CCR8 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

CCR8

SPECIES

Homo sapiens

STATE

Inactive

VERSION

2021-11-02

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

CCR5 (sequence similarity: 58%) PDB: 4MBS
Align

TEMPLATES

5UIW (CCR5)
4MBS (CCR5)
7O7F (CCR5)
6WWZ (CCR6)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 92.0 3.7 4.3
Side-chains 38.7 49.0 12.3

Number of backbone templates: 4
Number of rotamer templates: 47

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 22 S - CCR5 5UIW CCR5 5UIW
N-term 23 S - CCR5 5UIW CCR5 5UIW
N-term 24 P - CCR5 5UIW CCR5 5UIW
N-term 25 C - CCR5 5UIW CCR5 5UIW
N-term 26 D - CCR5 5UIW CCR5 5UIW
TM1 27 A 1.24x24 CCR5 5UIW - -
TM1 28 E 1.25x25 CCR5 5UIW CXCR4 4RWS
TM1 29 L 1.26x26 CCR5 5UIW succinate receptor 6RNK
TM1 30 I 1.27x27 CCR5 4MBS ETB receptor 5X93
TM1 31 Q 1.28x28 CCR5 4MBS - -
TM1 32 T 1.29x29 CCR5 4MBS BLT1 receptor 5X33
TM1 33 N 1.30x30 CCR5 4MBS - -
TM1 34 G 1.31x31 CCR5 4MBS CCR2 5T1A
TM1 35 K 1.32x32 CCR5 4MBS CXCR2 6LFL
TM1 36 L 1.33x33 CCR5 4MBS BLT1 receptor 7K15
TM1 37 L 1.34x34 CCR5 4MBS CCR5 4MBS
TM1 38 L 1.35x35 CCR5 4MBS CCR5 4MBS
TM1 39 A 1.36x36 CCR5 4MBS M5 receptor 6OL9
TM1 40 V 1.37x37 CCR5 4MBS ETB receptor 5X93
TM1 41 F 1.38x38 CCR5 4MBS succinate receptor 6RNK
TM1 42 Y 1.39x39 CCR5 4MBS CCR5 4MBS
TM1 43 C 1.40x40 CCR5 4MBS Y2 receptor 7DDZ
TM1 44 L 1.41x41 CCR5 4MBS CCR5 4MBS
TM1 45 L 1.42x42 CCR5 4MBS M3 receptor 5ZHP
TM1 46 F 1.43x43 CCR5 4MBS CCR5 4MBS
TM1 47 V 1.44x44 CCR5 4MBS AT1 receptor 4ZUD
TM1 48 F 1.45x45 CCR5 4MBS CCR5 4MBS
TM1 49 S 1.46x46 CCR5 4MBS CXCR2 6LFL
TM1 50 L 1.47x47 CCR5 4MBS CCR7 6QZH
TM1 51 L 1.48x48 CCR5 4MBS CCR7 6QZH
TM1 52 G 1.49x49 CCR5 4MBS CCR5 4MBS
TM1 53 N 1.50x50 CCR5 4MBS CCR5 4MBS
TM1 54 S 1.51x51 CCR5 4MBS CXCR2 6LFL
TM1 55 L 1.52x52 CCR5 4MBS CCR5 4MBS
TM1 56 V 1.53x53 CCR5 4MBS CCR5 4MBS
TM1 57 I 1.54x54 CCR5 4MBS CCR5 4MBS
TM1 58 L 1.55x55 CCR5 4MBS CCR5 4MBS
TM1 59 V 1.56x56 CCR5 4MBS CXCR2 6LFL
TM1 60 L 1.57x57 CCR5 4MBS CCR5 4MBS
