ADGRF5 homology model

PROTEIN CLASS

Class B2 (Adhesion)

RECEPTOR

ADGRF5

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-06-10

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

CRF2 receptor (sequence similarity: 9%) PDB: 6PB1
Align

TEMPLATES

6PB1 (CRF2 receptor)
6PB0 (CRF1 receptor)
4Z9G (CRF1 receptor)
7D77 (ADGRG3)
6P9Y (PAC1 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 76.6 4.5 19.0
Side-chains 18.6 27.9 53.4

Number of backbone templates: 5
Number of rotamer templates: 13

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 1002 P - CRF2 receptor 6PB1 CRF2 receptor 6PB1
N-term 1003 D - CRF2 receptor 6PB1 CRF2 receptor 6PB1
N-term 1004 P - CRF2 receptor 6PB1 CRF2 receptor 6PB1
N-term 1005 S - CRF2 receptor 6PB1 CRF2 receptor 6PB1
N-term 1006 S - CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM1 1007 L 1.34x34 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM1 1008 L 1.35x35 CRF2 receptor 6PB1 GLP-2 receptor 7D68
TM1 1009 G 1.36x36 CRF2 receptor 6PB1 - -
TM1 1010 I 1.37x37 CRF2 receptor 6PB1 - -
TM1 1011 L 1.38x38 CRF2 receptor 6PB1 - -
TM1 1012 L 1.39x39 CRF2 receptor 6PB1 calcitonin receptor-like receptor 6UVA
TM1 1013 D 1.40x40 CRF2 receptor 6PB1 - -
TM1 1014 I 1.41x41 CRF2 receptor 6PB1 CRF1 receptor 6PB0
TM1 1015 I 1.42x42 CRF2 receptor 6PB1 CRF1 receptor 6PB0
TM1 1016 S 1.43x43 CRF2 receptor 6PB1 ADGRG3 7D77
TM1 1017 Y 1.44x44 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM1 1018 V 1.45x45 CRF2 receptor 6PB1 PAC1 receptor 6P9Y
TM1 1019 G 1.46x46 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM1 1020 V 1.47x47 CRF2 receptor 6PB1 - -
TM1 1021 G 1.48x48 CRF2 receptor 6PB1 calcitonin receptor-like receptor 6UVA
TM1 1022 F 1.49x49 CRF2 receptor 6PB1 GLP-2 receptor 7D68
TM1 1023 S 1.50x50 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM1 1024 I 1.51x51 CRF2 receptor 6PB1 calcitonin receptor-like receptor 6UVA
TM1 1025 L 1.52x52 CRF2 receptor 6PB1 - -
TM1 1026 S 1.53x53 CRF2 receptor 6PB1 calcitonin receptor-like receptor 6UVA
TM1 1027 L 1.54x54 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM1 1028 A 1.55x55 CRF2 receptor 6PB1 ADGRG3 7D77
TM1 1029 A 1.56x56 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM1 1030 C 1.57x57 CRF2 receptor 6PB1 - -
TM1 1031 L 1.58x58 CRF2 receptor 6PB1 calcitonin receptor-like receptor 6UVA
TM1 1032 V 1.59x59 CRF2 receptor 6PB1 CRF1 receptor 6PB0
TM1 1033 V 1.60x60 CRF2 receptor 6PB1 - -
TM1 1034 E 1.61x61 CRF2 receptor 6PB1 - -
TM1 1035 A 1.62x62 CRF2 receptor 6PB1 ADGRG3 7D77
TM1 1036 V 1.63x63 CRF2 receptor 6PB1 - -
TM1 1037 V 1.64x64 CRF2 receptor 6PB1 - -
ICL1 1038 W - - - - -
ICL1 1039 K 12.48x48 - - - -
ICL1 1040 S 12.49x49 - - - -
ICL1 1041 V 12.50x50 - - - -
ICL1 1042 T 12.51x51 - - - -
TM2 1043 K 2.42x42 - - - -
TM2 1044 N 2.43x43 - - - -
TM2 1045 R 2.44x44 CRF2 receptor 6PB1 - -
TM2 1046 T 2.45x45 CRF2 receptor 6PB1 PAC1 receptor 6P9Y
