CXCR1 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

CXCR1

SPECIES

Homo sapiens

STATE

Inactive

VERSION

2020-09-02

MODEL

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PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

CCR7 (sequence similarity: 59%) PDB: 6QZH
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TEMPLATES

6WWZ (CCR6)
6QZH (CCR7)
5T1A (CCR2)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 76.9 16.8 6.3
Side-chains 30.7 53.1 16.2

Number of backbone templates: 3
Number of rotamer templates: 40

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 27 Y CCR6 6WWZ CCR6 6WWZ
N-term 28 S CCR6 6WWZ CCR6 6WWZ
N-term 29 P CCR6 6WWZ CCR6 6WWZ
N-term 30 C CCR6 6WWZ CCR6 6WWZ
N-term 31 M CCR6 6WWZ CCR6 6WWZ
TM1 32 L 1.25x25 CCR6 6WWZ - -
TM1 33 E 1.26x26 CCR6 6WWZ CCR6 6WWZ
TM1 34 T 1.27x27 CCR6 6WWZ - -
TM1 35 E 1.28x28 CCR6 6WWZ M4 receptor 5DSG
TM1 36 T 1.29x29 CCR6 6WWZ BLT1 receptor 5X33
TM1 37 L 1.30x30 CCR7 6QZH succinate receptor 6RNK
TM1 38 N 1.31x31 CCR7 6QZH CXCR4 3ODU
TM1 39 K 1.32x32 CCR7 6QZH CXCR4 3ODU
TM1 40 Y 1.33x33 CCR7 6QZH ETB receptor 5X93
TM1 41 V 1.34x34 CCR7 6QZH OX1 receptor 6TO7
TM1 42 V 1.35x35 CCR7 6QZH ghrelin receptor 6KO5
TM1 43 I 1.36x36 CCR7 6QZH OX1 receptor 6TO7
TM1 44 I 1.37x37 CCR7 6QZH CCR7 6QZH
TM1 45 A 1.38x38 CCR7 6QZH OX1 receptor 6TO7
TM1 46 Y 1.39x39 CCR7 6QZH CCR7 6QZH
TM1 47 A 1.40x40 CCR7 6QZH C5a1 receptor 5O9H
TM1 48 L 1.41x41 CCR7 6QZH CCR2 5T1A
TM1 49 V 1.42x42 CCR7 6QZH CCR2 5T1A
TM1 50 F 1.43x43 CCR7 6QZH CCR2 5T1A
TM1 51 L 1.44x44 CCR7 6QZH CXCR4 3ODU
TM1 52 L 1.45x45 CCR7 6QZH apelin receptor 5VBL
TM1 53 S 1.46x46 CCR7 6QZH NK1 receptor 6HLP
TM1 54 L 1.47x47 CCR7 6QZH CCR7 6QZH
TM1 55 L 1.48x48 CCR7 6QZH CCR7 6QZH
TM1 56 G 1.49x49 CCR7 6QZH CCR7 6QZH
TM1 57 N 1.50x50 CCR7 6QZH CCR7 6QZH
TM1 58 S 1.51x51 CCR7 6QZH CCR9 5LWE
TM1 59 L 1.52x52 CCR7 6QZH CCR7 6QZH
TM1 60 V 1.53x53 CCR7 6QZH CCR7 6QZH
TM1 61 M 1.54x54 CCR7 6QZH μ receptor 4DKL
TM1 62 L 1.55x55 CCR7 6QZH CCR7 6QZH
TM1 63 V 1.56x56 CCR7 6QZH CXCR4 3ODU
