CX3CR1 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

CX3CR1

SPECIES

Homo sapiens

STATE

Active

VERSION

2020-09-02

MODEL

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PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

US28 (sequence similarity: 57%) PDB: 5WB1
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TEMPLATES

5WB1 (US28)
5UIW (CCR5)
6WWZ (CCR6)
5UNF (AT2 receptor)
6RZ4 (CysLT1 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 82.6 7.2 10.2
Side-chains 35.2 46.8 18.1

Number of backbone templates: 5
Number of rotamer templates: 41

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 21 C - - - -
N-term 22 Y - - - -
N-term 23 I US28 5WB1 US28 5WB1
N-term 24 G US28 5WB1 US28 5WB1
N-term 25 D US28 5WB1 US28 5WB1
TM1 26 I 1.27x27 US28 5WB1 CysLT1 receptor 6RZ4
TM1 27 V 1.28x28 US28 5WB1 - -
TM1 28 V 1.29x29 US28 5WB1 - -
TM1 29 F 1.30x30 US28 5WB1 CCR6 6WWZ
TM1 30 G 1.31x31 US28 5WB1 A2A receptor 5WF5
TM1 31 T 1.32x32 US28 5WB1 α2B-adrenoceptor 6K41
TM1 32 V 1.33x33 US28 5WB1 AT1 receptor 6OS2
TM1 33 F 1.34x34 US28 5WB1 CCR6 6WWZ
TM1 34 L 1.35x35 US28 5WB1 Rhodopsin 4ZWJ
TM1 35 S 1.36x36 US28 5WB1 CysLT1 receptor 6RZ4
TM1 36 I 1.37x37 US28 5WB1 CCR6 6WWZ
TM1 37 F 1.38x38 US28 5WB1 EP3 receptor 6M9T
TM1 38 Y 1.39x39 US28 5WB1 US28 5WB1
TM1 39 S 1.40x40 US28 5WB1 CCR6 6WWZ
TM1 40 V 1.41x41 US28 5WB1 US28 5WB1
TM1 41 I 1.42x42 US28 5WB1 CCR6 6WWZ
TM1 42 F 1.43x43 US28 5WB1 US28 5WB1
TM1 43 A 1.44x44 US28 5WB1 δ receptor 6PT2
TM1 44 I 1.45x45 US28 5WB1 AT2 receptor 6JOD
TM1 45 G 1.46x46 US28 5WB1 US28 5WB1
TM1 46 L 1.47x47 US28 5WB1 CCR6 6WWZ
TM1 47 V 1.48x48 US28 5WB1 κ receptor 6B73
TM1 48 G 1.49x49 US28 5WB1 US28 5WB1
TM1 49 N 1.50x50 US28 5WB1 US28 5WB1
TM1 50 L 1.51x51 US28 5WB1 M1 receptor 6OIJ
TM1 51 L 1.52x52 US28 5WB1 US28 5WB1
TM1 52 V 1.53x53 US28 5WB1 US28 5WB1
TM1 53 V 1.54x54 US28 5WB1 CCR6 6WWZ
TM1 54 F 1.55x55 US28 5WB1 US28 5WB1
TM1 55 A 1.56x56 US28 5WB1 β2-adrenoceptor 3SN6
TM1 56 L 1.57x57 US28 5WB1 NTS1 receptor 6OSA
TM1 57 T 1.58x58 US28 5WB1 US28 5WB1
TM1 58 N 1.59x59 US28 5WB1 - -
TM1 59 S 1.60x60 CCR5 5UIW CB1 receptor 5XRA
ICL1 60 K 12.48x48 - - - -
ICL1 61 K 12.49x49 CCR6 6WWZ - -
ICL1 62 P 12.50x50 CCR6 6WWZ - -
ICL1 63 K 12.51x51 - - - -
TM2 64 S 2.37x37 US28 5WB1 CCR6 6WWZ
TM2 65 V 2.38x38 US28 5WB1 AT2 receptor 6JOD
