CXCR3 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

CXCR3

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-02-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

CXCR2 (sequence similarity: 61%) PDB: 6LFO
Align

TEMPLATES

6LFO (CXCR2)
6LFL (CXCR2)
3ODU (CXCR4)
6WWZ (CCR6)
6QZH (CCR7)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 90.2 5.4 4.4
Side-chains 41.1 44.4 14.5

Number of backbone templates: 5
Number of rotamer templates: 39

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 45 Q CXCR2 6LFO CXCR2 6LFO
N-term 46 D CXCR2 6LFO CXCR2 6LFO
N-term 47 F CXCR2 6LFO CXCR2 6LFO
N-term 48 S CXCR2 6LFO CXCR2 6LFO
N-term 49 L CXCR2 6LFO CXCR2 6LFO
TM1 50 N 1.29x29 CXCR2 6LFO AT1 receptor 6OS2
TM1 51 F 1.30x30 CXCR2 6LFO CCR6 6WWZ
TM1 52 D 1.31x31 CXCR2 6LFO - -
TM1 53 R 1.32x32 CXCR2 6LFO CCR6 6WWZ
TM1 54 A 1.33x33 CXCR2 6LFO M1 receptor 6OIJ
TM1 55 F 1.34x34 CXCR2 6LFO CXCR2 6LFO
TM1 56 L 1.35x35 CXCR2 6LFO Rhodopsin 4ZWJ
TM1 57 P 1.36x36 CXCR2 6LFO CCR6 6WWZ
TM1 58 A 1.37x37 CXCR2 6LFO μ receptor 5C1M
TM1 59 L 1.38x38 CXCR2 6LFO AT2 receptor 6JOD
TM1 60 Y 1.39x39 CXCR2 6LFO CXCR2 6LFO
TM1 61 S 1.40x40 CXCR2 6LFO CCR6 6WWZ
TM1 62 L 1.41x41 CXCR2 6LFO CXCR2 6LFO
TM1 63 L 1.42x42 CXCR2 6LFO NTS1 receptor 6OSA
TM1 64 F 1.43x43 CXCR2 6LFO CXCR2 6LFO
TM1 65 L 1.44x44 CXCR2 6LFO CXCR2 6LFO
TM1 66 L 1.45x45 CXCR2 6LFO CXCR2 6LFO
TM1 67 G 1.46x46 CXCR2 6LFO CCR6 6WWZ
TM1 68 L 1.47x47 CXCR2 6LFO CXCR2 6LFO
TM1 69 L 1.48x48 CXCR2 6LFO CXCR2 6LFO
TM1 70 G 1.49x49 CXCR2 6LFO CXCR2 6LFO
TM1 71 N 1.50x50 CXCR2 6LFO CXCR2 6LFO
TM1 72 G 1.51x51 CXCR2 6LFO FPR2/ALX 6LW5
TM1 73 A 1.52x52 CXCR2 6LFO CB2 receptor 6PT0
TM1 74 V 1.53x53 CXCR2 6LFO CXCR2 6LFO
TM1 75 A 1.54x54 CXCR2 6LFO NTS1 receptor 6PWC
TM1 76 A 1.55x55 CXCR2 6LFO 5-HT1B receptor 6G79
TM1 77 V 1.56x56 CXCR2 6LFO CXCR2 6LFO
TM1 78 L 1.57x57 CXCR2 6LFO NTS1 receptor 6OSA
TM1 79 L 1.58x58 CXCR2 6LFO CXCR2 6LFO
TM1 80 S 1.59x59 CXCR2 6LFO CB2 receptor 6PT0
TM1 81 R 1.60x60 CXCR4 3ODU US28 4XT1
ICL1 82 R 12.48x48 - - - -
ICL1 83 T 12.49x49 CCR6 6WWZ - -
