ADGRE4P homology model
PROTEIN CLASS
Class B2 (Adhesion)
RECEPTOR
SPECIES
Homo sapiens
STATE
Inactive
VERSION
2021-11-02
MODEL
MAIN TEMPLATE
TEMPLATES
7D77 (ADGRG3)
4K5Y (CRF1 receptor)
6WZG (secretin receptor)
None
4K5Y (CRF1 receptor)
6WZG (secretin receptor)
None
| Main template (%) | Additional templates (%) | No template - freely modelled (%) | |
|---|---|---|---|
| Backbone | 72.3 | 10.4 | 17.3 |
| Side-chains | 18.7 | 29.1 | 52.2 |
Number of backbone templates: 3
Number of rotamer templates: 18
| Segment | Seq.num. | AA | GPCRdb# | Backbone | PDB | Rotamer | PDB |
|---|---|---|---|---|---|---|---|
| N-term | 180 | V | - | - | - | - | - |
| N-term | 181 | A | - | - | - | - | - |
| N-term | 182 | L | - | - | - | - | - |
| N-term | 183 | A | - | - | - | - | - |
| N-term | 184 | P | - | - | - | - | - |
| TM1 | 185 | K | 1.34x34 | ADGRG3 | 7D77 | - | - |
| TM1 | 186 | E | 1.35x35 | ADGRG3 | 7D77 | - | - |
| TM1 | 187 | D | 1.36x36 | ADGRG3 | 7D77 | - | - |
| TM1 | 188 | P | 1.37x37 | CRF1 receptor | 4K5Y | - | - |
| TM1 | 189 | V | 1.38x38 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM1 | 190 | L | 1.39x39 | CRF1 receptor | 4K5Y | calcitonin receptor-like receptor | 7KNU |
| TM1 | 191 | T | 1.40x40 | CRF1 receptor | 4K5Y | ADGRG3 | 7D77 |
| TM1 | 192 | V | 1.41x41 | CRF1 receptor | 4K5Y | glucagon receptor | 5YQZ |
| TM1 | 193 | I | 1.42x42 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM1 | 194 | T | 1.43x43 | CRF1 receptor | 4K5Y | calcitonin receptor-like receptor | 7KNU |
| TM1 | 195 | Q | 1.44x44 | CRF1 receptor | 4K5Y | ADGRG3 | 7D77 |
| TM1 | 196 | V | 1.45x45 | CRF1 receptor | 4K5Y | glucagon receptor | 5YQZ |
| TM1 | 197 | G | 1.46x46 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM1 | 198 | L | 1.47x47 | CRF1 receptor | 4K5Y | - | - |
| TM1 | 199 | T | 1.48x48 | CRF1 receptor | 4K5Y | - | - |
| TM1 | 200 | I | 1.49x49 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM1 | 201 | S | 1.50x50 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM1 | 202 | L | 1.51x51 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM1 | 203 | L | 1.52x52 | CRF1 receptor | 4K5Y | - | - |
| TM1 | 204 | C | 1.53x53 | CRF1 receptor | 4K5Y | - | - |
| TM1 | 205 | L | 1.54x54 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM1 | 206 | F | 1.55x55 | CRF1 receptor | 4K5Y | GHRH receptor | 7CZ5 |
| TM1 | 207 | L | 1.56x56 | CRF1 receptor | 4K5Y | glucagon receptor | 5YQZ |
| TM1 | 208 | A | 1.57x57 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM1 | 209 | I | 1.58x58 | CRF1 receptor | 4K5Y | ADGRG3 | 7D77 |
| TM1 | 210 | L | 1.59x59 | CRF1 receptor | 4K5Y | PTH1 receptor | 6FJ3 |
| TM1 | 211 | T | 1.60x60 | CRF1 receptor | 4K5Y | - | - |
| TM1 | 212 | F | 1.61x61 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM1 | 213 | L | 1.62x62 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM1 | 214 | L | 1.63x63 | CRF1 receptor | 4K5Y | GIP receptor | 7DTY |
| TM1 | 215 | C | 1.64x64 | CRF1 receptor | 4K5Y | - | - |
| ICL1 | 216 | R | 12.48x48 | - | - | - | - |
