CXCR2 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive

VERSION

2020-09-02

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

CCR7 (sequence similarity: 64%) PDB: 6QZH

TEMPLATES

6WWZ (CCR6)
6QZH (CCR7)
5T1A (CCR2)
6LW5 (FPR2/ALX)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 79.7 14.9 5.4
Side-chains 33.1 52.0 14.9

Number of backbone templates: 4
Number of rotamer templates: 44

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 40 E CCR6 6WWZ CCR6 6WWZ
N-term 41 P CCR6 6WWZ CCR6 6WWZ
N-term 42 E CCR6 6WWZ CCR6 6WWZ
N-term 43 S CCR6 6WWZ CCR6 6WWZ
N-term 44 L CCR6 6WWZ CCR6 6WWZ
TM1 45 E 1.29x29 CCR6 6WWZ ETB receptor 5X93
TM1 46 I 1.30x30 CCR7 6QZH CCR2 5T1A
TM1 47 N 1.31x31 CCR7 6QZH CXCR4 3ODU
TM1 48 K 1.32x32 CCR7 6QZH CXCR4 3ODU
TM1 49 Y 1.33x33 CCR7 6QZH ETB receptor 5X93
TM1 50 F 1.34x34 CCR7 6QZH CCR7 6QZH
TM1 51 V 1.35x35 CCR7 6QZH ghrelin receptor 6KO5
TM1 52 V 1.36x36 CCR7 6QZH NOP receptor 5DHG
TM1 53 I 1.37x37 CCR7 6QZH CCR7 6QZH
TM1 54 I 1.38x38 CCR7 6QZH CXCR4 3ODU
TM1 55 Y 1.39x39 CCR7 6QZH CCR7 6QZH
TM1 56 A 1.40x40 CCR7 6QZH C5a1 receptor 5O9H
TM1 57 L 1.41x41 CCR7 6QZH CCR2 5T1A
TM1 58 V 1.42x42 CCR7 6QZH CCR2 5T1A
TM1 59 F 1.43x43 CCR7 6QZH CCR2 5T1A
TM1 60 L 1.44x44 CCR7 6QZH CXCR4 3ODU
TM1 61 L 1.45x45 CCR7 6QZH apelin receptor 5VBL
TM1 62 S 1.46x46 CCR7 6QZH NK1 receptor 6HLP
TM1 63 L 1.47x47 CCR7 6QZH CCR7 6QZH
TM1 64 L 1.48x48 CCR7 6QZH CCR7 6QZH
TM1 65 G 1.49x49 CCR7 6QZH CCR7 6QZH
TM1 66 N 1.50x50 CCR7 6QZH CCR7 6QZH
TM1 67 S 1.51x51 CCR7 6QZH CCR9 5LWE
TM1 68 L 1.52x52 CCR7 6QZH CCR7 6QZH
TM1 69 V 1.53x53 CCR7 6QZH CCR7 6QZH
TM1 70 M 1.54x54 CCR7 6QZH μ receptor 4DKL
TM1 71 L 1.55x55 CCR7 6QZH CCR7 6QZH
TM1 72 V 1.56x56 CCR7 6QZH CXCR4 3ODU
TM1 73 I 1.57x57 CCR7 6QZH AT1 receptor 4YAY
TM1 74 L 1.58x58 CCR7 6QZH NOP receptor 5DHG
TM1 75 Y 1.59x59 CCR7 6QZH CCR7 6QZH
TM1 76 S 1.60x60 CCR6 6WWZ apelin receptor 5VBL
ICL1 77 R 12.48x48 CCR7 6QZH ghrelin receptor 6KO5
