CCRL2 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active

VERSION

2020-09-02

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

NGL is a WebGL based 3D viewer powered by MMTF.

MAIN TEMPLATE

US28 (sequence similarity: 46%) PDB: 5WB1

TEMPLATES

5WB1 (US28)
5UIW (CCR5)
4ZUD (AT1 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 83.8 6.1 10.1
Side-chains 21.2 56.9 21.9

Number of backbone templates: 3
Number of rotamer templates: 41

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 25 A - - - -
N-term 26 E - - - -
N-term 27 Q US28 5WB1 US28 5WB1
N-term 28 C US28 5WB1 US28 5WB1
N-term 29 D US28 5WB1 US28 5WB1
TM1 30 K 1.24x24 US28 5WB1 - -
TM1 31 Y 1.25x25 US28 5WB1 - -
TM1 32 D 1.26x26 US28 5WB1 US28 5WB1
TM1 33 A 1.27x27 US28 5WB1 - -
TM1 34 Q 1.28x28 US28 5WB1 - -
TM1 35 A 1.29x29 US28 5WB1 ghrelin receptor 6KO5
TM1 36 L 1.30x30 US28 5WB1 PAR2 5NDD
TM1 37 S 1.31x31 US28 5WB1 US28 5WB1
TM1 38 A 1.32x32 US28 5WB1 μ receptor 5C1M
TM1 39 Q 1.33x33 US28 5WB1 CCR2 5T1A
TM1 40 L 1.34x34 US28 5WB1 FPR2/ALX 6LW5
TM1 41 V 1.35x35 US28 5WB1 CCR6 6WWZ
TM1 42 P 1.36x36 US28 5WB1 AT1 receptor 6OS2
TM1 43 S 1.37x37 US28 5WB1 PAR1 3VW7
TM1 44 L 1.38x38 US28 5WB1 US28 5WB1
TM1 45 C 1.39x39 US28 5WB1 CB2 receptor 6PT0
TM1 46 S 1.40x40 US28 5WB1 AT1 receptor 6OS2
TM1 47 A 1.41x41 US28 5WB1 δ receptor 6PT2
TM1 48 V 1.42x42 US28 5WB1 US28 5WB1
TM1 49 F 1.43x43 US28 5WB1 US28 5WB1
TM1 50 V 1.44x44 US28 5WB1 AT1 receptor 6OS2
TM1 51 I 1.45x45 US28 5WB1 AT2 receptor 6JOD
TM1 52 G 1.46x46 US28 5WB1 US28 5WB1
TM1 53 V 1.47x47 US28 5WB1 FPR2/ALX 6LW5
TM1 54 L 1.48x48 US28 5WB1 CCR6 6WWZ
TM1 55 D 1.49x49 US28 5WB1 - -
TM1 56 N 1.50x50 US28 5WB1 US28 5WB1
TM1 57 L 1.51x51 US28 5WB1 M1 receptor 6OIJ
TM1 58 L 1.52x52 US28 5WB1 US28 5WB1
TM1 59 V 1.53x53 US28 5WB1 US28 5WB1
TM1 60 V 1.54x54 US28 5WB1 AT1 receptor 6OS2
TM1 61 L 1.55x55 US28 5WB1 α2B-adrenoceptor 6K41
TM1 62 I 1.56x56 US28 5WB1 CCR5 5UIW
TM1 63 L 1.57x57 US28 5WB1 NTS1 receptor 6OSA
TM1 64 V 1.58x58 US28 5WB1 μ receptor 5C1M
TM1 65 K 1.59x59 US28 5WB1 - -
TM1 66 Y 1.60x60 CCR5 5UIW CCR5 5UIW
ICL1 67 K 12.48x48 - - - -
ICL1 68 G 12.49x49 AT1 receptor 4ZUD - -
ICL1 69 L 12.50x50 AT1 receptor 4ZUD AT1 receptor 4ZUD
ICL1 70 K 12.51x51 - - - -
TM2 71 R 2.37x37 US28 5WB1 CB1 receptor 6KPG
TM2 72 V 2.38x38 US28 5WB1 AT1 receptor 6OS2
TM2 73 E 2.39x39 US28 5WB1 - -
