FFA2 receptor homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

FFA2 receptor

SPECIES

Homo sapiens

STATE

Inactive

VERSION

2021-11-02

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

NGL is a WebGL based 3D viewer powered by MMTF.

MAIN TEMPLATE

CCR5 (sequence similarity: 32%) PDB: 4MBS
Align

TEMPLATES

4MBS (CCR5)
7D7M (EP4 receptor)
5NDD (PAR2)
5TZY (FFA1 receptor)
6PWC (NTS1 receptor)
6ME2 (MT1 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 80.1 12.8 7.1
Side-chains 17.2 64.9 17.9

Number of backbone templates: 6
Number of rotamer templates: 62

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 1 M - CCR5 4MBS CCR5 4MBS
N-term 2 L - CCR5 4MBS CCR5 4MBS
TM1 3 P 1.28x28 CCR5 4MBS MT1 receptor 6ME5
TM1 4 D 1.29x29 CCR5 4MBS CysLT1 receptor 6RZ5
TM1 5 W 1.30x30 CCR5 4MBS MT1 receptor 6ME2
TM1 6 K 1.31x31 CCR5 4MBS CCR7 6QZH
TM1 7 S 1.32x32 CCR5 4MBS CCR9 5LWE
TM1 8 S 1.33x33 CCR5 4MBS MT1 receptor 6ME2
TM1 9 L 1.34x34 CCR5 4MBS CCR5 4MBS
TM1 10 I 1.35x35 CCR5 4MBS κ receptor 4DJH
TM1 11 L 1.36x36 CCR5 4MBS D4 receptor 5WIV
TM1 12 M 1.37x37 CCR5 4MBS 5-HT1B receptor 4IAR
TM1 13 A 1.38x38 CCR5 4MBS Y2 receptor 7DDZ
TM1 14 Y 1.39x39 CCR5 4MBS CCR5 4MBS
TM1 15 I 1.40x40 CCR5 4MBS MT1 receptor 6ME2
TM1 16 I 1.41x41 CCR5 4MBS 5-HT2C receptor 6BQH
TM1 17 I 1.42x42 CCR5 4MBS H1 receptor 3RZE
TM1 18 F 1.43x43 CCR5 4MBS CCR5 4MBS
TM1 19 L 1.44x44 CCR5 4MBS H1 receptor 3RZE
TM1 20 T 1.45x45 CCR5 4MBS CXCR4 3ODU
TM1 21 G 1.46x46 CCR5 4MBS CCR5 4MBS
TM1 22 L 1.47x47 CCR5 4MBS κ receptor 4DJH
TM1 23 P 1.48x48 CCR5 4MBS Rhodopsin 1U19
TM1 24 A 1.49x49 CCR5 4MBS LPA1 receptor 4Z35
TM1 25 N 1.50x50 CCR5 4MBS CCR5 4MBS
TM1 26 L 1.51x51 CCR5 4MBS MT1 receptor 6ME2
TM1 27 L 1.52x52 CCR5 4MBS CCR5 4MBS
TM1 28 A 1.53x53 CCR5 4MBS EP4 receptor 5YWY
TM1 29 L 1.54x54 CCR5 4MBS H1 receptor 3RZE
TM1 30 R 1.55x55 CCR5 4MBS FFA1 receptor 5TZR
TM1 31 A 1.56x56 CCR5 4MBS H1 receptor 3RZE
TM1 32 F 1.57x57 CCR5 4MBS M5 receptor 6OL9
TM1 33 V 1.58x58 CCR5 4MBS δ receptor 4N6H
TM1 34 G 1.59x59 CCR5 4MBS TP receptor 6IIV
TM1 35 R 1.60x60 CCR5 4MBS DP2 receptor 7M8W
ICL1 36 I - - - - -
