CCR4 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive

VERSION

2020-09-02

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

CCR5 (sequence similarity: 76%) PDB: 5UIW

TEMPLATES

5UIW (CCR5)
6MEO (CCR5)
4MBS (CCR5)
6WWZ (CCR6)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 92.0 3.0 5.0
Side-chains 48.0 39.7 12.3

Number of backbone templates: 4
Number of rotamer templates: 36

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 26 P CCR5 5UIW CCR5 5UIW
N-term 27 K CCR5 5UIW CCR5 5UIW
N-term 28 P CCR5 5UIW CCR5 5UIW
N-term 29 C CCR5 5UIW CCR5 5UIW
N-term 30 T CCR5 5UIW CCR5 5UIW
TM1 31 K 1.24x24 CCR5 5UIW - -
TM1 32 E 1.25x25 CCR5 5UIW CXCR4 4RWS
TM1 33 G 1.26x26 CCR5 5UIW - -
TM1 34 I 1.27x27 CCR5 5UIW ETB receptor 5X93
TM1 35 K 1.28x28 CCR5 5UIW CCR5 5UIW
TM1 36 A 1.29x29 CCR5 5UIW NK1 receptor 6HLP
TM1 37 F 1.30x30 CCR5 5UIW CCR7 6QZH
TM1 38 G 1.31x31 CCR5 5UIW CCR2 5T1A
TM1 39 E 1.32x32 CCR5 5UIW OX2 receptor 5WS3
TM1 40 L 1.33x33 CCR5 5UIW BLT1 receptor 5X33
TM1 41 F 1.34x34 CCR5 5UIW CCR7 6QZH
TM1 42 L 1.35x35 CCR5 5UIW CCR5 5UIW
TM1 43 P 1.36x36 CCR5 5UIW CCR5 5UIW
TM1 44 P 1.37x37 CCR5 5UIW CCR5 5UIW
TM1 45 L 1.38x38 CCR5 5UIW CCR5 5UIW
TM1 46 Y 1.39x39 CCR5 5UIW CCR5 5UIW
TM1 47 S 1.40x40 CCR5 5UIW CCR5 5UIW
TM1 48 L 1.41x41 CCR5 5UIW CCR5 5UIW
TM1 49 V 1.42x42 CCR5 5UIW CCR5 5UIW
TM1 50 F 1.43x43 CCR5 5UIW CCR5 5UIW
TM1 51 V 1.44x44 CCR5 5UIW AT1 receptor 4ZUD
TM1 52 F 1.45x45 CCR5 5UIW CCR5 5UIW
TM1 53 G 1.46x46 CCR5 5UIW CCR5 5UIW
TM1 54 L 1.47x47 CCR5 5UIW CCR7 6QZH
TM1 55 L 1.48x48 CCR5 5UIW CCR7 6QZH
TM1 56 G 1.49x49 CCR5 5UIW CCR5 5UIW
TM1 57 N 1.50x50 CCR5 5UIW CCR5 5UIW
TM1 58 S 1.51x51 CCR5 5UIW CCR9 5LWE
TM1 59 V 1.52x52 CCR5 5UIW DP2 receptor 6D27
TM1 60 V 1.53x53 CCR5 5UIW CCR5 5UIW
TM1 61 V 1.54x54 CCR5 5UIW CCR2 5T1A
TM1 62 L 1.55x55 CCR5 5UIW CCR5 5UIW
TM1 63 V 1.56x56 CCR5 5UIW CXCR4 3ODU
TM1 64 L 1.57x57 CCR5 5UIW CCR5 5UIW
TM1 65 F 1.58x58 CCR5 5UIW apelin receptor 5VBL