TM2 66 T 2.39x39 US28 5WB1 CCR6 6WWZ
TM2 67 D 2.40x40 US28 5WB1 US28 5WB1
TM2 68 I 2.41x41 US28 5WB1 μ receptor 5C1M
TM2 69 Y 2.42x42 US28 5WB1 US28 5WB1
TM2 70 L 2.43x43 US28 5WB1 CCR6 6WWZ
TM2 71 L 2.44x44 US28 5WB1 CCR6 6WWZ
TM2 72 N 2.45x45 US28 5WB1 US28 5WB1
TM2 73 L 2.46x46 US28 5WB1 US28 5WB1
TM2 74 A 2.47x47 US28 5WB1 US28 5WB1
TM2 75 L 2.48x48 US28 5WB1 μ receptor 5C1M
TM2 76 S 2.49x49 US28 5WB1 NTS1 receptor 6OSA
TM2 77 D 2.50x50 US28 5WB1 US28 5WB1
TM2 78 L 2.51x51 US28 5WB1 US28 5WB1
TM2 79 L 2.52x52 US28 5WB1 US28 5WB1
TM2 80 F 2.53x53 US28 5WB1 US28 5WB1
TM2 81 V 2.54x54 US28 5WB1 US28 5WB1
TM2 82 A 2.55x55 US28 5WB1 AT2 receptor 6JOD
TM2 83 T 2.56x56 US28 5WB1 US28 5WB1
TM2 84 L 2.57x57 US28 5WB1 US28 5WB1
TM2 85 P 2.58x58 US28 5WB1 US28 5WB1
TM2 86 F 2.59x59 US28 5WB1 CCR6 6WWZ
TM2 87 W 2.60x60 US28 5WB1 US28 5WB1
TM2 88 T 2.61x61 US28 5WB1 M1 receptor 6OIJ
TM2 89 H 2.62x62 US28 5WB1 CCR5 5UIW
TM2 90 Y 2.63x63 US28 5WB1 US28 5WB1
TM2 91 L 2.64x64 US28 5WB1 US28 5WB1
TM2 92 I 2.65x65 US28 5WB1 A1 receptor 6D9H
TM2 93 N 2.66x66 US28 5WB1 CCR2 5T1A
ECL1 94 E - - - -
ECL1 95 K - - - -
ECL1 96 G - - - -
ECL1 97 L - - - -
ECL1 98 H - - - -
ECL1 99 N - - - -
ECL1 100 A - - - -
TM3 101 M 3.24x24 US28 5WB1 AT2 receptor 6JOD
TM3 102 C 3.25x25 US28 5WB1 US28 5WB1
TM3 103 K 3.26x26 US28 5WB1 CCR6 6WWZ
TM3 104 F 3.27x27 US28 5WB1 β2-adrenoceptor 3SN6
TM3 105 T 3.28x28 US28 5WB1 P2Y12 receptor 4NTJ
TM3 106 T 3.29x29 US28 5WB1 US28 5WB1
TM3 107 A 3.30x30 US28 5WB1 US28 5WB1
TM3 108 F 3.31x31 US28 5WB1 AT2 receptor 6JOD
TM3 109 F 3.32x32 US28 5WB1 US28 5WB1
TM3 110 F 3.33x33 US28 5WB1 CCR5 5UIW
TM3 111 I 3.34x34 US28 5WB1 CCR6 6WWZ
TM3 112 G 3.35x35 US28 5WB1 Rhodopsin 4ZWJ
TM3 113 F 3.36x36 US28 5WB1 CCR6 6WWZ
TM3 114 F 3.37x37 US28 5WB1 US28 5WB1
TM3 115 G 3.38x38 US28 5WB1 FPR2/ALX 6LW5
TM3 116 S 3.39x39 US28 5WB1 US28 5WB1
TM3 117 I 3.40x40 US28 5WB1 μ receptor 5C1M
TM3 118 F 3.41x41 US28 5WB1 μ receptor 5C1M
TM3 119 F 3.42x42 US28 5WB1 US28 5WB1
TM3 120 I 3.43x43 US28 5WB1 US28 5WB1
TM3 121 T 3.44x44 US28 5WB1 US28 5WB1
TM3 122 V 3.45x45 US28 5WB1 β2-adrenoceptor 3SN6
TM3 123 I 3.46x46 US28 5WB1 US28 5WB1
TM3 124 S 3.47x47 US28 5WB1 CCR6 6WWZ
TM3 125 I 3.48x48 US28 5WB1 AT1 receptor 6OS2
TM3 126 D 3.49x49 US28 5WB1 US28 5WB1
TM3 127 R 3.50x50 US28 5WB1 US28 5WB1
TM3 128 Y 3.51x51 US28 5WB1 US28 5WB1