ICL1 37 R - EP4 receptor 7D7M - -
ICL1 38 Q - EP4 receptor 7D7M - -
ICL1 39 P - EP4 receptor 7D7M - -
ICL1 40 Q - EP4 receptor 7D7M - -
ICL1 41 P - - - - -
TM2 42 A 2.37x37 CCR5 4MBS α2A-adrenoceptor 6KUX
TM2 43 P 2.38x38 CCR5 4MBS α2A-adrenoceptor 6KUX
TM2 44 V 2.39x39 CCR5 4MBS DP2 receptor 7M8W
TM2 45 H 2.40x40 CCR5 4MBS V2 receptor 7KH0
TM2 46 I 2.41x41 CCR5 4MBS CCR5 4MBS
TM2 47 L 2.42x42 CCR5 4MBS D3 receptor 3PBL
TM2 48 L 2.43x43 CCR5 4MBS CCR5 4MBS
TM2 49 L 2.44x44 CCR5 4MBS CCR5 4MBS
TM2 50 S 2.45x45 CCR5 4MBS MT1 receptor 6ME2
TM2 51 L 2.46x46 CCR5 4MBS CCR5 4MBS
TM2 52 T 2.47x47 CCR5 4MBS GnRH1 receptor 7BR3
TM2 53 L 2.48x48 CCR5 4MBS κ receptor 4DJH
TM2 54 A 2.49x49 CCR5 4MBS MT1 receptor 6ME2
TM2 55 D 2.50x50 CCR5 4MBS CCR5 4MBS
TM2 56 L 2.51x51 CCR5 4MBS CCR5 4MBS
TM2 57 L 2.52x52 CCR5 4MBS CCR2 5T1A
TM2 58 L 2.53x53 CCR5 4MBS 5-HT2A receptor 6A94
TM2 59 L 2.54x54 CCR5 4MBS CCR5 4MBS
TM2 60 L 2.55x55 CCR5 4MBS CCR5 4MBS
TM2 61 L 2.56x56 CCR5 4MBS - -
TM2 62 L 2.57x57 CCR5 4MBS CCR2 5T1A
TM2 63 P 2.58x58 CCR5 4MBS CCR5 4MBS
TM2 64 F 2.59x59 CCR5 4MBS CCR5 4MBS
TM2 65 K 2.60x60 CCR5 4MBS PAR2 5NDD
TM2 66 I 2.61x61 CCR5 4MBS H1 receptor 3RZE
TM2 67 I 2.62x62 CCR5 4MBS CCR9 5LWE
TM2 68 E 2.63x63 CCR5 4MBS FFA1 receptor 5TZY
TM2 69 A 2.64x64 CCR5 4MBS CCR5 4MBS
TM2 70 A 2.65x65 CCR5 4MBS CCR5 4MBS
TM2 71 S 2.66x66 CCR5 4MBS EP3 receptor 6AK3
ECL1 72 N - - - - -
ECL1 73 F - PAR2 5NDD - -
ECL1 74 R 23.49x49 PAR2 5NDD AT1 receptor 4ZUD
ECL1 75 W 23.50x50 PAR2 5NDD PAR2 5NDD
ECL1 76 Y 23.51x51 PAR2 5NDD CXCR4 3ODU
ECL1 77 L 23.52x52 - - - -
TM3 78 P 3.21x21 CCR5 4MBS 5-HT2C receptor 6BQH
TM3 79 K 3.22x22 CCR5 4MBS α2A-adrenoceptor 6KUX
TM3 80 V 3.23x23 CCR5 4MBS κ receptor 4DJH
TM3 81 V 3.24x24 CCR5 4MBS 5-HT1B receptor 4IAQ
TM3 82 C 3.25x25 CCR5 4MBS CCR5 4MBS
TM3 83 A 3.26x26 CCR5 4MBS 5-HT2A receptor 6A94
TM3 84 L 3.27x27 CCR5 4MBS CCR5 4MBS
TM3 85 T 3.28x28 CCR5 4MBS CCK1 receptor 7EZM
TM3 86 S 3.29x29 CCR5 4MBS AT1 receptor 4ZUD
TM3 87 F 3.30x30 CCR5 4MBS MT1 receptor 6ME2
TM3 88 G 3.31x31 CCR5 4MBS CB1 receptor 5TGZ
TM3 89 F 3.32x32 CCR5 4MBS DP2 receptor 7M8W
TM3 90 Y 3.33x33 CCR5 4MBS κ receptor 4DJH