ICL1 84 A 12.50x50 CCR6 6WWZ CCR6 6WWZ
ICL1 85 L 12.51x51 - - - -
TM2 86 S 2.37x37 CXCR2 6LFL CXCR2 6LFL
TM2 87 S 2.38x38 CXCR2 6LFO US28 5WB1
TM2 88 T 2.39x39 CXCR2 6LFO CXCR2 6LFO
TM2 89 D 2.40x40 CXCR2 6LFO CXCR2 6LFO
TM2 90 T 2.41x41 CXCR2 6LFO EP4 receptor 7D7M
TM2 91 F 2.42x42 CXCR2 6LFO AT1 receptor 6OS2
TM2 92 L 2.43x43 CXCR2 6LFO CXCR2 6LFO
TM2 93 L 2.44x44 CXCR2 6LFO CXCR2 6LFO
TM2 94 H 2.45x45 CXCR2 6LFO CXCR4 3ODU
TM2 95 L 2.46x46 CXCR2 6LFO CXCR2 6LFO
TM2 96 A 2.47x47 CXCR2 6LFO CXCR2 6LFO
TM2 97 V 2.48x48 CXCR2 6LFO AT2 receptor 6JOD
TM2 98 A 2.49x49 CXCR2 6LFO CXCR2 6LFO
TM2 99 D 2.50x50 CXCR2 6LFO CXCR2 6LFO
TM2 100 T 2.51x51 CXCR2 6LFO NOP receptor 5DHG
TM2 101 L 2.52x52 CXCR2 6LFO CXCR2 6LFO
TM2 102 L 2.53x53 CXCR2 6LFO AT2 receptor 6JOD
TM2 103 V 2.54x54 CXCR2 6LFO CCR6 6WWZ
TM2 104 L 2.55x55 CXCR2 6LFO CXCR2 6LFO
TM2 105 T 2.56x56 CXCR2 6LFO CXCR2 6LFO
TM2 106 L 2.57x57 CXCR2 6LFO CXCR2 6LFO
TM2 107 P 2.58x58 CXCR2 6LFO CXCR2 6LFO
TM2 108 L 2.59x59 CXCR2 6LFO AT2 receptor 6JOD
TM2 109 W 2.60x60 CXCR2 6LFO CXCR2 6LFO
TM2 110 A 2.61x61 CXCR2 6LFO CXCR2 6LFO
TM2 111 V 2.62x62 CXCR2 6LFO CCR6 6WWZ
TM2 112 D 2.63x63 CXCR2 6LFO δ receptor 6PT2
TM2 113 A 2.64x64 CXCR2 6LFO CCR7 6QZH
TM2 114 A 2.65x65 CXCR2 6LFO CCR6 6WWZ
TM2 115 V 2.66x66 CXCR2 6LFO CB2 receptor 6PT0
ECL1 116 Q 23.49x49 - - - -
ECL1 117 W 23.50x50 CXCR2 6LFL CXCR2 6LFL
ECL1 118 V 23.51x51 CXCR2 6LFL CCR6 6WWZ
ECL1 119 F 23.52x52 - - - -
TM3 120 G 3.21x21 CXCR2 6LFL CXCR2 6LFL
TM3 121 S 3.22x22 CXCR2 6LFO US28 5WB1
TM3 122 G 3.23x23 CXCR2 6LFO - -
TM3 123 L 3.24x24 CXCR2 6LFO CXCR2 6LFO
TM3 124 C 3.25x25 CXCR2 6LFO CXCR2 6LFO
TM3 125 K 3.26x26 CXCR2 6LFO CCR6 6WWZ
TM3 126 V 3.27x27 CXCR2 6LFO CXCR2 6LFO
TM3 127 A 3.28x28 CXCR2 6LFO AT1 receptor 6OS2
TM3 128 G 3.29x29 CXCR2 6LFO AT2 receptor 6JOD
TM3 129 A 3.30x30 CXCR2 6LFO AT1 receptor 6OS2
TM3 130 L 3.31x31 CXCR2 6LFO CXCR2 6LFO
TM3 131 F 3.32x32 CXCR2 6LFO US28 5WB1
TM3 132 N 3.33x33 CXCR2 6LFO GPBA receptor 7CFN
TM3 133 I 3.34x34 CXCR2 6LFO CCR6 6WWZ