ICL1 78 V 12.49x49 CCR7 6QZH - -
ICL1 79 G 12.50x50 CCR7 6QZH - -
ICL1 80 R 12.51x51 CCR7 6QZH OX2 receptor 5WS3
TM2 81 S 2.37x37 CCR7 6QZH CCR5 5UIW
TM2 82 V 2.38x38 CCR7 6QZH AT1 receptor 4ZUD
TM2 83 T 2.39x39 CCR7 6QZH CCR7 6QZH
TM2 84 D 2.40x40 CCR7 6QZH CCR7 6QZH
TM2 85 V 2.41x41 CCR7 6QZH AT1 receptor 4ZUD
TM2 86 Y 2.42x42 CCR7 6QZH CCR7 6QZH
TM2 87 L 2.43x43 CCR7 6QZH CCR7 6QZH
TM2 88 L 2.44x44 CCR7 6QZH CCR7 6QZH
TM2 89 N 2.45x45 CCR7 6QZH CCR7 6QZH
TM2 90 L 2.46x46 CCR7 6QZH CCR7 6QZH
TM2 91 A 2.47x47 CCR7 6QZH CCR7 6QZH
TM2 92 L 2.48x48 CCR7 6QZH AT1 receptor 4ZUD
TM2 93 A 2.49x49 CCR7 6QZH CCR7 6QZH
TM2 94 D 2.50x50 CCR7 6QZH CCR7 6QZH
TM2 95 L 2.51x51 CCR7 6QZH CCR2 5T1A
TM2 96 L 2.52x52 CCR7 6QZH CCR7 6QZH
TM2 97 F 2.53x53 CCR7 6QZH CCR7 6QZH
TM2 98 A 2.54x54 CCR7 6QZH D4 receptor 5WIV
TM2 99 L 2.55x55 CCR7 6QZH CCR7 6QZH
TM2 100 T 2.56x56 CCR7 6QZH CCR7 6QZH
TM2 101 L 2.57x57 CCR7 6QZH CCR7 6QZH
TM2 102 P 2.58x58 CCR7 6QZH CCR7 6QZH
TM2 103 I 2.59x59 CCR7 6QZH C5a1 receptor 6C1R
TM2 104 W 2.60x60 CCR7 6QZH CCR7 6QZH
TM2 105 A 2.61x61 CCR7 6QZH CCR7 6QZH
TM2 106 A 2.62x62 CCR7 6QZH δ receptor 4EJ4
TM2 107 S 2.63x63 CCR7 6QZH CCR7 6QZH
TM2 108 K 2.64x64 CCR7 6QZH - -
TM2 109 V 2.65x65 CCR7 6QZH CXCR4 3ODU
TM2 110 N 2.66x66 CCR7 6QZH CCR2 5T1A
ECL1 111 G 23.49x49 CCR7 6QZH MT1 receptor 6ME2
ECL1 112 W 23.50x50 CCR7 6QZH CCR7 6QZH
ECL1 113 I 23.51x51 CCR7 6QZH P2Y1 receptor 4XNW
ECL1 114 F 23.52x52 CCR7 6QZH CCR7 6QZH
TM3 115 G 3.21x21 CCR7 6QZH CCR7 6QZH
TM3 116 T 3.22x22 CCR7 6QZH apelin receptor 5VBL
TM3 117 F 3.23x23 CCR7 6QZH CXCR4 3ODU
TM3 118 L 3.24x24 CCR7 6QZH CXCR4 3ODU
TM3 119 C 3.25x25 CCR7 6QZH CCR7 6QZH
TM3 120 K 3.26x26 CCR7 6QZH CCR7 6QZH
TM3 121 V 3.27x27 CCR7 6QZH CCR9 5LWE
TM3 122 V 3.28x28 CCR7 6QZH CXCR4 3ODU
TM3 123 S 3.29x29 CCR7 6QZH AT1 receptor 4ZUD
TM3 124 L 3.30x30 CCR7 6QZH EP3 receptor 6M9T
TM3 125 L 3.31x31 CCR7 6QZH CCR2 5T1A
TM3 126 K 3.32x32 CCR7 6QZH - -
TM3 127 E 3.33x33 CCR7 6QZH ghrelin receptor 6KO5
