CXCR3 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive

VERSION

2020-09-02

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

CCR7 (sequence similarity: 61%) PDB: 6QZH

TEMPLATES

3ODU (CXCR4)
6QZH (CCR7)
5T1A (CCR2)
6WWZ (CCR6)
5UIW (CCR5)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 80.3 13.9 5.8
Side-chains 32.5 52.2 15.3

Number of backbone templates: 5
Number of rotamer templates: 41

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 45 Q CXCR4 3ODU CXCR4 3ODU
N-term 46 D CXCR4 3ODU CXCR4 3ODU
N-term 47 F CXCR4 3ODU CXCR4 3ODU
N-term 48 S CXCR4 3ODU CXCR4 3ODU
N-term 49 L CXCR4 3ODU CXCR4 3ODU
TM1 50 N 1.29x29 CXCR4 3ODU CXCR4 3ODU
TM1 51 F 1.30x30 CCR7 6QZH CCR7 6QZH
TM1 52 D 1.31x31 CCR7 6QZH - -
TM1 53 R 1.32x32 CCR7 6QZH CCR6 6WWZ
TM1 54 A 1.33x33 CCR7 6QZH apelin receptor 5VBL
TM1 55 F 1.34x34 CCR7 6QZH CCR7 6QZH
TM1 56 L 1.35x35 CCR7 6QZH CCR7 6QZH
TM1 57 P 1.36x36 CCR7 6QZH CCR7 6QZH
TM1 58 A 1.37x37 CCR7 6QZH apelin receptor 5VBL
TM1 59 L 1.38x38 CCR7 6QZH CCR2 5T1A
TM1 60 Y 1.39x39 CCR7 6QZH CCR7 6QZH
TM1 61 S 1.40x40 CCR7 6QZH CCR7 6QZH
TM1 62 L 1.41x41 CCR7 6QZH CCR2 5T1A
TM1 63 L 1.42x42 CCR7 6QZH ghrelin receptor 6KO5
TM1 64 F 1.43x43 CCR7 6QZH CXCR4 3ODU
TM1 65 L 1.44x44 CCR7 6QZH CXCR4 3ODU
TM1 66 L 1.45x45 CCR7 6QZH apelin receptor 5VBL
TM1 67 G 1.46x46 CCR7 6QZH CCR7 6QZH
TM1 68 L 1.47x47 CCR7 6QZH CCR7 6QZH
TM1 69 L 1.48x48 CCR7 6QZH CCR7 6QZH
TM1 70 G 1.49x49 CCR7 6QZH CCR7 6QZH
TM1 71 N 1.50x50 CCR7 6QZH CCR7 6QZH
TM1 72 G 1.51x51 CCR7 6QZH CCR7 6QZH
TM1 73 A 1.52x52 CCR7 6QZH Y1 receptor 5ZBH
TM1 74 V 1.53x53 CCR7 6QZH CCR7 6QZH
TM1 75 A 1.54x54 CCR7 6QZH NTS1 receptor 6PWC
TM1 76 A 1.55x55 CCR7 6QZH 5-HT1B receptor 4IAQ
TM1 77 V 1.56x56 CCR7 6QZH CXCR4 3ODU
TM1 78 L 1.57x57 CCR7 6QZH CCR2 5T1A
TM1 79 L 1.58x58 CCR7 6QZH NOP receptor 5DHG
TM1 80 S 1.59x59 CCR7 6QZH CB2 receptor 5ZTY
TM1 81 R 1.60x60 CXCR4 3ODU DP2 receptor 6D27
ICL1 82 R 12.48x48 CCR7 6QZH ghrelin receptor 6KO5