TM3 134 N 3.35x35 CXCR2 6LFO CXCR2 6LFO
TM3 135 F 3.36x36 CXCR2 6LFO CXCR2 6LFO
TM3 136 Y 3.37x37 CXCR2 6LFO CXCR2 6LFO
TM3 137 A 3.38x38 CXCR2 6LFO AT2 receptor 6JOD
TM3 138 G 3.39x39 CXCR2 6LFO CXCR2 6LFO
TM3 139 A 3.40x40 CXCR2 6LFO NTS1 receptor 6OSA
TM3 140 L 3.41x41 CXCR2 6LFO CXCR2 6LFO
TM3 141 L 3.42x42 CXCR2 6LFO CXCR2 6LFO
TM3 142 L 3.43x43 CXCR2 6LFO CXCR2 6LFO
TM3 143 A 3.44x44 CXCR2 6LFO CXCR2 6LFO
TM3 144 C 3.45x45 CXCR2 6LFO CXCR2 6LFO
TM3 145 I 3.46x46 CXCR2 6LFO CXCR2 6LFO
TM3 146 S 3.47x47 CXCR2 6LFO CXCR2 6LFO
TM3 147 F 3.48x48 CXCR2 6LFO M2 receptor 4MQT
TM3 148 D 3.49x49 CXCR2 6LFO CXCR2 6LFO
TM3 149 R 3.50x50 CXCR2 6LFO CXCR2 6LFO
TM3 150 Y 3.51x51 CXCR2 6LFO CXCR2 6LFO
TM3 151 L 3.52x52 CXCR2 6LFO CXCR2 6LFO
TM3 152 N 3.53x53 CXCR2 6LFO - -
TM3 153 I 3.54x54 CXCR2 6LFO CXCR2 6LFO
TM3 154 V 3.55x55 CXCR2 6LFO CXCR2 6LFO
TM3 155 H 3.56x56 CXCR2 6LFO CXCR2 6LFO
ICL2 156 A 34.50x50 CXCR2 6LFO CXCR2 6LFO
ICL2 157 T 34.51x51 CXCR2 6LFO CXCR2 6LFO
ICL2 158 Q 34.52x52 CXCR2 6LFO CysLT1 receptor 6RZ5
ICL2 159 L 34.53x53 CXCR2 6LFO - -
ICL2 160 Y 34.54x54 CXCR2 6LFO - -
ICL2 161 R 34.55x55 CXCR2 6LFO CCR6 6WWZ
ICL2 162 R 34.56x56 CXCR2 6LFO AT1 receptor 6OS2
ICL2 163 G 34.57x57 CXCR2 6LFO - -
TM4 164 P 4.38x38 CCR7 6QZH - -
TM4 165 P 4.39x39 CCR7 6QZH AT2 receptor 6JOD
TM4 166 A 4.40x40 CCR7 6QZH δ receptor 6PT2
TM4 167 R 4.41x41 CXCR2 6LFO CCR6 6WWZ
TM4 168 V 4.42x42 CXCR2 6LFO CXCR2 6LFO
TM4 169 T 4.43x43 CXCR2 6LFO D2 receptor 6VMS
TM4 170 L 4.44x44 CXCR2 6LFO US28 5WB1
TM4 171 T 4.45x45 CXCR2 6LFO AT1 receptor 6OS2
TM4 172 C 4.46x46 CXCR2 6LFO CXCR2 6LFO
TM4 173 L 4.47x47 CXCR2 6LFO CXCR2 6LFO
TM4 174 A 4.48x48 CXCR2 6LFO NTS1 receptor 6OSA
TM4 175 V 4.49x49 CXCR2 6LFO CCR6 6WWZ
TM4 176 W 4.50x50 CXCR2 6LFO CXCR2 6LFO
TM4 177 G 4.51x51 CXCR2 6LFO CXCR2 6LFO
TM4 178 L 4.52x52 CXCR2 6LFO CXCR2 6LFO
TM4 179 C 4.53x53 CXCR2 6LFO OT receptor 6TPK
TM4 180 L 4.54x54 CXCR2 6LFO CXCR2 6LFO
TM4 181 L 4.55x55 CXCR2 6LFO CXCR2 6LFO
TM4 182 F 4.56x56 CXCR2 6LFO EP4 receptor 7D7M
TM4 183 A 4.57x57 CXCR2 6LFO CXCR2 6LFO
