FFA2 receptor homology model
PROTEIN CLASS
Class A (Rhodopsin)
RECEPTOR
SPECIES
Homo sapiens
STATE
Inactive
VERSION
2021-01-08
MODEL
TEMPLATES
5UIW (CCR5)
7D7M (EP4 receptor)
5NDD (PAR2)
5TZY (FFA1 receptor)
6PWC (NTS1 receptor)
6ME2 (MT1 receptor)
None
7D7M (EP4 receptor)
5NDD (PAR2)
5TZY (FFA1 receptor)
6PWC (NTS1 receptor)
6ME2 (MT1 receptor)
None
| Main template (%) | Additional templates (%) | No template - freely modelled (%) | |
|---|---|---|---|
| Backbone | 80.1 | 12.8 | 7.1 |
| Side-chains | 17.6 | 63.9 | 18.6 |
Number of backbone templates: 6
Number of rotamer templates: 58
| Segment | Seq.num. | AA | GPCRdb# | Backbone | PDB | Rotamer | PDB |
|---|---|---|---|---|---|---|---|
| N-term | 1 | M | CCR5 | 5UIW | CCR5 | 5UIW | |
| N-term | 2 | L | CCR5 | 5UIW | CCR5 | 5UIW | |
| TM1 | 3 | P | 1.28x28 | CCR5 | 5UIW | MT1 receptor | 6ME5 |
| TM1 | 4 | D | 1.29x29 | CCR5 | 5UIW | CysLT1 receptor | 6RZ5 |
| TM1 | 5 | W | 1.30x30 | CCR5 | 5UIW | MT1 receptor | 6ME2 |
| TM1 | 6 | K | 1.31x31 | CCR5 | 5UIW | CCR7 | 6QZH |
| TM1 | 7 | S | 1.32x32 | CCR5 | 5UIW | CCR9 | 5LWE |
| TM1 | 8 | S | 1.33x33 | CCR5 | 5UIW | MT1 receptor | 6ME2 |
| TM1 | 9 | L | 1.34x34 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM1 | 10 | I | 1.35x35 | CCR5 | 5UIW | κ receptor | 4DJH |
| TM1 | 11 | L | 1.36x36 | CCR5 | 5UIW | D4 receptor | 5WIV |
| TM1 | 12 | M | 1.37x37 | CCR5 | 5UIW | 5-HT1B receptor | 4IAR |
| TM1 | 13 | A | 1.38x38 | CCR5 | 5UIW | Y1 receptor | 5ZBH |
| TM1 | 14 | Y | 1.39x39 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM1 | 15 | I | 1.40x40 | CCR5 | 5UIW | MT1 receptor | 6ME2 |
| TM1 | 16 | I | 1.41x41 | CCR5 | 5UIW | CXCR4 | 3ODU |
| TM1 | 17 | I | 1.42x42 | CCR5 | 5UIW | H1 receptor | 3RZE |
| TM1 | 18 | F | 1.43x43 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM1 | 19 | L | 1.44x44 | CCR5 | 5UIW | H1 receptor | 3RZE |
| TM1 | 20 | T | 1.45x45 | CCR5 | 5UIW | CXCR4 | 3ODU |
| TM1 | 21 | G | 1.46x46 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM1 | 22 | L | 1.47x47 | CCR5 | 5UIW | κ receptor | 6VI4 |
| TM1 | 23 | P | 1.48x48 | CCR5 | 5UIW | Rhodopsin | 1GZM |
| TM1 | 24 | A | 1.49x49 | CCR5 | 5UIW | LPA1 receptor | 4Z35 |
| TM1 | 25 | N | 1.50x50 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM1 | 26 | L | 1.51x51 | CCR5 | 5UIW | MT1 receptor | 6ME2 |
| TM1 | 27 | L | 1.52x52 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM1 | 28 | A | 1.53x53 | CCR5 | 5UIW | EP4 receptor | 5YWY |
| TM1 | 29 | L | 1.54x54 | CCR5 | 5UIW | H1 receptor | 3RZE |
| TM1 | 30 | R | 1.55x55 | CCR5 | 5UIW | FFA1 receptor | 5TZR |
| TM1 | 31 | A | 1.56x56 | CCR5 | 5UIW | H1 receptor | 3RZE |
| TM1 | 32 | F | 1.57x57 | CCR5 | 5UIW | M5 receptor | 6OL9 |