ICL1 83 T 12.49x49 CCR7 6QZH - -
ICL1 84 A 12.50x50 CCR7 6QZH CCR6 6WWZ
ICL1 85 L 12.51x51 CCR7 6QZH - -
TM2 86 S 2.37x37 CCR7 6QZH CXCR4 3ODU
TM2 87 S 2.38x38 CCR7 6QZH apelin receptor 5VBL
TM2 88 T 2.39x39 CCR7 6QZH CCR7 6QZH
TM2 89 D 2.40x40 CCR7 6QZH CCR7 6QZH
TM2 90 T 2.41x41 CCR7 6QZH CCR7 6QZH
TM2 91 F 2.42x42 CCR7 6QZH CCR9 5LWE
TM2 92 L 2.43x43 CCR7 6QZH CCR7 6QZH
TM2 93 L 2.44x44 CCR7 6QZH CCR7 6QZH
TM2 94 H 2.45x45 CCR7 6QZH CXCR4 3ODU
TM2 95 L 2.46x46 CCR7 6QZH CCR7 6QZH
TM2 96 A 2.47x47 CCR7 6QZH CCR7 6QZH
TM2 97 V 2.48x48 CCR7 6QZH CCR7 6QZH
TM2 98 A 2.49x49 CCR7 6QZH CCR7 6QZH
TM2 99 D 2.50x50 CCR7 6QZH CCR7 6QZH
TM2 100 T 2.51x51 CCR7 6QZH NOP receptor 5DHG
TM2 101 L 2.52x52 CCR7 6QZH CCR7 6QZH
TM2 102 L 2.53x53 CCR7 6QZH 5-HT2A receptor 6A94
TM2 103 V 2.54x54 CCR7 6QZH CXCR4 3ODU
TM2 104 L 2.55x55 CCR7 6QZH CCR7 6QZH
TM2 105 T 2.56x56 CCR7 6QZH CCR7 6QZH
TM2 106 L 2.57x57 CCR7 6QZH CCR7 6QZH
TM2 107 P 2.58x58 CCR7 6QZH CCR7 6QZH
TM2 108 L 2.59x59 CCR7 6QZH CCR2 5T1A
TM2 109 W 2.60x60 CCR7 6QZH CCR7 6QZH
TM2 110 A 2.61x61 CCR7 6QZH CCR7 6QZH
TM2 111 V 2.62x62 CCR7 6QZH CXCR4 3ODU
TM2 112 D 2.63x63 CCR7 6QZH CXCR4 3ODU
TM2 113 A 2.64x64 CCR7 6QZH CCR7 6QZH
TM2 114 A 2.65x65 CCR7 6QZH CCR7 6QZH
TM2 115 V 2.66x66 CCR7 6QZH DP2 receptor 6D26
ECL1 116 Q 23.49x49 CCR7 6QZH CCR5 5UIW
ECL1 117 W 23.50x50 CCR7 6QZH CCR7 6QZH
ECL1 118 V 23.51x51 CCR7 6QZH CCR7 6QZH
ECL1 119 F 23.52x52 CCR7 6QZH CCR7 6QZH
TM3 120 G 3.21x21 CCR7 6QZH CCR7 6QZH
TM3 121 S 3.22x22 CCR7 6QZH 5-HT2A receptor 6A94
TM3 122 G 3.23x23 CCR7 6QZH - -
TM3 123 L 3.24x24 CCR7 6QZH CXCR4 3ODU
TM3 124 C 3.25x25 CCR7 6QZH CCR7 6QZH
TM3 125 K 3.26x26 CCR7 6QZH CCR7 6QZH
TM3 126 V 3.27x27 CCR7 6QZH CCR9 5LWE
TM3 127 A 3.28x28 CCR7 6QZH AT1 receptor 4ZUD
TM3 128 G 3.29x29 CCR7 6QZH Rhodopsin 1GZM
TM3 129 A 3.30x30 CCR7 6QZH CCR7 6QZH
TM3 130 L 3.31x31 CCR7 6QZH CCR2 5T1A
TM3 131 F 3.32x32 CCR7 6QZH DP2 receptor 6D27
TM3 132 N 3.33x33 CCR7 6QZH - -