TM4 184 L 4.58x59 CXCR2 6LFO CXCR2 6LFO
TM4 185 P 4.59x60 CXCR2 6LFO CXCR2 6LFO
TM4 186 D 4.60x61 CXCR2 6LFO CXCR4 3ODU
TM4 187 F 4.61x62 CXCR2 6LFO CCR6 6WWZ
TM4 188 I 4.62x63 CXCR2 6LFO AT1 receptor 6OS2
TM4 189 F 4.63x64 CXCR2 6LFL CXCR2 6LFL
TM4 190 L 4.64x65 CXCR2 6LFL FPR2/ALX 6LW5
ECL2 191 S CXCR2 6LFO - -
ECL2 192 A CXCR2 6LFO - -
ECL2 193 H CXCR2 6LFO - -
ECL2 194 H CXCR2 6LFO - -
ECL2 195 D CXCR2 6LFO - -
ECL2 196 E CXCR2 6LFO - -
ECL2 197 R CXCR2 6LFO - -
ECL2 198 L CXCR2 6LFO - -
ECL2 199 N CXCR2 6LFO - -
ECL2 200 A CXCR2 6LFO - -
ECL2 201 T CXCR2 6LFO - -
ECL2 202 H - - - -
ECL2 203 C 45.50x50 CXCR2 6LFO CXCR2 6LFO
ECL2 204 Q 45.51x51 CXCR2 6LFO M5 receptor 6OL9
ECL2 205 Y 45.52x52 CXCR2 6LFO DP2 receptor 6D27
ECL2 206 N - - - -
TM5 207 F 5.30x31 CXCR2 6LFO ETB receptor 5X93
TM5 208 P 5.31x32 CXCR2 6LFO CCR6 6WWZ
TM5 209 Q 5.32x33 CXCR2 6LFO CCR5 5UIW
TM5 210 V 5.33x34 CXCR2 6LFO PAF receptor 5ZKQ
TM5 211 G 5.34x35 CXCR2 6LFO EP3 receptor 6M9T
TM5 212 R 5.35x36 CXCR2 6LFO CXCR2 6LFO
TM5 213 T 5.36x37 CXCR2 6LFO FPR2/ALX 6LW5
TM5 214 A 5.37x38 CXCR2 6LFO FPR2/ALX 6LW5
TM5 215 L 5.38x39 CXCR2 6LFO CXCR2 6LFO
TM5 216 R 5.39x40 CXCR2 6LFO CXCR2 6LFO
TM5 217 V 5.40x41 CXCR2 6LFO US28 5WB1
TM5 218 L 5.41x42 CXCR2 6LFO CXCR2 6LFO
TM5 219 Q 5.42x43 CXCR2 6LFO CCR7 6QZH
TM5 220 L 5.43x44 CXCR2 6LFO CCR6 6WWZ
TM5 221 V 5.44x45 CXCR2 6LFO FPR2/ALX 6LW5
TM5 222 A 5.45x46 CXCR2 6LFO M2 receptor 4MQT
TM5 223 G 5.46x461 CXCR2 6LFO CXCR2 6LFO
TM5 224 F 5.47x47 CXCR2 6LFO CXCR2 6LFO
TM5 225 L 5.48x48 CXCR2 6LFO AT1 receptor 6OS2
TM5 226 L 5.49x49 CXCR2 6LFO FPR2/ALX 6LW5
TM5 227 P 5.50x50 CXCR2 6LFO CXCR2 6LFO
TM5 228 L 5.51x51 CXCR2 6LFO CXCR2 6LFO
TM5 229 L 5.52x52 CXCR2 6LFO CXCR2 6LFO
TM5 230 V 5.53x53 CXCR2 6LFO US28 5WB1
TM5 231 M 5.54x54 CXCR2 6LFO CXCR2 6LFO
TM5 232 A 5.55x55 CXCR2 6LFO AT2 receptor 6JOD
TM5 233 Y 5.56x56 CXCR2 6LFO US28 5WB1
TM5 234 C 5.57x57 CXCR2 6LFO CXCR2 6LFO
TM5 235 Y 5.58x58 CXCR2 6LFO CXCR2 6LFO
TM5 236 A 5.59x59 CXCR2 6LFO LPA6 receptor 5XSZ
TM5 237 H 5.60x60 CXCR2 6LFO M2 receptor 4MQT