TM3 128 V 3.34x34 CCR7 6QZH CXCR4 3ODU
TM3 129 N 3.35x35 CCR7 6QZH CXCR4 3ODU
TM3 130 F 3.36x36 CCR7 6QZH CCR7 6QZH
TM3 131 Y 3.37x37 CCR7 6QZH CXCR4 3ODU
TM3 132 S 3.38x38 CCR7 6QZH CCR7 6QZH
TM3 133 G 3.39x39 CCR7 6QZH CCR7 6QZH
TM3 134 I 3.40x40 CCR7 6QZH CCR2 5T1A
TM3 135 L 3.41x41 CCR7 6QZH CCR9 5LWE
TM3 136 L 3.42x42 CCR7 6QZH CCR7 6QZH
TM3 137 L 3.43x43 CCR7 6QZH CCR7 6QZH
TM3 138 A 3.44x44 CCR7 6QZH CXCR4 3ODU
TM3 139 C 3.45x45 CCR7 6QZH CCR7 6QZH
TM3 140 I 3.46x46 CCR7 6QZH CCR7 6QZH
TM3 141 S 3.47x47 CCR7 6QZH CCR7 6QZH
TM3 142 V 3.48x48 CCR7 6QZH CCR9 5LWE
TM3 143 D 3.49x49 CCR7 6QZH CCR7 6QZH
TM3 144 R 3.50x50 CCR7 6QZH CCR7 6QZH
TM3 145 Y 3.51x51 CCR7 6QZH CCR7 6QZH
TM3 146 L 3.52x52 CCR7 6QZH CCR2 5T1A
TM3 147 A 3.53x53 CCR7 6QZH CCR7 6QZH
TM3 148 I 3.54x54 CCR7 6QZH CCR7 6QZH
TM3 149 V 3.55x55 CCR7 6QZH CCR7 6QZH
TM3 150 H 3.56x56 CCR2 5T1A CCR2 5T1A
ICL2 151 A 34.50x50 - - - -
ICL2 152 T 34.51x51 CCR2 5T1A CCR6 6WWZ
ICL2 153 R 34.52x52 CCR2 5T1A CCR9 5LWE
ICL2 154 T 34.53x53 CCR2 5T1A - -
ICL2 155 L 34.54x54 CCR2 5T1A CCR2 5T1A
ICL2 156 T 34.55x55 CCR2 5T1A CCR9 5LWE
ICL2 157 Q 34.56x56 - - - -
TM4 158 K 4.38x38 CCR7 6QZH CXCR4 3ODU
TM4 159 R 4.39x39 CCR7 6QZH apelin receptor 5VBL
TM4 160 Y 4.40x40 CCR7 6QZH - -
TM4 161 L 4.41x41 CCR7 6QZH C5a1 receptor 5O9H
TM4 162 V 4.42x42 CCR7 6QZH ghrelin receptor 6KO5
TM4 163 K 4.43x43 CCR7 6QZH CCR7 6QZH
TM4 164 F 4.44x44 CCR7 6QZH PAR1 3VW7
TM4 165 I 4.45x45 CCR7 6QZH κ receptor 6VI4
TM4 166 C 4.46x46 CCR7 6QZH CCR7 6QZH
TM4 167 L 4.47x47 CCR7 6QZH OX1 receptor 6TO7
TM4 168 S 4.48x48 CCR7 6QZH - -
TM4 169 I 4.49x49 CCR7 6QZH CCR7 6QZH
TM4 170 W 4.50x50 CCR7 6QZH CCR7 6QZH
TM4 171 G 4.51x51 CCR7 6QZH C5a1 receptor 5O9H
TM4 172 L 4.52x52 CCR7 6QZH CCR7 6QZH
TM4 173 S 4.53x53 CCR7 6QZH μ receptor 4DKL
TM4 174 L 4.54x54 CCR7 6QZH CXCR4 3ODU
TM4 175 L 4.55x55 CCR7 6QZH CXCR4 3ODU
TM4 176 L 4.56x56 CCR7 6QZH CCR7 6QZH
TM4 177 A 4.57x57 CCR7 6QZH apelin receptor 5VBL