TM3 133 I 3.34x34 CCR7 6QZH CCR2 5T1A
TM3 134 N 3.35x35 CCR7 6QZH CXCR4 3ODU
TM3 135 F 3.36x36 CCR7 6QZH CCR7 6QZH
TM3 136 Y 3.37x37 CCR7 6QZH CXCR4 3ODU
TM3 137 A 3.38x38 CCR7 6QZH AT1 receptor 4ZUD
TM3 138 G 3.39x39 CCR7 6QZH CCR7 6QZH
TM3 139 A 3.40x40 CCR7 6QZH apelin receptor 5VBL
TM3 140 L 3.41x41 CCR7 6QZH CCR9 5LWE
TM3 141 L 3.42x42 CCR7 6QZH CCR7 6QZH
TM3 142 L 3.43x43 CCR7 6QZH CCR7 6QZH
TM3 143 A 3.44x44 CCR7 6QZH CXCR4 3ODU
TM3 144 C 3.45x45 CCR7 6QZH CCR7 6QZH
TM3 145 I 3.46x46 CCR7 6QZH CCR7 6QZH
TM3 146 S 3.47x47 CCR7 6QZH CCR7 6QZH
TM3 147 F 3.48x48 CCR7 6QZH apelin receptor 5VBL
TM3 148 D 3.49x49 CCR7 6QZH CCR7 6QZH
TM3 149 R 3.50x50 CCR7 6QZH CCR7 6QZH
TM3 150 Y 3.51x51 CCR7 6QZH CCR7 6QZH
TM3 151 L 3.52x52 CCR7 6QZH CXCR4 3ODU
TM3 152 N 3.53x53 CCR7 6QZH - -
TM3 153 I 3.54x54 CCR7 6QZH CCR7 6QZH
TM3 154 V 3.55x55 CCR7 6QZH CCR7 6QZH
TM3 155 H 3.56x56 CXCR4 3ODU CXCR4 3ODU
ICL2 156 A 34.50x50 - - - -
ICL2 157 T 34.51x51 CCR2 5T1A CCR6 6WWZ
ICL2 158 Q 34.52x52 CCR2 5T1A CysLT1 receptor 6RZ5
ICL2 159 L 34.53x53 CCR2 5T1A - -
ICL2 160 Y 34.54x54 CCR2 5T1A - -
ICL2 161 R 34.55x55 CCR2 5T1A C5a1 receptor 5O9H
ICL2 162 R 34.56x56 CCR2 5T1A M4 receptor 6KP6
ICL2 163 G 34.57x57 - - - -
TM4 164 P 4.38x38 CCR7 6QZH - -
TM4 165 P 4.39x39 CCR7 6QZH μ receptor 4DKL
TM4 166 A 4.40x40 CCR7 6QZH δ receptor 4N6H
TM4 167 R 4.41x41 CCR7 6QZH OX2 receptor 5WS3
TM4 168 V 4.42x42 CCR7 6QZH ghrelin receptor 6KO5
TM4 169 T 4.43x43 CCR7 6QZH D2 receptor 6CM4
TM4 170 L 4.44x44 CCR7 6QZH CCR7 6QZH
TM4 171 T 4.45x45 CCR7 6QZH CCR2 5T1A
TM4 172 C 4.46x46 CCR7 6QZH CCR7 6QZH
TM4 173 L 4.47x47 CCR7 6QZH DP2 receptor 6D27
TM4 174 A 4.48x48 CCR7 6QZH NOP receptor 5DHG
TM4 175 V 4.49x49 CCR7 6QZH CXCR4 3ODU
TM4 176 W 4.50x50 CCR7 6QZH CCR7 6QZH
TM4 177 G 4.51x51 CCR7 6QZH C5a1 receptor 5O9H
TM4 178 L 4.52x52 CCR7 6QZH CCR7 6QZH
TM4 179 C 4.53x53 CCR7 6QZH OT receptor 6TPK
TM4 180 L 4.54x54 CCR7 6QZH CXCR4 3ODU
TM4 181 L 4.55x55 CCR7 6QZH CXCR4 3ODU