TM2 74 N 2.40x40 US28 5WB1 μ receptor 5C1M
TM2 75 I 2.41x41 US28 5WB1 μ receptor 5C1M
TM2 76 Y 2.42x42 US28 5WB1 US28 5WB1
TM2 77 L 2.43x43 US28 5WB1 AT1 receptor 6OS2
TM2 78 L 2.44x44 US28 5WB1 AT1 receptor 6OS2
TM2 79 N 2.45x45 US28 5WB1 US28 5WB1
TM2 80 L 2.46x46 US28 5WB1 US28 5WB1
TM2 81 A 2.47x47 US28 5WB1 US28 5WB1
TM2 82 V 2.48x48 US28 5WB1 AT2 receptor 6JOD
TM2 83 S 2.49x49 US28 5WB1 NTS1 receptor 6OSA
TM2 84 N 2.50x50 US28 5WB1 A2A receptor 5WF5
TM2 85 L 2.51x51 US28 5WB1 US28 5WB1
TM2 86 C 2.52x52 US28 5WB1 AT1 receptor 6OS2
TM2 87 F 2.53x53 US28 5WB1 US28 5WB1
TM2 88 L 2.54x54 US28 5WB1 AT1 receptor 6OS2
TM2 89 L 2.55x55 US28 5WB1 AT1 receptor 6OS2
TM2 90 T 2.56x56 US28 5WB1 US28 5WB1
TM2 91 L 2.57x57 US28 5WB1 US28 5WB1
TM2 92 P 2.58x58 US28 5WB1 US28 5WB1
TM2 93 F 2.59x59 US28 5WB1 CCR6 6WWZ
TM2 94 W 2.60x60 US28 5WB1 US28 5WB1
TM2 95 A 2.61x61 US28 5WB1 AT1 receptor 6OS2
TM2 96 H 2.62x62 US28 5WB1 CCR5 5UIW
TM2 97 A 2.63x63 US28 5WB1 5-HT2C receptor 6BQG
ECL1 98 G US28 5WB1 - -
ECL1 99 G US28 5WB1 - -
ECL1 100 D US28 5WB1 - -
ECL1 101 P US28 5WB1 - -
TM3 102 M 3.24x24 US28 5WB1 AT2 receptor 6JOD
TM3 103 C 3.25x25 US28 5WB1 US28 5WB1
TM3 104 K 3.26x26 US28 5WB1 AT1 receptor 6OS2
TM3 105 I 3.27x27 US28 5WB1 AT1 receptor 6OS2
TM3 106 L 3.28x28 US28 5WB1 US28 5WB1
TM3 107 I 3.29x29 US28 5WB1 μ receptor 5C1M
TM3 108 G 3.30x30 US28 5WB1 CCR6 6WWZ
TM3 109 L 3.31x31 US28 5WB1 M2 receptor 4MQT
TM3 110 Y 3.32x32 US28 5WB1 CCR6 6WWZ
TM3 111 F 3.33x33 US28 5WB1 CCR5 5UIW
TM3 112 V 3.34x34 US28 5WB1 US28 5WB1
TM3 113 G 3.35x35 US28 5WB1 Rhodopsin 4ZWJ
TM3 114 L 3.36x36 US28 5WB1 AT1 receptor 6OS2
TM3 115 Y 3.37x37 US28 5WB1 AT1 receptor 6OS2
TM3 116 S 3.38x38 US28 5WB1 α2B-adrenoceptor 6K41
TM3 117 E 3.39x39 US28 5WB1 - -
TM3 118 T 3.40x40 US28 5WB1 NOP receptor 5DHG
TM3 119 F 3.41x41 US28 5WB1 AT1 receptor 6OS2
TM3 120 F 3.42x42 US28 5WB1 US28 5WB1
TM3 121 N 3.43x43 US28 5WB1 - -
TM3 122 C 3.44x44 US28 5WB1 μ receptor 5C1M
TM3 123 L 3.45x45 US28 5WB1 M1 receptor 6OIJ
TM3 124 L 3.46x46 US28 5WB1 AT1 receptor 6OS2
TM3 125 T 3.47x47 US28 5WB1 CCR5 5UIW
TM3 126 V 3.48x48 US28 5WB1 μ receptor 5C1M
TM3 127 Q 3.49x49 US28 5WB1 PAR2 5NDD
TM3 128 R 3.50x50 US28 5WB1 US28 5WB1
TM3 129 Y 3.51x51 US28 5WB1 US28 5WB1
TM3 130 L 3.52x52 US28 5WB1 AT1 receptor 6OS2
TM3 131 V 3.53x53 US28 5WB1 Rhodopsin 4ZWJ
TM3 132 F 3.54x54 US28 5WB1 - -
TM3 133 L 3.55x55 US28 5WB1 FPR2/ALX 6LW5