TM2 1047 S 2.46x46 CRF2 receptor 6PB1 - -
TM2 1048 Y 2.47x47 CRF2 receptor 6PB1 - -
TM2 1049 M 2.48x48 CRF2 receptor 6PB1 - -
TM2 1050 R 2.49x49 CRF2 receptor 6PB1 - -
TM2 1051 H 2.50x50 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM2 1052 T 2.51x51 CRF2 receptor 6PB1 GHRH receptor 7CZ5
TM2 1053 C 2.52x52 CRF2 receptor 6PB1 - -
TM2 1054 I 2.53x53 CRF2 receptor 6PB1 - -
TM2 1055 V 2.54x54 CRF2 receptor 6PB1 - -
TM2 1056 N 2.55x55 CRF2 receptor 6PB1 - -
TM2 1057 I 2.56x56 CRF2 receptor 6PB1 - -
TM2 1058 A 2.57x57 CRF2 receptor 6PB1 - -
TM2 1059 A 2.58x58 CRF2 receptor 6PB1 - -
TM2 1060 S 2.59x59 CRF2 receptor 6PB1 - -
TM2 1061 L 2.60x60 CRF2 receptor 6PB1 ADGRG3 7D77
TM2 1062 L 2.61x61 CRF2 receptor 6PB1 - -
TM2 1063 V 2.62x62 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM2 1064 A 2.63x63 CRF2 receptor 6PB1 ADGRG3 7D77
TM2 1065 N 2.64x64 CRF2 receptor 6PB1 secretin receptor 6WZG
TM2 1066 T 2.65x65 CRF2 receptor 6PB1 - -
TM2 1067 W 2.66x66 CRF2 receptor 6PB1 - -
TM2 1068 F 2.67x67 CRF2 receptor 6PB1 - -
TM2 1069 I 2.68x68 CRF2 receptor 6PB1 - -
TM2 1070 V 2.69x69 CRF1 receptor 6PB0 GLP-2 receptor 7D68
TM2 1071 V 2.70x70 CRF1 receptor 6PB0 GLP-2 receptor 7D68
ECL1 1072 A - - - - -
ECL1 1073 A - - - - -
ECL1 1074 I - - - - -
ECL1 1075 Q - - - - -
ECL1 1076 D - - - - -
ECL1 1077 N - - - - -
ECL1 1078 R - - - - -
ECL1 1079 Y - - - - -
ECL1 1080 I - - - - -
ECL1 1081 L - - - - -
TM3 1082 C 3.25x25 ADGRG3 7D77 - -
TM3 1083 K 3.26x26 ADGRG3 7D77 - -
TM3 1084 T 3.27x27 CRF2 receptor 6PB1 GLP-2 receptor 7D68
TM3 1085 A 3.28x28 CRF2 receptor 6PB1 ADGRG3 7D77
TM3 1086 C 3.29x29 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM3 1087 V 3.30x30 CRF2 receptor 6PB1 - -
TM3 1088 A 3.31x31 CRF2 receptor 6PB1 ADGRG3 7D77
TM3 1089 A 3.32x32 CRF2 receptor 6PB1 VPAC1 receptor 6VN7
TM3 1090 T 3.33x33 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM3 1091 F 3.34x34 CRF2 receptor 6PB1 calcitonin receptor-like receptor 6UVA
TM3 1092 F 3.35x35 CRF2 receptor 6PB1 PAC1 receptor 6P9Y
TM3 1093 I 3.36x36 CRF2 receptor 6PB1 - -
TM3 1094 H 3.37x37 CRF2 receptor 6PB1 ADGRG3 7D77
TM3 1095 F 3.38x38 CRF2 receptor 6PB1 GHRH receptor 7CZ5
TM3 1096 F 3.39x39 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM3 1097 Y 3.40x40 CRF2 receptor 6PB1 - -
TM3 1098 L 3.41x41 CRF2 receptor 6PB1 ADGRG3 7D77
TM3 1099 S 3.42x42 CRF2 receptor 6PB1 PAC1 receptor 6P9Y
TM3 1100 V 3.43x43 CRF2 receptor 6PB1 - -
TM3 1101 F 3.44x44 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM3 1102 F 3.45x45 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM3 1103 W 3.46x46 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM3 1104 M 3.47x47 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM3 1105 L 3.48x48 CRF2 receptor 6PB1 calcitonin receptor-like receptor 6UVA
TM3 1106 T 3.49x49 CRF2 receptor 6PB1 - -
TM3 1107 L 3.50x50 CRF2 receptor 6PB1 - -