TM1 61 V 1.58x58 CCR5 4MBS μ receptor 4DKL
TM1 62 V 1.59x59 CCR5 4MBS M5 receptor 6OL9
TM1 63 C 1.60x60 CCR5 4MBS CCR5 6MEO
ICL1 64 K 12.48x48 - - - -
ICL1 65 K 12.49x49 CCR6 6WWZ - -
ICL1 66 L 12.50x50 CCR6 6WWZ CCR7 6QZH
ICL1 67 R 12.51x51 - - - -
TM2 68 S 2.37x37 CCR5 4MBS CCR5 4MBS
TM2 69 I 2.38x38 CCR5 4MBS C5a1 receptor 6C1Q
TM2 70 T 2.39x39 CCR5 4MBS CCR5 4MBS
TM2 71 D 2.40x40 CCR5 4MBS CCR5 4MBS
TM2 72 V 2.41x41 CCR5 4MBS CXCR2 6LFL
TM2 73 Y 2.42x42 CCR5 4MBS CCR5 4MBS
TM2 74 L 2.43x43 CCR5 4MBS CCR5 4MBS
TM2 75 L 2.44x44 CCR5 4MBS CCR5 4MBS
TM2 76 N 2.45x45 CCR5 4MBS CCR5 4MBS
TM2 77 L 2.46x46 CCR5 4MBS CCR5 4MBS
TM2 78 A 2.47x47 CCR5 4MBS CCR5 4MBS
TM2 79 L 2.48x48 CCR5 4MBS CXCR2 6LFL
TM2 80 S 2.49x49 CCR5 4MBS CCR5 4MBS
TM2 81 D 2.50x50 CCR5 4MBS CCR5 4MBS
TM2 82 L 2.51x51 CCR5 4MBS CCR5 4MBS
TM2 83 L 2.52x52 CCR5 4MBS CCR2 5T1A
TM2 84 F 2.53x53 CCR5 4MBS CCR5 4MBS
TM2 85 V 2.54x54 CCR5 4MBS CXCR4 3ODU
TM2 86 F 2.55x55 CCR5 4MBS 5-HT2A receptor 6A94
TM2 87 S 2.56x56 CCR5 4MBS M5 receptor 6OL9
TM2 88 F 2.57x57 CCR5 4MBS Rhodopsin 1U19
TM2 89 P 2.58x58 CCR5 4MBS CCR5 4MBS
TM2 90 F 2.59x59 CCR5 4MBS CCR5 4MBS
TM2 91 Q 2.60x60 CCR5 4MBS κ receptor 4DJH
TM2 92 T 2.61x61 CCR5 4MBS M5 receptor 6OL9
TM2 93 Y 2.62x62 CCR5 4MBS CCR7 6QZH
TM2 94 Y 2.63x63 CCR5 4MBS CCR5 4MBS
TM2 95 L 2.64x64 CCR5 4MBS BLT1 receptor 7K15
TM2 96 L 2.65x65 CCR5 4MBS κ receptor 4DJH
TM2 97 D 2.66x66 CCR5 4MBS US28 5WB2
ECL1 98 Q 23.49x49 CCR5 4MBS CCR5 4MBS
ECL1 99 W 23.50x50 CCR5 4MBS CCR5 4MBS
ECL1 100 V 23.51x51 CCR5 4MBS CCR2 5T1A
ECL1 101 F 23.52x52 CCR5 4MBS CCR5 4MBS
TM3 102 G 3.21x21 CCR5 4MBS CCR5 4MBS
TM3 103 T 3.22x22 CCR5 4MBS CXCR2 6LFL
TM3 104 V 3.23x23 CCR5 4MBS κ receptor 4DJH
TM3 105 M 3.24x24 CCR5 4MBS CCR5 4MBS
TM3 106 C 3.25x25 CCR5 4MBS CCR5 4MBS
TM3 107 K 3.26x26 CCR5 4MBS CCR2 5T1A
TM3 108 V 3.27x27 CCR5 4MBS CXCR2 6LFL
TM3 109 V 3.28x28 CCR5 4MBS CXCR2 6LFL
TM3 110 S 3.29x29 CCR5 4MBS CXCR2 6LFL
TM3 111 G 3.30x30 CCR5 4MBS CCR5 4MBS
TM3 112 F 3.31x31 CCR5 4MBS NK1 receptor 6HLP
