CCR3 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

CCR3

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-11-02

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

CCR5 (sequence similarity: 66%) PDB: 7O7F
Align

TEMPLATES

5UIW (CCR5)
7O7F (CCR5)
4MBS (CCR5)
6WWZ (CCR6)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 87.7 7.3 5.0
Side-chains 50.0 36.4 13.6

Number of backbone templates: 4
Number of rotamer templates: 41

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 21 G - CCR5 5UIW CCR5 5UIW
N-term 22 L - CCR5 5UIW CCR5 5UIW
N-term 23 L - CCR5 5UIW CCR5 5UIW
N-term 24 C - CCR5 5UIW CCR5 5UIW
N-term 25 E - CCR5 5UIW CCR5 5UIW
TM1 26 K 1.24x24 CCR5 5UIW CCR5 7F1T
TM1 27 A 1.25x25 CCR5 7O7F succinate receptor 6RNK
TM1 28 D 1.26x26 CCR5 7O7F US28 5WB1
TM1 29 T 1.27x27 CCR5 7O7F 5-HT2A receptor 6A94
TM1 30 R 1.28x28 CCR5 7O7F CCR6 6WWZ
TM1 31 A 1.29x29 CCR5 7O7F ghrelin receptor 6KO5
TM1 32 L 1.30x30 CCR5 7O7F V2 receptor 7KH0
TM1 33 M 1.31x31 CCR5 7O7F Y1 receptor 5ZBH
TM1 34 A 1.32x32 CCR5 7O7F CCR5 7O7F
TM1 35 Q 1.33x33 CCR5 7O7F CCR2 5T1A
TM1 36 F 1.34x34 CCR5 7O7F CCR6 6WWZ
TM1 37 V 1.35x35 CCR5 7O7F CCR6 6WWZ
TM1 38 P 1.36x36 CCR5 7O7F CCR5 7O7F
TM1 39 P 1.37x37 CCR5 7O7F CCR5 7O7F
TM1 40 L 1.38x38 CCR5 7O7F CCR5 7O7F
TM1 41 Y 1.39x39 CCR5 7O7F CCR5 7O7F
TM1 42 S 1.40x40 CCR5 7O7F CCR5 7O7F
TM1 43 L 1.41x41 CCR5 7O7F CCR5 7O7F
TM1 44 V 1.42x42 CCR5 7O7F CCR5 7O7F
TM1 45 F 1.43x43 CCR5 7O7F CCR5 7O7F
TM1 46 T 1.44x44 CCR5 7O7F 5-HT1E receptor 7E33
TM1 47 V 1.45x45 CCR5 7O7F AT1 receptor 6DO1
TM1 48 G 1.46x46 CCR5 7O7F CCR5 7O7F
TM1 49 L 1.47x47 CCR5 7O7F CCR6 6WWZ
TM1 50 L 1.48x48 CCR5 7O7F CCR6 6WWZ
TM1 51 G 1.49x49 CCR5 7O7F CCR5 7O7F
TM1 52 N 1.50x50 CCR5 7O7F CCR5 7O7F
TM1 53 V 1.51x51 CCR5 7O7F δ receptor 6PT2
TM1 54 V 1.52x52 CCR5 7O7F AT2 receptor 5UNG
TM1 55 V 1.53x53 CCR5 7O7F CCR5 7O7F
TM1 56 V 1.54x54 CCR5 7O7F CCR6 6WWZ
TM1 57 M 1.55x55 CCR5 7O7F 5-HT2C receptor 6BQG
TM1 58 I 1.56x56 CCR5 7O7F CCR5 7O7F