TM1 66 K 1.59x59 CCR5 5UIW ETB receptor 5X93
TM1 67 Y 1.60x60 CCR5 5UIW CCR5 5UIW
ICL1 68 K 12.48x48 - - - -
ICL1 69 R 12.49x49 CCR6 6WWZ apelin receptor 5VBL
ICL1 70 L 12.50x50 CCR6 6WWZ CCR7 6QZH
ICL1 71 R 12.51x51 - - - -
TM2 72 S 2.37x37 CCR5 5UIW CCR5 5UIW
TM2 73 M 2.38x38 CCR5 5UIW CCR5 5UIW
TM2 74 T 2.39x39 CCR5 5UIW CCR5 5UIW
TM2 75 D 2.40x40 CCR5 5UIW CCR5 5UIW
TM2 76 V 2.41x41 CCR5 5UIW AT1 receptor 4ZUD
TM2 77 Y 2.42x42 CCR5 5UIW CCR5 5UIW
TM2 78 L 2.43x43 CCR5 5UIW CCR5 5UIW
TM2 79 L 2.44x44 CCR5 5UIW CCR5 5UIW
TM2 80 N 2.45x45 CCR5 5UIW CCR5 5UIW
TM2 81 L 2.46x46 CCR5 5UIW CCR5 5UIW
TM2 82 A 2.47x47 CCR5 5UIW CCR5 5UIW
TM2 83 I 2.48x48 CCR5 5UIW CCR5 5UIW
TM2 84 S 2.49x49 CCR5 5UIW CCR5 5UIW
TM2 85 D 2.50x50 CCR5 5UIW CCR5 5UIW
TM2 86 L 2.51x51 CCR5 5UIW CCR5 5UIW
TM2 87 L 2.52x52 CCR5 5UIW CCR2 5T1A
TM2 88 F 2.53x53 CCR5 5UIW CCR5 5UIW
TM2 89 V 2.54x54 CCR5 5UIW CXCR4 3ODU
TM2 90 F 2.55x55 CCR5 5UIW 5-HT2A receptor 6A94
TM2 91 S 2.56x56 CCR5 5UIW DP2 receptor 6D27
TM2 92 L 2.57x57 CCR5 5UIW CCR2 5T1A
TM2 93 P 2.58x58 CCR5 5UIW CCR5 5UIW
TM2 94 F 2.59x59 CCR5 5UIW CCR5 5UIW
TM2 95 W 2.60x60 CCR5 5UIW CCR5 5UIW
TM2 96 G 2.61x61 CCR5 5UIW NOP receptor 5DHG
TM2 97 Y 2.62x62 CCR5 5UIW CCR7 6QZH
TM2 98 Y 2.63x63 CCR5 5UIW CCR5 5UIW
TM2 99 A 2.64x64 CCR5 5UIW CCR5 5UIW
TM2 100 A 2.65x65 CCR5 5UIW CCR5 5UIW
TM2 101 D 2.66x66 CCR5 5UIW US28 5WB1
ECL1 102 Q 23.49x49 CCR5 5UIW CCR5 5UIW
ECL1 103 W 23.50x50 CCR5 5UIW CCR5 5UIW
ECL1 104 V 23.51x51 CCR5 5UIW CCR2 5T1A
ECL1 105 F 23.52x52 CCR5 5UIW CCR5 5UIW
TM3 106 G 3.21x21 CCR5 5UIW CCR5 5UIW
TM3 107 L 3.22x22 CCR5 5UIW BLT1 receptor 5X33
TM3 108 G 3.23x23 CCR5 5UIW - -
TM3 109 L 3.24x24 CCR5 5UIW CXCR4 3ODU
TM3 110 C 3.25x25 CCR5 5UIW CCR5 5UIW
TM3 111 K 3.26x26 CCR5 5UIW CCR2 5T1A
TM3 112 M 3.27x27 CCR5 5UIW A1 receptor 5UEN
TM3 113 I 3.28x28 CCR5 5UIW CCR7 6QZH
TM3 114 S 3.29x29 CCR5 5UIW AT1 receptor 4ZUD
TM3 115 W 3.30x30 CCR5 5UIW - -
TM3 116 M 3.31x31 CCR5 5UIW CCR9 5LWE