TM4 178 L 4.58x59 CCR7 6QZH CCR5 5UIW
TM4 179 P 4.59x60 CCR7 6QZH CCR7 6QZH
TM4 180 V 4.60x61 CCR7 6QZH apelin receptor 5VBL
TM4 181 L 4.61x62 CCR7 6QZH CCR7 6QZH
TM4 182 L 4.62x63 CCR7 6QZH CCR7 6QZH
TM4 183 F 4.63x64 CCR7 6QZH CCR2 5T1A
TM4 184 R 4.64x65 CCR2 5T1A AT1 receptor 4ZUD
ECL2 185 R CCR7 6QZH - -
ECL2 186 T CCR7 6QZH - -
ECL2 187 V CCR7 6QZH - -
ECL2 188 Y CCR7 6QZH - -
ECL2 189 S CCR7 6QZH - -
ECL2 190 S CCR7 6QZH CCR7 6QZH
ECL2 191 N CCR7 6QZH - -
ECL2 192 V CCR7 6QZH - -
ECL2 193 S CCR7 6QZH - -
ECL2 194 P CCR7 6QZH - -
ECL2 195 A CCR7 6QZH - -
ECL2 196 C 45.50x50 CCR7 6QZH CCR7 6QZH
ECL2 197 Y 45.51x51 CCR7 6QZH apelin receptor 5VBL
ECL2 198 E 45.52x52 CCR7 6QZH OX2 receptor 5WS3
ECL2 199 D FPR2/ALX 6LW5 FPR2/ALX 6LW5
ECL2 200 M - - - -
ECL2 201 G FPR2/ALX 6LW5 - -
ECL2 202 N FPR2/ALX 6LW5 - -
ECL2 203 N FPR2/ALX 6LW5 - -
ECL2 204 T FPR2/ALX 6LW5 - -
ECL2 205 A FPR2/ALX 6LW5 - -
TM5 206 N 5.33x34 CCR6 6WWZ CysLT1 receptor 6RZ4
TM5 207 W 5.34x35 CCR6 6WWZ CCR6 6WWZ
TM5 208 R 5.35x36 CCR7 6QZH Y1 receptor 5ZBH
TM5 209 M 5.36x37 CCR7 6QZH A2A receptor 3VG9
TM5 210 L 5.37x38 CCR7 6QZH μ receptor 4DKL
TM5 211 L 5.38x39 CCR7 6QZH AT1 receptor 4ZUD
TM5 212 R 5.39x40 CCR7 6QZH FFA1 receptor 5TZY
TM5 213 I 5.40x41 CCR7 6QZH CCR2 5T1A
TM5 214 L 5.41x42 CCR7 6QZH Y1 receptor 5ZBH
TM5 215 P 5.42x43 CCR7 6QZH - -
TM5 216 Q 5.43x44 CCR7 6QZH P2Y12 receptor 4NTJ
TM5 217 S 5.44x45 CCR7 6QZH ETB receptor 5X93
TM5 218 F 5.45x46 CCR7 6QZH μ receptor 4DKL
TM5 219 G 5.46x461 CCR7 6QZH CCR7 6QZH
TM5 220 F 5.47x47 CCR7 6QZH CCR7 6QZH
TM5 221 I 5.48x48 CCR7 6QZH CXCR4 3ODU
TM5 222 V 5.49x49 CCR7 6QZH CCR7 6QZH
TM5 223 P 5.50x50 CCR7 6QZH CCR7 6QZH
TM5 224 L 5.51x51 CCR7 6QZH CCR7 6QZH
TM5 225 L 5.52x52 CCR7 6QZH CCR7 6QZH
TM5 226 I 5.53x53 CCR7 6QZH CCR2 5T1A
TM5 227 M 5.54x54 CCR7 6QZH CCR7 6QZH
TM5 228 L 5.55x55 CCR7 6QZH CXCR4 3ODU
TM5 229 F 5.56x56 CCR7 6QZH CCR7 6QZH
TM5 230 C 5.57x57 CCR7 6QZH CCR7 6QZH