TM1 59 L 1.57x57 CCR5 7O7F CCR5 7O7F
TM1 60 I 1.58x58 CCR5 7O7F CCR5 7O7F
TM1 61 K 1.59x59 CCR5 7O7F OX2 receptor 7L1V
TM1 62 Y 1.60x60 CCR5 7O7F AT1 receptor 6DO1
ICL1 63 R 12.48x48 - - - -
ICL1 64 R 12.49x49 CCR6 6WWZ apelin receptor 5VBL
ICL1 65 L 12.50x50 CCR6 6WWZ β2-adrenoceptor 3SN6
ICL1 66 R 12.51x51 - - - -
TM2 67 I 2.37x37 CCR5 7O7F - -
TM2 68 M 2.38x38 CCR5 7O7F CCR5 7O7F
TM2 69 T 2.39x39 CCR5 7O7F CCR5 7O7F
TM2 70 N 2.40x40 CCR5 7O7F μ receptor 5C1M
TM2 71 I 2.41x41 CCR5 7O7F CCR5 7O7F
TM2 72 Y 2.42x42 CCR5 7O7F CCR5 7O7F
TM2 73 L 2.43x43 CCR5 7O7F CCR5 7O7F
TM2 74 L 2.44x44 CCR5 7O7F CCR5 7O7F
TM2 75 N 2.45x45 CCR5 7O7F CCR5 7O7F
TM2 76 L 2.46x46 CCR5 7O7F CCR5 7O7F
TM2 77 A 2.47x47 CCR5 7O7F CCR5 7O7F
TM2 78 I 2.48x48 CCR5 7O7F CCR5 7O7F
TM2 79 S 2.49x49 CCR5 7O7F CCR5 7O7F
TM2 80 D 2.50x50 CCR5 7O7F CCR5 7O7F
TM2 81 L 2.51x51 CCR5 7O7F CCR5 7O7F
TM2 82 L 2.52x52 CCR5 7O7F CCR6 6WWZ
TM2 83 F 2.53x53 CCR5 7O7F CCR5 7O7F
TM2 84 L 2.54x54 CCR5 7O7F CCR5 7O7F
TM2 85 V 2.55x55 CCR5 7O7F A2A receptor 4UHR
TM2 86 T 2.56x56 CCR5 7O7F CCR5 7O7F
TM2 87 L 2.57x57 CCR5 7O7F CCR6 6WWZ
TM2 88 P 2.58x58 CCR5 7O7F CCR5 7O7F
TM2 89 F 2.59x59 CCR5 7O7F CCR5 7O7F
TM2 90 W 2.60x60 CCR5 7O7F CCR5 7O7F
TM2 91 I 2.61x61 CCR5 7O7F FPR2/ALX 6OMM
TM2 92 H 2.62x62 CCR5 7O7F CCR5 7O7F
TM2 93 Y 2.63x63 CCR5 7O7F CCR5 7O7F
TM2 94 V 2.64x64 CCR5 7O7F β1-adrenoceptor 7BU7
TM2 95 R 2.65x65 CCR5 7O7F - -
TM2 96 G 2.66x66 CCR6 6WWZ A2A receptor 3QAK
TM2 97 H 2.67x67 CCR6 6WWZ 5-HT1D receptor 7E32
ECL1 98 N 23.49x49 - - - -
ECL1 99 W 23.50x50 CCR5 4MBS CCR5 4MBS
ECL1 100 V 23.51x51 CCR5 4MBS CCR6 6WWZ
ECL1 101 F 23.52x52 - - - -
TM3 102 G 3.21x21 CCR5 7O7F CCR5 7O7F
TM3 103 H 3.22x22 CCR5 7O7F OX1 receptor 6TO7
TM3 104 G 3.23x23 CCR5 7O7F - -
TM3 105 M 3.24x24 CCR5 7O7F CCR5 7O7F
TM3 106 C 3.25x25 CCR5 7O7F CCR5 7O7F
TM3 107 K 3.26x26 CCR5 7O7F CCR6 6WWZ
TM3 108 L 3.27x27 CCR5 7O7F CCR5 7O7F
TM3 109 L 3.28x28 CCR5 7O7F CCR5 7O7F
TM3 110 S 3.29x29 CCR5 7O7F CXCR2 6LFO