TM3 113 Y 3.32x32 CCR5 4MBS CCR5 4MBS
TM3 114 Y 3.33x33 CCR5 4MBS κ receptor 4DJH
TM3 115 I 3.34x34 CCR5 4MBS CCR5 4MBS
TM3 116 G 3.35x35 CCR5 4MBS CCR5 4MBS
TM3 117 F 3.36x36 CCR5 4MBS CCR5 4MBS
TM3 118 Y 3.37x37 CCR5 4MBS CXCR2 6LFL
TM3 119 S 3.38x38 CCR5 4MBS CCR5 4MBS
TM3 120 S 3.39x39 CCR5 4MBS CXCR4 3ODU
TM3 121 M 3.40x40 CCR5 4MBS CCR7 6QZH
TM3 122 F 3.41x41 CCR5 4MBS CCR5 4MBS
TM3 123 F 3.42x42 CCR5 4MBS CCR5 4MBS
TM3 124 I 3.43x43 CCR5 4MBS CCR5 4MBS
TM3 125 T 3.44x44 CCR5 4MBS AT1 receptor 4ZUD
TM3 126 L 3.45x45 CCR5 4MBS CCR5 4MBS
TM3 127 M 3.46x46 CCR5 4MBS κ receptor 4DJH
TM3 128 S 3.47x47 CCR5 4MBS CCR7 6QZH
TM3 129 V 3.48x48 CCR5 4MBS CXCR2 6LFL
TM3 130 D 3.49x49 CCR5 4MBS CCR5 4MBS
TM3 131 R 3.50x50 CCR5 4MBS CCR5 4MBS
TM3 132 Y 3.51x51 CCR5 4MBS CCR5 4MBS
TM3 133 L 3.52x52 CCR5 4MBS CCR5 4MBS
TM3 134 A 3.53x53 CCR5 4MBS CCR5 4MBS
TM3 135 V 3.54x54 CCR5 4MBS CCR5 4MBS
TM3 136 V 3.55x55 CCR5 4MBS CCR5 4MBS
TM3 137 H 3.56x56 CCR5 4MBS CCR5 4MBS
ICL2 138 A 34.50x50 CCR5 4MBS CCR5 4MBS
ICL2 139 V 34.51x51 CCR5 4MBS CCR5 4MBS
ICL2 140 Y 34.52x52 CCR5 4MBS - -
ICL2 141 A 34.53x53 CCR5 4MBS CCR5 4MBS
ICL2 142 L 34.54x54 CCR5 4MBS CCR5 4MBS
ICL2 143 K 34.55x55 CCR5 4MBS CCR5 7F1T
ICL2 144 V 34.56x56 CCR5 4MBS BLT1 receptor 5X33
ICL2 145 R 34.57x57 CCR5 4MBS CCR5 4MBS
TM4 146 T 4.38x38 CCR5 4MBS CCR5 4MBS
TM4 147 I 4.39x39 CCR5 4MBS CysLT2 receptor 6RZ6
TM4 148 R 4.40x40 CCR5 4MBS μ receptor 4DKL
TM4 149 M 4.41x41 CCR5 4MBS BLT1 receptor 7K15
TM4 150 G 4.42x42 CCR5 4MBS CCR5 4MBS
TM4 151 T 4.43x43 CCR5 4MBS D2 receptor 6LUQ
TM4 152 T 4.44x44 CCR5 4MBS 5-HT1D receptor 7E32
TM4 153 L 4.45x45 CCR5 4MBS BLT1 receptor 5X33
TM4 154 C 4.46x46 CCR5 4MBS CCR7 6QZH
TM4 155 L 4.47x47 CCR5 4MBS CXCR2 6LFL
TM4 156 A 4.48x48 CCR5 4MBS NOP receptor 5DHH
TM4 157 V 4.49x49 CCR5 4MBS CXCR4 3ODU
TM4 158 W 4.50x50 CCR5 4MBS CCR5 4MBS
TM4 159 L 4.51x51 CCR5 4MBS CCR2 5T1A
TM4 160 T 4.52x52 CCR5 4MBS - -
TM4 161 A 4.53x53 CCR5 4MBS CCR5 4MBS
TM4 162 I 4.54x54 CCR5 4MBS 5-HT2C receptor 6BQH