TM3 134 H 3.56x56 CCR5 5UIW CCR5 5UIW
ICL2 135 K 34.50x50 - - - -
ICL2 136 G 34.51x51 - - - -
ICL2 137 N 34.52x52 - - - -
ICL2 138 F 34.53x53 - - - -
ICL2 139 F 34.54x54 - - - -
ICL2 140 S 34.55x55 - - - -
ICL2 141 A 34.56x56 - - - -
ICL2 142 R 34.57x57 - - - -
ICL2 143 R 34.58x58 - - - -
TM4 144 R 4.38x38 US28 5WB1 OT receptor 6TPK
TM4 145 V 4.39x39 US28 5WB1 US28 5WB1
TM4 146 P 4.40x40 US28 5WB1 CCR6 6WWZ
TM4 147 C 4.41x41 US28 5WB1 - -
TM4 148 G 4.42x42 US28 5WB1 CCR5 5UIW
TM4 149 I 4.43x43 US28 5WB1 Rhodopsin 4ZWJ
TM4 150 I 4.44x44 US28 5WB1 CCR6 6WWZ
TM4 151 T 4.45x45 US28 5WB1 AT1 receptor 6OS2
TM4 152 S 4.46x46 US28 5WB1 US28 5WB1
TM4 153 V 4.47x47 US28 5WB1 μ receptor 5C1M
TM4 154 L 4.48x48 US28 5WB1 AT2 receptor 6JOD
TM4 155 A 4.49x49 US28 5WB1 M2 receptor 4MQT
TM4 156 W 4.50x50 US28 5WB1 US28 5WB1
TM4 157 V 4.51x51 US28 5WB1 δ receptor 6PT2
TM4 158 T 4.52x52 US28 5WB1 - -
TM4 159 A 4.53x53 US28 5WB1 US28 5WB1
TM4 160 I 4.54x54 US28 5WB1 5-HT2C receptor 6BQG
TM4 161 L 4.55x55 US28 5WB1 AT1 receptor 6OS2
TM4 162 A 4.56x56 US28 5WB1 AT1 receptor 6OS2
TM4 163 T 4.57x57 US28 5WB1 FPR2/ALX 6LW5
TM4 164 L 4.58x59 US28 5WB1 AT1 receptor 6OS2
TM4 165 P 4.59x60 US28 5WB1 US28 5WB1
TM4 166 E 4.60x61 US28 5WB1 CCR7 6QZH
TM4 167 F 4.61x62 US28 5WB1 US28 5WB1
TM4 168 V 4.62x63 US28 5WB1 5-HT2C receptor 6BQG
TM4 169 V 4.63x64 CCR5 5UIW OX2 receptor 5WS3
TM4 170 Y 4.64x65 CCR5 5UIW - -
ECL2 171 K - - - -
ECL2 172 P CCR5 5UIW - -
ECL2 173 Q CCR5 5UIW CCR5 5UIW
ECL2 174 M CCR5 5UIW - -
ECL2 175 E CCR5 5UIW CCR5 5UIW
ECL2 176 D CCR5 5UIW - -
ECL2 177 Q CCR5 5UIW - -
ECL2 178 K CCR5 5UIW - -
ECL2 179 Y CCR5 5UIW CCR5 5UIW
ECL2 180 K - - - -
ECL2 181 C 45.50x50 US28 5WB1 US28 5WB1
ECL2 182 A 45.51x51 US28 5WB1 AT1 receptor 6OS2
ECL2 183 F 45.52x52 US28 5WB1 A2A receptor 4UHR
ECL2 184 S - - - -
ECL2 185 R - - - -
ECL2 186 T - - - -
ECL2 187 P - - - -
ECL2 188 F - - - -
ECL2 189 L - - - -
ECL2 190 P - - - -
ECL2 191 A - - - -
TM5 192 D 5.30x31 CCR5 5UIW κ receptor 4DJH
TM5 193 E 5.31x32 CCR5 5UIW apelin receptor 5VBL
TM5 194 T 5.32x33 CCR5 5UIW NTS1 receptor 6OSA
TM5 195 F 5.33x34 US28 5WB1 CCR5 5UIW
TM5 196 W 5.34x35 US28 5WB1 CCR6 6WWZ
TM5 197 K 5.35x36 US28 5WB1 CCR6 6WWZ
TM5 198 H 5.36x37 US28 5WB1 - -
TM5 199 F 5.37x38 US28 5WB1 κ receptor 6B73
TM5 200 L 5.38x39 US28 5WB1 US28 5WB1
TM5 201 T 5.39x40 US28 5WB1 M2 receptor 4MQT