TM3 91 S 3.34x34 CCR5 4MBS ghrelin receptor 6KO5
TM3 92 S 3.35x35 CCR5 4MBS MT1 receptor 6ME2
TM3 93 I 3.36x36 CCR5 4MBS Y1 receptor 5ZBH
TM3 94 Y 3.37x37 CCR5 4MBS AT1 receptor 4ZUD
TM3 95 C 3.38x38 CCR5 4MBS PAR2 5NDD
TM3 96 S 3.39x39 CCR5 4MBS MT1 receptor 6ME2
TM3 97 T 3.40x40 CCR5 4MBS Y2 receptor 7DDZ
TM3 98 W 3.41x41 CCR5 4MBS MT1 receptor 6ME2
TM3 99 L 3.42x42 CCR5 4MBS AT1 receptor 4ZUD
TM3 100 L 3.43x43 CCR5 4MBS κ receptor 4DJH
TM3 101 A 3.44x44 CCR5 4MBS CXCR4 3ODU
TM3 102 G 3.45x45 CCR5 4MBS MT1 receptor 6ME2
TM3 103 I 3.46x46 CCR5 4MBS MT1 receptor 6ME2
TM3 104 S 3.47x47 CCR5 4MBS κ receptor 4DJH
TM3 105 I 3.48x48 CCR5 4MBS CCR5 4MBS
TM3 106 E 3.49x49 CCR5 4MBS ghrelin receptor 6KO5
TM3 107 R 3.50x50 CCR5 4MBS CCR5 4MBS
TM3 108 Y 3.51x51 CCR5 4MBS CCR5 4MBS
TM3 109 L 3.52x52 CCR5 4MBS CCR5 4MBS
TM3 110 G 3.53x53 CCR5 4MBS FFA1 receptor 5TZY
TM3 111 V 3.54x54 CCR5 4MBS CCR5 4MBS
TM3 112 A 3.55x55 CCR5 4MBS CCR9 5LWE
TM3 113 F 3.56x56 CCR5 4MBS ghrelin receptor 6KO5
ICL2 114 P 34.50x50 - - - -
ICL2 115 V 34.51x51 FFA1 receptor 5TZY CCR5 4MBS
ICL2 116 Q 34.52x52 FFA1 receptor 5TZY CCK1 receptor 7EZM
ICL2 117 Y 34.53x53 FFA1 receptor 5TZY FFA1 receptor 5TZY
ICL2 118 K 34.54x54 FFA1 receptor 5TZY ghrelin receptor 6KO5
ICL2 119 L 34.55x55 FFA1 receptor 5TZY α2A-adrenoceptor 6KUX
ICL2 120 S 34.56x56 FFA1 receptor 5TZY - -
ICL2 121 R 34.57x57 - - - -
TM4 122 R 4.38x38 CCR5 4MBS OT receptor 6TPK
TM4 123 P 4.39x39 CCR5 4MBS κ receptor 4DJH
TM4 124 L 4.40x40 CCR5 4MBS κ receptor 4DJH
TM4 125 Y 4.41x41 CCR5 4MBS CCR9 5LWE
TM4 126 G 4.42x42 CCR5 4MBS CCR5 4MBS
TM4 127 V 4.43x43 CCR5 4MBS CCR5 4MBS
TM4 128 I 4.44x44 CCR5 4MBS κ receptor 4DJH
TM4 129 A 4.45x45 CCR5 4MBS apelin receptor 5VBL
TM4 130 A 4.46x46 CCR5 4MBS S1P5 receptor 7EW1
TM4 131 L 4.47x47 CCR5 4MBS MT1 receptor 6ME2
TM4 132 V 4.48x48 CCR5 4MBS apelin receptor 5VBL
TM4 133 A 4.49x49 CCR5 4MBS H1 receptor 3RZE
TM4 134 W 4.50x50 CCR5 4MBS CCR5 4MBS
TM4 135 V 4.51x51 CCR5 4MBS CCR5 4MBS
TM4 136 M 4.52x52 CCR5 4MBS Rhodopsin 1U19
TM4 137 S 4.53x53 CCR5 4MBS κ receptor 4DJH
TM4 138 F 4.54x54 CCR5 4MBS H1 receptor 3RZE