TM4 182 F 4.56x56 CCR7 6QZH EP4 receptor 5YWY
TM4 183 A 4.57x57 CCR7 6QZH apelin receptor 5VBL
TM4 184 L 4.58x59 CCR7 6QZH CCR5 5UIW
TM4 185 P 4.59x60 CCR7 6QZH CCR7 6QZH
TM4 186 D 4.60x61 CCR7 6QZH CXCR4 3ODU
TM4 187 F 4.61x62 CCR7 6QZH CXCR4 3ODU
TM4 188 I 4.62x63 CCR7 6QZH CXCR4 3ODU
TM4 189 F 4.63x64 CCR7 6QZH CXCR4 3ODU
TM4 190 L 4.64x65 CXCR4 3ODU FPR2/ALX 6LW5
ECL2 191 S CCR7 6QZH - -
ECL2 192 A CCR7 6QZH - -
ECL2 193 H CCR7 6QZH - -
ECL2 194 H CCR7 6QZH - -
ECL2 195 D CCR7 6QZH - -
ECL2 196 E CCR7 6QZH - -
ECL2 197 R CCR7 6QZH - -
ECL2 198 L CCR7 6QZH - -
ECL2 199 N CCR7 6QZH - -
ECL2 200 A CCR7 6QZH CCR7 6QZH
ECL2 201 T CCR7 6QZH - -
ECL2 202 H CCR7 6QZH - -
ECL2 203 C 45.50x50 CCR7 6QZH CCR7 6QZH
ECL2 204 Q 45.51x51 CCR7 6QZH M5 receptor 6OL9
ECL2 205 Y 45.52x52 CCR7 6QZH DP2 receptor 6D27
ECL2 206 N - - - -
ECL2 207 F CXCR4 3ODU - -
ECL2 208 P CXCR4 3ODU CXCR4 3ODU
ECL2 209 Q - - - -
TM5 210 V 5.33x34 CXCR4 3ODU PAF receptor 5ZKQ
TM5 211 G 5.34x35 CXCR4 3ODU OT receptor 6TPK
TM5 212 R 5.35x36 CCR7 6QZH Y1 receptor 5ZBH
TM5 213 T 5.36x37 CCR7 6QZH δ receptor 4N6H
TM5 214 A 5.37x38 CCR7 6QZH C5a1 receptor 5O9H
TM5 215 L 5.38x39 CCR7 6QZH AT1 receptor 4ZUD
TM5 216 R 5.39x40 CCR7 6QZH FFA1 receptor 5TZY
TM5 217 V 5.40x41 CCR7 6QZH CCR7 6QZH
TM5 218 L 5.41x42 CCR7 6QZH Y1 receptor 5ZBH
TM5 219 Q 5.42x43 CCR7 6QZH CCR7 6QZH
TM5 220 L 5.43x44 CCR7 6QZH C5a1 receptor 5O9H
TM5 221 V 5.44x45 CCR7 6QZH CCR7 6QZH
TM5 222 A 5.45x46 CCR7 6QZH M2 receptor 5ZKC
TM5 223 G 5.46x461 CCR7 6QZH CCR7 6QZH
TM5 224 F 5.47x47 CCR7 6QZH CCR7 6QZH
TM5 225 L 5.48x48 CCR7 6QZH CCR7 6QZH
TM5 226 L 5.49x49 CCR7 6QZH CXCR4 3ODU
TM5 227 P 5.50x50 CCR7 6QZH CCR7 6QZH
TM5 228 L 5.51x51 CCR7 6QZH CCR7 6QZH
TM5 229 L 5.52x52 CCR7 6QZH CCR7 6QZH
TM5 230 V 5.53x53 CCR7 6QZH CXCR4 3ODU
TM5 231 M 5.54x54 CCR7 6QZH CCR7 6QZH
TM5 232 A 5.55x55 CCR7 6QZH DP2 receptor 6D27
TM5 233 Y 5.56x56 CCR7 6QZH NK1 receptor 6HLP
TM5 234 C 5.57x57 CCR7 6QZH CCR7 6QZH