TM3 111 G 3.30x30 CCR5 7O7F CCR5 7O7F
TM3 112 F 3.31x31 CCR5 7O7F AT2 receptor 5UNG
TM3 113 Y 3.32x32 CCR5 7O7F CCR5 7O7F
TM3 114 H 3.33x33 CCR5 7O7F CCR2 5T1A
TM3 115 T 3.34x34 CCR5 7O7F CCK1 receptor 7EZM
TM3 116 G 3.35x35 CCR5 7O7F CCR5 7O7F
TM3 117 L 3.36x36 CCR5 7O7F AT1 receptor 6DO1
TM3 118 Y 3.37x37 CCR5 7O7F CXCR2 6LFO
TM3 119 S 3.38x38 CCR5 7O7F CCR5 7O7F
TM3 120 E 3.39x39 CCR5 7O7F - -
TM3 121 I 3.40x40 CCR5 7O7F CCR5 7O7F
TM3 122 F 3.41x41 CCR5 7O7F CCR5 7O7F
TM3 123 F 3.42x42 CCR5 7O7F CCR5 7O7F
TM3 124 I 3.43x43 CCR5 7O7F CCR5 7O7F
TM3 125 I 3.44x44 CCR5 7O7F CCR5 7O7F
TM3 126 L 3.45x45 CCR5 7O7F CCR5 7O7F
TM3 127 L 3.46x46 CCR5 7O7F CCR5 7O7F
TM3 128 T 3.47x47 CCR5 7O7F CCR5 7O7F
TM3 129 I 3.48x48 CCR5 7O7F CCR5 7O7F
TM3 130 D 3.49x49 CCR5 7O7F CCR5 7O7F
TM3 131 R 3.50x50 CCR5 7O7F CCR5 7O7F
TM3 132 Y 3.51x51 CCR5 7O7F CCR5 7O7F
TM3 133 L 3.52x52 CCR5 7O7F CCR5 7O7F
TM3 134 A 3.53x53 CCR5 7O7F CCR5 7O7F
TM3 135 I 3.54x54 CCR5 7O7F CCR6 6WWZ
TM3 136 V 3.55x55 CCR5 7O7F CCR5 7O7F
TM3 137 H 3.56x56 CCR5 7O7F CCR5 7O7F
ICL2 138 A 34.50x50 - - - -
ICL2 139 V 34.51x51 CCR5 4MBS CCR5 4MBS
ICL2 140 F 34.52x52 CCR5 4MBS CCR5 4MBS
ICL2 141 A 34.53x53 CCR5 4MBS CCR5 4MBS
ICL2 142 L 34.54x54 CCR5 4MBS CCR5 4MBS
ICL2 143 R 34.55x55 CCR5 4MBS CCR6 6WWZ
ICL2 144 A 34.56x56 CCR5 4MBS CCR5 4MBS
ICL2 145 R 34.57x57 - - - -
TM4 146 T 4.38x38 CCR5 7O7F CCR5 7O7F
TM4 147 V 4.39x39 CCR5 7O7F CCR5 7O7F
TM4 148 T 4.40x40 CCR5 7O7F CCR5 7O7F
TM4 149 F 4.41x41 CCR5 7O7F CCR5 7O7F
TM4 150 G 4.42x42 CCR5 7O7F CCR5 7O7F
TM4 151 V 4.43x43 CCR5 7O7F CCR5 7O7F
TM4 152 I 4.44x44 CCR5 7O7F CCR6 6WWZ
TM4 153 T 4.45x45 CCR5 7O7F CCR5 7O7F
TM4 154 S 4.46x46 CCR5 7O7F CCR5 7O7F
TM4 155 I 4.47x47 CCR5 7O7F AT1 receptor 6DO1
TM4 156 V 4.48x48 CCR5 7O7F CCR6 6WWZ
TM4 157 T 4.49x49 CCR5 7O7F CCR5 7O7F
TM4 158 W 4.50x50 CCR5 7O7F CCR5 7O7F
TM4 159 G 4.51x51 CCR5 7O7F CCR6 6WWZ
TM4 160 L 4.52x52 CCR5 7O7F CCR6 6WWZ
TM4 161 A 4.53x53 CCR5 7O7F CCR5 7O7F
TM4 162 V 4.54x54 CCR5 7O7F CCR5 7O7F