TM3 129 L 3.52x52 US28 5WB1 AT1 receptor 6OS2
TM3 130 A 3.53x53 US28 5WB1 US28 5WB1
TM3 131 I 3.54x54 US28 5WB1 US28 5WB1
TM3 132 V 3.55x55 US28 5WB1 US28 5WB1
TM3 133 L 3.56x56 CCR5 5UIW - -
ICL2 134 A 34.50x50 - - - -
ICL2 135 A 34.51x51 CCR5 5UIW C5a1 receptor 5O9H
ICL2 136 N 34.52x52 CCR5 5UIW - -
ICL2 137 S 34.53x53 CCR5 5UIW CCR6 6WWZ
ICL2 138 M 34.54x54 CCR5 5UIW - -
ICL2 139 N 34.55x55 CCR5 5UIW FPR2/ALX 6LW5
ICL2 140 N 34.56x56 CCR5 5UIW - -
ICL2 141 R 34.57x57 - - - -
TM4 142 T 4.38x38 US28 5WB1 μ receptor 5C1M
TM4 143 V 4.39x39 US28 5WB1 US28 5WB1
TM4 144 Q 4.40x40 US28 5WB1 - -
TM4 145 H 4.41x41 US28 5WB1 Rhodopsin 4ZWJ
TM4 146 G 4.42x42 US28 5WB1 CCR5 5UIW
TM4 147 V 4.43x43 US28 5WB1 CB1 receptor 6N4B
TM4 148 T 4.44x44 US28 5WB1 - -
TM4 149 I 4.45x45 US28 5WB1 CCR6 6WWZ
TM4 150 S 4.46x46 US28 5WB1 US28 5WB1
TM4 151 L 4.47x47 US28 5WB1 CCR6 6WWZ
TM4 152 G 4.48x48 US28 5WB1 FPR2/ALX 6LW5
TM4 153 V 4.49x49 US28 5WB1 CCR6 6WWZ
TM4 154 W 4.50x50 US28 5WB1 US28 5WB1
TM4 155 A 4.51x51 US28 5WB1 5-HT2C receptor 6BQG
TM4 156 A 4.52x52 US28 5WB1 NTS1 receptor 6OSA
TM4 157 A 4.53x53 US28 5WB1 US28 5WB1
TM4 158 I 4.54x54 US28 5WB1 5-HT2C receptor 6BQG
TM4 159 L 4.55x55 US28 5WB1 AT2 receptor 6JOD
TM4 160 V 4.56x56 US28 5WB1 δ receptor 6PT2
TM4 161 A 4.57x57 US28 5WB1 US28 5WB1
TM4 162 A 4.58x59 US28 5WB1 D4 receptor 5WIV
TM4 163 P 4.59x60 US28 5WB1 US28 5WB1
TM4 164 Q 4.60x61 US28 5WB1 NK1 receptor 6HLP
TM4 165 F 4.61x62 US28 5WB1 US28 5WB1
TM4 166 M 4.62x63 US28 5WB1 US28 5WB1
TM4 167 F 4.63x64 CCR5 5UIW CCR5 5UIW
TM4 168 T 4.64x65 CCR5 5UIW CCR5 5UIW
ECL2 169 K - - - -
ECL2 170 Q - - - -
ECL2 171 K - - - -
ECL2 172 E - - - -
ECL2 173 N - - - -
ECL2 174 E - - - -
ECL2 175 C 45.50x50 US28 5WB1 US28 5WB1
ECL2 176 L 45.51x51 US28 5WB1 A2A receptor 4UHR
ECL2 177 G 45.52x52 US28 5WB1 - -
ECL2 178 D - - - -
ECL2 179 Y AT2 receptor 5UNF - -
ECL2 180 P AT2 receptor 5UNF AT2 receptor 5UNF
ECL2 181 E AT2 receptor 5UNF - -
ECL2 182 V AT2 receptor 5UNF - -
ECL2 183 L - - - -
TM5 184 Q 5.31x32 CCR5 5UIW NOP receptor 5DHG
TM5 185 E 5.32x33 CCR5 5UIW - -
TM5 186 I 5.33x34 US28 5WB1 NK1 receptor 6HLP
TM5 187 W 5.34x35 US28 5WB1 CCR6 6WWZ
TM5 188 P 5.35x36 US28 5WB1 US28 5WB1
TM5 189 V 5.36x37 US28 5WB1 CXCR4 3ODU
TM5 190 L 5.37x38 US28 5WB1 CCR6 6WWZ
TM5 191 R 5.38x39 US28 5WB1 FPR2/ALX 6LW5