TM3 1108 G 3.51x51 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM3 1109 L 3.52x52 CRF2 receptor 6PB1 PAC1 receptor 6P9Y
TM3 1110 M 3.53x53 CRF2 receptor 6PB1 - -
TM3 1111 L 3.54x54 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM3 1112 F 3.55x55 CRF2 receptor 6PB1 PAC1 receptor 6P9Y
TM3 1113 Y 3.56x56 CRF2 receptor 6PB1 - -
TM3 1114 R 3.57x57 CRF2 receptor 6PB1 - -
TM3 1115 L 3.58x58 CRF2 receptor 6PB1 PAC1 receptor 6P9Y
TM3 1116 V 3.59x59 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM3 1117 F 3.60x60 CRF2 receptor 6PB1 GLP-1 receptor 6X19
ICL2 1118 I - - - - -
ICL2 1119 L - - - - -
ICL2 1120 H - - - - -
ICL2 1121 E - - - - -
ICL2 1122 T - - - - -
ICL2 1123 S - - - - -
ICL2 1124 R - - - - -
ICL2 1125 S - - - - -
TM4 1126 T 4.40x41 CRF1 receptor 4Z9G - -
TM4 1127 Q 4.41x42 CRF2 receptor 6PB1 - -
TM4 1128 K 4.42x43 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM4 1129 A 4.43x44 CRF2 receptor 6PB1 - -
TM4 1130 I 4.44x45 CRF2 receptor 6PB1 - -
TM4 1131 A 4.45x46 CRF2 receptor 6PB1 - -
TM4 1132 F 4.46x47 CRF2 receptor 6PB1 - -
TM4 1133 C 4.47x48 CRF2 receptor 6PB1 CRF1 receptor 6PB0
TM4 1134 L 4.48x49 CRF2 receptor 6PB1 calcitonin receptor-like receptor 6UVA
TM4 1135 G 4.49x491 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM4 1136 Y 4.50x50 CRF2 receptor 6PB1 - -
TM4 1137 G 4.51x51 CRF2 receptor 6PB1 CRF1 receptor 6PB0
TM4 1138 C 4.52x52 CRF2 receptor 6PB1 - -
TM4 1139 P 4.53x53 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM4 1140 L 4.54x54 CRF2 receptor 6PB1 calcitonin receptor-like receptor 6UVA
TM4 1141 A 4.55x55 CRF2 receptor 6PB1 - -
TM4 1142 I 4.56x56 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM4 1143 S 4.57x57 CRF2 receptor 6PB1 - -
TM4 1144 V 4.58x58 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM4 1145 I 4.59x59 CRF2 receptor 6PB1 calcitonin receptor-like receptor 6UVA
TM4 1146 T 4.60x60 CRF2 receptor 6PB1 ADGRG3 7D77
TM4 1147 L 4.61x61 CRF2 receptor 6PB1 - -
TM4 1148 G 4.62x62 CRF2 receptor 6PB1 - -
TM4 1149 A 4.63x63 CRF2 receptor 6PB1 calcitonin receptor-like receptor 6UVA
TM4 1150 T 4.64x64 CRF2 receptor 6PB1 - -
ECL2 1151 Q - - - - -
ECL2 1152 P - - - - -
ECL2 1153 R - - - - -
ECL2 1154 E - - - - -
ECL2 1155 V - - - - -
ECL2 1156 Y - - - - -
ECL2 1157 T - - - - -
ECL2 1158 R - - - - -
ECL2 1159 K - - - - -
ECL2 1160 N - - - - -
ECL2 1161 V - - - - -
ECL2 1162 C 45.50x50 CRF2 receptor 6PB1 CRF2 receptor 6PB1
ECL2 1163 W 45.51x51 CRF2 receptor 6PB1 CRF2 receptor 6PB1
ECL2 1164 L 45.52x52 CRF2 receptor 6PB1 CT receptor 6NIY
ECL2 1165 N - - - - -
ECL2 1166 W - - - - -
ECL2 1167 E - - - - -
ECL2 1168 D - - - - -
TM5 1169 T 5.33x33 PAC1 receptor 6P9Y - -
TM5 1170 K 5.34x34 PAC1 receptor 6P9Y - -
TM5 1171 A 5.35x35 PAC1 receptor 6P9Y PAC1 receptor 6P9Y
TM5 1172 L 5.36x36 CRF2 receptor 6PB1 calcitonin receptor-like receptor 6UVA
TM5 1173 L 5.37x37 CRF2 receptor 6PB1 calcitonin receptor-like receptor 6UVA
