FZD8 homology model

PROTEIN CLASS

Class F (Frizzled)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active

VERSION

2020-10-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

NGL is a WebGL based 3D viewer powered by MMTF.

MAIN TEMPLATE

SMO (sequence similarity: 40%) PDB: 6XBM

TEMPLATES

6XBM (SMO)
4JKV (SMO)
6BD4 (FZD4)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 62.5 10.8 26.7
Side-chains 21.9 27.5 50.6

Number of backbone templates: 3
Number of rotamer templates: 5

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 265 H SMO 6XBM SMO 6XBM
N-term 266 N SMO 6XBM SMO 6XBM
N-term 267 P SMO 6XBM SMO 6XBM
N-term 268 F SMO 6XBM SMO 6XBM
N-term 269 F SMO 6XBM SMO 6XBM
TM1 270 S 1.25x25 SMO 6XBM FZD4 6BD4
TM1 271 Q 1.26x26 SMO 6XBM - -
TM1 272 D 1.27x27 SMO 6XBM - -
TM1 273 E 1.28x28 SMO 6XBM SMO 6XBM
TM1 274 R 1.29x29 SMO 6XBM - -
TM1 275 A 1.30x30 SMO 6XBM - -
TM1 276 F 1.31x31 SMO 6XBM FZD4 6BD4
TM1 277 T 1.32x32 SMO 6XBM FZD4 6BD4
TM1 278 V 1.33x33 SMO 6XBM - -
TM1 279 F 1.34x34 SMO 6XBM - -
TM1 280 W 1.35x35 SMO 6XBM FZD4 6BD4
TM1 281 I 1.36x36 SMO 6XBM SMO 6XBM
TM1 282 G 1.37x37 SMO 6XBM - -
TM1 283 L 1.38x38 SMO 6XBM - -
TM1 284 W 1.39x39 SMO 6XBM FZD4 6BD4
TM1 285 S 1.40x40 SMO 6XBM SMO 6D32
TM1 286 V 1.41x41 SMO 6XBM - -
TM1 287 L 1.42x42 SMO 6XBM FZD4 6BD4
TM1 288 C 1.43x43 SMO 6XBM FZD4 6BD4
TM1 289 F 1.44x44 SMO 6XBM FZD4 6BD4
TM1 290 V 1.45x45 SMO 6XBM - -
TM1 291 S 1.46x46 SMO 6XBM FZD4 6BD4
TM1 292 T 1.47x47 SMO 6XBM SMO 6XBM
TM1 293 F 1.48x48 SMO 6XBM SMO 6D32
TM1 294 A 1.49x49 SMO 6XBM - -
TM1 295 T 1.50x50 SMO 6XBM SMO 6XBM
TM1 296 V 1.51x51 SMO 6XBM FZD4 6BD4
TM1 297 S 1.52x52 SMO 6XBM - -
TM1 298 T 1.53x53 SMO 6XBM SMO 6XBM
TM1 299 F 1.54x54 SMO 6XBM SMO 6XBM
TM1 300 L 1.55x55 SMO 6XBM FZD4 6BD4
TM1 301 I 1.56x56 SMO 6XBM FZD4 6BD4
TM1 302 D 1.57x57 SMO 6XBM SMO 6XBM
ICL1 303 M 12.47x47 - - - -
ICL1 304 E 12.48x48 FZD4 6BD4 - -
ICL1 305 R 12.49x49 FZD4 6BD4 FZD4 6BD4
ICL1 306 F 12.50x50 FZD4 6BD4 FZD4 6BD4
ICL1 307 K 12.51x51 - - - -
TM2 308 Y 2.39x39 SMO 6XBM SMO 6XBM
TM2 309 P 2.40x40 SMO 6XBM SMO 6XBM
TM2 310 E 2.41x41 SMO 6XBM FZD4 6BD4
TM2 311 R 2.42x42 SMO 6XBM FZD4 6BD4
TM2 312 P 2.43x43 SMO 6XBM FZD4 6BD4
TM2 313 I 2.44x44 SMO 6XBM FZD4 6BD4
TM2 314 I 2.45x45 SMO 6XBM FZD4 6BD4