TM3 117 Y 3.32x32 CCR5 5UIW CCR5 5UIW
TM3 118 L 3.33x33 CCR5 5UIW C5a1 receptor 5O9H
TM3 119 V 3.34x34 CCR5 5UIW CXCR4 3ODU
TM3 120 G 3.35x35 CCR5 5UIW CCR5 5UIW
TM3 121 F 3.36x36 CCR5 5UIW CCR5 5UIW
TM3 122 Y 3.37x37 CCR5 5UIW CXCR4 3ODU
TM3 123 S 3.38x38 CCR5 5UIW CCR5 5UIW
TM3 124 G 3.39x39 CCR5 5UIW CCR5 5UIW
TM3 125 I 3.40x40 CCR5 5UIW CCR5 5UIW
TM3 126 F 3.41x41 CCR5 5UIW CCR5 5UIW
TM3 127 F 3.42x42 CCR5 5UIW CCR5 5UIW
TM3 128 V 3.43x43 CCR5 5UIW H1 receptor 3RZE
TM3 129 M 3.44x44 CCR5 5UIW CCR9 5LWE
TM3 130 L 3.45x45 CCR5 5UIW CCR5 5UIW
TM3 131 M 3.46x46 CCR5 5UIW μ receptor 4DKL
TM3 132 S 3.47x47 CCR5 5UIW CCR7 6QZH
TM3 133 I 3.48x48 CCR5 5UIW CCR5 5UIW
TM3 134 D 3.49x49 CCR5 5UIW CCR5 5UIW
TM3 135 R 3.50x50 CCR5 5UIW CCR5 5UIW
TM3 136 Y 3.51x51 CCR5 5UIW CCR5 5UIW
TM3 137 L 3.52x52 CCR5 5UIW CCR5 5UIW
TM3 138 A 3.53x53 CCR5 5UIW CCR5 5UIW
TM3 139 I 3.54x54 CCR5 5UIW CCR2 5T1A
TM3 140 V 3.55x55 CCR5 5UIW CCR5 5UIW
TM3 141 H 3.56x56 CCR5 5UIW CCR5 5UIW
ICL2 142 A 34.50x50 CCR5 5UIW CCR5 5UIW
ICL2 143 V 34.51x51 CCR5 5UIW CCR5 4MBS
ICL2 144 F 34.52x52 CCR5 5UIW CCR5 5UIW
ICL2 145 S 34.53x53 CCR5 5UIW BLT1 receptor 5X33
ICL2 146 L 34.54x54 CCR5 5UIW CCR5 4MBS
ICL2 147 R 34.55x55 CCR5 5UIW C5a1 receptor 5O9H
ICL2 148 A 34.56x56 CCR5 5UIW CCR5 5UIW
ICL2 149 R 34.57x57 CCR5 5UIW CCR5 5UIW
TM4 150 T 4.38x38 CCR5 5UIW CCR5 5UIW
TM4 151 L 4.39x39 CCR5 5UIW CCR7 6QZH
TM4 152 T 4.40x40 CCR5 5UIW CCR5 5UIW
TM4 153 Y 4.41x41 CCR5 5UIW CCR9 5LWE
TM4 154 G 4.42x42 CCR5 5UIW CCR5 5UIW
TM4 155 V 4.43x43 CCR5 5UIW CCR5 5UIW
TM4 156 I 4.44x44 CCR5 5UIW μ receptor 4DKL
TM4 157 T 4.45x45 CCR5 5UIW CCR5 5UIW
TM4 158 S 4.46x46 CCR5 5UIW CCR5 5UIW
TM4 159 L 4.47x47 CCR5 5UIW DP2 receptor 6D27
TM4 160 A 4.48x48 CCR5 5UIW NOP receptor 5DHG
TM4 161 T 4.49x49 CCR5 5UIW CCR5 5UIW
TM4 162 W 4.50x50 CCR5 5UIW CCR5 5UIW
TM4 163 S 4.51x51 CCR5 5UIW - -
TM4 164 V 4.52x52 CCR5 5UIW CCR5 5UIW
TM4 165 A 4.53x53 CCR5 5UIW CCR5 5UIW