TM5 238 I 5.61x61 CXCR2 6LFO CCR6 6WWZ
TM5 239 L 5.62x62 CXCR2 6LFO CXCR2 6LFO
TM5 240 A 5.63x63 CXCR2 6LFO FPR2/ALX 6LW5
TM5 241 V 5.64x64 CXCR2 6LFO D2 receptor 6VMS
TM5 242 L 5.65x65 CXCR2 6LFO CXCR2 6LFO
TM5 243 L 5.66x66 CXCR2 6LFO AT2 receptor 6JOD
TM5 244 V 5.67x67 CXCR2 6LFO US28 5WB1
TM5 245 S 5.68x68 CXCR2 6LFO US28 5WB1
ICL3 246 R CXCR2 6LFO - -
ICL3 247 G CXCR2 6LFO - -
ICL3 248 Q CXCR2 6LFO - -
TM6 249 R 6.29x29 CXCR2 6LFO α2B-adrenoceptor 6K41
TM6 250 R 6.30x30 CXCR2 6LFO CCR6 6WWZ
TM6 251 L 6.31x31 CXCR2 6LFO A1 receptor 6D9H
TM6 252 R 6.32x32 CXCR2 6LFO CXCR2 6LFO
TM6 253 A 6.33x33 CXCR2 6LFO CXCR2 6LFO
TM6 254 M 6.34x34 CXCR2 6LFO CXCR2 6LFO
TM6 255 R 6.35x35 CXCR2 6LFO CXCR2 6LFO
TM6 256 L 6.36x36 CXCR2 6LFO κ receptor 6B73
TM6 257 V 6.37x37 CXCR2 6LFO μ receptor 5C1M
TM6 258 V 6.38x38 CXCR2 6LFO CB1 receptor 6N4B
TM6 259 V 6.39x39 CXCR2 6LFO μ receptor 5C1M
TM6 260 V 6.40x40 CXCR2 6LFO CXCR2 6LFO
TM6 261 V 6.41x41 CXCR2 6LFO CXCR2 6LFO
TM6 262 V 6.42x42 CXCR2 6LFO δ receptor 6PT2
TM6 263 A 6.43x43 CXCR2 6LFO AT2 receptor 6JOD
TM6 264 F 6.44x44 CXCR2 6LFO CXCR2 6LFO
TM6 265 A 6.45x45 CXCR2 6LFO A1 receptor 6D9H
TM6 266 L 6.46x46 CXCR2 6LFO CXCR2 6LFO
TM6 267 C 6.47x47 CXCR2 6LFO CXCR2 6LFO
TM6 268 W 6.48x48 CXCR2 6LFO CXCR2 6LFO
TM6 269 T 6.49x49 CXCR2 6LFO μ receptor 5C1M
TM6 270 P 6.50x50 CXCR2 6LFO CXCR2 6LFO
TM6 271 Y 6.51x51 CXCR2 6LFO CXCR2 6LFO
TM6 272 H 6.52x52 CXCR2 6LFO AT2 receptor 6JOD
TM6 273 L 6.53x53 CXCR2 6LFO CXCR2 6LFO
TM6 274 V 6.54x54 CXCR2 6LFO CXCR2 6LFO
TM6 275 V 6.55x55 CXCR2 6LFO μ receptor 5C1M
TM6 276 L 6.56x56 CXCR2 6LFO CXCR2 6LFO
TM6 277 V 6.57x57 CXCR2 6LFO CCR6 6WWZ
TM6 278 D 6.58x58 CXCR2 6LFO CXCR2 6LFO
TM6 279 I 6.59x59 CXCR2 6LFO D2 receptor 6VMS
TM6 280 L 6.60x60 CXCR2 6LFO CXCR2 6LFO
TM6 281 M 6.61x61 CXCR2 6LFO CXCR2 6LFO
TM6 282 D 6.62x62 CXCR2 6LFO - -
TM6 283 L 6.63x63 CXCR4 3ODU CXCR4 3ODU
TM6 284 G 6.64x64 CXCR4 3ODU AT2 receptor 6JOD
ECL3 285 A - - - -
ECL3 286 L CXCR4 3ODU - -
ECL3 287 A CXCR4 3ODU - -
ECL3 288 R - - - -