TM2 315 F 2.46x46 SMO 6XBM FZD4 6BD4
TM2 316 L 2.47x47 SMO 6XBM FZD4 6BD4
TM2 317 S 2.48x48 SMO 6XBM FZD4 6BD4
TM2 318 A 2.49x49 SMO 6XBM SMO 6XBM
TM2 319 C 2.50x50 SMO 6XBM SMO 6XBM
TM2 320 Y 2.51x51 SMO 6XBM FZD4 6BD4
TM2 321 L 2.52x52 SMO 6XBM - -
TM2 322 F 2.53x53 SMO 6XBM - -
TM2 323 V 2.54x54 SMO 6XBM - -
TM2 324 S 2.55x55 SMO 6XBM SMO 6XBM
TM2 325 V 2.56x56 SMO 6XBM - -
TM2 326 G 2.57x57 SMO 6XBM SMO 6XBM
TM2 327 Y 2.58x58 SMO 6XBM FZD4 6BD4
TM2 328 L 2.59x59 SMO 6XBM SMO 6XBM
TM2 329 V 2.60x60 SMO 6XBM FZD4 6BD4
TM2 330 R 2.61x61 SMO 6XBM FZD4 6BD4
TM2 331 L 2.62x62 SMO 6XBM - -
TM2 332 V 2.63x63 FZD4 6BD4 - -
TM2 333 A 2.64x64 FZD4 6BD4 - -
TM2 334 G 2.65x65 FZD4 6BD4 FZD4 6BD4
ECL1 335 H - - - -
ECL1 336 E - - - -
ECL1 337 K - - - -
ECL1 338 V - - - -
ECL1 339 A - - - -
ECL1 340 C - - - -
ECL1 341 S - - - -
ECL1 342 G - - - -
ECL1 343 G - - - -
ECL1 344 A - - - -
ECL1 345 P - - - -
ECL1 346 G - - - -
ECL1 347 A - - - -
ECL1 348 G - - - -
ECL1 349 G - - - -
ECL1 350 A - - - -
ECL1 351 G - - - -
ECL1 352 G - - - -
ECL1 353 A - - - -
ECL1 354 G - - - -
ECL1 355 G - - - -
ECL1 356 A - - - -
ECL1 357 A - - - -
ECL1 358 A - - - -
ECL1 359 G - - - -
ECL1 360 A - - - -
ECL1 361 G - - - -
ECL1 362 A - - - -
ECL1 363 A - - - -
ECL1 364 G - - - -
ECL1 365 A - - - -
ECL1 366 G - - - -
ECL1 367 A - - - -
ECL1 368 G - - - -
ECL1 369 G - - - -
ECL1 370 P - - - -
ECL1 371 G - - - -
ECL1 372 G - - - -
ECL1 373 R - - - -
ECL1 374 G - - - -
ECL1 375 E - - - -
ECL1 376 Y - - - -
ECL1 377 E - - - -
ECL1 378 E - - - -
ECL1 379 L - - - -
ECL1 380 G - - - -
ECL1 381 A - - - -
ECL1 382 V - - - -
ECL1 383 E - - - -
ECL1 384 Q - - - -
ECL1 385 H - - - -
ECL1 386 V - - - -
ECL1 387 R - - - -
ECL1 388 Y - - - -
ECL1 389 E - - - -
ECL1 390 T - - - -
ECL1 391 T - - - -
ECL1 392 G - - - -
TM3 393 P 3.22x22 FZD4 6BD4 - -
TM3 394 A 3.23x23 SMO 6XBM - -
TM3 395 L 3.24x24 SMO 6XBM - -
TM3 396 C 3.25x25 SMO 6XBM SMO 6XBM
TM3 397 T 3.26x26 SMO 6XBM - -
TM3 398 V 3.27x27 SMO 6XBM - -
TM3 399 V 3.28x28 SMO 6XBM - -
TM3 400 F 3.29x29 SMO 6XBM SMO 6XBM
TM3 401 L 3.30x30 SMO 6XBM FZD4 6BD4
TM3 402 L 3.31x31 SMO 6XBM FZD4 6BD4
TM3 403 V 3.32x32 SMO 6XBM SMO 6XBM
TM3 404 Y 3.33x33 SMO 6XBM SMO 6XBM
TM3 405 F 3.34x34 SMO 6XBM FZD4 6BD4
TM3 406 F 3.35x35 SMO 6XBM FZD4 6BD4
TM3 407 G 3.36x36 SMO 6XBM FZD4 6BD4
