34x34 | - | - | - | - |
| TM5 | 337 | F | 5.35x35 | - | - | - | - |
| TM5 | 338 | I | 5.36x36 | CRF1 receptor | 4Z9G | secretin receptor | 6WZG |
| TM5 | 339 | W | 5.37x37 | CRF1 receptor | 4Z9G | GLP-1 receptor | 5VEW |
| TM5 | 340 | S | 5.38x38 | CRF1 receptor | 4Z9G | - | - |
| TM5 | 341 | F | 5.39x39 | CRF1 receptor | 4Z9G | - | - |
| TM5 | 342 | M | 5.40x40 | CRF1 receptor | 4Z9G | - | - |
| TM5 | 343 | G | 5.41x41 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM5 | 344 | P | 5.42x42 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM5 | 345 | V | 5.43x43 | CRF1 receptor | 4Z9G | glucagon receptor | 5XEZ |
| TM5 | 346 | A | 5.44x44 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM5 | 347 | V | 5.45x45 | CRF1 receptor | 4Z9G | - | - |
| TM5 | 348 | I | 5.46x46 | CRF1 receptor | 4Z9G | - | - |
| TM5 | 349 | I | 5.47x47 | CRF1 receptor | 4Z9G | glucagon receptor | 5XEZ |
| TM5 | 350 | L | 5.48x48 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM5 | 351 | I | 5.49x49 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM5 | 352 | N | 5.50x50 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM5 | 353 | L | 5.51x51 | CRF1 receptor | 4Z9G | calcitonin receptor-like receptor | 6UUS |
| TM5 | 354 | V | 5.52x52 | CRF1 receptor | 4Z9G | CRF2 receptor | 6PB1 |
| TM5 | 355 | F | 5.53x53 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM5 | 356 | Y | 5.54x54 | CRF1 receptor | 4Z9G | - | - |
| TM5 | 357 | F | 5.55x55 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM5 | 358 | Q | 5.56x56 | CRF1 receptor | 4Z9G | - | - |
| TM5 | 359 | V | 5.57x57 | CRF1 receptor | 4Z9G | GLP-1 receptor | 5VEW |
| TM5 | 360 | L | 5.58x58 | CRF1 receptor | 4Z9G | secretin receptor | 6WZG |
| TM5 | 361 | W | 5.59x59 | CRF1 receptor | 4Z9G | - | - |
| TM5 | 362 | I | 5.60x60 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM5 | 363 | L | 5.61x61 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM5 | 364 | R | 5.62x62 | CRF1 receptor | 4Z9G | - | - |
| TM5 | 365 | S | 5.63x63 | CRF1 receptor | 4Z9G | GLP-1 receptor | 5VEW |
| TM5 | 366 | K | 5.64x64 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM5 | 367 | L | 5.65x65 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| ICL3 | 368 | S | - | - | - | - | |
| ICL3 | 369 | S | - | - | - | - | |
| ICL3 | 370 | L | - | - | - | - | |
| ICL3 | 371 | N | - | - | - | - | |
| ICL3 | 372 | K | - | - | - | - | |
| ICL3 | 374 | V | - | - | - | - | |
| ICL3 | 375 | S | - | - | - | - | |
| ICL3 | 376 | T | - | - | - | - | |
| ICL3 | 377 | I | - | - | - | - | |
| ICL3 | 378 | Q | - | - | - | - | |
| TM6 | 379 | D | 6.34x34 | CRF1 receptor | 4Z9G | - | - |
| TM6 | 380 | T | 6.35x35 | CRF1 receptor | 4Z9G | - | - |
| TM6 | 381 | R | 6.36x36 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM6 | 382 | V | 6.37x37 | CRF1 receptor | 4Z9G | - | - |
| TM6 | 383 | M | 6.38x38 | CRF1 receptor | 4Z9G | - | - |
| TM6 | 384 | T | 6.39x39 | CRF1 receptor | 4Z9G | - | - |
| TM6 | 385 | F | 6.40x40 | CRF1 receptor | 4Z9G | - | - |
| TM6 | 386 | K | 6.41x41 | CRF1 receptor | 4Z9G | - | - |
| TM6 | 387 | A | 6.42x42 | CRF1 receptor | 4Z9G | - | - |
| TM6 | 388 | I | 6.43x43 | CRF1 receptor | 4Z9G | - | - |
| TM6 | 389 | S | 6.44x44 | CRF1 receptor | 4Z9G | - | - |
| TM6 | 390 | Q | 6.45x45 | CRF1 receptor | 4Z9G | - | - |
| TM6 | 391 | L | 6.46x46 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM6 | 392 | F | 6.47x47 | CRF1 receptor | 4Z9G | - | - |
| TM6 | 393 | I | 6.48x48 | CRF1 receptor | 4Z9G | - | - |
| TM6 | 394 | L | 6.49x49 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM6 | 395 | G | 6.50x50 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM6 | 396 | C | 6.51x51 | CRF1 receptor | 4Z9G | - | - |
| TM6 | 397 | S | 6.52x52 | CRF1 receptor | 4Z9G | - | - |
| TM6 | 398 | W | 6.53x53 | CRF1 receptor | 4Z9G | - | - |