| ICL1 | 217 | P | 12.49x49 | ADGRG3 | 7D77 | - | - |
| ICL1 | 218 | I | 12.50x50 | ADGRG3 | 7D77 | CRF1 receptor | 4Z9G |
| ICL1 | 219 | Q | 12.51x51 | - | - | - | - |
| TM2 | 220 | N | 2.44x44 | CRF1 receptor | 4K5Y | - | - |
| TM2 | 221 | T | 2.45x45 | CRF1 receptor | 4K5Y | glucagon receptor | 5YQZ |
| TM2 | 222 | S | 2.46x46 | CRF1 receptor | 4K5Y | - | - |
| TM2 | 223 | T | 2.47x47 | CRF1 receptor | 4K5Y | - | - |
| TM2 | 224 | S | 2.48x48 | CRF1 receptor | 4K5Y | - | - |
| TM2 | 225 | L | 2.49x49 | CRF1 receptor | 4K5Y | calcitonin receptor-like receptor | 7KNU |
| TM2 | 226 | H | 2.50x50 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM2 | 227 | L | 2.51x51 | CRF1 receptor | 4K5Y | GLP-1 receptor | 6LN2 |
| TM2 | 228 | E | 2.52x52 | CRF1 receptor | 4K5Y | - | - |
| TM2 | 229 | L | 2.53x53 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM2 | 230 | S | 2.54x54 | CRF1 receptor | 4K5Y | - | - |
| TM2 | 231 | L | 2.55x55 | CRF1 receptor | 4K5Y | glucagon receptor | 5EE7 |
| TM2 | 232 | C | 2.56x56 | CRF1 receptor | 4K5Y | - | - |
| TM2 | 233 | L | 2.57x57 | CRF1 receptor | 4K5Y | ADGRG3 | 7D77 |
| TM2 | 234 | F | 2.58x58 | CRF1 receptor | 4K5Y | ADGRG3 | 7D77 |
| TM2 | 235 | L | 2.59x59 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM2 | 236 | A | 2.60x60 | CRF1 receptor | 4K5Y | - | - |
| TM2 | 237 | H | 2.61x61 | CRF1 receptor | 4K5Y | - | - |
| TM2 | 238 | L | 2.62x62 | CRF1 receptor | 4K5Y | GLP-1 receptor | 6LN2 |
| TM2 | 239 | L | 2.63x63 | CRF1 receptor | 4K5Y | - | - |
| TM2 | 240 | F | 2.64x64 | CRF1 receptor | 4K5Y | ADGRG3 | 7D77 |
| TM2 | 241 | L | 2.65x65 | CRF1 receptor | 4K5Y | glucagon receptor | 5YQZ |
| TM2 | 242 | T | 2.66x66 | CRF1 receptor | 4K5Y | - | - |
| TM2 | 243 | G | 2.67x67 | CRF1 receptor | 4K5Y | - | - |
| TM2 | 244 | I | 2.68x68 | CRF1 receptor | 4K5Y | - | - |
| TM2 | 245 | N | 2.69x69 | CRF1 receptor | 4K5Y | - | - |
| TM2 | 246 | R | 2.70x70 | CRF1 receptor | 4K5Y | - | - |
| ECL1 | 247 | T | - | - | - | - | - |
| ECL1 | 248 | E | - | - | - | - | - |
| ECL1 | 249 | P | - | - | - | - | - |
| ECL1 | 250 | E | - | - | - | - | - |
| TM3 | 251 | V | 3.27x27 | CRF1 receptor | 4K5Y | calcitonin receptor-like receptor | 7KNU |
| TM3 | 252 | L | 3.28x28 | CRF1 receptor | 4K5Y | GHRH receptor | 7CZ5 |
| TM3 | 253 | C | 3.29x29 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM3 | 254 | S | 3.30x30 | CRF1 receptor | 4K5Y | - | - |
| TM3 | 255 | I | 3.31x31 | CRF1 receptor | 4K5Y | CT receptor | 6NIY |
| TM3 | 256 | I | 3.32x32 | CRF1 receptor | 4K5Y | CRF2 receptor | 6PB1 |
| TM3 | 257 | A | 3.33x33 | CRF1 receptor | 4K5Y | glucagon receptor | 5YQZ |
| TM3 | 258 | G | 3.34x34 | CRF1 receptor | 4K5Y | - | - |
| TM3 | 259 | L | 3.35x35 | CRF1 receptor | 4K5Y | GLP-1 receptor | 6LN2 |
| TM3 | 260 | L | 3.36x36 | CRF1 receptor | 4K5Y | GLP-2 receptor | 7D68 |
| TM3 | 261 | H | 3.37x37 | CRF1 receptor | 4K5Y | ADGRG3 | 7D77 |
| TM3 | 262 | F | 3.38x38 | CRF1 receptor | 4K5Y | GHRH receptor | 7CZ5 |
| TM3 | 263 | L | 3.39x39 | CRF1 receptor | 4K5Y | calcitonin receptor-like receptor | 7KNU |