TM5 235 Y 5.58x58 CCR7 6QZH CCR7 6QZH
TM5 236 A 5.59x59 CCR7 6QZH BLT1 receptor 5X33
TM5 237 H 5.60x60 CCR7 6QZH M2 receptor 5ZKC
TM5 238 I 5.61x61 CCR7 6QZH CCR7 6QZH
TM5 239 L 5.62x62 CCR7 6QZH CCR5 5UIW
TM5 240 A 5.63x63 CCR6 6WWZ A1 receptor 5N2S
TM5 241 V 5.64x64 CCR6 6WWZ D2 receptor 6CM4
TM5 242 L 5.65x65 CCR6 6WWZ CCR6 6WWZ
TM5 243 L 5.66x66 CCR6 6WWZ CCR5 5UIW
TM5 244 V 5.67x67 CCR6 6WWZ NTS1 receptor 4BUO
TM5 245 S 5.68x68 CCR6 6WWZ NK1 receptor 6HLL
ICL3 246 R - - - -
ICL3 247 G - - - -
ICL3 248 Q - - - -
ICL3 249 R - - - -
TM6 250 R 6.30x30 CXCR4 3ODU CCR5 5UIW
TM6 251 L 6.31x31 CXCR4 3ODU A1 receptor 5UEN
TM6 252 R 6.32x32 CXCR4 3ODU CCR5 5UIW
TM6 253 A 6.33x33 CXCR4 3ODU CXCR4 3ODU
TM6 254 M 6.34x34 CXCR4 3ODU D4 receptor 6IQL
TM6 255 R 6.35x35 CCR7 6QZH CCR2 5T1A
TM6 256 L 6.36x36 CCR7 6QZH CCR5 5UIW
TM6 257 V 6.37x37 CCR7 6QZH μ receptor 4DKL
TM6 258 V 6.38x38 CCR7 6QZH CXCR4 3ODU
TM6 259 V 6.39x39 CCR7 6QZH apelin receptor 5VBL
TM6 260 V 6.40x40 CCR7 6QZH CCR7 6QZH
TM6 261 V 6.41x41 CCR7 6QZH CCR7 6QZH
TM6 262 V 6.42x42 CCR7 6QZH CCR7 6QZH
TM6 263 A 6.43x43 CCR7 6QZH CXCR4 3ODU
TM6 264 F 6.44x44 CCR7 6QZH CCR7 6QZH
TM6 265 A 6.45x45 CCR7 6QZH apelin receptor 5VBL
TM6 266 L 6.46x46 CCR7 6QZH CCR2 5T1A
TM6 267 C 6.47x47 CCR7 6QZH CXCR4 3ODU
TM6 268 W 6.48x48 CCR7 6QZH CXCR4 3ODU
TM6 269 T 6.49x49 CCR7 6QZH CCR2 5T1A
TM6 270 P 6.50x50 CCR7 6QZH CCR7 6QZH
TM6 271 Y 6.51x51 CCR7 6QZH CCR7 6QZH
TM6 272 H 6.52x52 CCR7 6QZH apelin receptor 5VBL
TM6 273 L 6.53x53 CCR7 6QZH apelin receptor 5VBL
TM6 274 V 6.54x54 CCR7 6QZH CCR7 6QZH
TM6 275 V 6.55x55 CCR7 6QZH CCR7 6QZH
TM6 276 L 6.56x56 CCR7 6QZH CCR7 6QZH
TM6 277 V 6.57x57 CCR7 6QZH CCR9 5LWE
TM6 278 D 6.58x58 CCR7 6QZH CXCR4 3ODU
TM6 279 I 6.59x59 CXCR4 3ODU D2 receptor 6CM4
TM6 280 L 6.60x60 CXCR4 3ODU AT1 receptor 4ZUD
TM6 281 M 6.61x61 CXCR4 3ODU - -
TM6 282 D 6.62x62 CXCR4 3ODU - -
TM6 283 L 6.63x63 CXCR4 3ODU CXCR4 3ODU
TM6 284 G 6.64x64 CXCR4 3ODU AT1 receptor 4ZUD
