CaS receptor homology model

PROTEIN CLASS

Class C (Glutamate)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active

VERSION

2020-10-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

mGlu5 receptor (sequence similarity: 52%) PDB: 4OO9

TEMPLATES

4OO9 (mGlu5 receptor)
6FFI (mGlu5 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 83.6 1.1 15.3
Side-chains 30.2 10.2 59.6

Number of backbone templates: 2
Number of rotamer templates: 5

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 606 L mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
N-term 607 S mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
N-term 608 W mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
N-term 609 T mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
N-term 610 E mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 611 P 1.38x38 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 612 F 1.39x39 mGlu5 receptor 4OO9 - -
TM1 613 G 1.40x40 mGlu5 receptor 4OO9 - -
TM1 614 I 1.41x41 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 615 A 1.42x42 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 616 L 1.43x43 mGlu5 receptor 4OO9 GABAB2 7C7S
TM1 617 T 1.44x44 mGlu5 receptor 4OO9 - -
TM1 618 L 1.45x45 mGlu5 receptor 4OO9 - -
TM1 619 F 1.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 620 A 1.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 621 V 1.48x48 mGlu5 receptor 4OO9 - -
TM1 622 L 1.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 623 G 1.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 624 I 1.51x51 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM1 625 F 1.52x52 mGlu5 receptor 4OO9 - -
TM1 626 L 1.53x53 mGlu5 receptor 4OO9 GABAB1 6W2Y
TM1 627 T 1.54x54 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 628 A 1.55x55 mGlu5 receptor 4OO9 - -
TM1 629 F 1.56x56 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 630 V 1.57x57 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 631 L 1.58x58 mGlu5 receptor 4OO9 GABAB2 7C7S
TM1 632 G 1.59x59 mGlu5 receptor 4OO9 - -
TM1 633 V 1.60x60 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 634 F 1.61x61 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 635 I 1.62x62 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 636 K 1.63x63 mGlu5 receptor 4OO9 GABAB2 7C7S
TM1 637 F 1.64x64 mGlu5 receptor 4OO9 - -
ICL1 638 R mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL1 639 N mGlu5 receptor 4OO9 - -
ICL1 640 T 12.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL1 641 P 12.48x48 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL1 642 I 12.49x49 mGlu5 receptor 4OO9 - -
ICL1 643 V 12.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL1 644 K 12.51x51 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL1 645 A 12.52x52 mGlu5 receptor 4OO9 - -
ICL1 646 T 12.53x53 mGlu5 receptor 4OO9 - -
TM2 647 N 2.35x35 mGlu5 receptor 4OO9 - -
TM2 648 R 2.36x36 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 649 E 2.37x37 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 650 L 2.38x38 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 651 S 2.39x39 mGlu5 receptor 4OO9 - -
TM2 652 Y 2.40x40 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 653 L 2.41x41 mGlu5 receptor 4OO9 GABAB2 7C7S
TM2 654 L 2.42x42 mGlu5 receptor 4OO9 - -
TM2 655 L 2.43x43 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 656 F 2.44x44 mGlu5 receptor 4OO9 - -