| TM3 | 264 | Y | 3.40x40 | CRF1 receptor | 4K5Y | - | - |
| TM3 | 265 | L | 3.41x41 | CRF1 receptor | 4K5Y | ADGRG3 | 7D77 |
| TM3 | 266 | A | 3.42x42 | CRF1 receptor | 4K5Y | glucagon receptor | 5YQZ |
| TM3 | 267 | C | 3.43x43 | CRF1 receptor | 4K5Y | - | - |
| TM3 | 268 | F | 3.44x44 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM3 | 269 | T | 3.45x45 | CRF1 receptor | 4K5Y | ADGRG3 | 7D77 |
| TM3 | 270 | W | 3.46x46 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM3 | 271 | M | 3.47x47 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM3 | 272 | L | 3.48x48 | CRF1 receptor | 4K5Y | glucagon receptor | 5YQZ |
| TM3 | 273 | L | 3.49x49 | CRF1 receptor | 4K5Y | ADGRG3 | 7D77 |
| TM3 | 274 | E | 3.50x50 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM3 | 275 | G | 3.51x51 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM3 | 276 | L | 3.52x52 | CRF1 receptor | 4K5Y | glucagon receptor | 5YQZ |
| TM3 | 277 | H | 3.53x53 | CRF1 receptor | 4K5Y | ADGRG3 | 7D77 |
| TM3 | 278 | L | 3.54x54 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM3 | 279 | F | 3.55x55 | CRF1 receptor | 4K5Y | PAC1 receptor | 6P9Y |
| TM3 | 280 | L | 3.56x56 | CRF1 receptor | 4K5Y | ADGRG3 | 7D77 |
| TM3 | 281 | T | 3.57x57 | CRF1 receptor | 4K5Y | - | - |
| TM3 | 282 | V | 3.58x58 | CRF1 receptor | 4K5Y | - | - |
| TM3 | 283 | R | 3.59x59 | CRF1 receptor | 4K5Y | - | - |
| TM3 | 284 | N | 3.60x60 | CRF1 receptor | 4K5Y | - | - |
| ICL2 | 285 | L | - | - | - | - | - |
| ICL2 | 286 | K | - | - | - | - | - |
| ICL2 | 287 | V | - | - | - | - | - |
| ICL2 | 288 | A | - | - | - | - | - |
| ICL2 | 289 | N | - | - | - | - | - |
| ICL2 | 290 | Y | - | - | - | - | - |
| ICL2 | 291 | T | - | - | - | - | - |
| ICL2 | 292 | S | - | - | - | - | - |
| ICL2 | 293 | T | - | - | - | - | - |
| ICL2 | 294 | G | - | - | - | - | - |
| ICL2 | 295 | R | - | - | - | - | - |
| TM4 | 296 | F | 4.40x41 | CRF1 receptor | 4K5Y | - | - |
| TM4 | 297 | K | 4.41x42 | CRF1 receptor | 4K5Y | - | - |
| TM4 | 298 | K | 4.42x43 | CRF1 receptor | 4K5Y | CRF1 receptor | 6PB0 |
| TM4 | 299 | R | 4.43x44 | CRF1 receptor | 4K5Y | GLP-1 receptor | 5VEW |
| TM4 | 300 | F | 4.44x45 | CRF1 receptor | 4K5Y | - | - |
| TM4 | 301 | M | 4.45x46 | CRF1 receptor | 4K5Y | - | - |
| TM4 | 302 | Y | 4.46x47 | CRF1 receptor | 4K5Y | calcitonin receptor-like receptor | 7KNU |
| TM4 | 303 | P | 4.47x48 | CRF1 receptor | 4K5Y | - | - |
| TM4 | 304 | V | 4.48x49 | CRF1 receptor | 4K5Y | ADGRG3 | 7D77 |
| TM4 | 305 | G | 4.49x491 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM4 | 306 | Y | 4.50x50 | CRF1 receptor | 4K5Y | - | - |
| TM4 | 307 | G | 4.51x51 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM4 | 308 | I | 4.52x52 | CRF1 receptor | 4K5Y | CRF2 receptor | 6PB1 |
| TM4 | 309 | P | 4.53x53 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM4 | 310 | A | 4.54x54 | CRF1 receptor | 4K5Y | glucagon receptor | 5EE7 |
| TM4 | 311 | V | 4.55x55 | CRF1 receptor | 4K5Y | CT receptor | 6NIY |