| TM1 | 33 | V | 1.58x58 | CCR5 | 5UIW | δ receptor | 4N6H |
| TM1 | 34 | G | 1.59x59 | CCR5 | 5UIW | TP receptor | 6IIV |
| TM1 | 35 | R | 1.60x60 | CCR5 | 5UIW | DP2 receptor | 6D27 |
| ICL1 | 36 | I | - | - | - | - | |
| ICL1 | 37 | R | EP4 receptor | 7D7M | - | - | |
| ICL1 | 38 | Q | EP4 receptor | 7D7M | - | - | |
| ICL1 | 39 | P | EP4 receptor | 7D7M | - | - | |
| ICL1 | 40 | Q | EP4 receptor | 7D7M | - | - | |
| ICL1 | 41 | P | - | - | - | - | |
| TM2 | 42 | A | 2.37x37 | CCR5 | 5UIW | α2A-adrenoceptor | 6KUX |
| TM2 | 43 | P | 2.38x38 | CCR5 | 5UIW | α2A-adrenoceptor | 6KUX |
| TM2 | 44 | V | 2.39x39 | CCR5 | 5UIW | DP2 receptor | 6D27 |
| TM2 | 45 | H | 2.40x40 | CCR5 | 5UIW | NTS1 receptor | 4XES |
| TM2 | 46 | I | 2.41x41 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM2 | 47 | L | 2.42x42 | CCR5 | 5UIW | D3 receptor | 3PBL |
| TM2 | 48 | L | 2.43x43 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM2 | 49 | L | 2.44x44 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM2 | 50 | S | 2.45x45 | CCR5 | 5UIW | MT1 receptor | 6ME2 |
| TM2 | 51 | L | 2.46x46 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM2 | 52 | T | 2.47x47 | CCR5 | 5UIW | GnRH1 receptor | 7BR3 |
| TM2 | 53 | L | 2.48x48 | CCR5 | 5UIW | κ receptor | 6VI4 |
| TM2 | 54 | A | 2.49x49 | CCR5 | 5UIW | MT1 receptor | 6ME2 |
| TM2 | 55 | D | 2.50x50 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM2 | 56 | L | 2.51x51 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM2 | 57 | L | 2.52x52 | CCR5 | 5UIW | κ receptor | 6VI4 |
| TM2 | 58 | L | 2.53x53 | CCR5 | 5UIW | 5-HT2A receptor | 6A94 |
| TM2 | 59 | L | 2.54x54 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM2 | 60 | L | 2.55x55 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM2 | 61 | L | 2.56x56 | CCR5 | 5UIW | - | - |
| TM2 | 62 | L | 2.57x57 | CCR5 | 5UIW | CXCR4 | 3ODU |
| TM2 | 63 | P | 2.58x58 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM2 | 64 | F | 2.59x59 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM2 | 65 | K | 2.60x60 | CCR5 | 5UIW | PAR2 | 5NDD |
| TM2 | 66 | I | 2.61x61 | CCR5 | 5UIW | H1 receptor | 3RZE |
| TM2 | 67 | I | 2.62x62 | CCR5 | 5UIW | CCR9 | 5LWE |
| TM2 | 68 | E | 2.63x63 | CCR5 | 5UIW | FFA1 receptor | 5TZY |
| TM2 | 69 | A | 2.64x64 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM2 | 70 | A | 2.65x65 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM2 | 71 | S | 2.66x66 | CCR5 | 5UIW | EP3 receptor | 6AK3 |
| ECL1 | 72 | N | - | - | - | - | |
| ECL1 | 73 | F | PAR2 | 5NDD | - | - | |
| ECL1 | 74 | R | 23.49x49 | PAR2 | 5NDD | AT1 receptor | 4ZUD |
| ECL1 | 75 | W | 23.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| ECL1 | 76 | Y | 23.51x51 | PAR2 | 5NDD | CXCR4 | 3ODU |