TM5 231 Y 5.58x58 CCR7 6QZH CCR7 6QZH
TM5 232 G 5.59x59 CCR7 6QZH μ receptor 4DKL
TM5 233 F 5.60x60 CCR7 6QZH apelin receptor 5VBL
TM5 234 T 5.61x61 CCR7 6QZH 5-HT2A receptor 6A94
TM5 235 L 5.62x62 CCR7 6QZH CCR5 5UIW
TM5 236 R 5.63x63 CCR6 6WWZ NOP receptor 5DHG
TM5 237 T 5.64x64 CCR6 6WWZ CCR6 6WWZ
TM5 238 L 5.65x65 CCR6 6WWZ CCR6 6WWZ
TM5 239 F 5.66x66 CCR6 6WWZ - -
TM5 240 K 5.67x67 CCR6 6WWZ 5-HT2A receptor 6A94
TM5 241 A 5.68x68 CCR6 6WWZ CCR6 6WWZ
ICL3 242 H - - - -
ICL3 243 M - - - -
ICL3 244 G - - - -
ICL3 245 Q - - - -
TM6 246 K 6.30x30 CCR6 6WWZ CXCR4 3ODU
TM6 247 H 6.31x31 CCR6 6WWZ CCR6 6WWZ
TM6 248 R 6.32x32 CCR6 6WWZ CCR5 5UIW
TM6 249 A 6.33x33 CCR6 6WWZ CCR6 6WWZ
TM6 250 M 6.34x34 CCR6 6WWZ D4 receptor 6IQL
TM6 251 R 6.35x35 CCR7 6QZH CCR2 5T1A
TM6 252 V 6.36x36 CCR7 6QZH CCR7 6QZH
TM6 253 I 6.37x37 CCR7 6QZH CCR7 6QZH
TM6 254 F 6.38x38 CCR7 6QZH CCR2 5T1A
TM6 255 A 6.39x39 CCR7 6QZH CCR7 6QZH
TM6 256 V 6.40x40 CCR7 6QZH CCR7 6QZH
TM6 257 V 6.41x41 CCR7 6QZH CCR7 6QZH
TM6 258 L 6.42x42 CCR7 6QZH CXCR4 3ODU
TM6 259 I 6.43x43 CCR7 6QZH MT2 receptor 6ME6
TM6 260 F 6.44x44 CCR7 6QZH CCR7 6QZH
TM6 261 L 6.45x45 CCR7 6QZH D4 receptor 5WIV
TM6 262 L 6.46x46 CCR7 6QZH CCR2 5T1A
TM6 263 C 6.47x47 CCR7 6QZH CXCR4 3ODU
TM6 264 W 6.48x48 CCR7 6QZH CCR2 5T1A
TM6 265 L 6.49x49 CCR7 6QZH CCR7 6QZH
TM6 266 P 6.50x50 CCR7 6QZH CCR7 6QZH
TM6 267 Y 6.51x51 CCR7 6QZH CCR7 6QZH
TM6 268 N 6.52x52 CCR7 6QZH CCR7 6QZH
TM6 269 L 6.53x53 CCR7 6QZH apelin receptor 5VBL
TM6 270 V 6.54x54 CCR7 6QZH CCR7 6QZH
TM6 271 L 6.55x55 CCR7 6QZH CCR5 5UIW
TM6 272 L 6.56x56 CCR7 6QZH CCR7 6QZH
TM6 273 A 6.57x57 CCR7 6QZH CCR7 6QZH
TM6 274 D 6.58x58 CCR7 6QZH CXCR4 3ODU
TM6 275 T 6.59x59 CCR2 5T1A CCR2 5T1A
TM6 276 L 6.60x60 CCR2 5T1A AT1 receptor 4ZUD
TM6 277 M 6.61x61 CCR2 5T1A - -
TM6 278 R 6.62x62 CCR2 5T1A α2C-adrenoceptor 6KUW
TM6 279 T 6.63x63 CCR2 5T1A LPA6 receptor 5XSZ
TM6 280 Q 6.64x64 CCR2 5T1A - -
ECL3 281 V - - - -
ECL3 282 I - - - -
ECL3 283 Q - - - -