TM4 163 M 4.55x55 CCR5 4MBS - -
TM4 164 A 4.56x56 CCR5 4MBS CCR5 4MBS
TM4 165 T 4.57x57 CCR5 4MBS CXCR4 3ODU
TM4 166 I 4.58x59 CCR5 4MBS CCR7 6QZH
TM4 167 P 4.59x60 CCR5 4MBS CCR5 4MBS
TM4 168 L 4.60x61 CCR5 4MBS Y2 receptor 7DDZ
TM4 169 L 4.61x62 CCR5 4MBS CCR7 6QZH
TM4 170 V 4.62x63 CCR5 4MBS apelin receptor 5VBL
TM4 171 F 4.63x64 CCR5 4MBS CCR5 4MBS
TM4 172 Y 4.64x65 CCR5 4MBS - -
ECL2 173 Q - CCR5 4MBS - -
ECL2 174 V - CCR5 4MBS - -
ECL2 175 A - CCR5 4MBS - -
ECL2 176 S - CCR5 4MBS - -
ECL2 177 E - CCR5 4MBS CCR5 4MBS
ECL2 178 D - CCR5 4MBS - -
ECL2 179 G - CCR5 4MBS - -
ECL2 180 V - CCR5 4MBS - -
ECL2 181 L - CCR5 4MBS - -
ECL2 182 Q - CCR5 4MBS - -
ECL2 183 C 45.50x50 CCR5 4MBS CCR5 4MBS
ECL2 184 Y 45.51x51 CCR5 4MBS CXCR2 6LFL
ECL2 185 S 45.52x52 CCR5 4MBS CCR5 4MBS
ECL2 186 F - - - - -
ECL2 187 Y - - - - -
ECL2 188 N - - - - -
ECL2 189 Q - - - - -
TM5 190 Q 5.30x31 CCR5 4MBS CCR5 4MBS
TM5 191 T 5.31x32 CCR5 4MBS μ receptor 4DKL
TM5 192 L 5.32x33 CCR5 4MBS P2Y1 receptor 4XNW
TM5 193 K 5.33x34 CCR5 4MBS succinate receptor 6RNK
TM5 194 W 5.34x35 CCR5 4MBS CCR5 4MBS
TM5 195 K 5.35x36 CCR5 4MBS CCR5 5UIW
TM5 196 I 5.36x37 CCR5 4MBS CCR7 6QZH
TM5 197 F 5.37x38 CCR5 4MBS CCR5 4MBS
TM5 198 T 5.38x39 CCR5 4MBS δ receptor 4EJ4
TM5 199 N 5.39x40 CCR5 4MBS GnRH1 receptor 7BR3
TM5 200 F 5.40x41 CCR5 4MBS CXCR4 3ODU
TM5 201 K 5.41x42 CCR5 4MBS CCR5 4MBS
TM5 202 M 5.42x43 CCR5 4MBS Rhodopsin 1U19
TM5 203 N 5.43x44 CCR5 4MBS CCR2 5T1A
TM5 204 I 5.44x45 CCR5 4MBS CCR5 4MBS
TM5 205 L 5.45x46 CCR5 4MBS CCR5 4MBS
TM5 206 G 5.46x461 CCR5 4MBS CCR5 4MBS
TM5 207 L 5.47x47 CCR5 4MBS CCR5 4MBS
TM5 208 L 5.48x48 CCR5 4MBS CCR7 6QZH
TM5 209 I 5.49x49 CCR5 4MBS κ receptor 4DJH
TM5 210 P 5.50x50 CCR5 4MBS CCR5 4MBS
TM5 211 F 5.51x51 CCR5 4MBS AT1 receptor 4ZUD
TM5 212 T 5.52x52 CCR5 4MBS apelin receptor 5VBL
TM5 213 I 5.53x53 CCR5 4MBS CCR2 5T1A
TM5 214 F 5.54x54 CCR5 4MBS - -
TM5 215 M 5.55x55 CCR5 4MBS CCK1 receptor 7EZM
TM5 216 F 5.56x56 CCR5 4MBS CCR7 6QZH
TM5 217 C 5.57x57 CCR5 4MBS CCR5 4MBS