TM7 289 N 7.24x23 CXCR2 6LFO CCR5 5UIW
TM7 290 C 7.25x24 CXCR2 6LFO CXCR2 6LFO
TM7 291 G 7.26x25 CXCR2 6LFO - -
TM7 292 R 7.27x26 CXCR2 6LFO CXCR2 6LFO
TM7 293 E 7.28x27 CXCR2 6LFO CCR6 6WWZ
TM7 294 S 7.29x28 CXCR2 6LFO CCR2 5T1A
TM7 295 R 7.30x29 CXCR2 6LFO CCR5 5UIW
TM7 296 V 7.31x30 CXCR2 6LFO AT1 receptor 6OS2
TM7 297 D 7.32x31 CXCR2 6LFO CXCR2 6LFO
TM7 298 V 7.33x32 CXCR2 6LFO μ receptor 5C1M
TM7 299 A 7.34x33 CXCR2 6LFO CXCR2 6LFO
TM7 300 K 7.35x34 CXCR2 6LFO CCR6 6WWZ
TM7 301 S 7.36x35 CXCR2 6LFO D2 receptor 6VMS
TM7 302 V 7.37x36 CXCR2 6LFO CCR6 6WWZ
TM7 303 T 7.38x37 CXCR2 6LFO CXCR2 6LFO
TM7 304 S 7.39x38 CXCR2 6LFO FPR2/ALX 6LW5
TM7 305 G 7.40x39 CXCR2 6LFO P2Y1 receptor 4XNW
TM7 306 L 7.41x40 CXCR2 6LFO CXCR2 6LFO
TM7 307 G 7.42x41 CXCR2 6LFO CXCR2 6LFO
TM7 308 Y 7.43x42 CXCR2 6LFO AT1 receptor 6OS2
TM7 309 M 7.44x43 CXCR2 6LFO - -
TM7 310 H 7.45x45 CXCR2 6LFO CXCR2 6LFO
TM7 311 C 7.46x46 CXCR2 6LFO CCR6 6WWZ
TM7 312 C 7.47x47 CXCR2 6LFO CXCR2 6LFO
TM7 313 L 7.48x48 CXCR2 6LFO CXCR2 6LFO
TM7 314 N 7.49x49 CXCR2 6LFO CXCR2 6LFO
TM7 315 P 7.50x50 CXCR2 6LFO CXCR2 6LFO
TM7 316 L 7.51x51 CXCR2 6LFO CXCR2 6LFO
TM7 317 L 7.52x52 CXCR2 6LFO CCR6 6WWZ
TM7 318 Y 7.53x53 CXCR2 6LFO CXCR2 6LFO
TM7 319 A 7.54x54 CXCR2 6LFO CXCR2 6LFO
TM7 320 F 7.55x55 CXCR2 6LFO CXCR2 6LFO
TM7 321 V 7.56x56 CXCR2 6LFO AT2 receptor 6JOD
H8 322 G 8.47x47 CXCR2 6LFO CXCR2 6LFO
H8 323 V 8.48x48 CXCR2 6LFO - -
H8 324 K 8.49x49 CXCR2 6LFO CXCR2 6LFO
H8 325 F 8.50x50 CXCR2 6LFO CXCR2 6LFO
H8 326 R 8.51x51 CXCR2 6LFO CXCR2 6LFO
H8 327 E 8.52x52 CXCR2 6LFO FPR2/ALX 6LW5
H8 328 R 8.53x53 CXCR2 6LFO FPR2/ALX 6LW5
H8 329 M 8.54x54 CXCR2 6LFO Rhodopsin 4ZWJ
H8 330 W 8.55x55 CXCR2 6LFO - -
H8 331 M 8.56x56 CXCR2 6LFO M5 receptor 6OL9
H8 332 L 8.57x57 CXCR2 6LFO AT1 receptor 6OS2
H8 333 L 8.58x58 CXCR2 6LFO CXCR2 6LFO
H8 334 L 8.59x59 CXCR2 6LFO apelin receptor 5VBL
H8 335 R 8.60x60 CXCR2 6LFO - -
H8 336 L 8.61x61 CXCR2 6LFO CCR6 6WWZ
C-term 337 G - - - -
C-term 338 C - - - -
C-term 339 P - - - -
C-term 340 N - - - -
C-term 341 Q - - - -