| ECL1 | 77 | L | 23.52x52 | - | - | - | - |
| TM3 | 78 | P | 3.21x21 | CCR5 | 5UIW | 5-HT2C receptor | 6BQH |
| TM3 | 79 | K | 3.22x22 | CCR5 | 5UIW | α2A-adrenoceptor | 6KUX |
| TM3 | 80 | V | 3.23x23 | CCR5 | 5UIW | κ receptor | 6VI4 |
| TM3 | 81 | V | 3.24x24 | CCR5 | 5UIW | 5-HT1B receptor | 4IAQ |
| TM3 | 82 | C | 3.25x25 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM3 | 83 | A | 3.26x26 | CCR5 | 5UIW | 5-HT2A receptor | 6A94 |
| TM3 | 84 | L | 3.27x27 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM3 | 85 | T | 3.28x28 | CCR5 | 5UIW | P2Y12 receptor | 4NTJ |
| TM3 | 86 | S | 3.29x29 | CCR5 | 5UIW | AT1 receptor | 4ZUD |
| TM3 | 87 | F | 3.30x30 | CCR5 | 5UIW | MT1 receptor | 6ME2 |
| TM3 | 88 | G | 3.31x31 | CCR5 | 5UIW | CB1 receptor | 5TGZ |
| TM3 | 89 | F | 3.32x32 | CCR5 | 5UIW | DP2 receptor | 6D27 |
| TM3 | 90 | Y | 3.33x33 | CCR5 | 5UIW | H1 receptor | 3RZE |
| TM3 | 91 | S | 3.34x34 | CCR5 | 5UIW | ghrelin receptor | 6KO5 |
| TM3 | 92 | S | 3.35x35 | CCR5 | 5UIW | MT1 receptor | 6ME2 |
| TM3 | 93 | I | 3.36x36 | CCR5 | 5UIW | Y1 receptor | 5ZBH |
| TM3 | 94 | Y | 3.37x37 | CCR5 | 5UIW | CXCR4 | 3ODU |
| TM3 | 95 | C | 3.38x38 | CCR5 | 5UIW | PAR2 | 5NDD |
| TM3 | 96 | S | 3.39x39 | CCR5 | 5UIW | MT1 receptor | 6ME2 |
| TM3 | 97 | T | 3.40x40 | CCR5 | 5UIW | NOP receptor | 5DHG |
| TM3 | 98 | W | 3.41x41 | CCR5 | 5UIW | MT1 receptor | 6ME2 |
| TM3 | 99 | L | 3.42x42 | CCR5 | 5UIW | AT1 receptor | 4ZUD |
| TM3 | 100 | L | 3.43x43 | CCR5 | 5UIW | κ receptor | 6VI4 |
| TM3 | 101 | A | 3.44x44 | CCR5 | 5UIW | CXCR4 | 3ODU |
| TM3 | 102 | G | 3.45x45 | CCR5 | 5UIW | MT1 receptor | 6ME2 |
| TM3 | 103 | I | 3.46x46 | CCR5 | 5UIW | MT1 receptor | 6ME2 |
| TM3 | 104 | S | 3.47x47 | CCR5 | 5UIW | κ receptor | 6VI4 |
| TM3 | 105 | I | 3.48x48 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM3 | 106 | E | 3.49x49 | CCR5 | 5UIW | ghrelin receptor | 6KO5 |
| TM3 | 107 | R | 3.50x50 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM3 | 108 | Y | 3.51x51 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM3 | 109 | L | 3.52x52 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM3 | 110 | G | 3.53x53 | CCR5 | 5UIW | FFA1 receptor | 5TZY |
| TM3 | 111 | V | 3.54x54 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM3 | 112 | A | 3.55x55 | CCR5 | 5UIW | CCR9 | 5LWE |
| TM3 | 113 | F | 3.56x56 | CCR5 | 5UIW | ghrelin receptor | 6KO5 |
| ICL2 | 114 | P | 34.50x50 | - | - | - | - |
| ICL2 | 115 | V | 34.51x51 | FFA1 receptor | 5TZY | CCR5 | 4MBS |
| ICL2 | 116 | Q | 34.52x52 | FFA1 receptor | 5TZY | CysLT1 receptor | 6RZ5 |
| ICL2 | 117 | Y | 34.53x53 | FFA1 receptor | 5TZY | FFA1 receptor | 5TZY |