ECL3 284 E - - - -
TM7 285 T 7.24x23 CCR6 6WWZ NTS1 receptor 4BUO
TM7 286 C 7.25x24 CCR7 6QZH CCR7 6QZH
TM7 287 E 7.26x25 CCR7 6QZH CCR7 6QZH
TM7 288 R 7.27x26 CCR7 6QZH - -
TM7 289 R 7.28x27 CCR7 6QZH OX2 receptor 5WS3
TM7 290 N 7.29x28 CCR7 6QZH CCR5 5UIW
TM7 291 H 7.30x29 CCR7 6QZH - -
TM7 292 I 7.31x30 CCR7 6QZH CCR9 5LWE
TM7 293 D 7.32x31 CCR7 6QZH CCR2 5T1A
TM7 294 R 7.33x32 CCR7 6QZH D4 receptor 5WIU
TM7 295 A 7.34x33 CCR7 6QZH CCR7 6QZH
TM7 296 L 7.35x34 CCR7 6QZH NOP receptor 5DHG
TM7 297 D 7.36x35 CCR7 6QZH CCR7 6QZH
TM7 298 A 7.37x36 CCR7 6QZH D4 receptor 5WIV
TM7 299 T 7.38x37 CCR7 6QZH CCR7 6QZH
TM7 300 E 7.39x38 CCR7 6QZH CCR2 5T1A
TM7 301 I 7.40x39 CCR7 6QZH MC4 receptor 6W25
TM7 302 L 7.41x40 CCR7 6QZH CCR7 6QZH
TM7 303 G 7.42x41 CCR7 6QZH CCR2 5T1A
TM7 304 I 7.43x42 CCR7 6QZH GPR52 6LI1
TM7 305 L 7.44x43 CCR7 6QZH BLT1 receptor 5X33
TM7 306 H 7.45x45 CCR7 6QZH CCR2 5T1A
TM7 307 S 7.46x46 CCR7 6QZH CCR9 5LWE
TM7 308 C 7.47x47 CCR7 6QZH CCR7 6QZH
TM7 309 L 7.48x48 CCR7 6QZH CXCR4 3ODU
TM7 310 N 7.49x49 CCR7 6QZH CCR7 6QZH
TM7 311 P 7.50x50 CCR7 6QZH CCR7 6QZH
TM7 312 L 7.51x51 CCR7 6QZH AT1 receptor 4ZUD
TM7 313 I 7.52x52 CCR7 6QZH CCR2 5T1A
TM7 314 Y 7.53x53 CCR7 6QZH CCR7 6QZH
TM7 315 A 7.54x54 CCR7 6QZH CCR7 6QZH
TM7 316 F 7.55x55 CCR7 6QZH CCR7 6QZH
TM7 317 I 7.56x56 CCR6 6WWZ CCR6 6WWZ
H8 318 G 8.47x47 CCR6 6WWZ CCR6 6WWZ
H8 319 Q 8.48x48 CCR6 6WWZ CCR6 6WWZ
H8 320 K 8.49x49 CCR7 6QZH CCR7 6QZH
H8 321 F 8.50x50 CCR7 6QZH CCR7 6QZH
H8 322 R 8.51x51 CCR7 6QZH CCR7 6QZH
H8 323 H 8.52x52 CCR7 6QZH CB1 receptor 5TGZ
H8 324 G 8.53x53 CCR7 6QZH NK1 receptor 6HLP
H8 325 L 8.54x54 CCR7 6QZH CCR2 5T1A
H8 326 L 8.55x55 CCR7 6QZH CCR5 5UIW
H8 327 K 8.56x56 CCR7 6QZH CCR9 5LWE
H8 328 I 8.57x57 CCR7 6QZH α2A-adrenoceptor 6KUX
H8 329 L 8.58x58 CCR7 6QZH CCR9 5LWE
H8 330 A 8.59x59 CCR6 6WWZ CB2 receptor 5ZTY
C-term 331 I - - - -
C-term 332 H - - - -
C-term 333 G - - - -
C-term 334 L - - - -
C-term 335 I - - - -