TM3 408 M 3.37x37 SMO 6XBM SMO 6XBM
TM3 409 A 3.38x38 SMO 6XBM SMO 6XBM
TM3 410 S 3.39x39 SMO 6XBM FZD4 6BD4
TM3 411 S 3.40x40 SMO 6XBM FZD4 6BD4
TM3 412 I 3.41x41 SMO 6XBM FZD4 6BD4
TM3 413 W 3.42x42 SMO 6XBM SMO 6XBM
TM3 414 W 3.43x43 SMO 6XBM FZD4 6BD4
TM3 415 V 3.44x44 SMO 6XBM SMO 6XBM
TM3 416 I 3.45x45 SMO 6XBM FZD4 6BD4
TM3 417 L 3.46x46 SMO 6XBM SMO 6XBM
TM3 418 S 3.47x47 SMO 6XBM - -
TM3 419 L 3.48x48 SMO 6XBM FZD4 6BD4
TM3 420 T 3.49x49 SMO 6XBM FZD4 6BD4
TM3 421 W 3.50x50 SMO 6XBM SMO 6XBM
TM3 422 F 3.51x51 SMO 6XBM FZD4 6BD4
TM3 423 L 3.52x52 SMO 6XBM FZD4 6BD4
TM3 424 A 3.53x53 SMO 6XBM FZD4 6BD4
TM3 425 A 3.54x54 SMO 6XBM FZD4 6BD4
TM3 426 G 3.55x55 SMO 6XBM FZD4 6BD4
ICL2 427 M - - - -
ICL2 428 K FZD4 6BD4 FZD4 6BD4
ICL2 429 W FZD4 6BD4 FZD4 6BD4
ICL2 430 G FZD4 6BD4 FZD4 6BD4
ICL2 431 N FZD4 6BD4 - -
ICL2 432 E FZD4 6BD4 FZD4 6BD4
ICL2 433 A FZD4 6BD4 FZD4 6BD4
ICL2 434 I FZD4 6BD4 FZD4 6BD4
ICL2 435 A FZD4 6BD4 - -
ICL2 436 G - - - -
TM4 437 Y 4.41x41 SMO 6XBM - -
TM4 438 S 4.42x42 SMO 6XBM FZD4 6BD4
TM4 439 Q 4.43x43 SMO 6XBM - -
TM4 440 Y 4.44x44 SMO 6XBM SMO 6XBM
TM4 441 F 4.45x45 SMO 6XBM SMO 6XBM
TM4 442 H 4.46x46 SMO 6XBM SMO 6XBM
TM4 443 L 4.47x47 SMO 6XBM SMO 6XBM
TM4 444 A 4.48x48 SMO 6XBM FZD4 6BD4
TM4 445 A 4.49x49 SMO 6XBM FZD4 6BD4
TM4 446 W 4.50x50 SMO 6XBM SMO 6XBM
TM4 447 L 4.51x51 SMO 6XBM - -
TM4 448 V 4.52x52 SMO 6XBM - -
TM4 449 P 4.53x53 SMO 6XBM SMO 6XBM
TM4 450 S 4.54x54 SMO 6XBM - -
TM4 451 V 4.55x55 SMO 6XBM SMO 6XBM
TM4 452 K 4.56x56 SMO 6XBM FZD4 6BD4
TM4 453 S 4.57x57 SMO 6XBM - -
TM4 454 I 4.58x58 SMO 6XBM FZD4 6BD4
TM4 455 A 4.59x59 SMO 6XBM SMO 6XBM
TM4 456 V 4.60x60 SMO 6XBM - -
TM4 457 L 4.61x61 SMO 6XBM SMO 6XBM
TM4 458 A 4.62x62 SMO 6XBM SMO 6XBM
TM4 459 L 4.63x63 SMO 6XBM - -
TM4 460 S 4.64x64 SMO 6XBM - -
ECL2 461 S SMO 6XBM - -
ECL2 462 V SMO 6XBM SMO 6XBM
ECL2 463 D SMO 6XBM SMO 6XBM
ECL2 464 G SMO 6XBM SMO 6XBM
ECL2 465 D SMO 6XBM SMO 6XBM
ECL2 466 P SMO 6XBM - -
ECL2 467 V SMO 6XBM SMO 6XBM
ECL2 468 A SMO 6XBM - -
ECL2 469 G SMO 6XBM SMO 6XBM
ECL2 470 I SMO 6XBM SMO 6XBM
ECL2 471 C 45.50x50 SMO 6XBM SMO 6XBM
ECL2 472 Y 45.51x51 SMO 6XBM FZD4 6BD4
ECL2 473 V 45.52x52 SMO 6XBM SMO 6XBM
ECL2 474 G SMO 6XBM SMO 6XBM
ECL2 475 N SMO 6XBM - -
ECL2 476 Q SMO 6XBM - -
TM5 477 S 5.39x40 SMO 6XBM - -