TM4 166 V 4.54x54 CCR5 5UIW CCR5 5UIW
TM4 167 F 4.55x55 CCR5 5UIW CCR5 5UIW
TM4 168 A 4.56x56 CCR5 5UIW CCR5 5UIW
TM4 169 S 4.57x57 CCR5 5UIW CCR5 5UIW
TM4 170 L 4.58x59 CCR5 5UIW CCR5 5UIW
TM4 171 P 4.59x60 CCR5 5UIW CCR5 5UIW
TM4 172 G 4.60x61 CCR5 5UIW CCR5 6MEO
TM4 173 F 4.61x62 CCR5 5UIW CXCR4 3ODU
TM4 174 L 4.62x63 CCR5 5UIW CCR7 6QZH
TM4 175 F 4.63x64 CCR5 5UIW CCR5 5UIW
TM4 176 S 4.64x65 CCR5 5UIW NK1 receptor 6HLP
ECL2 177 T CCR5 5UIW - -
ECL2 178 C CCR5 5UIW - -
ECL2 179 Y CCR5 5UIW - -
ECL2 180 T CCR5 5UIW - -
ECL2 181 E CCR5 5UIW CCR5 5UIW
ECL2 182 R CCR5 5UIW - -
ECL2 183 N CCR5 5UIW - -
ECL2 184 H CCR5 5UIW - -
ECL2 185 T CCR5 5UIW - -
ECL2 186 Y CCR5 5UIW - -
ECL2 187 C 45.50x50 CCR5 5UIW CCR5 5UIW
ECL2 188 K 45.51x51 CCR5 5UIW NK1 receptor 6HLP
ECL2 189 T 45.52x52 CCR5 5UIW US28 4XT1
ECL2 190 K - - - -
ECL2 191 Y - - - -
ECL2 192 S - - - -
ECL2 193 L - - - -
TM5 194 N 5.30x31 CCR5 5UIW - -
TM5 195 S 5.31x32 CCR5 5UIW δ receptor 4N6H
TM5 196 T 5.32x33 CCR5 5UIW NTS1 receptor 4BUO
TM5 197 T 5.33x34 CCR5 5UIW EP4 receptor 5YWY
TM5 198 W 5.34x35 CCR5 5UIW CCR5 5UIW
TM5 199 K 5.35x36 CCR5 5UIW CCR5 5UIW
TM5 200 V 5.36x37 CCR5 5UIW CXCR4 3ODU
TM5 201 L 5.37x38 CCR5 5UIW μ receptor 4DKL
TM5 202 S 5.38x39 CCR5 5UIW - -
TM5 203 S 5.39x40 CCR5 5UIW EP4 receptor 5YWY
TM5 204 L 5.40x41 CCR5 5UIW CCR5 5UIW
TM5 205 E 5.41x42 CCR5 5UIW US28 5WB1
TM5 206 I 5.42x43 CCR5 5UIW CCR5 5UIW
TM5 207 N 5.43x44 CCR5 5UIW CCR2 5T1A
TM5 208 I 5.44x45 CCR5 5UIW CCR5 5UIW
TM5 209 L 5.45x46 CCR5 5UIW CCR5 5UIW
TM5 210 G 5.46x461 CCR5 5UIW CCR5 5UIW
TM5 211 L 5.47x47 CCR5 5UIW CCR5 5UIW
TM5 212 V 5.48x48 CCR5 5UIW CCR5 5UIW
TM5 213 I 5.49x49 CCR5 5UIW κ receptor 6VI4
TM5 214 P 5.50x50 CCR5 5UIW CCR5 5UIW
TM5 215 L 5.51x51 CCR5 5UIW CCR5 5UIW
TM5 216 G 5.52x52 CCR5 5UIW OX1 receptor 6TO7
TM5 217 I 5.53x53 CCR5 5UIW CCR2 5T1A
TM5 218 M 5.54x54 CCR5 5UIW CCR5 5UIW
TM5 219 L 5.55x55 CCR5 5UIW CXCR4 3ODU
TM5 220 F 5.56x56 CCR5 5UIW CCR7 6QZH
TM5 221 C 5.57x57 CCR5 5UIW CCR5 5UIW