TM4 163 L 4.55x55 CCR5 7O7F CXCR2 6LFO
TM4 164 A 4.56x56 CCR5 7O7F CCR5 7O7F
TM4 165 A 4.57x57 CCR5 7O7F CXCR2 6LFO
TM4 166 L 4.58x59 CCR5 7O7F CCR5 7O7F
TM4 167 P 4.59x60 CCR5 7O7F CCR5 7O7F
TM4 168 E 4.60x61 CCR5 7O7F CCR7 6QZH
TM4 169 F 4.61x62 CCR5 7O7F CCR6 6WWZ
TM4 170 I 4.62x63 CCR5 7O7F CCR5 7O7F
TM4 171 F 4.63x64 CCR5 7O7F CCR5 7O7F
TM4 172 Y 4.64x65 CCR5 7O7F - -
ECL2 173 E - CCR5 7O7F - -
ECL2 174 T - CCR5 7O7F - -
ECL2 175 E - CCR5 7O7F - -
ECL2 176 E - CCR5 7O7F - -
ECL2 177 L - CCR5 7O7F - -
ECL2 178 F - CCR5 7O7F - -
ECL2 179 E - CCR5 7O7F - -
ECL2 180 E - CCR5 7O7F - -
ECL2 181 T - CCR5 7O7F - -
ECL2 182 L - CCR5 7O7F - -
ECL2 183 C 45.50x50 CCR5 7O7F CCR5 7O7F
ECL2 184 S 45.51x51 CCR5 7O7F CCR5 7O7F
ECL2 185 A 45.52x52 CCR5 7O7F V2 receptor 7KH0
ECL2 186 L - CCR5 7O7F - -
ECL2 187 Y - CCR5 7O7F - -
ECL2 188 P - CCR5 7O7F CCR5 7O7F
ECL2 189 E - CCR5 7O7F - -
ECL2 190 D - CCR5 7O7F - -
TM5 191 T 5.30x31 CCR5 7O7F DP2 receptor 7M8W
TM5 192 V 5.31x32 CCR5 7O7F - -
TM5 193 Y 5.32x33 CCR5 7O7F - -
TM5 194 S 5.33x34 CCR5 7O7F US28 5WB1
TM5 195 W 5.34x35 CCR5 7O7F CCR5 7O7F
TM5 196 R 5.35x36 CCR5 7O7F CXCR2 6LFO
TM5 197 H 5.36x37 CCR5 7O7F 5-HT1A receptor 7E2X
TM5 198 F 5.37x38 CCR5 7O7F CCR5 7O7F
TM5 199 H 5.38x39 CCR5 7O7F CCR2 5T1A
TM5 200 T 5.39x40 CCR5 7O7F CCR5 7O7F
TM5 201 L 5.40x41 CCR5 7O7F CCR5 7O7F
TM5 202 R 5.41x42 CCR5 7O7F - -
TM5 203 M 5.42x43 CCR5 7O7F Rhodopsin 4X1H
TM5 204 T 5.43x44 CCR5 7O7F 5-HT1D receptor 7E32
TM5 205 I 5.44x45 CCR5 7O7F CCR5 7O7F
TM5 206 F 5.45x46 CCR5 7O7F CCR6 6WWZ
TM5 207 C 5.46x461 CCR5 7O7F A2A receptor 4UHR
TM5 208 L 5.47x47 CCR5 7O7F CCR5 7O7F
TM5 209 V 5.48x48 CCR5 7O7F CCR5 7O7F
TM5 210 L 5.49x49 CCR5 7O7F CCR5 7O7F
TM5 211 P 5.50x50 CCR5 7O7F CCR5 7O7F
TM5 212 L 5.51x51 CCR5 7O7F CCR5 7O7F
TM5 213 L 5.52x52 CCR5 7O7F CCR5 7O7F
TM5 214 V 5.53x53 CCR5 7O7F CCR5 7O7F
TM5 215 M 5.54x54 CCR5 7O7F CCR5 7O7F
TM5 216 A 5.55x55 CCR5 7O7F AT2 receptor 5UNG
TM5 217 I 5.56x56 CCR5 7O7F CCR5 7O7F
TM5 218 C 5.57x57 CCR5 7O7F CCR5 7O7F