TM5 192 N 5.39x40 US28 5WB1 US28 5WB1
TM5 193 V 5.40x41 US28 5WB1 US28 5WB1
TM5 194 E 5.41x42 US28 5WB1 US28 5WB1
TM5 195 T 5.42x43 US28 5WB1 M1 receptor 6OIJ
TM5 196 N 5.43x44 US28 5WB1 AT2 receptor 6JOD
TM5 197 F 5.44x45 US28 5WB1 5-HT2C receptor 6BQG
TM5 198 L 5.45x46 US28 5WB1 AT2 receptor 6JOD
TM5 199 G 5.46x461 US28 5WB1 CCR6 6WWZ
TM5 200 F 5.47x47 US28 5WB1 US28 5WB1
TM5 201 L 5.48x48 US28 5WB1 AT1 receptor 6OS2
TM5 202 L 5.49x49 US28 5WB1 FPR2/ALX 6LW5
TM5 203 P 5.50x50 US28 5WB1 US28 5WB1
TM5 204 L 5.51x51 US28 5WB1 US28 5WB1
TM5 205 L 5.52x52 US28 5WB1 μ receptor 5C1M
TM5 206 I 5.53x53 US28 5WB1 μ receptor 5C1M
TM5 207 M 5.54x54 US28 5WB1 CCR6 6WWZ
TM5 208 S 5.55x55 US28 5WB1 US28 5WB1
TM5 209 Y 5.56x56 US28 5WB1 US28 5WB1
TM5 210 C 5.57x57 US28 5WB1 US28 5WB1
TM5 211 Y 5.58x58 US28 5WB1 US28 5WB1
TM5 212 F 5.59x59 US28 5WB1 AT2 receptor 6JOD
TM5 213 R 5.60x60 US28 5WB1 US28 5WB1
TM5 214 I 5.61x61 US28 5WB1 US28 5WB1
TM5 215 I 5.62x62 US28 5WB1 μ receptor 5C1M
TM5 216 Q 5.63x63 US28 5WB1 β2-adrenoceptor 3SN6
TM5 217 T 5.64x64 US28 5WB1 CCR6 6WWZ
TM5 218 L 5.65x65 US28 5WB1 CCR6 6WWZ
TM5 219 F 5.66x66 US28 5WB1 - -
TM5 220 S 5.67x67 US28 5WB1 μ receptor 5C1M
TM5 221 C 5.68x68 US28 5WB1 CCR5 6MEO
ICL3 222 K - - - -
ICL3 223 N CCR6 6WWZ CCR6 6WWZ
ICL3 224 H CCR6 6WWZ - -
ICL3 225 K - - - -
TM6 226 K 6.30x30 US28 5WB1 US28 5WB1
TM6 227 A 6.31x31 US28 5WB1 - -
TM6 228 K 6.32x32 US28 5WB1 CCR6 6WWZ
TM6 229 A 6.33x33 US28 5WB1 CCR6 6WWZ
TM6 230 I 6.34x34 US28 5WB1 CCR6 6WWZ
TM6 231 K 6.35x35 US28 5WB1 AT2 receptor 6JOD
TM6 232 L 6.36x36 US28 5WB1 κ receptor 6B73
TM6 233 I 6.37x37 US28 5WB1 CCR6 6WWZ
TM6 234 L 6.38x38 US28 5WB1 μ receptor 5C1M
TM6 235 L 6.39x39 US28 5WB1 CB1 receptor 6N4B
TM6 236 V 6.40x40 US28 5WB1 US28 5WB1
TM6 237 V 6.41x41 US28 5WB1 US28 5WB1
TM6 238 I 6.42x42 US28 5WB1 Rhodopsin 4ZWJ
TM6 239 V 6.43x43 US28 5WB1 US28 5WB1
TM6 240 F 6.44x44 US28 5WB1 US28 5WB1
TM6 241 F 6.45x45 US28 5WB1 AT1 receptor 6OS2
TM6 242 L 6.46x46 US28 5WB1 β2-adrenoceptor 3SN6
TM6 243 F 6.47x47 US28 5WB1 US28 5WB1
TM6 244 W 6.48x48 US28 5WB1 US28 5WB1
TM6 245 T 6.49x49 US28 5WB1 μ receptor 5C1M
TM6 246 P 6.50x50 US28 5WB1 US28 5WB1
TM6 247 Y 6.51x51 US28 5WB1 US28 5WB1
TM6 248 N 6.52x52 US28 5WB1 CCR6 6WWZ
TM6 249 V 6.53x53 US28 5WB1 AT2 receptor 6JOD
TM6 250 M 6.54x54 US28 5WB1 M1 receptor 6OIJ