| ICL2 | 118 | K | 34.54x54 | FFA1 receptor | 5TZY | ghrelin receptor | 6KO5 |
| ICL2 | 119 | L | 34.55x55 | FFA1 receptor | 5TZY | α2A-adrenoceptor | 6KUX |
| ICL2 | 120 | S | 34.56x56 | FFA1 receptor | 5TZY | - | - |
| ICL2 | 121 | R | 34.57x57 | - | - | - | - |
| TM4 | 122 | R | 4.38x38 | CCR5 | 5UIW | OT receptor | 6TPK |
| TM4 | 123 | P | 4.39x39 | CCR5 | 5UIW | κ receptor | 6VI4 |
| TM4 | 124 | L | 4.40x40 | CCR5 | 5UIW | κ receptor | 6VI4 |
| TM4 | 125 | Y | 4.41x41 | CCR5 | 5UIW | CCR9 | 5LWE |
| TM4 | 126 | G | 4.42x42 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM4 | 127 | V | 4.43x43 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM4 | 128 | I | 4.44x44 | CCR5 | 5UIW | κ receptor | 6VI4 |
| TM4 | 129 | A | 4.45x45 | CCR5 | 5UIW | apelin receptor | 5VBL |
| TM4 | 130 | A | 4.46x46 | CCR5 | 5UIW | - | - |
| TM4 | 131 | L | 4.47x47 | CCR5 | 5UIW | MT1 receptor | 6ME2 |
| TM4 | 132 | V | 4.48x48 | CCR5 | 5UIW | apelin receptor | 5VBL |
| TM4 | 133 | A | 4.49x49 | CCR5 | 5UIW | H1 receptor | 3RZE |
| TM4 | 134 | W | 4.50x50 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM4 | 135 | V | 4.51x51 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM4 | 136 | M | 4.52x52 | CCR5 | 5UIW | Rhodopsin | 1GZM |
| TM4 | 137 | S | 4.53x53 | CCR5 | 5UIW | H1 receptor | 3RZE |
| TM4 | 138 | F | 4.54x54 | CCR5 | 5UIW | H1 receptor | 3RZE |
| TM4 | 139 | G | 4.55x55 | CCR5 | 5UIW | 5-HT2C receptor | 6BQH |
| TM4 | 140 | H | 4.56x56 | CCR5 | 5UIW | FFA1 receptor | 5TZY |
| TM4 | 141 | C | 4.57x57 | FFA1 receptor | 5TZY | CCR9 | 5LWE |
| TM4 | 142 | T | 4.58x58 | FFA1 receptor | 5TZY | - | - |
| TM4 | 143 | I | 4.59x59 | FFA1 receptor | 5TZY | H1 receptor | 3RZE |
| TM4 | 144 | V | 4.60x60 | CCR5 | 5UIW | μ receptor | 4DKL |
| TM4 | 145 | I | 4.61x61 | CCR5 | 5UIW | H1 receptor | 3RZE |
| TM4 | 146 | I | 4.62x62 | CCR5 | 5UIW | CCR5 | 5UIW |
| ECL2 | 147 | V | - | - | - | - | |
| ECL2 | 148 | Q | NTS1 receptor | 6PWC | - | - | |
| ECL2 | 149 | Y | NTS1 receptor | 6PWC | - | - | |
| ECL2 | 150 | L | NTS1 receptor | 6PWC | - | - | |
| ECL2 | 151 | N | NTS1 receptor | 6PWC | - | - | |
| ECL2 | 152 | T | NTS1 receptor | 6PWC | - | - | |
| ECL2 | 153 | T | NTS1 receptor | 6PWC | - | - | |
| ECL2 | 154 | E | NTS1 receptor | 6PWC | - | - | |
| ECL2 | 155 | Q | NTS1 receptor | 6PWC | - | - | |
| ECL2 | 156 | V | NTS1 receptor | 6PWC | - | - | |
| ECL2 | 157 | R | NTS1 receptor | 6PWC | - | - | |
| ECL2 | 158 | S | NTS1 receptor | 6PWC | - | - | |
| ECL2 | 159 | G | NTS1 receptor | 6PWC | NTS1 receptor | 6PWC | |
| ECL2 | 160 | N | NTS1 receptor | 6PWC | - | - | |
| ECL2 | 161 | E | NTS1 receptor | 6PWC | - | - | |
| ECL2 | 162 | I | NTS1 receptor | 6PWC | - | - | |