TM5 219 Y 5.58x58 CCR5 7O7F CCR5 7O7F
TM5 220 T 5.59x59 CCR5 7O7F CCR6 6WWZ
TM5 221 G 5.60x60 CCR5 7O7F CCR5 7O7F
TM5 222 I 5.61x61 CCR5 7O7F CCR5 7O7F
TM5 223 I 5.62x62 CCR5 7O7F μ receptor 5C1M
TM5 224 K 5.63x63 CCR5 7O7F CCR5 7O7F
TM5 225 T 5.64x64 CCR5 7O7F CCR5 7O7F
TM5 226 L 5.65x65 CCR5 7O7F CCR5 7O7F
TM5 227 L 5.66x66 CCR5 7O7F CCR5 7O7F
TM5 228 R 5.67x67 CCR5 7O7F CCR5 7O7F
TM5 229 C 5.68x68 CCR5 7O7F CCR5 7O7F
ICL3 230 P - - - - -
ICL3 231 S - - - - -
TM6 232 K 6.28x28 CCR5 7O7F CCR5 7O7F
TM6 233 K 6.29x29 CCR5 7O7F CCR5 7O7F
TM6 234 K 6.30x30 CCR5 7O7F CXCR2 6LFO
TM6 235 Y 6.31x31 CCR5 7O7F - -
TM6 236 K 6.32x32 CCR5 7O7F CCR6 6WWZ
TM6 237 A 6.33x33 CCR5 7O7F CCR5 7O7F
TM6 238 I 6.34x34 CCR5 7O7F CCR6 6WWZ
TM6 239 R 6.35x35 CCR5 7O7F CCR5 7O7F
TM6 240 L 6.36x36 CCR5 7O7F CCR5 7O7F
TM6 241 I 6.37x37 CCR5 7O7F CCR5 7O7F
TM6 242 F 6.38x38 CCR5 7O7F CCR5 7O7F
TM6 243 V 6.39x39 CCR5 7O7F μ receptor 5C1M
TM6 244 I 6.40x40 CCR5 7O7F CCR5 7O7F
TM6 245 M 6.41x41 CCR5 7O7F CCR5 7O7F
TM6 246 A 6.42x42 CCR5 7O7F μ receptor 5C1M
TM6 247 V 6.43x43 CCR5 7O7F CCR5 7O7F
TM6 248 F 6.44x44 CCR5 7O7F CCR6 6WWZ
TM6 249 F 6.45x45 CCR5 7O7F CCR5 7O7F
TM6 250 I 6.46x46 CCR5 7O7F AT2 receptor 5UNG
TM6 251 F 6.47x47 CCR5 7O7F CCR5 7O7F
TM6 252 W 6.48x48 CCR5 7O7F CCR5 7O7F
TM6 253 T 6.49x49 CCR5 7O7F μ receptor 5C1M
TM6 254 P 6.50x50 CCR5 7O7F CCR5 7O7F
TM6 255 Y 6.51x51 CCR5 7O7F CCR5 7O7F
TM6 256 N 6.52x52 CCR5 7O7F CCR5 7O7F
TM6 257 V 6.53x53 CCR5 7O7F AT2 receptor 5UNG
TM6 258 A 6.54x54 CCR5 7O7F CCK1 receptor 7EZM
TM6 259 I 6.55x55 CCR5 7O7F κ receptor 6B73
TM6 260 L 6.56x56 CCR5 7O7F CCR5 7O7F
TM6 261 L 6.57x57 CCR5 7O7F CCR5 7O7F
TM6 262 S 6.58x58 CCR5 7O7F 5-HT2C receptor 6BQG
TM6 263 S 6.59x59 CCR5 7O7F GPR52 6LI3
TM6 264 Y 6.60x60 CCR5 7O7F CCK1 receptor 7EZM
TM6 265 Q 6.61x61 CCR5 7O7F CCR5 7O7F
TM6 266 S 6.62x62 CCR5 4MBS apelin receptor 5VBL
TM6 267 I 6.63x63 CCR5 4MBS - -
TM6 268 L 6.64x64 CCR5 4MBS - -
TM6 269 F 6.65x65 CCR5 4MBS - -