TM4 139 G 4.55x55 CCR5 4MBS 5-HT2C receptor 6BQH
TM4 140 H 4.56x56 CCR5 4MBS FFA1 receptor 5TZY
TM4 141 C 4.57x57 FFA1 receptor 5TZY CCR9 5LWE
TM4 142 T 4.58x58 FFA1 receptor 5TZY - -
TM4 143 I 4.59x59 FFA1 receptor 5TZY H1 receptor 3RZE
TM4 144 V 4.60x60 CCR5 4MBS μ receptor 4DKL
TM4 145 I 4.61x61 CCR5 4MBS κ receptor 4DJH
TM4 146 I 4.62x62 CCR5 4MBS CCR5 4MBS
ECL2 147 V - - - - -
ECL2 148 Q - NTS1 receptor 6PWC - -
ECL2 149 Y - NTS1 receptor 6PWC - -
ECL2 150 L - NTS1 receptor 6PWC - -
ECL2 151 N - NTS1 receptor 6PWC - -
ECL2 152 T - NTS1 receptor 6PWC - -
ECL2 153 T - NTS1 receptor 6PWC - -
ECL2 154 E - NTS1 receptor 6PWC - -
ECL2 155 Q - NTS1 receptor 6PWC - -
ECL2 156 V - NTS1 receptor 6PWC - -
ECL2 157 R - NTS1 receptor 6PWC - -
ECL2 158 S - NTS1 receptor 6PWC - -
ECL2 159 G - NTS1 receptor 6PWC NTS1 receptor 6PWC
ECL2 160 N - NTS1 receptor 6PWC - -
ECL2 161 E - NTS1 receptor 6PWC - -
ECL2 162 I - NTS1 receptor 6PWC - -
ECL2 163 T - - - - -
ECL2 164 C 45.50x50 CCR5 4MBS CCR5 4MBS
ECL2 165 Y 45.51x51 CCR5 4MBS apelin receptor 5VBL
ECL2 166 E 45.52x52 CCR5 4MBS OX2 receptor 5WQC
ECL2 167 N - CCR5 4MBS - -
ECL2 168 F - CCR5 4MBS CCR5 4MBS
ECL2 169 T - CCR5 4MBS - -
ECL2 170 D - CCR5 4MBS - -
ECL2 171 N - CCR5 4MBS - -
TM5 172 Q 5.31x32 CCR5 4MBS NOP receptor 5DHH
TM5 173 L 5.32x33 CCR5 4MBS P2Y1 receptor 4XNW
TM5 174 D 5.33x34 CCR5 4MBS - -
TM5 175 V 5.34x35 CCR5 4MBS - -
TM5 176 V 5.35x36 CCR5 4MBS CXCR4 3ODU
TM5 177 L 5.36x37 CCR5 4MBS κ receptor 4DJH
TM5 178 P 5.37x38 CCR5 4MBS FFA1 receptor 5TZY
TM5 179 V 5.38x39 CCR5 4MBS NTS1 receptor 4BUO
TM5 180 R 5.39x40 CCR5 4MBS FFA1 receptor 5TZY
TM5 181 L 5.40x41 CCR5 4MBS CCR5 4MBS
TM5 182 E 5.41x42 CCR5 4MBS US28 5WB1
TM5 183 L 5.42x43 CCR5 4MBS ETB receptor 5X93
TM5 184 C 5.43x44 CCR5 4MBS α2A-adrenoceptor 6KUX
TM5 185 L 5.44x45 CCR5 4MBS δ receptor 4N6H
TM5 186 V 5.45x46 CCR5 4MBS 5-HT2C receptor 6BQH
TM5 187 L 5.46x461 CCR5 4MBS Y2 receptor 7DDZ
TM5 188 F 5.47x47 CCR5 4MBS MT1 receptor 6ME2
TM5 189 F 5.48x48 CCR5 4MBS 5-HT2C receptor 6BQH
TM5 190 I 5.49x49 CCR5 4MBS κ receptor 4DJH
TM5 191 P 5.50x50 CCR5 4MBS CCR5 4MBS
TM5 192 M 5.51x51 CCR5 4MBS MT1 receptor 6ME2