| TM4 | 312 | I | 4.56x56 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM4 | 313 | I | 4.57x57 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM4 | 314 | A | 4.58x58 | CRF1 receptor | 4K5Y | PTH1 receptor | 6FJ3 |
| TM4 | 315 | V | 4.59x59 | CRF1 receptor | 4K5Y | PTH1 receptor | 6FJ3 |
| TM4 | 316 | S | 4.60x60 | CRF1 receptor | 4K5Y | - | - |
| TM4 | 317 | A | 4.61x61 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM4 | 318 | I | 4.62x62 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM4 | 319 | V | 4.63x63 | CRF1 receptor | 4K5Y | glucagon receptor | 5YQZ |
| TM4 | 320 | G | 4.64x64 | CRF1 receptor | 4K5Y | - | - |
| ECL2 | 321 | P | - | - | - | - | - |
| ECL2 | 322 | Q | - | - | - | - | - |
| ECL2 | 323 | N | - | - | - | - | - |
| ECL2 | 324 | Y | - | - | - | - | - |
| ECL2 | 325 | G | - | - | - | - | - |
| ECL2 | 326 | T | - | - | - | - | - |
| ECL2 | 327 | F | - | - | - | - | - |
| ECL2 | 328 | T | - | - | - | - | - |
| ECL2 | 329 | C | 45.50x50 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| ECL2 | 330 | W | 45.51x51 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| ECL2 | 331 | L | 45.52x52 | CRF1 receptor | 4K5Y | CT receptor | 6NIY |
| ECL2 | 332 | K | - | - | - | - | - |
| ECL2 | 333 | L | - | secretin receptor | 6WZG | - | - |
| ECL2 | 334 | D | - | - | - | - | - |
| TM5 | 335 | K | 5.33x33 | secretin receptor | 6WZG | - | - |
| TM5 | 336 | G | 5.34x34 | secretin receptor | 6WZG | PTH2 receptor | 7F16 |
| TM5 | 337 | F | 5.35x35 | secretin receptor | 6WZG | - | - |
| TM5 | 338 | I | 5.36x36 | CRF1 receptor | 4K5Y | secretin receptor | 6WZG |
| TM5 | 339 | W | 5.37x37 | CRF1 receptor | 4K5Y | glucagon receptor | 5YQZ |
| TM5 | 340 | S | 5.38x38 | CRF1 receptor | 4K5Y | - | - |
| TM5 | 341 | F | 5.39x39 | CRF1 receptor | 4K5Y | - | - |
| TM5 | 342 | M | 5.40x40 | CRF1 receptor | 4K5Y | - | - |
| TM5 | 343 | G | 5.41x41 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM5 | 344 | P | 5.42x42 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM5 | 345 | V | 5.43x43 | CRF1 receptor | 4K5Y | glucagon receptor | 5YQZ |
| TM5 | 346 | A | 5.44x44 | CRF1 receptor | 4K5Y | CRF1 receptor | 4Z9G |
| TM5 | 347 | V | 5.45x45 | CRF1 receptor | 4K5Y | - | - |
| TM5 | 348 | I | 5.46x46 | CRF1 receptor | 4K5Y | - | - |
| TM5 | 349 | I | 5.47x47 | CRF1 receptor | 4K5Y | glucagon receptor | 5YQZ |
| TM5 | 350 | L | 5.48x48 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM5 | 351 | I | 5.49x49 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM5 | 352 | N | 5.50x50 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM5 | 353 | L | 5.51x51 | CRF1 receptor | 4K5Y | calcitonin receptor-like receptor | 7KNU |
| TM5 | 354 | V | 5.52x52 | CRF1 receptor | 4K5Y | ADGRG3 | 7D77 |
| TM5 | 355 | F | 5.53x53 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM5 | 356 | Y | 5.54x54 | CRF1 receptor | 4K5Y | - | - |
| TM5 | 357 | F | 5.55x55 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM5 | 358 | Q | 5.56x56 | CRF1 receptor | 4K5Y | - | - |
| TM5 | 359 | V | 5.57x57 | CRF1 receptor | 4K5Y | GLP-1 receptor | 6LN2 |