TM5 1174 A 5.38x38 CRF2 receptor 6PB1 - -
TM5 1175 F 5.39x39 CRF2 receptor 6PB1 - -
TM5 1176 A 5.40x40 CRF2 receptor 6PB1 - -
TM5 1177 I 5.41x41 CRF2 receptor 6PB1 - -
TM5 1178 P 5.42x42 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM5 1179 A 5.43x43 CRF2 receptor 6PB1 - -
TM5 1180 L 5.44x44 CRF2 receptor 6PB1 ADGRG3 7D77
TM5 1181 I 5.45x45 CRF2 receptor 6PB1 ADGRG3 7D77
TM5 1182 I 5.46x46 CRF2 receptor 6PB1 - -
TM5 1183 V 5.47x47 CRF2 receptor 6PB1 GLP-2 receptor 7D68
TM5 1184 V 5.48x48 CRF2 receptor 6PB1 CT receptor 6NIY
TM5 1185 V 5.49x49 CRF2 receptor 6PB1 calcitonin receptor-like receptor 6UVA
TM5 1186 N 5.50x50 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM5 1187 I 5.51x51 CRF2 receptor 6PB1 - -
TM5 1188 T 5.52x52 CRF2 receptor 6PB1 - -
TM5 1189 I 5.53x53 CRF2 receptor 6PB1 GLP-2 receptor 7D68
TM5 1190 T 5.54x54 CRF2 receptor 6PB1 - -
TM5 1191 I 5.55x55 CRF2 receptor 6PB1 PAC1 receptor 6P9Y
TM5 1192 V 5.56x56 CRF2 receptor 6PB1 - -
TM5 1193 V 5.57x57 CRF2 receptor 6PB1 ADGRG3 7D77
TM5 1194 I 5.58x58 CRF2 receptor 6PB1 PAC1 receptor 6P9Y
TM5 1195 T 5.59x59 CRF2 receptor 6PB1 - -
TM5 1196 K 5.60x60 CRF2 receptor 6PB1 ADGRG3 7D77
TM5 1197 I 5.61x61 CRF2 receptor 6PB1 ADGRG3 7D77
TM5 1198 L 5.62x62 CRF2 receptor 6PB1 VPAC1 receptor 6VN7
TM5 1199 R 5.63x63 CRF2 receptor 6PB1 secretin receptor 6WZG
TM5 1200 P 5.64x64 CRF2 receptor 6PB1 - -
TM5 1201 S 5.65x65 CRF2 receptor 6PB1 ADGRG3 7D77
TM5 1202 I 5.66x66 CRF2 receptor 6PB1 - -
TM5 1203 G 5.67x67 CRF2 receptor 6PB1 - -
TM5 1204 D 5.68x68 ADGRG3 7D77 - -
ICL3 1205 K - - - - -
ICL3 1206 P - - - - -
ICL3 1207 C - - - - -
ICL3 1208 K - - - - -
ICL3 1209 Q - - - - -
ICL3 1210 E - - - - -
ICL3 1211 K - - - - -
ICL3 1212 S - - - - -
TM6 1213 S 6.34x34 CRF2 receptor 6PB1 - -
TM6 1214 L 6.35x35 CRF2 receptor 6PB1 - -
TM6 1215 F 6.36x36 CRF2 receptor 6PB1 glucagon receptor 6WPW
TM6 1216 Q 6.37x37 CRF2 receptor 6PB1 - -
TM6 1217 I 6.38x38 CRF2 receptor 6PB1 - -
TM6 1218 S 6.39x39 CRF2 receptor 6PB1 GHRH receptor 7CZ5
TM6 1219 K 6.40x40 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM6 1220 S 6.41x41 CRF2 receptor 6PB1 PAC1 receptor 6P9Y
TM6 1221 I 6.42x42 CRF2 receptor 6PB1 - -
TM6 1222 G 6.43x43 CRF2 receptor 6PB1 - -
TM6 1223 V 6.44x44 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM6 1224 L 6.45x45 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM6 1225 T 6.46x46 CRF2 receptor 6PB1 - -
TM6 1226 P 6.47x47 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM6 1227 L 6.48x48 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM6 1228 L 6.49x49 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM6 1229 G 6.50x50 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM6 1230 L 6.51x51 CRF2 receptor 6PB1 - -
TM6 1231 T 6.52x52 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM6 1232 W 6.53x53 CRF2 receptor 6PB1 ADGRG3 7D77
TM6 1233 G 6.54x54 CRF2 receptor 6PB1 ADGRG3 7D77