TM6 251 I 6.55x55 US28 5WB1 κ receptor 6B73
TM6 252 F 6.56x56 US28 5WB1 US28 5WB1
TM6 253 L 6.57x57 US28 5WB1 AT2 receptor 6JOD
TM6 254 E 6.58x58 US28 5WB1 GPR52 6LI3
TM6 255 T 6.59x59 US28 5WB1 US28 5WB1
TM6 256 L 6.60x60 US28 5WB1 US28 5WB1
TM6 257 K 6.61x61 US28 5WB1 US28 4XT1
TM6 258 L 6.62x62 US28 5WB1 US28 5WB1
TM6 259 Y 6.63x63 US28 5WB1 CCR9 5LWE
TM6 260 D 6.64x64 US28 5WB1 P2Y1 receptor 4XNW
ECL3 261 F - - - -
ECL3 262 F CysLT1 receptor 6RZ4 - -
ECL3 263 P - - - -
TM7 264 S 7.24x23 US28 5WB1 US28 5WB1
TM7 265 C 7.25x24 US28 5WB1 US28 5WB1
TM7 266 D 7.26x25 US28 5WB1 CysLT1 receptor 6RZ4
TM7 267 M 7.27x26 US28 5WB1 - -
TM7 268 R 7.28x27 US28 5WB1 OX1 receptor 6TO7
TM7 269 K 7.29x28 US28 5WB1 CCR6 6WWZ
TM7 270 D 7.30x29 US28 5WB1 S1P1 receptor 3V2Y
TM7 271 L 7.31x30 US28 5WB1 US28 5WB1
TM7 272 R 7.32x31 US28 5WB1 LPA6 receptor 5XSZ
TM7 273 L 7.33x32 US28 5WB1 AT2 receptor 6JOD
TM7 274 A 7.34x33 US28 5WB1 US28 5WB1
TM7 275 L 7.35x34 US28 5WB1 US28 5WB1
TM7 276 S 7.36x35 US28 5WB1 D2 receptor 6VMS
TM7 277 V 7.37x36 US28 5WB1 CCR6 6WWZ
TM7 278 T 7.38x37 US28 5WB1 US28 5WB1
TM7 279 E 7.39x38 US28 5WB1 US28 5WB1
TM7 280 T 7.40x39 US28 5WB1 CCR5 5UIW
TM7 281 V 7.41x40 US28 5WB1 PAR1 3VW7
TM7 282 A 7.42x41 US28 5WB1 US28 5WB1
TM7 283 F 7.43x42 US28 5WB1 US28 5WB1
TM7 284 S 7.44x43 US28 5WB1 Rhodopsin 4ZWJ
TM7 285 H 7.45x45 US28 5WB1 US28 5WB1
TM7 286 C 7.46x46 US28 5WB1 US28 5WB1
TM7 287 C 7.47x47 US28 5WB1 US28 5WB1
TM7 288 L 7.48x48 US28 5WB1 US28 5WB1
TM7 289 N 7.49x49 US28 5WB1 US28 5WB1
TM7 290 P 7.50x50 US28 5WB1 US28 5WB1
TM7 291 L 7.51x51 US28 5WB1 US28 5WB1
TM7 292 I 7.52x52 US28 5WB1 β2-adrenoceptor 3SN6
TM7 293 Y 7.53x53 US28 5WB1 US28 5WB1
TM7 294 A 7.54x54 US28 5WB1 CCR6 6WWZ
TM7 295 F 7.55x55 US28 5WB1 US28 5WB1
TM7 296 A 7.56x56 US28 5WB1 CysLT2 receptor 6RZ6
H8 297 G 8.47x47 US28 5WB1 US28 5WB1
H8 298 E 8.48x48 US28 5WB1 CCR2 5T1A
H8 299 K 8.49x49 US28 5WB1 CCR6 6WWZ
H8 300 F 8.50x50 US28 5WB1 US28 5WB1
H8 301 R 8.51x51 US28 5WB1 US28 5WB1
H8 302 R 8.52x52 US28 5WB1 AT1 receptor 6OS2
H8 303 Y 8.53x53 US28 5WB1 CCR6 6WWZ
H8 304 L 8.54x54 US28 5WB1 US28 5WB1
H8 305 Y 8.55x55 US28 5WB1 - -
H8 306 H 8.56x56 US28 5WB1 FPR2/ALX 6LW5
H8 307 L 8.57x57 US28 5WB1 US28 5WB1
H8 308 Y 8.58x58 US28 5WB1 - -
C-term 309 G - - - -
C-term 310 K - - - -
C-term 311 C - - - -
C-term 312 L - - - -
C-term 313 A - - - -