| TM5 | 360 | L | 5.58x58 | CRF1 receptor | 4K5Y | secretin receptor | 6WZG |
| TM5 | 361 | W | 5.59x59 | CRF1 receptor | 4K5Y | ADGRG3 | 7D77 |
| TM5 | 362 | I | 5.60x60 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM5 | 363 | L | 5.61x61 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM5 | 364 | R | 5.62x62 | CRF1 receptor | 4K5Y | - | - |
| TM5 | 365 | S | 5.63x63 | CRF1 receptor | 4K5Y | GLP-1 receptor | 6LN2 |
| TM5 | 366 | K | 5.64x64 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM5 | 367 | L | 5.65x65 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM5 | 368 | S | 5.66x66 | ADGRG3 | 7D77 | - | - |
| TM5 | 369 | S | 5.67x67 | ADGRG3 | 7D77 | - | - |
| TM5 | 370 | L | 5.68x68 | ADGRG3 | 7D77 | - | - |
| ICL3 | 371 | N | - | - | - | - | - |
| ICL3 | 372 | K | - | - | - | - | - |
| ICL3 | 373 | E | - | - | - | - | - |
| ICL3 | 374 | V | - | - | - | - | - |
| ICL3 | 375 | S | - | - | - | - | - |
| ICL3 | 376 | T | - | - | - | - | - |
| ICL3 | 377 | I | - | - | - | - | - |
| ICL3 | 378 | Q | - | - | - | - | - |
| TM6 | 379 | D | 6.34x34 | CRF1 receptor | 4K5Y | - | - |
| TM6 | 380 | T | 6.35x35 | CRF1 receptor | 4K5Y | - | - |
| TM6 | 381 | R | 6.36x36 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM6 | 382 | V | 6.37x37 | CRF1 receptor | 4K5Y | - | - |
| TM6 | 383 | M | 6.38x38 | CRF1 receptor | 4K5Y | - | - |
| TM6 | 384 | T | 6.39x39 | CRF1 receptor | 4K5Y | - | - |
| TM6 | 385 | F | 6.40x40 | CRF1 receptor | 4K5Y | - | - |
| TM6 | 386 | K | 6.41x41 | CRF1 receptor | 4K5Y | - | - |
| TM6 | 387 | A | 6.42x42 | CRF1 receptor | 4K5Y | - | - |
| TM6 | 388 | I | 6.43x43 | CRF1 receptor | 4K5Y | - | - |
| TM6 | 389 | S | 6.44x44 | CRF1 receptor | 4K5Y | - | - |
| TM6 | 390 | Q | 6.45x45 | CRF1 receptor | 4K5Y | - | - |
| TM6 | 391 | L | 6.46x46 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM6 | 392 | F | 6.47x47 | CRF1 receptor | 4K5Y | - | - |
| TM6 | 393 | I | 6.48x48 | CRF1 receptor | 4K5Y | - | - |
| TM6 | 394 | L | 6.49x49 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM6 | 395 | G | 6.50x50 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM6 | 396 | C | 6.51x51 | CRF1 receptor | 4K5Y | - | - |
| TM6 | 397 | S | 6.52x52 | CRF1 receptor | 4K5Y | - | - |
| TM6 | 398 | W | 6.53x53 | CRF1 receptor | 4K5Y | ADGRG3 | 7D77 |
| TM6 | 399 | G | 6.54x54 | CRF1 receptor | 4K5Y | ADGRG3 | 7D77 |
| TM6 | 400 | L | 6.55x55 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM6 | 401 | G | 6.56x56 | CRF1 receptor | 4K5Y | - | - |
| TM6 | 402 | F | 6.57x57 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM6 | 403 | F | 6.58x58 | CRF1 receptor | 4K5Y | - | - |
| ECL3 | 404 | M | - | - | - | - | - |
| ECL3 | 405 | V | - | - | - | - | - |
| ECL3 | 406 | E | - | - | - | - | - |
| ECL3 | 407 | E | - | - | - | - | - |
| ECL3 | 408 | V | - | - | - | - | - |
| ECL3 | 409 | G | - | - | - | - | - |
| TM7 | 410 | K | 7.32x31 | CRF1 receptor | 4K5Y | - | - |
| TM7 | 411 | T | 7.33x32 | CRF1 receptor | 4K5Y | glucagon receptor | 5YQZ |