TM1 64 I 1.57x57 CCR7 6QZH AT1 receptor 4YAY
TM1 65 L 1.58x58 CCR7 6QZH BLT1 receptor 5X33
TM1 66 Y 1.59x59 CCR7 6QZH CCR7 6QZH
TM1 67 S 1.60x60 CCR6 6WWZ apelin receptor 5VBL
ICL1 68 R 12.48x48 - - - -
ICL1 69 V 12.49x49 CCR6 6WWZ - -
ICL1 70 G 12.50x50 CCR6 6WWZ - -
ICL1 71 R 12.51x51 - - - -
TM2 72 S 2.37x37 CCR7 6QZH CCR5 5UIW
TM2 73 V 2.38x38 CCR7 6QZH AT1 receptor 4ZUD
TM2 74 T 2.39x39 CCR7 6QZH CCR7 6QZH
TM2 75 D 2.40x40 CCR7 6QZH CCR7 6QZH
TM2 76 V 2.41x41 CCR7 6QZH AT1 receptor 4ZUD
TM2 77 Y 2.42x42 CCR7 6QZH CCR7 6QZH
TM2 78 L 2.43x43 CCR7 6QZH CCR7 6QZH
TM2 79 L 2.44x44 CCR7 6QZH CCR7 6QZH
TM2 80 N 2.45x45 CCR7 6QZH CCR7 6QZH
TM2 81 L 2.46x46 CCR7 6QZH CCR7 6QZH
TM2 82 A 2.47x47 CCR7 6QZH CCR7 6QZH
TM2 83 L 2.48x48 CCR7 6QZH AT1 receptor 4ZUD
TM2 84 A 2.49x49 CCR7 6QZH CCR7 6QZH
TM2 85 D 2.50x50 CCR7 6QZH CCR7 6QZH
TM2 86 L 2.51x51 CCR7 6QZH CCR2 5T1A
TM2 87 L 2.52x52 CCR7 6QZH CCR7 6QZH
TM2 88 F 2.53x53 CCR7 6QZH CCR7 6QZH
TM2 89 A 2.54x54 CCR7 6QZH D4 receptor 5WIV
TM2 90 L 2.55x55 CCR7 6QZH CCR7 6QZH
TM2 91 T 2.56x56 CCR7 6QZH CCR7 6QZH
TM2 92 L 2.57x57 CCR7 6QZH CCR7 6QZH
TM2 93 P 2.58x58 CCR7 6QZH CCR7 6QZH
TM2 94 I 2.59x59 CCR7 6QZH C5a1 receptor 6C1R
TM2 95 W 2.60x60 CCR7 6QZH CCR7 6QZH
TM2 96 A 2.61x61 CCR7 6QZH CCR7 6QZH
TM2 97 A 2.62x62 CCR7 6QZH δ receptor 4N6H
TM2 98 S 2.63x63 CCR7 6QZH CCR7 6QZH
TM2 99 K 2.64x64 CCR7 6QZH - -
TM2 100 V 2.65x65 CCR7 6QZH CXCR4 3ODU
TM2 101 N 2.66x66 CCR7 6QZH CCR2 5T1A
ECL1 102 G 23.49x49 - - - -
ECL1 103 W 23.50x50 CCR6 6WWZ CCR6 6WWZ
ECL1 104 I 23.51x51 CCR6 6WWZ P2Y1 receptor 4XNW
ECL1 105 F 23.52x52 - - - -
TM3 106 G 3.21x21 CCR7 6QZH CCR7 6QZH
TM3 107 T 3.22x22 CCR7 6QZH apelin receptor 5VBL
TM3 108 F 3.23x23 CCR7 6QZH CXCR4 3ODU
TM3 109 L 3.24x24 CCR7 6QZH CXCR4 3ODU
TM3 110 C 3.25x25 CCR7 6QZH CCR7 6QZH
TM3 111 K 3.26x26 CCR7 6QZH CCR7 6QZH
TM3 112 V 3.27x27 CCR7 6QZH CCR9 5LWE
TM3 113 V 3.28x28 CCR7 6QZH CXCR4 3ODU
TM3 114 S 3.29x29 CCR7 6QZH AT1 receptor 4ZUD
TM3 115 L 3.30x30 CCR7 6QZH EP3 receptor 6M9T