| ECL2 | 163 | T | - | - | - | - | |
| ECL2 | 164 | C | 45.50x50 | CCR5 | 5UIW | CCR5 | 5UIW |
| ECL2 | 165 | Y | 45.51x51 | CCR5 | 5UIW | apelin receptor | 5VBL |
| ECL2 | 166 | E | 45.52x52 | CCR5 | 5UIW | OX2 receptor | 5WS3 |
| ECL2 | 167 | N | CCR5 | 5UIW | - | - | |
| ECL2 | 168 | F | CCR5 | 5UIW | CCR5 | 5UIW | |
| ECL2 | 169 | T | CCR5 | 5UIW | - | - | |
| ECL2 | 170 | D | CCR5 | 5UIW | - | - | |
| ECL2 | 171 | N | CCR5 | 5UIW | - | - | |
| TM5 | 172 | Q | 5.31x32 | CCR5 | 5UIW | NOP receptor | 5DHG |
| TM5 | 173 | L | 5.32x33 | CCR5 | 5UIW | P2Y1 receptor | 4XNW |
| TM5 | 174 | D | 5.33x34 | CCR5 | 5UIW | - | - |
| TM5 | 175 | V | 5.34x35 | CCR5 | 5UIW | - | - |
| TM5 | 176 | V | 5.35x36 | CCR5 | 5UIW | CXCR4 | 3ODU |
| TM5 | 177 | L | 5.36x37 | CCR5 | 5UIW | κ receptor | 6VI4 |
| TM5 | 178 | P | 5.37x38 | CCR5 | 5UIW | FFA1 receptor | 5TZY |
| TM5 | 179 | V | 5.38x39 | CCR5 | 5UIW | C5a1 receptor | 5O9H |
| TM5 | 180 | R | 5.39x40 | CCR5 | 5UIW | FFA1 receptor | 5TZY |
| TM5 | 181 | L | 5.40x41 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM5 | 182 | E | 5.41x42 | CCR5 | 5UIW | US28 | 5WB1 |
| TM5 | 183 | L | 5.42x43 | CCR5 | 5UIW | ETB receptor | 5X93 |
| TM5 | 184 | C | 5.43x44 | CCR5 | 5UIW | α2A-adrenoceptor | 6KUX |
| TM5 | 185 | L | 5.44x45 | CCR5 | 5UIW | δ receptor | 4N6H |
| TM5 | 186 | V | 5.45x46 | CCR5 | 5UIW | CXCR4 | 3ODU |
| TM5 | 187 | L | 5.46x461 | CCR5 | 5UIW | GnRH1 receptor | 7BR3 |
| TM5 | 188 | F | 5.47x47 | CCR5 | 5UIW | MT1 receptor | 6ME2 |
| TM5 | 189 | F | 5.48x48 | CCR5 | 5UIW | 5-HT2C receptor | 6BQH |
| TM5 | 190 | I | 5.49x49 | CCR5 | 5UIW | κ receptor | 6VI4 |
| TM5 | 191 | P | 5.50x50 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM5 | 192 | M | 5.51x51 | CCR5 | 5UIW | MT1 receptor | 6ME2 |
| TM5 | 193 | A | 5.52x52 | CCR5 | 5UIW | DP2 receptor | 6D27 |
| TM5 | 194 | V | 5.53x53 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM5 | 195 | T | 5.54x54 | CCR5 | 5UIW | D3 receptor | 3PBL |
| TM5 | 196 | I | 5.55x55 | CCR5 | 5UIW | MT1 receptor | 6ME2 |
| TM5 | 197 | F | 5.56x56 | CCR5 | 5UIW | MT1 receptor | 6ME2 |
| TM5 | 198 | C | 5.57x57 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM5 | 199 | Y | 5.58x58 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM5 | 200 | W | 5.59x59 | CCR5 | 5UIW | D4 receptor | 5WIV |
| TM5 | 201 | R | 5.60x60 | CCR5 | 5UIW | MT1 receptor | 6ME2 |
| TM5 | 202 | F | 5.61x61 | CCR5 | 5UIW | - | - |
| TM5 | 203 | V | 5.62x62 | CCR5 | 5UIW | Rhodopsin | 1GZM |
| TM5 | 204 | W | 5.63x63 | CCR5 | 5UIW | CB1 receptor | 5TGZ |
| TM5 | 205 | I | 5.64x64 | CCR5 | 5UIW | α2A-adrenoceptor | 6KUX |
| TM5 | 206 | M | 5.65x65 | CCR5 | 5UIW | ETB receptor | 5X93 |