| TM6 | 399 | G | 6.54x54 | CRF1 receptor | 4Z9G | - | - |
| TM6 | 400 | L | 6.55x55 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM6 | 401 | G | 6.56x56 | CRF1 receptor | 4Z9G | - | - |
| TM6 | 402 | F | 6.57x57 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM6 | 403 | F | 6.58x58 | CRF1 receptor | 4Z9G | - | - |
| TM6 | 404 | M | 6.59x59 | PAC1 receptor | 6M1H | - | - |
| ECL3 | 405 | V | - | - | - | - | |
| ECL3 | 406 | E | - | - | - | - | |
| ECL3 | 407 | E | - | - | - | - | |
| ECL3 | 408 | V | - | - | - | - | |
| ECL3 | 409 | G | - | - | - | - | |
| TM7 | 410 | K | 7.32x31 | CRF1 receptor | 6P9X | CT receptor | 6NIY |
| TM7 | 411 | T | 7.33x32 | CRF1 receptor | 4Z9G | glucagon receptor | 5YQZ |
| TM7 | 412 | I | 7.34x33 | CRF1 receptor | 4Z9G | - | - |
| TM7 | 413 | G | 7.35x34 | CRF1 receptor | 4Z9G | CT receptor | 6NIY |
| TM7 | 414 | S | 7.36x35 | CRF1 receptor | 4Z9G | glucagon receptor | 5XEZ |
| TM7 | 415 | I | 7.37x36 | CRF1 receptor | 4Z9G | GLP-1 receptor | 5VEW |
| TM7 | 416 | I | 7.38x37 | CRF1 receptor | 4Z9G | - | - |
| TM7 | 417 | A | 7.39x38 | CRF1 receptor | 4Z9G | - | - |
| TM7 | 418 | Y | 7.40x39 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM7 | 419 | S | 7.41x40 | CRF1 receptor | 4Z9G | - | - |
| TM7 | 420 | F | 7.42x41 | CRF1 receptor | 4Z9G | - | - |
| TM7 | 421 | T | 7.43x42 | CRF1 receptor | 4Z9G | - | - |
| TM7 | 422 | I | 7.44x43 | CRF1 receptor | 4Z9G | calcitonin receptor-like receptor | 6UUS |
| TM7 | 423 | I | 7.45x44 | CRF1 receptor | 4Z9G | - | - |
| TM7 | 424 | N | 7.46x45 | CRF1 receptor | 4Z9G | PTH1 receptor | 6FJ3 |
| TM7 | 425 | T | 7.47x46 | CRF1 receptor | 4Z9G | - | - |
| TM7 | 426 | L | 7.48x47 | CRF1 receptor | 4Z9G | - | - |
| TM7 | 427 | Q | 7.49x49 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM7 | 428 | G | 7.50x50 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM7 | 429 | V | 7.51x51 | CRF1 receptor | 4Z9G | - | - |
| TM7 | 430 | L | 7.52x52 | CRF1 receptor | 4Z9G | glucagon receptor | 5XEZ |
| TM7 | 431 | L | 7.53x53 | CRF1 receptor | 4Z9G | - | - |
| TM7 | 432 | F | 7.54x54 | CRF1 receptor | 4Z9G | - | - |
| TM7 | 433 | V | 7.55x55 | CRF1 receptor | 4Z9G | CRF1 receptor | 4Z9G |
| TM7 | 434 | V | 7.56x56 | CRF1 receptor | 4Z9G | - | - |
| TM7 | 435 | H | 7.57x57 | secretin receptor | 6WZG | - | - |
| TM7 | 436 | C | 7.58x58 | secretin receptor | 6WZG | secretin receptor | 6WZG |
| TM7 | 437 | L | 7.59x59 | secretin receptor | 6WZG | - | - |
| TM7 | 438 | L | 7.60x60 | secretin receptor | 6WZG | secretin receptor | 6WZG |
| H8 | 439 | N | 8.47x47 | secretin receptor | 6WZG | secretin receptor | 6WZG |
| H8 | 440 | R | 8.48x48 | secretin receptor | 6WZG | - | - |
| H8 | 441 | Q | 8.49x49 | secretin receptor | 6WZG | - | - |
| H8 | 442 | V | 8.50x50 | secretin receptor | 6WZG | secretin receptor | 6WZG |
| H8 | 443 | R | 8.51x51 | secretin receptor | 6WZG | CRF1 receptor | 6P9X |
| H8 | 444 | L | 8.52x52 | secretin receptor | 6WZG | GLP-1 receptor | 5VEW |
| H8 | 445 | I | 8.53x53 | secretin receptor | 6WZG | calcitonin receptor-like receptor | 6UUS |
| H8 | 446 | I | 8.54x54 | secretin receptor | 6WZG | PTH1 receptor | 6FJ3 |
| H8 | 447 | L | 8.55x55 | secretin receptor | 6WZG | - | - |
| H8 | 448 | S | 8.56x56 | secretin receptor | 6WZG | - | - |
| H8 | 449 | V | 8.57x57 | secretin receptor | 6WZG | - | - |
| H8 | 450 | I | 8.58x58 | secretin receptor | 6WZG | - | - |
| H8 | 451 | S | 8.59x59 | secretin receptor | 6WZG | secretin receptor | 6WZG |
| H8 | 452 | L | 8.60x60 | secretin receptor | 6WZG | - | - |
| H8 | 453 | V | 8.61x61 | secretin receptor | 6WZG | - | - |
| H8 | 454 | P | 8.62x62 | secretin receptor | 6WZG | - | - |
| H8 | 455 | K | 8.63x63 | secretin receptor | 6WZG | - | - |
| C-term | 456 | S | - | - | - | - | |
| C-term | 457 | N | - | - | - | - |