TM5 193 A 5.52x52 CCR5 4MBS DP2 receptor 7M8W
TM5 194 V 5.53x53 CCR5 4MBS CCR5 4MBS
TM5 195 T 5.54x54 CCR5 4MBS D3 receptor 3PBL
TM5 196 I 5.55x55 CCR5 4MBS MT1 receptor 6ME2
TM5 197 F 5.56x56 CCR5 4MBS MT1 receptor 6ME2
TM5 198 C 5.57x57 CCR5 4MBS CCR5 4MBS
TM5 199 Y 5.58x58 CCR5 4MBS CCR5 4MBS
TM5 200 W 5.59x59 CCR5 4MBS D4 receptor 5WIV
TM5 201 R 5.60x60 CCR5 4MBS MT1 receptor 6ME2
TM5 202 F 5.61x61 CCR5 4MBS - -
TM5 203 V 5.62x62 CCR5 4MBS Rhodopsin 1GZM
TM5 204 W 5.63x63 CCR5 4MBS CB1 receptor 5TGZ
TM5 205 I 5.64x64 CCR5 4MBS α2A-adrenoceptor 6KUX
TM5 206 M 5.65x65 CCR5 4MBS ETB receptor 5X93
TM5 207 L 5.66x66 CCR5 4MBS CCR5 4MBS
TM5 208 S 5.67x67 CCR5 4MBS κ receptor 4DJH
ICL3 209 Q - - - - -
ICL3 210 P - - - - -
ICL3 211 L - - - - -
ICL3 212 V - - - - -
TM6 213 G 6.26x27 PAR2 5NDD CXCR4 3ODU
TM6 214 A 6.27x28 CCR5 4MBS - -
TM6 215 Q 6.28x29 CCR5 4MBS CXCR4 3ODU
TM6 216 R 6.29x30 CCR5 4MBS CCR5 4MBS
TM6 217 R 6.30x31 CCR5 4MBS H1 receptor 3RZE
TM6 218 R 6.31x32 CCR5 4MBS CCR5 4MBS
TM6 219 R 6.32x33 CCR5 4MBS PAR2 5NDD
TM6 220 A 6.33x34 CCR5 4MBS H1 receptor 3RZE
TM6 221 V 6.34x35 CCR5 4MBS MT1 receptor 6ME2
TM6 222 G 6.35x36 CCR5 4MBS CysLT1 receptor 6RZ4
TM6 223 L 6.36x37 CCR5 4MBS H1 receptor 3RZE
TM6 224 A 6.37x38 CCR5 4MBS DP2 receptor 7M8W
TM6 225 V 6.38x39 CCR5 4MBS MT1 receptor 6ME2
TM6 226 V 6.39x40 CCR5 4MBS MT1 receptor 6ME2
TM6 227 T 6.40x41 CCR5 4MBS CysLT2 receptor 6RZ6
TM6 228 L 6.41x42 CCR5 4MBS AT1 receptor 4ZUD
TM6 229 L 6.42x43 CCR5 4MBS MT1 receptor 6ME2
TM6 230 N 6.43x44 CCR5 4MBS - -
TM6 231 F 6.44x45 CCR5 4MBS CCR5 4MBS
TM6 232 L 6.45x46 PAR2 5NDD PAR2 5NDD
TM6 233 V 6.46x461 PAR2 5NDD P2Y1 receptor 4XNW
TM6 234 C 6.47x47 PAR2 5NDD PAR2 5NDD
TM6 235 F 6.48x48 CCR5 4MBS MT1 receptor 6ME2
TM6 236 G 6.49x49 CCR5 4MBS DP2 receptor 7M8W
TM6 237 P 6.50x50 CCR5 4MBS CCR5 4MBS
TM6 238 Y 6.51x51 CCR5 4MBS CCR5 4MBS
TM6 239 N 6.52x52 CCR5 4MBS CCR5 4MBS
TM6 240 V 6.53x53 CCR5 4MBS DP2 receptor 7M8W
TM6 241 S 6.54x54 CCR5 4MBS α2C-adrenoceptor 6KUW
TM6 242 H 6.55x55 CCR5 4MBS D3 receptor 3PBL
TM6 243 L 6.56x56 CCR5 4MBS CCR5 4MBS
TM6 244 V 6.57x57 CCR5 4MBS H1 receptor 3RZE