| TM5 | 207 | L | 5.66x66 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM5 | 208 | S | 5.67x67 | CCR5 | 5UIW | PAR1 | 3VW7 |
| ICL3 | 209 | Q | - | - | - | - | |
| ICL3 | 210 | P | - | - | - | - | |
| ICL3 | 211 | L | - | - | - | - | |
| ICL3 | 212 | V | - | - | - | - | |
| TM6 | 213 | G | 6.26x27 | PAR2 | 5NDD | CXCR4 | 3ODU |
| TM6 | 214 | A | 6.27x28 | CCR5 | 5UIW | α2C-adrenoceptor | 6KUW |
| TM6 | 215 | Q | 6.28x29 | CCR5 | 5UIW | CXCR4 | 3ODU |
| TM6 | 216 | R | 6.29x30 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM6 | 217 | R | 6.30x31 | CCR5 | 5UIW | H1 receptor | 3RZE |
| TM6 | 218 | R | 6.31x32 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM6 | 219 | R | 6.32x33 | CCR5 | 5UIW | PAR2 | 5NDD |
| TM6 | 220 | A | 6.33x34 | CCR5 | 5UIW | H1 receptor | 3RZE |
| TM6 | 221 | V | 6.34x35 | CCR5 | 5UIW | MT1 receptor | 6ME2 |
| TM6 | 222 | G | 6.35x36 | CCR5 | 5UIW | CysLT1 receptor | 6RZ4 |
| TM6 | 223 | L | 6.36x37 | CCR5 | 5UIW | H1 receptor | 3RZE |
| TM6 | 224 | A | 6.37x38 | CCR5 | 5UIW | D3 receptor | 3PBL |
| TM6 | 225 | V | 6.38x39 | CCR5 | 5UIW | MT1 receptor | 6ME2 |
| TM6 | 226 | V | 6.39x40 | CCR5 | 5UIW | MT1 receptor | 6ME2 |
| TM6 | 227 | T | 6.40x41 | CCR5 | 5UIW | CysLT2 receptor | 6RZ6 |
| TM6 | 228 | L | 6.41x42 | CCR5 | 5UIW | CXCR4 | 3ODU |
| TM6 | 229 | L | 6.42x43 | CCR5 | 5UIW | MT1 receptor | 6ME2 |
| TM6 | 230 | N | 6.43x44 | CCR5 | 5UIW | - | - |
| TM6 | 231 | F | 6.44x45 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM6 | 232 | L | 6.45x46 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 233 | V | 6.46x461 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM6 | 234 | C | 6.47x47 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 235 | F | 6.48x48 | CCR5 | 5UIW | MT1 receptor | 6ME2 |
| TM6 | 236 | G | 6.49x49 | CCR5 | 5UIW | DP2 receptor | 6D27 |
| TM6 | 237 | P | 6.50x50 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM6 | 238 | Y | 6.51x51 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM6 | 239 | N | 6.52x52 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM6 | 240 | V | 6.53x53 | CCR5 | 5UIW | ghrelin receptor | 6KO5 |
| TM6 | 241 | S | 6.54x54 | CCR5 | 5UIW | α2C-adrenoceptor | 6KUW |
| TM6 | 242 | H | 6.55x55 | CCR5 | 5UIW | D3 receptor | 3PBL |
| TM6 | 243 | L | 6.56x56 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM6 | 244 | V | 6.57x57 | CCR5 | 5UIW | H1 receptor | 3RZE |
| TM6 | 245 | G | 6.58x58 | CCR5 | 5UIW | Rhodopsin | 6I9K |
| TM6 | 246 | Y | 6.59x59 | CCR5 | 5UIW | NK1 receptor | 6HLP |
| TM6 | 247 | H | 6.60x60 | CCR5 | 5UIW | D3 receptor | 3PBL |
| TM6 | 248 | Q | 6.61x61 | CCR5 | 5UIW | CCR5 | 5UIW |
| ECL3 | 249 | R | - | - | - | - | |
| ECL3 | 250 | K | - | - | - | - | |