TM2 657 S 2.45x45 mGlu5 receptor 4OO9 - -
TM2 658 L 2.46x46 mGlu5 receptor 4OO9 - -
TM2 659 L 2.47x47 mGlu5 receptor 4OO9 - -
TM2 660 C 2.48x48 mGlu5 receptor 4OO9 - -
TM2 661 C 2.49x49 mGlu5 receptor 4OO9 - -
TM2 662 F 2.50x50 mGlu5 receptor 4OO9 - -
TM2 663 S 2.51x51 mGlu5 receptor 4OO9 - -
TM2 664 S 2.52x52 mGlu5 receptor 4OO9 GABAB2 7C7S
TM2 665 S 2.53x53 mGlu5 receptor 4OO9 - -
TM2 666 L 2.54x54 mGlu5 receptor 4OO9 - -
TM2 667 F 2.55x55 mGlu5 receptor 4OO9 - -
TM2 668 F 2.56x56 mGlu5 receptor 4OO9 GABAB2 7C7S
TM2 669 I 2.57x57 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ECL1 670 G - - - -
ECL1 671 E mGlu5 receptor 6FFI - -
ECL1 672 P - - - -
TM3 673 Q 3.25x25 mGlu5 receptor 6FFI - -
TM3 674 D 3.26x26 mGlu5 receptor 4OO9 - -
TM3 675 W 3.27x27 mGlu5 receptor 4OO9 - -
TM3 676 T 3.28x28 mGlu5 receptor 4OO9 - -
TM3 677 C 3.29x29 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 678 R 3.30x30 mGlu5 receptor 4OO9 - -
TM3 679 L 3.31x31 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 680 R 3.32x32 mGlu5 receptor 4OO9 GABAB2 7C7S
TM3 681 Q 3.33x33 mGlu5 receptor 4OO9 - -
TM3 682 P 3.34x34 mGlu5 receptor 4OO9 - -
TM3 683 A 3.35x35 mGlu5 receptor 4OO9 - -
TM3 684 F 3.36x36 mGlu5 receptor 4OO9 - -
TM3 685 G 3.37x37 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 686 I 3.38x38 mGlu5 receptor 4OO9 - -
TM3 687 S 3.39x39 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 688 F 3.40x40 mGlu5 receptor 4OO9 GABAB1 6W2Y
TM3 689 V 3.41x41 mGlu5 receptor 4OO9 - -
TM3 690 L 3.42x42 mGlu5 receptor 4OO9 GABAB1 6W2Y
TM3 691 C 3.43x43 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM3 692 I 3.44x44 mGlu5 receptor 4OO9 - -
TM3 693 S 3.45x45 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 694 C 3.46x46 mGlu5 receptor 4OO9 - -
TM3 695 I 3.47x47 mGlu5 receptor 4OO9 - -
TM3 696 L 3.48x48 mGlu5 receptor 4OO9 - -
TM3 697 V 3.49x49 mGlu5 receptor 4OO9 - -
TM3 698 K 3.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 699 T 3.51x51 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 700 N 3.52x52 mGlu5 receptor 4OO9 mGlu5 receptor 6N52
TM3 701 R 3.53x53 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 702 V 3.54x54 mGlu5 receptor 4OO9 GABAB2 7C7S
TM3 703 L 3.55x55 mGlu5 receptor 4OO9 - -
TM3 704 L 3.56x56 mGlu5 receptor 4OO9 - -
TM3 705 V 3.57x57 mGlu5 receptor 4OO9 - -
TM3 706 F 3.58x58 mGlu5 receptor 4OO9 GABAB2 7C7S
ICL2 707 E - - - -
ICL2 708 A - - - -
ICL2 709 K - - - -
ICL2 710 I - - - -
ICL2 711 P - - - -
ICL2 712 T - - - -
ICL2 713 S - - - -
ICL2 714 F - - - -
ICL2 715 H - - - -
ICL2 716 R - - - -
ICL2 717 K - - - -
ICL2 718 W - - - -
ICL2 719 W - - - -
TM4 720 G 4.28x28 mGlu5 receptor 4OO9 - -
TM4 721 L 4.29x29 mGlu5 receptor 4OO9 - -
TM4 722 N 4.30x30 mGlu5 receptor 4OO9 - -
TM4 723 L 4.31x31 mGlu5 receptor 4OO9 - -
TM4 724 Q 4.32x32 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 725 F 4.33x33 mGlu5 receptor 4OO9 - -
TM4 726 L 4.34x34 mGlu5 receptor 4OO9 - -
TM4 727 L 4.35x35 mGlu5 receptor 4OO9 - -
TM4 728 V 4.36x36 mGlu5 receptor 4OO9 GABAB2 7C7S
TM4 729 F 4.37x37 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 730 L 4.38x38 mGlu5 receptor 4OO9 GABAB1 6W2Y
TM4 731 C 4.39x39 mGlu5 receptor 4OO9 - -
TM4 732 T 4.40x40 mGlu5 receptor 4OO9 - -
TM4 733 F 4.41x41 mGlu5 receptor 4OO9 - -
TM4 734 M 4.42x42 mGlu5 receptor 4OO9 - -