TM5 222 Y 5.58x58 CCR5 5UIW CCR5 5UIW
TM5 223 S 5.59x59 CCR5 5UIW CCR5 5UIW
TM5 224 M 5.60x60 CCR5 5UIW LPA6 receptor 5XSZ
TM5 225 I 5.61x61 CCR5 5UIW CCR5 5UIW
TM5 226 I 5.62x62 CCR5 5UIW CCR7 6QZH
TM5 227 R 5.63x63 CCR5 5UIW NOP receptor 5DHG
TM5 228 T 5.64x64 CCR5 5UIW CCR5 5UIW
TM5 229 L 5.65x65 CCR5 5UIW CCR5 5UIW
TM5 230 Q 5.66x66 CCR5 5UIW DP2 receptor 6D27
TM5 231 H 5.67x67 CCR5 5UIW - -
TM5 232 C 5.68x68 CCR5 6MEO CCR5 6MEO
ICL3 233 K - - - -
ICL3 234 N CCR6 6WWZ CCR6 6WWZ
ICL3 235 E CCR6 6WWZ - -
ICL3 236 K - - - -
TM6 237 K 6.30x30 CCR5 5UIW CXCR4 3ODU
TM6 238 N 6.31x31 CCR5 5UIW - -
TM6 239 K 6.32x32 CCR5 5UIW CXCR4 3ODU
TM6 240 A 6.33x33 CCR5 5UIW CCR5 6MEO
TM6 241 V 6.34x34 CCR5 5UIW CCR5 5UIW
TM6 242 K 6.35x35 CCR5 5UIW CCR7 6QZH
TM6 243 M 6.36x36 CCR5 5UIW μ receptor 4DKL
TM6 244 I 6.37x37 CCR5 5UIW CCR5 5UIW
TM6 245 F 6.38x38 CCR5 5UIW CCR5 5UIW
TM6 246 A 6.39x39 CCR5 5UIW CCR7 6QZH
TM6 247 V 6.40x40 CCR5 5UIW CCR7 6QZH
TM6 248 V 6.41x41 CCR5 5UIW CCR7 6QZH
TM6 249 V 6.42x42 CCR5 5UIW CCR7 6QZH
TM6 250 L 6.43x43 CCR5 5UIW 5-HT2A receptor 6A94
TM6 251 F 6.44x44 CCR5 5UIW CCR7 6QZH
TM6 252 L 6.45x45 CCR5 5UIW Rhodopsin 1GZM
TM6 253 G 6.46x46 CCR5 5UIW NOP receptor 5DHG
TM6 254 F 6.47x47 CCR5 5UIW CCR5 5UIW
TM6 255 W 6.48x48 CCR5 5UIW CCR5 5UIW
TM6 256 T 6.49x49 CCR5 5UIW CCR2 5T1A
TM6 257 P 6.50x50 CCR5 5UIW CCR5 5UIW
TM6 258 Y 6.51x51 CCR5 5UIW CCR5 5UIW
TM6 259 N 6.52x52 CCR5 5UIW CCR5 5UIW
TM6 260 I 6.53x53 CCR5 5UIW CCR5 5UIW
TM6 261 V 6.54x54 CCR5 5UIW CCR5 5UIW
TM6 262 L 6.55x55 CCR5 5UIW CCR5 5UIW
TM6 263 F 6.56x56 CCR5 5UIW AT1 receptor 4ZUD
TM6 264 L 6.57x57 CCR5 5UIW CCR5 5UIW
TM6 265 E 6.58x58 CCR5 5UIW κ receptor 6VI4
TM6 266 T 6.59x59 CCR5 5UIW CCR5 5UIW
TM6 267 L 6.60x60 CCR5 5UIW AT1 receptor 4ZUD
TM6 268 V 6.61x61 CCR5 5UIW LPA6 receptor 5XSZ
TM6 269 E 6.62x62 CCR5 4MBS CCR5 6AKX
TM6 270 L 6.63x63 CCR5 4MBS CXCR4 3ODU
TM6 271 E 6.64x64 CCR5 4MBS CXCR4 3ODU
TM6 272 V 6.65x65 CCR5 4MBS - -