TM3 116 L 3.31x31 CCR7 6QZH CCR2 5T1A
TM3 117 K 3.32x32 CCR7 6QZH - -
TM3 118 E 3.33x33 CCR7 6QZH ghrelin receptor 6KO5
TM3 119 V 3.34x34 CCR7 6QZH CXCR4 3ODU
TM3 120 N 3.35x35 CCR7 6QZH CXCR4 3ODU
TM3 121 F 3.36x36 CCR7 6QZH CCR7 6QZH
TM3 122 Y 3.37x37 CCR7 6QZH CXCR4 3ODU
TM3 123 S 3.38x38 CCR7 6QZH CCR7 6QZH
TM3 124 G 3.39x39 CCR7 6QZH CCR7 6QZH
TM3 125 I 3.40x40 CCR7 6QZH CCR2 5T1A
TM3 126 L 3.41x41 CCR7 6QZH CCR9 5LWE
TM3 127 L 3.42x42 CCR7 6QZH CCR7 6QZH
TM3 128 L 3.43x43 CCR7 6QZH CCR7 6QZH
TM3 129 A 3.44x44 CCR7 6QZH CXCR4 3ODU
TM3 130 C 3.45x45 CCR7 6QZH CCR7 6QZH
TM3 131 I 3.46x46 CCR7 6QZH CCR7 6QZH
TM3 132 S 3.47x47 CCR7 6QZH CCR7 6QZH
TM3 133 V 3.48x48 CCR7 6QZH CCR9 5LWE
TM3 134 D 3.49x49 CCR7 6QZH CCR7 6QZH
TM3 135 R 3.50x50 CCR7 6QZH CCR7 6QZH
TM3 136 Y 3.51x51 CCR7 6QZH CCR7 6QZH
TM3 137 L 3.52x52 CCR7 6QZH CCR2 5T1A
TM3 138 A 3.53x53 CCR7 6QZH CCR7 6QZH
TM3 139 I 3.54x54 CCR7 6QZH CCR7 6QZH
TM3 140 V 3.55x55 CCR7 6QZH CCR7 6QZH
TM3 141 H 3.56x56 CCR2 5T1A CCR2 5T1A
ICL2 142 A 34.50x50 - - - -
ICL2 143 T 34.51x51 CCR2 5T1A CCR6 6WWZ
ICL2 144 R 34.52x52 CCR2 5T1A CCR9 5LWE
ICL2 145 T 34.53x53 CCR2 5T1A - -
ICL2 146 L 34.54x54 CCR2 5T1A CCR2 5T1A
ICL2 147 T 34.55x55 CCR2 5T1A CCR9 5LWE
ICL2 148 Q 34.56x56 - - - -
TM4 149 K 4.38x38 CCR7 6QZH CXCR4 3ODU
TM4 150 R 4.39x39 CCR7 6QZH apelin receptor 5VBL
TM4 151 H 4.40x40 CCR7 6QZH - -
TM4 152 L 4.41x41 CCR7 6QZH C5a1 receptor 5O9H
TM4 153 V 4.42x42 CCR7 6QZH ghrelin receptor 6KO5
TM4 154 K 4.43x43 CCR7 6QZH CCR7 6QZH
TM4 155 F 4.44x44 CCR7 6QZH CysLT1 receptor 6RZ4
TM4 156 V 4.45x45 CCR7 6QZH CXCR4 3ODU
TM4 157 C 4.46x46 CCR7 6QZH CCR7 6QZH
TM4 158 L 4.47x47 CCR7 6QZH OX1 receptor 6TO7
TM4 159 G 4.48x48 CCR7 6QZH CCR7 6QZH
TM4 160 C 4.49x49 CCR7 6QZH A2A receptor 3VG9
TM4 161 W 4.50x50 CCR7 6QZH CCR7 6QZH
TM4 162 G 4.51x51 CCR7 6QZH C5a1 receptor 5O9H
TM4 163 L 4.52x52 CCR7 6QZH CCR7 6QZH
TM4 164 S 4.53x53 CCR7 6QZH μ receptor 4DKL
TM4 165 M 4.54x54 CCR7 6QZH CysLT2 receptor 6RZ6
TM4 166 N 4.55x55 CCR7 6QZH - -