ECL3 270 G - - - - -
ECL3 271 N - - - - -
TM7 272 D 7.24x23 CCR5 7O7F AT1 receptor 6DO1
TM7 273 C 7.25x24 CCR5 7O7F CCR5 7O7F
TM7 274 E 7.26x25 CCR5 7O7F CXCR2 6LFO
TM7 275 R 7.27x26 CCR5 7O7F CXCR2 6LFO
TM7 276 S 7.28x27 CCR5 7O7F CCR5 7O7F
TM7 277 K 7.29x28 CCR5 7O7F CCR6 6WWZ
TM7 278 H 7.30x29 CCR5 7O7F CXCR2 6LFO
TM7 279 L 7.31x30 CCR5 7O7F CCR5 7O7F
TM7 280 D 7.32x31 CCR5 7O7F CCR5 7O7F
TM7 281 L 7.33x32 CCR5 7O7F AT2 receptor 5UNG
TM7 282 V 7.34x33 CCR5 7O7F β2-adrenoceptor 3SN6
TM7 283 M 7.35x34 CCR5 7O7F CCR5 7O7F
TM7 284 L 7.36x35 CCR5 7O7F β3-adrenoceptor 7DH5
TM7 285 V 7.37x36 CCR5 7O7F CCR5 7O7F
TM7 286 T 7.38x37 CCR5 7O7F CCR5 7O7F
TM7 287 E 7.39x38 CCR5 7O7F CCR5 7O7F
TM7 288 V 7.40x39 CCR5 7O7F CCR6 6WWZ
TM7 289 I 7.41x40 CCR5 7O7F AT1 receptor 6DO1
TM7 290 A 7.42x41 CCR5 7O7F CCR6 6WWZ
TM7 291 Y 7.43x42 CCR5 7O7F AT1 receptor 6DO1
TM7 292 S 7.44x43 CCR5 7O7F Rhodopsin 5W0P
TM7 293 H 7.45x45 CCR5 7O7F CCR5 7O7F
TM7 294 C 7.46x46 CCR5 7O7F CCR5 7O7F
TM7 295 C 7.47x47 CCR5 7O7F CCR5 7O7F
TM7 296 M 7.48x48 CCR5 7O7F A1 receptor 6D9H
TM7 297 N 7.49x49 CCR5 7O7F CCR5 7O7F
TM7 298 P 7.50x50 CCR5 7O7F CCR5 7O7F
TM7 299 V 7.51x51 CCR5 7O7F CCR6 6WWZ
TM7 300 I 7.52x52 CCR5 7O7F CCR5 7O7F
TM7 301 Y 7.53x53 CCR5 7O7F CCR5 7O7F
TM7 302 A 7.54x54 CCR5 7O7F CCR5 7O7F
TM7 303 F 7.55x55 CCR5 7O7F CCR5 7O7F
TM7 304 V 7.56x56 CCR5 7O7F CCR5 7O7F
H8 305 G 8.47x47 CCR5 7O7F CCR5 7O7F
H8 306 E 8.48x48 CCR5 7O7F CCR5 7O7F
H8 307 R 8.49x49 CCR5 7O7F AT2 receptor 5UNG
H8 308 F 8.50x50 CCR5 7O7F CCR5 7O7F
H8 309 R 8.51x51 CCR5 7O7F CCR5 7O7F
H8 310 K 8.52x52 CCR5 7O7F MT1 receptor 7DB6
H8 311 Y 8.53x53 CCR5 7O7F CCR5 7O7F
H8 312 L 8.54x54 CCR5 7O7F CCR5 7O7F
H8 313 R 8.55x55 CCR5 7O7F AT2 receptor 6JOD
H8 314 H 8.56x56 CCR5 7O7F FPR2/ALX 6OMM
H8 315 F 8.57x57 CCR5 7O7F CCR5 7O7F
H8 316 F 8.58x58 CCR5 7O7F CCR5 7O7F
H8 317 H 8.59x59 CCR5 7O7F D2 receptor 6VMS
C-term 318 R - - - - -
C-term 319 H - - - - -
C-term 320 L - - - - -
C-term 321 L - - - - -
C-term 322 M - - - - -