ECL3 273 L - - - -
ECL3 274 Q - - - -
TM7 275 D 7.24x23 CCR5 5UIW AT1 receptor 4ZUD
TM7 276 C 7.25x24 CCR5 5UIW CCR5 5UIW
TM7 277 T 7.26x25 CCR5 5UIW P2Y12 receptor 4NTJ
TM7 278 F 7.27x26 CCR5 5UIW CXCR4 3ODU
TM7 279 E 7.28x27 CCR5 5UIW CXCR4 3ODU
TM7 280 R 7.29x28 CCR5 5UIW US28 5WB1
TM7 281 Y 7.30x29 CCR5 5UIW - -
TM7 282 L 7.31x30 CCR5 5UIW CCR5 5UIW
TM7 283 D 7.32x31 CCR5 5UIW CCR5 5UIW
TM7 284 Y 7.33x32 CCR5 5UIW ghrelin receptor 6KO5
TM7 285 A 7.34x33 CCR5 5UIW CCR5 5UIW
TM7 286 I 7.35x34 CCR5 5UIW CXCR4 3ODU
TM7 287 Q 7.36x35 CCR5 5UIW CCR5 5UIW
TM7 288 A 7.37x36 CCR5 5UIW NK1 receptor 6HLP
TM7 289 T 7.38x37 CCR5 5UIW CCR5 5UIW
TM7 290 E 7.39x38 CCR5 5UIW CCR5 5UIW
TM7 291 T 7.40x39 CCR5 5UIW CCR5 5UIW
TM7 292 L 7.41x40 CCR5 5UIW CCR5 5UIW
TM7 293 A 7.42x41 CCR5 5UIW CCR7 6QZH
TM7 294 F 7.43x42 CCR5 5UIW CXCR4 3ODU
TM7 295 V 7.44x43 CCR5 5UIW CCR7 6QZH
TM7 296 H 7.45x45 CCR5 5UIW CCR5 5UIW
TM7 297 C 7.46x46 CCR5 5UIW CCR5 5UIW
TM7 298 C 7.47x47 CCR5 5UIW CCR5 5UIW
TM7 299 L 7.48x48 CCR5 5UIW CXCR4 3ODU
TM7 300 N 7.49x49 CCR5 5UIW CCR5 5UIW
TM7 301 P 7.50x50 CCR5 5UIW CCR5 5UIW
TM7 302 I 7.51x51 CCR5 5UIW CCR5 5UIW
TM7 303 I 7.52x52 CCR5 5UIW CCR5 5UIW
TM7 304 Y 7.53x53 CCR5 5UIW CCR5 5UIW
TM7 305 F 7.54x54 CCR5 5UIW P2Y1 receptor 4XNW
TM7 306 F 7.55x55 CCR5 5UIW CCR5 5UIW
TM7 307 L 7.56x56 CCR5 5UIW μ receptor 4DKL
H8 308 G 8.47x47 CCR5 5UIW CCR5 5UIW
H8 309 E 8.48x48 CCR5 5UIW CCR5 4MBS
H8 310 K 8.49x49 CCR5 5UIW CCR2 5T1A
H8 311 F 8.50x50 CCR5 5UIW CCR5 5UIW
H8 312 R 8.51x51 CCR5 5UIW CCR5 5UIW
H8 313 K 8.52x52 CCR5 5UIW H1 receptor 3RZE
H8 314 Y 8.53x53 CCR5 5UIW CCR5 5UIW
H8 315 I 8.54x54 CCR5 5UIW - -
H8 316 L 8.55x55 CCR5 5UIW CCR5 5UIW
H8 317 Q 8.56x56 CCR5 5UIW LPA1 receptor 4Z36
H8 318 L 8.57x57 CCR5 5UIW δ receptor 4N6H
H8 319 F 8.58x58 CCR5 5UIW CCR5 5UIW
H8 320 K 8.59x59 CCR5 5UIW CCR9 5LWE
C-term 321 T - - - -
C-term 322 C - - - -
C-term 323 R - - - -
C-term 324 G - - - -
C-term 325 L - - - -