| ECL3 | 251 | S | - | - | - | - | |
| ECL3 | 252 | P | - | - | - | - | |
| TM7 | 253 | W | 7.33x32 | CCR5 | 5UIW | MT1 receptor | 6ME2 |
| TM7 | 254 | W | 7.34x33 | CCR5 | 5UIW | CXCR4 | 3ODU |
| TM7 | 255 | R | 7.35x34 | CCR5 | 5UIW | BLT1 receptor | 5X33 |
| TM7 | 256 | S | 7.36x35 | CCR5 | 5UIW | CXCR4 | 3ODU |
| TM7 | 257 | I | 7.37x36 | CCR5 | 5UIW | CXCR4 | 3ODU |
| TM7 | 258 | A | 7.38x37 | CCR5 | 5UIW | A1 receptor | 5UEN |
| TM7 | 259 | V | 7.39x38 | CCR5 | 5UIW | 5-HT2C receptor | 6BQH |
| TM7 | 260 | V | 7.40x39 | CCR5 | 5UIW | ghrelin receptor | 6KO5 |
| TM7 | 261 | F | 7.41x40 | CCR5 | 5UIW | α2A-adrenoceptor | 6KUX |
| TM7 | 262 | S | 7.42x41 | CCR5 | 5UIW | apelin receptor | 5VBL |
| TM7 | 263 | S | 7.43x42 | CCR5 | 5UIW | ETB receptor | 5X93 |
| TM7 | 264 | L | 7.44x43 | CCR5 | 5UIW | 5-HT2A receptor | 6A94 |
| TM7 | 265 | N | 7.45x45 | CCR5 | 5UIW | MT1 receptor | 6ME2 |
| TM7 | 266 | A | 7.46x46 | CCR5 | 5UIW | ghrelin receptor | 6KO5 |
| TM7 | 267 | S | 7.47x47 | CCR5 | 5UIW | κ receptor | 6VI4 |
| TM7 | 268 | L | 7.48x48 | CCR5 | 5UIW | MT1 receptor | 6ME2 |
| TM7 | 269 | D | 7.49x49 | CCR5 | 5UIW | GnRH1 receptor | 7BR3 |
| TM7 | 270 | P | 7.50x50 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM7 | 271 | L | 7.51x51 | CCR5 | 5UIW | H1 receptor | 3RZE |
| TM7 | 272 | L | 7.52x52 | CCR5 | 5UIW | κ receptor | 6VI4 |
| TM7 | 273 | F | 7.53x53 | CCR5 | 5UIW | - | - |
| TM7 | 274 | Y | 7.54x54 | CCR5 | 5UIW | ETB receptor | 5X93 |
| TM7 | 275 | F | 7.55x55 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM7 | 276 | S | 7.56x56 | CCR5 | 5UIW | 5-HT1B receptor | 4IAQ |
| H8 | 277 | S | 8.47x47 | CCR5 | 5UIW | OX2 receptor | 5WS3 |
| H8 | 278 | S | 8.48x48 | CCR5 | 5UIW | GPR52 | 6LI1 |
| H8 | 279 | V | 8.49x49 | CCR5 | 5UIW | GPR52 | 6LI3 |
| H8 | 280 | V | 8.50x50 | CCR5 | 5UIW | EP4 receptor | 5YWY |
| H8 | 281 | R | 8.51x51 | CCR5 | 5UIW | CCR5 | 5UIW |
| H8 | 282 | R | 8.52x52 | CCR5 | 5UIW | κ receptor | 6VI4 |
| H8 | 283 | A | 8.53x53 | CCR5 | 5UIW | 5-HT2C receptor | 6BQH |
| H8 | 284 | F | 8.54x54 | CCR5 | 5UIW | H1 receptor | 3RZE |
| H8 | 285 | G | 8.55x55 | CCR5 | 5UIW | 5-HT2B receptor | 4IB4 |
| H8 | 286 | R | 8.56x56 | CCR5 | 5UIW | MT1 receptor | 6ME2 |
| H8 | 287 | G | 8.57x57 | CCR5 | 5UIW | - | - |
| H8 | 288 | L | 8.58x58 | CCR5 | 5UIW | H1 receptor | 3RZE |
| H8 | 289 | Q | 8.59x59 | CCR5 | 5UIW | CCR5 | 5UIW |
| H8 | 290 | V | 8.60x60 | MT1 receptor | 6ME2 | - | - |
| H8 | 291 | L | 8.61x61 | MT1 receptor | 6ME2 | MT1 receptor | 6ME3 |
| C-term | 292 | R | - | - | - | - | |
| C-term | 293 | N | - | - | - | - | |
| C-term | 294 | Q | - | - | - | - | |
| C-term | 295 | G | - | - | - | - | |
| C-term | 296 | S | - | - | - | - |