TM6 245 G 6.58x58 CCR5 4MBS Rhodopsin 6I9K
TM6 246 Y 6.59x59 CCR5 4MBS NK1 receptor 6HLP
TM6 247 H 6.60x60 CCR5 4MBS D2 receptor 7DFP
TM6 248 Q 6.61x61 CCR5 4MBS CCR5 4MBS
ECL3 249 R - - - - -
ECL3 250 K - - - - -
ECL3 251 S - - - - -
ECL3 252 P - - - - -
TM7 253 W 7.33x32 CCR5 4MBS MT1 receptor 6ME2
TM7 254 W 7.34x33 CCR5 4MBS CXCR4 3ODU
TM7 255 R 7.35x34 CCR5 4MBS BLT1 receptor 7K15
TM7 256 S 7.36x35 CCR5 4MBS CXCR4 3ODU
TM7 257 I 7.37x36 CCR5 4MBS AT1 receptor 4ZUD
TM7 258 A 7.38x37 CCR5 4MBS A1 receptor 5UEN
TM7 259 V 7.39x38 CCR5 4MBS 5-HT2C receptor 6BQH
TM7 260 V 7.40x39 CCR5 4MBS ghrelin receptor 6KO5
TM7 261 F 7.41x40 CCR5 4MBS α2A-adrenoceptor 6KUX
TM7 262 S 7.42x41 CCR5 4MBS apelin receptor 5VBL
TM7 263 S 7.43x42 CCR5 4MBS ETB receptor 5X93
TM7 264 L 7.44x43 CCR5 4MBS 5-HT2A receptor 6A94
TM7 265 N 7.45x45 CCR5 4MBS MT1 receptor 6ME2
TM7 266 A 7.46x46 CCR5 4MBS ghrelin receptor 6KO5
TM7 267 S 7.47x47 CCR5 4MBS κ receptor 4DJH
TM7 268 L 7.48x48 CCR5 4MBS MT1 receptor 6ME2
TM7 269 D 7.49x49 CCR5 4MBS GnRH1 receptor 7BR3
TM7 270 P 7.50x50 CCR5 4MBS CCR5 4MBS
TM7 271 L 7.51x51 CCR5 4MBS H1 receptor 3RZE
TM7 272 L 7.52x52 CCR5 4MBS κ receptor 4DJH
TM7 273 F 7.53x53 CCR5 4MBS EP2 receptor 7CX2
TM7 274 Y 7.54x54 CCR5 4MBS ETB receptor 5X93
TM7 275 F 7.55x55 CCR5 4MBS CCR5 4MBS
TM7 276 S 7.56x56 CCR5 4MBS 5-HT1B receptor 4IAQ
H8 277 S 8.47x47 CCR5 4MBS OX2 receptor 5WQC
H8 278 S 8.48x48 CCR5 4MBS Y2 receptor 7DDZ
H8 279 V 8.49x49 CCR5 4MBS GPR52 6LI3
H8 280 V 8.50x50 CCR5 4MBS EP4 receptor 5YWY
H8 281 R 8.51x51 CCR5 4MBS MT1 receptor 6ME2
H8 282 R 8.52x52 CCR5 4MBS CCR2 5T1A
H8 283 A 8.53x53 CCR5 4MBS 5-HT2C receptor 6BQH
H8 284 F 8.54x54 CCR5 4MBS κ receptor 4DJH
H8 285 G 8.55x55 CCR5 4MBS 5-HT2B receptor 5TVN
H8 286 R 8.56x56 CCR5 4MBS MT1 receptor 6ME2
H8 287 G 8.57x57 CCR5 4MBS - -
H8 288 L 8.58x58 CCR5 4MBS H1 receptor 3RZE
H8 289 Q 8.59x59 CCR5 4MBS CCR5 7F1T
H8 290 V 8.60x60 MT1 receptor 6ME2 BILF1 7JHJ
H8 291 L 8.61x61 MT1 receptor 6ME2 MT1 receptor 6ME3
C-term 292 R - - - - -
C-term 293 N - - - - -
C-term 294 Q - - - - -
C-term 295 G - - - - -
C-term 296 S - - - - -