TM5 478 L 5.40x41 SMO 6XBM FZD4 6BD4
TM5 479 D 5.41x42 SMO 6XBM FZD4 6BD4
TM5 480 N 5.42x43 SMO 6XBM - -
TM5 481 L 5.43x44 SMO 6XBM FZD4 6BD4
TM5 482 R 5.44x45 SMO 6XBM - -
TM5 483 G 5.45x46 SMO 6XBM SMO 6XBM
TM5 484 F 5.46x461 SMO 6XBM SMO 6XBM
TM5 485 V 5.47x47 SMO 6XBM SMO 6XBM
TM5 486 L 5.48x48 SMO 6XBM SMO 6XBM
TM5 487 A 5.49x49 SMO 6XBM SMO 6XBM
TM5 488 P 5.50x50 SMO 6XBM SMO 6XBM
TM5 489 L 5.51x51 SMO 6XBM FZD4 6BD4
TM5 490 V 5.52x52 SMO 6XBM - -
TM5 491 I 5.53x53 SMO 6XBM - -
TM5 492 Y 5.54x54 SMO 6XBM FZD4 6BD4
TM5 493 L 5.55x55 SMO 6XBM SMO 6XBM
TM5 494 F 5.56x56 SMO 6XBM - -
TM5 495 I 5.57x57 SMO 6XBM FZD4 6BD4
TM5 496 G 5.58x58 SMO 6XBM SMO 6XBM
TM5 497 T 5.59x59 SMO 6XBM FZD4 6BD4
TM5 498 M 5.60x60 SMO 6XBM - -
TM5 499 F 5.61x61 SMO 6XBM SMO 6XBM
TM5 500 L 5.62x62 SMO 6XBM SMO 6XBM
TM5 501 L 5.63x63 SMO 6XBM - -
TM5 502 A 5.64x64 SMO 6XBM FZD4 6BD4
TM5 503 G 5.65x65 SMO 6XBM SMO 6XBM
TM5 504 F 5.66x66 SMO 6XBM - -
TM5 505 V 5.67x67 SMO 6XBM FZD4 6BD4
TM5 506 S 5.68x68 SMO 6XBM - -
TM5 507 L 5.69x69 SMO 6XBM SMO 6XBM
TM5 508 F 5.70x70 SMO 6XBM SMO 6XBM
TM5 509 R 5.71x71 SMO 6XBM - -
TM5 510 I 5.72x72 SMO 6XBM SMO 6XBM
TM5 511 R 5.73x73 SMO 4JKV FZD4 6BD4
TM5 512 S 5.74x74 SMO 4JKV SMO 4JKV
TM5 513 V 5.75x75 SMO 4JKV - -
TM5 514 I 5.76x76 SMO 4JKV - -
ICL3 515 K - - - -
ICL3 516 Q - - - -
ICL3 517 Q - - - -
ICL3 518 D - - - -
ICL3 519 G - - - -
ICL3 522 K - - - -
ICL3 523 T - - - -
ICL3 524 H - - - -
ICL3 525 K - - - -
ICL3 526 L - - - -
TM6 527 E 6.27x27 SMO 6XBM - -
TM6 528 K 6.28x28 SMO 6XBM - -
TM6 529 L 6.29x29 SMO 6XBM FZD4 6BD4
TM6 530 M 6.30x30 SMO 6XBM SMO 6XBM
TM6 531 I 6.31x31 SMO 6XBM - -
TM6 532 R 6.32x32 SMO 6XBM SMO 6XBM
TM6 533 L 6.33x33 SMO 6XBM SMO 6XBM
TM6 534 G 6.34x34 SMO 6XBM SMO 6XBM
TM6 535 L 6.35x35 SMO 6XBM - -
TM6 536 F 6.36x36 SMO 6XBM SMO 6XBM
TM6 537 T 6.37x37 SMO 6XBM - -
TM6 538 V 6.38x38 SMO 6XBM FZD4 6BD4
TM6 539 L 6.39x39 SMO 6XBM SMO 6XBM
TM6 540 Y 6.40x40 SMO 6XBM FZD4 6BD4
TM6 541 T 6.41x41 SMO 6XBM FZD4 6BD4
TM6 542 V 6.42x42 SMO 6XBM FZD4 6BD4
TM6 543 P 6.43x43 SMO 6XBM FZD4 6BD4
TM6 544 A 6.44x44 SMO 6XBM FZD4 6BD4
TM6 545 A 6.45x45 SMO 6XBM - -
TM6 546 V 6.46x46 SMO 6XBM - -
TM6 547 V 6.47x47 SMO 6XBM FZD4 6BD4
TM6 548 V 6.48x48 SMO 6XBM - -
TM6 549 A 6.49x49 SMO 6XBM FZD4 6BD4