TM4 735 Q 4.43x43 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 736 I 4.44x44 mGlu5 receptor 4OO9 - -
TM4 737 V 4.45x45 mGlu5 receptor 4OO9 - -
TM4 738 I 4.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 739 C 4.47x47 mGlu5 receptor 4OO9 - -
TM4 740 V 4.48x48 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 741 I 4.49x49 mGlu5 receptor 4OO9 GABAB1 6W2Y
TM4 742 W 4.50x50 mGlu5 receptor 4OO9 GABAB2 7C7S
TM4 743 L 4.51x51 mGlu5 receptor 4OO9 - -
TM4 744 Y 4.52x52 mGlu5 receptor 4OO9 - -
TM4 745 T 4.53x53 mGlu5 receptor 4OO9 - -
TM4 746 A 4.54x54 mGlu5 receptor 4OO9 - -
ECL2 747 P mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ECL2 748 P mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ECL2 749 S mGlu5 receptor 4OO9 - -
ECL2 750 S mGlu5 receptor 4OO9 - -
ECL2 751 Y mGlu5 receptor 4OO9 - -
ECL2 752 R - - - -
ECL2 753 N - - - -
ECL2 754 Q - - - -
ECL2 755 E - - - -
ECL2 756 L - - - -
ECL2 757 E - - - -
ECL2 758 D - - - -
ECL2 759 E - - - -
ECL2 760 I mGlu5 receptor 4OO9 - -
ECL2 761 I mGlu5 receptor 4OO9 - -
ECL2 762 F mGlu5 receptor 4OO9 - -
ECL2 763 I mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ECL2 764 T - - - -
ECL2 765 C 45.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ECL2 766 H 45.51x51 mGlu5 receptor 4OO9 - -
ECL2 767 E 45.52x52 mGlu5 receptor 4OO9 - -
ECL2 768 G - - - -
TM5 769 S 5.36x36 mGlu5 receptor 6FFI mGlu1 receptor 4OR2
TM5 770 L 5.37x37 mGlu5 receptor 4OO9 - -
TM5 771 M 5.38x38 mGlu5 receptor 4OO9 - -
TM5 772 A 5.39x39 mGlu5 receptor 4OO9 - -
TM5 773 L 5.40x40 mGlu5 receptor 4OO9 GABAB2 7C7S
TM5 774 G 5.41x41 mGlu5 receptor 4OO9 GABAB2 7C7S
TM5 775 F 5.42x42 mGlu5 receptor 4OO9 - -
TM5 776 L 5.43x43 mGlu5 receptor 4OO9 - -
TM5 777 I 5.44x44 mGlu5 receptor 4OO9 - -
TM5 778 G 5.45x45 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 779 Y 5.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 780 T 5.47x47 mGlu5 receptor 4OO9 - -
TM5 781 C 5.48x48 mGlu5 receptor 4OO9 - -
TM5 782 L 5.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 783 L 5.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 784 A 5.51x51 mGlu5 receptor 4OO9 - -
TM5 785 A 5.52x52 mGlu5 receptor 4OO9 - -
TM5 786 I 5.53x53 mGlu5 receptor 4OO9 - -
TM5 787 C 5.54x54 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 788 F 5.55x55 mGlu5 receptor 4OO9 - -
TM5 789 F 5.56x56 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 790 F 5.57x57 mGlu5 receptor 4OO9 - -
TM5 791 A 5.58x58 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 792 F 5.59x59 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 793 K 5.60x60 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 794 S 5.61x61 mGlu5 receptor 4OO9 - -
ICL3 795 R mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL3 796 K mGlu5 receptor 4OO9 - -
ICL3 797 L mGlu5 receptor 4OO9 - -
ICL3 798 P mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL3 799 E mGlu5 receptor 4OO9 - -
ICL3 800 N mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL3 801 F mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL3 802 N mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 803 E 6.35x35 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 804 A 6.36x36 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 805 K 6.37x37 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 806 F 6.38x38 mGlu5 receptor 4OO9 - -