ECL3 285 A - - - -
ECL3 286 L - - - -
ECL3 287 A - - - -
ECL3 288 R - - - -
TM7 289 N 7.24x23 CXCR4 3ODU CCR5 5UIW
TM7 290 C 7.25x24 CCR7 6QZH CCR7 6QZH
TM7 291 G 7.26x25 CCR7 6QZH - -
TM7 292 R 7.27x26 CCR7 6QZH - -
TM7 293 E 7.28x27 CCR7 6QZH CXCR4 3ODU
TM7 294 S 7.29x28 CCR7 6QZH CCR2 5T1A
TM7 295 R 7.30x29 CCR7 6QZH CCR5 5UIW
TM7 296 V 7.31x30 CCR7 6QZH CXCR4 3ODU
TM7 297 D 7.32x31 CCR7 6QZH CCR2 5T1A
TM7 298 V 7.33x32 CCR7 6QZH μ receptor 4DKL
TM7 299 A 7.34x33 CCR7 6QZH CCR7 6QZH
TM7 300 K 7.35x34 CCR7 6QZH CCR6 6WWZ
TM7 301 S 7.36x35 CCR7 6QZH CXCR4 3ODU
TM7 302 V 7.37x36 CCR7 6QZH CCR7 6QZH
TM7 303 T 7.38x37 CCR7 6QZH CCR7 6QZH
TM7 304 S 7.39x38 CCR7 6QZH CB1 receptor 5TGZ
TM7 305 G 7.40x39 CCR7 6QZH P2Y1 receptor 4XNW
TM7 306 L 7.41x40 CCR7 6QZH CCR7 6QZH
TM7 307 G 7.42x41 CCR7 6QZH CCR2 5T1A
TM7 308 Y 7.43x42 CCR7 6QZH AT1 receptor 4ZUD
TM7 309 M 7.44x43 CCR7 6QZH - -
TM7 310 H 7.45x45 CCR7 6QZH CXCR4 3ODU
TM7 311 C 7.46x46 CCR7 6QZH CCR7 6QZH
TM7 312 C 7.47x47 CCR7 6QZH CCR7 6QZH
TM7 313 L 7.48x48 CCR7 6QZH CXCR4 3ODU
TM7 314 N 7.49x49 CCR7 6QZH CCR7 6QZH
TM7 315 P 7.50x50 CCR7 6QZH CCR7 6QZH
TM7 316 L 7.51x51 CCR7 6QZH AT1 receptor 4ZUD
TM7 317 L 7.52x52 CCR7 6QZH CCR7 6QZH
TM7 318 Y 7.53x53 CCR7 6QZH CCR7 6QZH
TM7 319 A 7.54x54 CCR7 6QZH CCR7 6QZH
TM7 320 F 7.55x55 CCR7 6QZH CCR7 6QZH
TM7 321 V 7.56x56 CCR2 5T1A CCR2 5T1A
H8 322 G 8.47x47 CCR2 5T1A CCR2 5T1A
H8 323 V 8.48x48 CCR2 5T1A - -
H8 324 K 8.49x49 CCR7 6QZH CCR7 6QZH
H8 325 F 8.50x50 CCR7 6QZH CCR7 6QZH
H8 326 R 8.51x51 CCR7 6QZH CCR7 6QZH
H8 327 E 8.52x52 CCR7 6QZH OX2 receptor 5WS3
H8 328 R 8.53x53 CCR7 6QZH FPR2/ALX 6LW5
H8 329 M 8.54x54 CCR7 6QZH Rhodopsin 1GZM
H8 330 W 8.55x55 CCR7 6QZH - -
H8 331 M 8.56x56 CCR7 6QZH M5 receptor 6OL9
H8 332 L 8.57x57 CCR7 6QZH δ receptor 4N6H
H8 333 L 8.58x58 CCR7 6QZH CCR9 5LWE
H8 334 L 8.59x59 CCR5 5UIW apelin receptor 5VBL
C-term 335 R - - - -
C-term 336 L - - - -
C-term 337 G - - - -
C-term 338 C - - - -
C-term 339 P - - - -