TM5 202 L 5.40x41 US28 5WB1 AT1 receptor 6OS2
TM5 203 K 5.41x42 US28 5WB1 CCR5 5UIW
TM5 204 M 5.42x43 US28 5WB1 Rhodopsin 4ZWJ
TM5 205 N 5.43x44 US28 5WB1 AT1 receptor 6OS2
TM5 206 I 5.44x45 US28 5WB1 μ receptor 5C1M
TM5 207 S 5.45x46 US28 5WB1 PAF receptor 5ZKQ
TM5 208 V 5.46x461 US28 5WB1 PAR2 5NDD
TM5 209 L 5.47x47 US28 5WB1 GPR52 6LI3
TM5 210 V 5.48x48 US28 5WB1 US28 5WB1
TM5 211 L 5.49x49 US28 5WB1 FPR2/ALX 6LW5
TM5 212 P 5.50x50 US28 5WB1 US28 5WB1
TM5 213 L 5.51x51 US28 5WB1 US28 5WB1
TM5 214 F 5.52x52 US28 5WB1 PAR2 5NDD
TM5 215 I 5.53x53 US28 5WB1 AT1 receptor 6OS2
TM5 216 F 5.54x54 US28 5WB1 - -
TM5 217 T 5.55x55 US28 5WB1 μ receptor 5C1M
TM5 218 F 5.56x56 US28 5WB1 CCR6 6WWZ
TM5 219 L 5.57x57 US28 5WB1 M2 receptor 4MQT
TM5 220 Y 5.58x58 US28 5WB1 US28 5WB1
TM5 221 V 5.59x59 US28 5WB1 PAR1 3VW7
TM5 222 Q 5.60x60 US28 5WB1 Rhodopsin 4ZWJ
TM5 223 M 5.61x61 US28 5WB1 μ receptor 5C1M
TM5 224 R 5.62x62 US28 5WB1 AT2 receptor 6JOD
TM5 225 K 5.63x63 US28 5WB1 AT1 receptor 6OS2
TM5 226 T 5.64x64 US28 5WB1 CCR6 6WWZ
TM5 227 L 5.65x65 US28 5WB1 AT1 receptor 6OS2
TM5 228 R 5.66x66 US28 5WB1 δ receptor 6PT2
TM5 229 F 5.67x67 US28 5WB1 - -
ICL3 230 R US28 5WB1 - -
ICL3 231 E US28 5WB1 - -
ICL3 232 Q US28 5WB1 - -
TM6 233 R 6.30x30 US28 5WB1 CCR6 6WWZ
TM6 234 Y 6.31x31 US28 5WB1 - -
TM6 235 S 6.32x32 US28 5WB1 PAR1 3VW7
TM6 236 L 6.33x33 US28 5WB1 CB2 receptor 6PT0
TM6 237 F 6.34x34 US28 5WB1 AT1 receptor 6OS2
TM6 238 K 6.35x35 US28 5WB1 AT1 receptor 6OS2
TM6 239 L 6.36x36 US28 5WB1 κ receptor 6B73
TM6 240 V 6.37x37 US28 5WB1 μ receptor 5C1M
TM6 241 F 6.38x38 US28 5WB1 GPR52 6LI3
TM6 242 A 6.39x39 US28 5WB1 US28 5WB1
TM6 243 I 6.40x40 US28 5WB1 AT1 receptor 6OS2
TM6 244 M 6.41x41 US28 5WB1 β2-adrenoceptor 3SN6
TM6 245 V 6.42x42 US28 5WB1 δ receptor 6PT2
TM6 246 V 6.43x43 US28 5WB1 US28 5WB1
TM6 247 F 6.44x44 US28 5WB1 US28 5WB1
TM6 248 L 6.45x45 US28 5WB1 CCR6 6WWZ
TM6 249 L 6.46x46 US28 5WB1 α2B-adrenoceptor 6K41
TM6 250 M 6.47x47 US28 5WB1 5-HT2C receptor 6BQG
TM6 251 W 6.48x48 US28 5WB1 US28 5WB1
TM6 252 A 6.49x49 US28 5WB1 δ receptor 6PT2
TM6 253 P 6.50x50 US28 5WB1 US28 5WB1
TM6 254 Y 6.51x51 US28 5WB1 US28 5WB1
TM6 255 N 6.52x52 US28 5WB1 CCR6 6WWZ
TM6 256 I 6.53x53 US28 5WB1 AT1 receptor 6OS2
TM6 257 A 6.54x54 US28 5WB1 ETB receptor 5X93
TM6 258 F 6.55x55 US28 5WB1 GPR52 6LI3
TM6 259 F 6.56x56 US28 5WB1 US28 5WB1