TM6 1234 F 6.55x55 CRF2 receptor 6PB1 - -
TM6 1235 G 6.56x56 CRF1 receptor 4Z9G - -
TM6 1236 L 6.57x57 CRF1 receptor 4Z9G - -
TM6 1237 T 6.58x58 CRF1 receptor 4Z9G - -
ECL3 1238 T - - - - -
ECL3 1239 V - - - - -
ECL3 1240 F - - - - -
ECL3 1241 P - - - - -
ECL3 1242 G - - - - -
ECL3 1243 T - - - - -
TM7 1244 N 7.35x34 CRF2 receptor 6PB1 - -
TM7 1245 L 7.36x35 CRF2 receptor 6PB1 GLP-2 receptor 7D68
TM7 1246 V 7.37x36 CRF2 receptor 6PB1 CRF1 receptor 6PB0
TM7 1247 F 7.38x37 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM7 1248 H 7.39x38 CRF2 receptor 6PB1 - -
TM7 1249 I 7.40x39 CRF2 receptor 6PB1 - -
TM7 1250 I 7.41x40 CRF2 receptor 6PB1 calcitonin receptor-like receptor 6UVA
TM7 1251 F 7.42x41 CRF2 receptor 6PB1 ADGRG3 7D77
TM7 1252 A 7.43x42 CRF2 receptor 6PB1 ADGRG3 7D77
TM7 1253 I 7.44x43 CRF2 receptor 6PB1 calcitonin receptor-like receptor 6UVA
TM7 1254 L 7.45x44 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM7 1255 N 7.46x45 CRF2 receptor 6PB1 ADGRG3 7D77
TM7 1256 V 7.47x46 CRF2 receptor 6PB1 - -
TM7 1257 F 7.48x47 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM7 1258 Q 7.49x49 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM7 1259 G 7.50x50 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM7 1260 L 7.51x51 CRF2 receptor 6PB1 calcitonin receptor-like receptor 6UVA
TM7 1261 F 7.52x52 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM7 1262 I 7.53x53 CRF2 receptor 6PB1 ADGRG3 7D77
TM7 1263 L 7.54x54 CRF2 receptor 6PB1 - -
TM7 1264 L 7.55x55 CRF2 receptor 6PB1 GLP-2 receptor 7D68
TM7 1265 F 7.56x56 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM7 1266 G 7.57x57 CRF2 receptor 6PB1 - -
TM7 1267 C 7.58x58 CRF2 receptor 6PB1 CRF2 receptor 6PB1
TM7 1268 L 7.59x59 CRF2 receptor 6PB1 - -
TM7 1269 W 7.60x60 CRF2 receptor 6PB1 - -
TM7 1270 D 7.61x61 ADGRG3 7D77 - -
H8 1271 L 8.48x48 CRF2 receptor 6PB1 - -
H8 1272 K 8.49x49 CRF2 receptor 6PB1 - -
H8 1273 V 8.50x50 CRF2 receptor 6PB1 CRF2 receptor 6PB1
H8 1274 Q 8.51x51 CRF2 receptor 6PB1 calcitonin receptor-like receptor 6UVA
H8 1275 E 8.52x52 CRF2 receptor 6PB1 - -
H8 1276 A 8.53x53 CRF2 receptor 6PB1 CRF2 receptor 6PB1
H8 1277 L 8.54x54 CRF2 receptor 6PB1 calcitonin receptor-like receptor 6UVA
H8 1278 L 8.55x55 CRF2 receptor 6PB1 - -
H8 1279 N 8.56x56 CRF2 receptor 6PB1 - -
H8 1280 K 8.57x57 CRF2 receptor 6PB1 PAC1 receptor 6P9Y
H8 1281 F 8.58x58 CRF2 receptor 6PB1 - -
H8 1282 S 8.59x59 CRF2 receptor 6PB1 PTH1 receptor 6NBI
H8 1283 L 8.60x60 CRF2 receptor 6PB1 - -
H8 1284 S 8.61x61 CRF2 receptor 6PB1 - -
H8 1285 R 8.62x62 CRF2 receptor 6PB1 glucagon receptor 6WPW
H8 1286 W 8.63x63 CRF2 receptor 6PB1 - -
C-term 1287 S - CRF2 receptor 6PB1 CRF2 receptor 6PB1
C-term 1288 S - CRF2 receptor 6PB1 CRF2 receptor 6PB1
C-term 1289 Q - CRF2 receptor 6PB1 CRF2 receptor 6PB1
C-term 1290 H - CRF2 receptor 6PB1 CRF2 receptor 6PB1
C-term 1291 S - - - - -