TM6 550 C 6.50x50 SMO 6XBM SMO 6XBM
TM6 551 L 6.51x51 SMO 6XBM - -
TM6 552 F 6.52x52 SMO 6XBM SMO 6XBM
TM6 553 Y 6.53x53 SMO 6XBM SMO 6XBM
TM6 554 E 6.54x54 SMO 6XBM FZD4 6BD4
TM6 555 Q 6.55x55 SMO 6XBM - -
TM6 556 H 6.56x56 SMO 6XBM - -
TM6 557 N 6.57x57 SMO 6XBM SMO 6XBM
TM6 558 R 6.58x58 SMO 6XBM - -
TM6 559 P 6.59x59 SMO 6XBM - -
TM6 560 R 6.60x60 SMO 6XBM - -
TM6 561 W 6.61x61 SMO 6XBM SMO 6XBM
TM6 562 E 6.62x62 SMO 6XBM SMO 6XBM
ECL3 563 A - - - -
ECL3 564 T - - - -
ECL3 565 H - - - -
ECL3 566 N - - - -
ECL3 567 C - - - -
ECL3 568 P - - - -
ECL3 569 C - - - -
ECL3 570 L - - - -
ECL3 571 R - - - -
ECL3 572 D - - - -
ECL3 573 L - - - -
ECL3 574 Q - - - -
ECL3 575 P - - - -
ECL3 576 D - - - -
ECL3 577 Q - - - -
ECL3 578 A - - - -
ECL3 579 R - - - -
ECL3 580 R - - - -
ECL3 581 P - - - -
TM7 582 D 7.34x34 FZD4 6BD4 - -
TM7 583 Y 7.35x35 SMO 6XBM - -
TM7 584 A 7.36x36 SMO 6XBM FZD4 6BD4
TM7 585 V 7.37x37 SMO 6XBM SMO 6XBM
TM7 586 F 7.38x38 SMO 6XBM - -
TM7 587 M 7.39x39 SMO 6XBM FZD4 6BD4
TM7 588 L 7.40x40 SMO 6XBM FZD4 6BD4
TM7 589 K 7.41x41 SMO 6XBM FZD4 6BD4
TM7 590 Y 7.42x42 SMO 6XBM - -
TM7 591 F 7.43x43 SMO 6XBM SMO 6XBM
TM7 592 M 7.44x44 SMO 6XBM FZD4 6BD4
TM7 593 C 7.45x45 SMO 6XBM - -
TM7 594 L 7.46x46 SMO 6XBM FZD4 6BD4
TM7 595 V 7.47x47 SMO 6XBM - -
TM7 596 V 7.48x48 SMO 6XBM FZD4 6BD4
TM7 597 G 7.49x49 SMO 6XBM SMO 6XBM
TM7 598 I 7.50x50 SMO 6XBM SMO 6XBM
TM7 599 T 7.51x51 SMO 6XBM FZD4 6BD4
TM7 600 S 7.52x52 SMO 6XBM FZD4 6BD4
TM7 601 G 7.53x53 SMO 6XBM FZD4 6BD4
TM7 602 V 7.54x54 SMO 6XBM - -
TM7 603 W 7.55x55 FZD4 6BD4 FZD4 6BD4
TM7 604 V 7.56x56 FZD4 6BD4 SMO 6O3C
TM7 605 W 7.57x57 FZD4 6BD4 FZD4 6BD4
H8 606 S 8.47x47 FZD4 6BD4 FZD4 6BD4
H8 607 G 8.48x48 FZD4 6BD4 - -
H8 608 K 8.49x49 FZD4 6BD4 FZD4 6BD4
H8 609 T 8.50x50 FZD4 6BD4 FZD4 6BD4
H8 610 L 8.51x51 FZD4 6BD4 FZD4 6BD4
H8 611 E 8.52x52 FZD4 6BD4 - -
H8 612 S 8.53x53 FZD4 6BD4 - -
H8 613 W 8.54x54 FZD4 6BD4 FZD4 6BD4
H8 614 R 8.55x55 FZD4 6BD4 SMO 6O3C
H8 615 S 8.56x56 FZD4 6BD4 - -
H8 616 L 8.57x57 FZD4 6BD4 - -
H8 617 C 8.58x58 FZD4 6BD4 - -
H8 618 T 8.59x59 FZD4 6BD4 - -
H8 619 R 8.60x60 FZD4 6BD4 FZD4 6BD4
H8 620 C 8.61x61 FZD4 6BD4 - -
H8 621 C 8.62x62 FZD4 6BD4 - -
C-term 622 W - - - -
C-term 623 A - - - -
C-term 624 S - - - -
C-term 625 K - - - -
C-term 626 G - - - -