TM4 167 L 4.56x56 CCR7 6QZH CCR7 6QZH
TM4 168 S 4.57x57 CCR7 6QZH CCR7 6QZH
TM4 169 L 4.58x59 CCR7 6QZH CCR5 5UIW
TM4 170 P 4.59x60 CCR7 6QZH CCR7 6QZH
TM4 171 F 4.60x61 CCR7 6QZH Y1 receptor 5ZBH
TM4 172 F 4.61x62 CCR7 6QZH CXCR4 3ODU
TM4 173 L 4.62x63 CCR7 6QZH CCR7 6QZH
TM4 174 F 4.63x64 CCR7 6QZH CCR2 5T1A
TM4 175 R 4.64x65 CCR2 5T1A AT1 receptor 4ZUD
ECL2 176 Q CCR7 6QZH - -
ECL2 177 A CCR7 6QZH - -
ECL2 178 Y CCR7 6QZH - -
ECL2 179 H CCR7 6QZH - -
ECL2 180 P CCR7 6QZH - -
ECL2 181 N CCR7 6QZH - -
ECL2 182 N CCR7 6QZH - -
ECL2 183 S CCR7 6QZH - -
ECL2 184 S CCR7 6QZH - -
ECL2 185 P CCR7 6QZH - -
ECL2 186 V CCR7 6QZH - -
ECL2 187 C 45.50x50 CCR7 6QZH CCR7 6QZH
ECL2 188 Y 45.51x51 CCR7 6QZH apelin receptor 5VBL
ECL2 189 E 45.52x52 CCR7 6QZH OX1 receptor 6TO7
ECL2 190 V CCR7 6QZH CCR7 6QZH
ECL2 191 L CCR7 6QZH - -
ECL2 192 G CCR7 6QZH - -
ECL2 193 N CCR7 6QZH - -
ECL2 194 D CCR7 6QZH - -
TM5 195 T 5.31x32 CCR6 6WWZ μ receptor 4DKL
TM5 196 A 5.32x33 CCR6 6WWZ AT2 receptor 6JOD
TM5 197 K 5.33x34 CCR6 6WWZ succinate receptor 6RNK
TM5 198 W 5.34x35 CCR6 6WWZ CCR6 6WWZ
TM5 199 R 5.35x36 CCR7 6QZH Y1 receptor 5ZBH
TM5 200 M 5.36x37 CCR7 6QZH A2A receptor 3VG9
TM5 201 V 5.37x38 CCR7 6QZH CXCR4 3ODU
TM5 202 L 5.38x39 CCR7 6QZH AT1 receptor 4ZUD
TM5 203 R 5.39x40 CCR7 6QZH FFA1 receptor 5TZY
TM5 204 I 5.40x41 CCR7 6QZH CCR2 5T1A
TM5 205 L 5.41x42 CCR7 6QZH Y1 receptor 5ZBH
TM5 206 P 5.42x43 CCR7 6QZH - -
TM5 207 H 5.43x44 CCR7 6QZH - -
TM5 208 T 5.44x45 CCR7 6QZH apelin receptor 5VBL
TM5 209 F 5.45x46 CCR7 6QZH μ receptor 4DKL
TM5 210 G 5.46x461 CCR7 6QZH CCR7 6QZH
TM5 211 F 5.47x47 CCR7 6QZH CCR7 6QZH
TM5 212 I 5.48x48 CCR7 6QZH CXCR4 3ODU
TM5 213 V 5.49x49 CCR7 6QZH CCR7 6QZH
TM5 214 P 5.50x50 CCR7 6QZH CCR7 6QZH
TM5 215 L 5.51x51 CCR7 6QZH CCR7 6QZH
TM5 216 F 5.52x52 CCR7 6QZH ghrelin receptor 6KO5
TM5 217 V 5.53x53 CCR7 6QZH CCR5 5UIW
TM5 218 M 5.54x54 CCR7 6QZH CCR7 6QZH
TM5 219 L 5.55x55 CCR7 6QZH CXCR4 3ODU
TM5 220 F 5.56x56 CCR7 6QZH CCR7 6QZH
TM5 221 C 5.57x57 CCR7 6QZH CCR7 6QZH
TM5 222 Y 5.58x58 CCR7 6QZH CCR7 6QZH