TM6 260 L 6.57x57 US28 5WB1 AT1 receptor 6OS2
TM6 261 S 6.58x58 US28 5WB1 5-HT2C receptor 6BQG
TM6 262 T 6.59x59 US28 5WB1 US28 5WB1
TM6 263 F 6.60x60 US28 5WB1 M2 receptor 4MQT
TM6 264 K 6.61x61 US28 5WB1 US28 4XT1
TM6 265 E 6.62x62 US28 5WB1 CCR5 6AKX
TM6 266 H 6.63x63 US28 5WB1 CysLT1 receptor 6RZ4
TM6 267 F 6.64x64 US28 5WB1 CCR5 4MBS
ECL3 268 S - - - -
ECL3 269 L AT1 receptor 4ZUD - -
ECL3 270 S - - - -
TM7 271 D 7.24x23 US28 5WB1 AT1 receptor 6OS2
TM7 272 C 7.25x24 US28 5WB1 US28 5WB1
TM7 273 K 7.26x25 US28 5WB1 - -
TM7 274 S 7.27x26 US28 5WB1 CCR6 6WWZ
TM7 275 S 7.28x27 US28 5WB1 CCR5 5UIW
TM7 276 Y 7.29x28 US28 5WB1 - -
TM7 277 N 7.30x29 US28 5WB1 Y1 receptor 5ZBH
TM7 278 L 7.31x30 US28 5WB1 US28 5WB1
TM7 279 D 7.32x31 US28 5WB1 AT1 receptor 6OS2
TM7 280 K 7.33x32 US28 5WB1 CB2 receptor 6PT0
TM7 281 S 7.34x33 US28 5WB1 μ receptor 5C1M
TM7 282 V 7.35x34 US28 5WB1 FPR2/ALX 6LW5
TM7 283 H 7.36x35 US28 5WB1 μ receptor 5C1M
TM7 284 I 7.37x36 US28 5WB1 AT1 receptor 6OS2
TM7 285 T 7.38x37 US28 5WB1 US28 5WB1
TM7 286 K 7.39x38 US28 5WB1 - -
TM7 287 L 7.40x39 US28 5WB1 AT2 receptor 6JOD
TM7 288 I 7.41x40 US28 5WB1 AT1 receptor 6OS2
TM7 289 A 7.42x41 US28 5WB1 US28 5WB1
TM7 290 T 7.43x42 US28 5WB1 PAR2 5NDD
TM7 291 T 7.44x43 US28 5WB1 μ receptor 5C1M
TM7 292 H 7.45x45 US28 5WB1 US28 5WB1
TM7 293 C 7.46x46 US28 5WB1 US28 5WB1
TM7 294 C 7.47x47 US28 5WB1 US28 5WB1
TM7 295 I 7.48x48 US28 5WB1 M2 receptor 4MQT
TM7 296 N 7.49x49 US28 5WB1 US28 5WB1
TM7 297 P 7.50x50 US28 5WB1 US28 5WB1
TM7 298 L 7.51x51 US28 5WB1 US28 5WB1
TM7 299 L 7.52x52 US28 5WB1 US28 5WB1
TM7 300 Y 7.53x53 US28 5WB1 US28 5WB1
TM7 301 A 7.54x54 US28 5WB1 CCR6 6WWZ
TM7 302 F 7.55x55 US28 5WB1 US28 5WB1
TM7 303 L 7.56x56 US28 5WB1 AT1 receptor 6OS2
H8 304 D 8.47x47 US28 5WB1 δ receptor 6PT2
H8 305 G 8.48x48 US28 5WB1 CB2 receptor 6PT0
H8 306 T 8.49x49 US28 5WB1 M2 receptor 4MQT
H8 307 F 8.50x50 US28 5WB1 US28 5WB1
H8 308 S 8.51x51 US28 5WB1 LPA1 receptor 4Z35
H8 309 K 8.52x52 US28 5WB1 D2 receptor 6VMS
H8 310 Y 8.53x53 US28 5WB1 AT1 receptor 6OS2
H8 311 L 8.54x54 US28 5WB1 US28 5WB1
H8 312 C 8.55x55 US28 5WB1 - -
H8 313 R 8.56x56 US28 5WB1 α2B-adrenoceptor 6K41
H8 314 C 8.57x57 US28 5WB1 CB2 receptor 6PT0
H8 315 F 8.58x58 US28 5WB1 AT2 receptor 6JOD
H8 316 H 8.59x59 US28 5WB1 D2 receptor 6VMS
C-term 317 L - - - -
C-term 318 R - - - -
C-term 319 S - - - -
C-term 320 N - - - -
C-term 321 T - - - -