| TM7 | 412 | I | 7.34x33 | CRF1 receptor | 4K5Y | - | - |
| TM7 | 413 | G | 7.35x34 | CRF1 receptor | 4K5Y | CT receptor | 6NIY |
| TM7 | 414 | S | 7.36x35 | CRF1 receptor | 4K5Y | glucagon receptor | 5YQZ |
| TM7 | 415 | I | 7.37x36 | CRF1 receptor | 4K5Y | GLP-1 receptor | 6LN2 |
| TM7 | 416 | I | 7.38x37 | CRF1 receptor | 4K5Y | - | - |
| TM7 | 417 | A | 7.39x38 | CRF1 receptor | 4K5Y | - | - |
| TM7 | 418 | Y | 7.40x39 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM7 | 419 | S | 7.41x40 | CRF1 receptor | 4K5Y | - | - |
| TM7 | 420 | F | 7.42x41 | CRF1 receptor | 4K5Y | ADGRG3 | 7D77 |
| TM7 | 421 | T | 7.43x42 | CRF1 receptor | 4K5Y | - | - |
| TM7 | 422 | I | 7.44x43 | CRF1 receptor | 4K5Y | calcitonin receptor-like receptor | 7KNU |
| TM7 | 423 | I | 7.45x44 | CRF1 receptor | 4K5Y | - | - |
| TM7 | 424 | N | 7.46x45 | CRF1 receptor | 4K5Y | PTH1 receptor | 6FJ3 |
| TM7 | 425 | T | 7.47x46 | CRF1 receptor | 4K5Y | - | - |
| TM7 | 426 | L | 7.48x47 | CRF1 receptor | 4K5Y | ADGRG3 | 7D77 |
| TM7 | 427 | Q | 7.49x49 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM7 | 428 | G | 7.50x50 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM7 | 429 | V | 7.51x51 | CRF1 receptor | 4K5Y | ADGRG3 | 7D77 |
| TM7 | 430 | L | 7.52x52 | CRF1 receptor | 4K5Y | glucagon receptor | 5YQZ |
| TM7 | 431 | L | 7.53x53 | CRF1 receptor | 4K5Y | - | - |
| TM7 | 432 | F | 7.54x54 | CRF1 receptor | 4K5Y | - | - |
| TM7 | 433 | V | 7.55x55 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM7 | 434 | V | 7.56x56 | CRF1 receptor | 4K5Y | - | - |
| TM7 | 435 | H | 7.57x57 | CRF1 receptor | 4K5Y | - | - |
| TM7 | 436 | C | 7.58x58 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM7 | 437 | L | 7.59x59 | CRF1 receptor | 4K5Y | - | - |
| TM7 | 438 | L | 7.60x60 | CRF1 receptor | 4K5Y | CRF1 receptor | 4K5Y |
| TM7 | 439 | N | 7.61x61 | ADGRG3 | 7D77 | - | - |
| H8 | 440 | R | 8.48x48 | secretin receptor | 6WZG | - | - |
| H8 | 441 | Q | 8.49x49 | secretin receptor | 6WZG | - | - |
| H8 | 442 | V | 8.50x50 | secretin receptor | 6WZG | secretin receptor | 6WZG |
| H8 | 443 | R | 8.51x51 | secretin receptor | 6WZG | CRF1 receptor | 6PB0 |
| H8 | 444 | L | 8.52x52 | secretin receptor | 6WZG | GLP-1 receptor | 5VEW |
| H8 | 445 | I | 8.53x53 | secretin receptor | 6WZG | calcitonin receptor-like receptor | 7KNU |
| H8 | 446 | I | 8.54x54 | secretin receptor | 6WZG | PTH1 receptor | 6FJ3 |
| H8 | 447 | L | 8.55x55 | secretin receptor | 6WZG | - | - |
| H8 | 448 | S | 8.56x56 | secretin receptor | 6WZG | - | - |
| H8 | 449 | V | 8.57x57 | secretin receptor | 6WZG | - | - |
| H8 | 450 | I | 8.58x58 | secretin receptor | 6WZG | - | - |
| H8 | 451 | S | 8.59x59 | secretin receptor | 6WZG | secretin receptor | 6WZG |
| H8 | 452 | L | 8.60x60 | secretin receptor | 6WZG | - | - |
| H8 | 453 | V | 8.61x61 | secretin receptor | 6WZG | - | - |
| H8 | 454 | P | 8.62x62 | secretin receptor | 6WZG | - | - |
| H8 | 455 | K | 8.63x63 | secretin receptor | 6WZG | - | - |
| C-term | 456 | S | - | - | - | - | - |
| C-term | 457 | N | - | - | - | - | - |