TM5 218 Y 5.58x58 CCR5 4MBS CCR5 4MBS
TM5 219 I 5.59x59 CCR5 4MBS M4 receptor 6KP6
TM5 220 K 5.60x60 CCR5 4MBS Y1 receptor 5ZBH
TM5 221 I 5.61x61 CCR5 4MBS CCR5 4MBS
TM5 222 L 5.62x62 CCR5 4MBS CCR5 4MBS
TM5 223 H 5.63x63 CCR5 4MBS 5-HT1E receptor 7E33
TM5 224 Q 5.64x64 CCR5 4MBS Rhodopsin 6I9K
TM5 225 L 5.65x65 CCR5 4MBS CCR5 4MBS
TM5 226 K 5.66x66 CCR5 4MBS κ receptor 4DJH
TM5 227 R 5.67x67 CCR5 4MBS CCR5 4MBS
TM5 228 C 5.68x68 CCR5 7O7F CCR5 7O7F
ICL3 229 Q - - - - -
ICL3 230 N - - - - -
TM6 231 H 6.28x28 CCR5 4MBS - -
TM6 232 N 6.29x29 CCR5 4MBS κ receptor 4DJH
TM6 233 K 6.30x30 CCR5 4MBS CXCR2 6LFL
TM6 234 T 6.31x31 CCR5 4MBS C5a1 receptor 6C1Q
TM6 235 K 6.32x32 CCR5 4MBS CCR2 5T1A
TM6 236 A 6.33x33 CCR5 4MBS CCR5 6MEO
TM6 237 I 6.34x34 CCR5 4MBS CCR6 6WWZ
TM6 238 R 6.35x35 CCR5 4MBS CCR5 4MBS
TM6 239 L 6.36x36 CCR5 4MBS CCR5 4MBS
TM6 240 V 6.37x37 CCR5 4MBS κ receptor 4DJH
TM6 241 L 6.38x38 CCR5 4MBS κ receptor 4DJH
TM6 242 I 6.39x39 CCR5 4MBS CXCR4 3ODU
TM6 243 V 6.40x40 CCR5 4MBS CCR7 6QZH
TM6 244 V 6.41x41 CCR5 4MBS CCR7 6QZH
TM6 245 I 6.42x42 CCR5 4MBS CCR5 4MBS
TM6 246 A 6.43x43 CCR5 4MBS CXCR4 3ODU
TM6 247 S 6.44x44 CCR5 4MBS - -
TM6 248 L 6.45x45 CCR5 4MBS CXCR2 6LFL
TM6 249 L 6.46x46 CCR5 4MBS CCR5 4MBS
TM6 250 F 6.47x47 CCR5 4MBS CCR5 4MBS
TM6 251 W 6.48x48 CCR5 4MBS CCR5 4MBS
TM6 252 V 6.49x49 CCR5 4MBS PAF receptor 5ZKQ
TM6 253 P 6.50x50 CCR5 4MBS CCR5 4MBS
TM6 254 F 6.51x51 CCR5 4MBS 5-HT2A receptor 6A94
TM6 255 N 6.52x52 CCR5 4MBS CCR5 4MBS
TM6 256 V 6.53x53 CCR5 4MBS NOP receptor 5DHH
TM6 257 V 6.54x54 CCR5 4MBS CCR5 4MBS
TM6 258 L 6.55x55 CCR5 4MBS CCR5 4MBS
TM6 259 F 6.56x56 CCR5 4MBS AT1 receptor 4ZUD
TM6 260 L 6.57x57 CCR5 4MBS CCR5 4MBS
TM6 261 T 6.58x58 CCR5 4MBS α2A-adrenoceptor 6KUX
TM6 262 S 6.59x59 CCR5 4MBS CXCR4 3ODU
TM6 263 L 6.60x60 CCR5 4MBS CXCR2 6LFL
TM6 264 H 6.61x61 CCR5 4MBS Rhodopsin 1U19
TM6 265 S 6.62x62 CCR5 4MBS apelin receptor 5VBL
TM6 266 M 6.63x63 CCR5 4MBS AT2 receptor 5UNG
TM6 267 H 6.64x64 CCR5 4MBS - -