TM5 223 G 5.59x59 CCR7 6QZH μ receptor 4DKL
TM5 224 F 5.60x60 CCR7 6QZH C5a1 receptor 5O9H
TM5 225 T 5.61x61 CCR7 6QZH 5-HT2A receptor 6A94
TM5 226 L 5.62x62 CCR7 6QZH CCR5 5UIW
TM5 227 R 5.63x63 CCR6 6WWZ OX1 receptor 6TO7
TM5 228 T 5.64x64 CCR6 6WWZ CCR6 6WWZ
TM5 229 L 5.65x65 CCR6 6WWZ CCR6 6WWZ
TM5 230 F 5.66x66 CCR6 6WWZ - -
TM5 231 K 5.67x67 CCR6 6WWZ 5-HT2A receptor 6A94
TM5 232 A 5.68x68 CCR6 6WWZ CCR6 6WWZ
ICL3 233 H - - - -
ICL3 234 M - - - -
ICL3 235 G - - - -
ICL3 236 Q - - - -
TM6 237 K 6.30x30 CCR6 6WWZ CXCR4 3ODU
TM6 238 H 6.31x31 CCR6 6WWZ CCR6 6WWZ
TM6 239 R 6.32x32 CCR6 6WWZ CCR5 5UIW
TM6 240 A 6.33x33 CCR6 6WWZ CCR6 6WWZ
TM6 241 M 6.34x34 CCR6 6WWZ D4 receptor 6IQL
TM6 242 R 6.35x35 CCR7 6QZH CCR2 5T1A
TM6 243 V 6.36x36 CCR7 6QZH CCR7 6QZH
TM6 244 I 6.37x37 CCR7 6QZH CCR7 6QZH
TM6 245 F 6.38x38 CCR7 6QZH CCR2 5T1A
TM6 246 A 6.39x39 CCR7 6QZH CCR7 6QZH
TM6 247 V 6.40x40 CCR7 6QZH CCR7 6QZH
TM6 248 V 6.41x41 CCR7 6QZH CCR7 6QZH
TM6 249 L 6.42x42 CCR7 6QZH CXCR4 3ODU
TM6 250 I 6.43x43 CCR7 6QZH MT2 receptor 6ME6
TM6 251 F 6.44x44 CCR7 6QZH CCR7 6QZH
TM6 252 L 6.45x45 CCR7 6QZH 5-HT2C receptor 6BQH
TM6 253 L 6.46x46 CCR7 6QZH CCR2 5T1A
TM6 254 C 6.47x47 CCR7 6QZH CXCR4 3ODU
TM6 255 W 6.48x48 CCR7 6QZH CCR2 5T1A
TM6 256 L 6.49x49 CCR7 6QZH CCR7 6QZH
TM6 257 P 6.50x50 CCR7 6QZH CCR7 6QZH
TM6 258 Y 6.51x51 CCR7 6QZH CCR7 6QZH
TM6 259 N 6.52x52 CCR7 6QZH CCR7 6QZH
TM6 260 L 6.53x53 CCR7 6QZH apelin receptor 5VBL
TM6 261 V 6.54x54 CCR7 6QZH CCR7 6QZH
TM6 262 L 6.55x55 CCR7 6QZH CCR5 5UIW
TM6 263 L 6.56x56 CCR7 6QZH CCR7 6QZH
TM6 264 A 6.57x57 CCR7 6QZH CCR7 6QZH
TM6 265 D 6.58x58 CCR7 6QZH CXCR4 3ODU
TM6 266 T 6.59x59 CCR2 5T1A CCR2 5T1A
TM6 267 L 6.60x60 CCR2 5T1A AT1 receptor 4ZUD
TM6 268 M 6.61x61 CCR2 5T1A - -
TM6 269 R 6.62x62 CCR2 5T1A α2C-adrenoceptor 6KUW
TM6 270 T 6.63x63 CCR2 5T1A LPA6 receptor 5XSZ
TM6 271 Q 6.64x64 CCR2 5T1A - -
ECL3 272 V - - - -
ECL3 273 I - - - -
ECL3 274 Q - - - -
ECL3 275 E - - - -
TM7 276 S 7.24x23 CCR6 6WWZ CCR6 6WWZ