TM6 807 I 6.39x39 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 808 T 6.40x40 mGlu5 receptor 4OO9 - -
TM6 809 F 6.41x41 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 810 S 6.42x42 mGlu5 receptor 4OO9 GABAB2 7C7S
TM6 811 M 6.43x43 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 812 L 6.44x44 mGlu5 receptor 4OO9 - -
TM6 813 I 6.45x45 mGlu5 receptor 4OO9 - -
TM6 814 F 6.46x46 mGlu5 receptor 4OO9 - -
TM6 815 F 6.47x47 mGlu5 receptor 4OO9 - -
TM6 816 I 6.48x48 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 817 V 6.49x49 mGlu5 receptor 4OO9 - -
TM6 818 W 6.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 819 I 6.51x51 mGlu5 receptor 4OO9 GABAB2 7C7S
TM6 820 S 6.52x52 mGlu5 receptor 4OO9 - -
TM6 821 F 6.53x53 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 822 I 6.54x54 mGlu5 receptor 4OO9 - -
TM6 823 P 6.55x55 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 824 A 6.56x56 mGlu5 receptor 4OO9 - -
TM6 825 Y 6.57x57 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 826 A 6.58x58 mGlu5 receptor 4OO9 - -
TM6 827 S 6.59x59 mGlu5 receptor 4OO9 - -
ECL3 828 T - - - -
ECL3 829 Y - - - -
ECL3 830 G - - - -
ECL3 831 K - - - -
TM7 832 F 7.27x28 mGlu5 receptor 4OO9 - -
TM7 833 V 7.28x29 mGlu5 receptor 4OO9 - -
TM7 834 S 7.29x30 mGlu5 receptor 4OO9 - -
TM7 835 A 7.30x31 mGlu5 receptor 4OO9 GABAB1 6W2Y
TM7 836 V 7.31x32 mGlu5 receptor 4OO9 - -
TM7 837 E 7.32x33 mGlu5 receptor 4OO9 - -
TM7 838 V 7.33x34 mGlu5 receptor 4OO9 - -
TM7 839 I 7.34x35 mGlu5 receptor 4OO9 - -
TM7 840 A 7.35x36 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM7 841 I 7.36x37 mGlu5 receptor 4OO9 GABAB2 7C7S
TM7 842 L 7.37x38 mGlu5 receptor 4OO9 - -
TM7 843 A 7.38x39 mGlu5 receptor 4OO9 - -
TM7 844 A 7.39x40 mGlu5 receptor 4OO9 - -
TM7 845 S 7.40x41 mGlu5 receptor 4OO9 GABAB2 7C7S
TM7 846 F 7.41x42 mGlu5 receptor 4OO9 - -
TM7 847 G 7.42x43 mGlu5 receptor 4OO9 - -
TM7 848 L 7.43x44 mGlu5 receptor 4OO9 - -
TM7 849 L 7.44x45 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 850 A 7.45x46 mGlu5 receptor 4OO9 - -
TM7 851 C 7.46x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 852 I 7.47x471 mGlu5 receptor 4OO9 - -
TM7 853 F 7.48x48 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 854 F 7.49x49 mGlu5 receptor 4OO9 - -
TM7 855 N 7.50x50 mGlu5 receptor 4OO9 - -
TM7 856 K 7.51x51 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 857 I 7.52x52 mGlu5 receptor 4OO9 - -
TM7 858 Y 7.53x53 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 859 I 7.54x54 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 860 I 7.55x55 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 861 L 7.56x56 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 862 F 7.57x57 mGlu5 receptor 4OO9 - -
TM7 863 K 7.58x58 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 864 P 8.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 865 S 8.47x47 mGlu5 receptor 4OO9 - -
H8 866 R 8.48x48 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 867 N 8.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 868 T 8.50x50 - - - -
H8 869 I 8.51x51 - - - -
H8 870 E 8.52x52 - - - -
H8 871 E 8.53x53 - - - -
H8 872 V 8.54x54 - - - -
H8 873 R 8.55x55 - - - -
H8 874 C 8.56x56 - - - -
H8 875 S 8.57x57 - - - -
C-term 876 T - - - -
C-term 877 A - - - -
C-term 878 A - - - -
C-term 879 H - - - -
C-term 880 A - - - -