TM6 268 I 6.65x65 CCR5 4MBS - -
ECL3 269 L - CCR5 4MBS - -
ECL3 270 D - CCR5 4MBS - -
TM7 271 G 7.24x23 CCR5 4MBS CXCR4 3ODU
TM7 272 C 7.25x24 CCR5 4MBS CCR5 4MBS
TM7 273 S 7.26x25 CCR5 4MBS CCR5 4MBS
TM7 274 I 7.27x26 CCR5 4MBS AT1 receptor 4ZUD
TM7 275 S 7.28x27 CCR5 4MBS CCR5 5UIW
TM7 276 Q 7.29x28 CCR5 4MBS PAF receptor 5ZKQ
TM7 277 Q 7.30x29 CCR5 4MBS CCR2 5T1A
TM7 278 L 7.31x30 CCR5 4MBS CCR5 4MBS
TM7 279 T 7.32x31 CCR5 4MBS μ receptor 4DKL
TM7 280 Y 7.33x32 CCR5 4MBS ghrelin receptor 6KO5
TM7 281 A 7.34x33 CCR5 4MBS CCR5 4MBS
TM7 282 T 7.35x34 CCR5 4MBS CCR2 5T1A
TM7 283 H 7.36x35 CCR5 4MBS μ receptor 4DKL
TM7 284 V 7.37x36 CCR5 4MBS CCR5 4MBS
TM7 285 T 7.38x37 CCR5 4MBS CCR5 4MBS
TM7 286 E 7.39x38 CCR5 4MBS CCR5 4MBS
TM7 287 I 7.40x39 CCR5 4MBS CXCR2 6LFL
TM7 288 I 7.41x40 CCR5 4MBS CCR9 5LWE
TM7 289 S 7.42x41 CCR5 4MBS apelin receptor 5VBL
TM7 290 F 7.43x42 CCR5 4MBS CXCR4 3ODU
TM7 291 T 7.44x43 CCR5 4MBS CCR5 4MBS
TM7 292 H 7.45x45 CCR5 4MBS CCR5 4MBS
TM7 293 C 7.46x46 CCR5 4MBS CCR5 4MBS
TM7 294 C 7.47x47 CCR5 4MBS CCR5 4MBS
TM7 295 V 7.48x48 CCR5 4MBS CCR7 6QZH
TM7 296 N 7.49x49 CCR5 4MBS CCR5 4MBS
TM7 297 P 7.50x50 CCR5 4MBS CCR5 4MBS
TM7 298 V 7.51x51 CCR5 4MBS CCR9 5LWE
TM7 299 I 7.52x52 CCR5 4MBS CCR5 4MBS
TM7 300 Y 7.53x53 CCR5 4MBS CCR5 4MBS
TM7 301 A 7.54x54 CCR5 4MBS CCR5 4MBS
TM7 302 F 7.55x55 CCR5 4MBS CCR5 4MBS
TM7 303 V 7.56x56 CCR5 4MBS CCR5 4MBS
H8 304 G 8.47x47 CCR5 4MBS CCR5 4MBS
H8 305 E 8.48x48 CCR5 4MBS CCR5 4MBS
H8 306 K 8.49x49 CCR5 4MBS CCR2 5T1A
H8 307 F 8.50x50 CCR5 4MBS CCR5 4MBS
H8 308 K 8.51x51 CCR5 4MBS κ receptor 4DJH
H8 309 K 8.52x52 CCR5 4MBS Y2 receptor 7DDZ
H8 310 H 8.53x53 CCR5 4MBS PAR2 5NDD
H8 311 L 8.54x54 CCR5 4MBS CCR5 5UIW
H8 312 S 8.55x55 CCR5 4MBS CCR2 5T1A
H8 313 E 8.56x56 CCR5 4MBS β2-adrenoceptor 4GBR
H8 314 I 8.57x57 CCR5 4MBS CXCR2 6LFL
H8 315 F 8.58x58 CCR5 4MBS CCR5 4MBS
H8 316 Q 8.59x59 CCR5 4MBS CCR5 7F1T
C-term 317 K - - - - -
C-term 318 S - - - - -
C-term 319 C - - - - -
C-term 320 S - - - - -
C-term 321 Q - - - - -