TM7 277 C 7.25x24 CCR7 6QZH CCR7 6QZH
TM7 278 E 7.26x25 CCR7 6QZH CCR7 6QZH
TM7 279 R 7.27x26 CCR7 6QZH - -
TM7 280 R 7.28x27 CCR7 6QZH OX1 receptor 6TO7
TM7 281 N 7.29x28 CCR7 6QZH CCR5 5UIW
TM7 282 N 7.30x29 CCR7 6QZH Y1 receptor 5ZBH
TM7 283 I 7.31x30 CCR7 6QZH CCR9 5LWE
TM7 284 G 7.32x31 CCR7 6QZH 5-HT2A receptor 6A94
TM7 285 R 7.33x32 CCR7 6QZH DP2 receptor 6D27
TM7 286 A 7.34x33 CCR7 6QZH CCR7 6QZH
TM7 287 L 7.35x34 CCR7 6QZH δ receptor 4N6H
TM7 288 D 7.36x35 CCR7 6QZH CCR7 6QZH
TM7 289 A 7.37x36 CCR7 6QZH D4 receptor 5WIV
TM7 290 T 7.38x37 CCR7 6QZH CCR7 6QZH
TM7 291 E 7.39x38 CCR7 6QZH CCR2 5T1A
TM7 292 I 7.40x39 CCR7 6QZH MC4 receptor 6W25
TM7 293 L 7.41x40 CCR7 6QZH CCR7 6QZH
TM7 294 G 7.42x41 CCR7 6QZH CCR2 5T1A
TM7 295 F 7.43x42 CCR7 6QZH CXCR4 3ODU
TM7 296 L 7.44x43 CCR7 6QZH BLT1 receptor 5X33
TM7 297 H 7.45x45 CCR7 6QZH CCR2 5T1A
TM7 298 S 7.46x46 CCR7 6QZH CCR9 5LWE
TM7 299 C 7.47x47 CCR7 6QZH CCR7 6QZH
TM7 300 L 7.48x48 CCR7 6QZH CXCR4 3ODU
TM7 301 N 7.49x49 CCR7 6QZH CCR7 6QZH
TM7 302 P 7.50x50 CCR7 6QZH CCR7 6QZH
TM7 303 I 7.51x51 CCR7 6QZH CCR2 5T1A
TM7 304 I 7.52x52 CCR7 6QZH CCR2 5T1A
TM7 305 Y 7.53x53 CCR7 6QZH CCR7 6QZH
TM7 306 A 7.54x54 CCR7 6QZH CCR7 6QZH
TM7 307 F 7.55x55 CCR7 6QZH CCR7 6QZH
TM7 308 I 7.56x56 CCR6 6WWZ CCR6 6WWZ
H8 309 G 8.47x47 CCR6 6WWZ CCR6 6WWZ
H8 310 Q 8.48x48 CCR6 6WWZ CCR6 6WWZ
H8 311 N 8.49x49 CCR7 6QZH μ receptor 4DKL
H8 312 F 8.50x50 CCR7 6QZH CCR7 6QZH
H8 313 R 8.51x51 CCR7 6QZH CCR7 6QZH
H8 314 H 8.52x52 CCR7 6QZH CB1 receptor 5TGZ
H8 315 G 8.53x53 CCR7 6QZH NK1 receptor 6HLP
H8 316 F 8.54x54 CCR7 6QZH μ receptor 4DKL
H8 317 L 8.55x55 CCR7 6QZH CCR5 5UIW
H8 318 K 8.56x56 CCR7 6QZH CCR9 5LWE
H8 319 I 8.57x57 CCR7 6QZH MT1 receptor 6ME2
H8 320 L 8.58x58 CCR7 6QZH CCR9 5LWE
H8 321 A 8.59x59 CCR6 6WWZ CB2 receptor 5ZTY
H8 322 M 8.60x60 CCR6 6WWZ apelin receptor 5VBL
H8 323 H 8.61x61 CCR6 6WWZ A2A receptor 3VG9
H8 324 G 8.62x62 CCR6 6WWZ CCR9 5LWE
C-term 325 L - - - -
C-term 326 V - - - -
C-term 327 S - - - -
C-term 328 K - - - -
C-term 329 E - - - -