GnRH1 receptor homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active

VERSION

2020-09-02

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

κ receptor (sequence similarity: 36%) PDB: 6B73

TEMPLATES

6TPK (OT receptor)
6B73 (κ receptor)
5WS3 (OX2 receptor)
6TO7 (OX1 receptor)
5ZBQ (Y1 receptor)
6OSA (NTS1 receptor)
4UHR (A2A receptor)
5VBL (apelin receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 72.3 11.9 15.8
Side-chains 15.2 59.7 25.1

Number of backbone templates: 8
Number of rotamer templates: 54

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 26 G - - - -
N-term 27 N - - - -
N-term 28 L - - - -
N-term 29 P - - - -
N-term 30 T - - - -
TM1 31 L 1.28x28 OT receptor 6TPK US28 5WB1
TM1 32 T 1.29x29 OT receptor 6TPK M2 receptor 4MQT
TM1 33 L 1.30x30 κ receptor 6B73 PAR2 5NDD
TM1 34 S 1.31x31 κ receptor 6B73 NTS1 receptor 6OSA
TM1 35 G 1.32x32 κ receptor 6B73 D4 receptor 5WIV
TM1 36 K 1.33x33 κ receptor 6B73 S1P1 receptor 3V2Y
TM1 37 I 1.34x34 κ receptor 6B73 κ receptor 6B73
TM1 38 R 1.35x35 κ receptor 6B73 - -
TM1 39 V 1.36x36 κ receptor 6B73 5-HT1B receptor 6G79
TM1 40 T 1.37x37 κ receptor 6B73 AT1 receptor 6OS2
TM1 41 V 1.38x38 κ receptor 6B73 κ receptor 6B73
TM1 42 T 1.39x39 κ receptor 6B73 M1 receptor 6OIJ
TM1 43 F 1.40x40 κ receptor 6B73 Rhodopsin 4ZWJ
TM1 44 F 1.41x41 κ receptor 6B73 α2B-adrenoceptor 6K41
TM1 45 L 1.42x42 κ receptor 6B73 NTS1 receptor 6OSA
TM1 46 F 1.43x43 κ receptor 6B73 κ receptor 6B73
TM1 47 L 1.44x44 κ receptor 6B73 5-HT1B receptor 6G79
TM1 48 L 1.45x45 κ receptor 6B73 Rhodopsin 4ZWJ
TM1 49 S 1.46x46 κ receptor 6B73 A1 receptor 6D9H
TM1 50 A 1.47x47 κ receptor 6B73 CB2 receptor 6PT0
TM1 51 T 1.48x48 κ receptor 6B73 M1 receptor 6OIJ
TM1 52 F 1.49x49 κ receptor 6B73 - -
TM1 53 N 1.50x50 κ receptor 6B73 κ receptor 6B73
TM1 54 A 1.51x51 κ receptor 6B73 5-HT1B receptor 6G79
TM1 55 S 1.52x52 κ receptor 6B73 - -
TM1 56 F 1.53x53 κ receptor 6B73 - -
TM1 57 L 1.54x54 κ receptor 6B73 NTS1 receptor 6OSA
TM1 58 L 1.55x55 κ receptor 6B73 α2B-adrenoceptor 6K41
TM1 59 K 1.56x56 κ receptor 6B73 - -
TM1 60 L 1.57x57 κ receptor 6B73 NTS1 receptor 6OSA
TM1 61 Q 1.58x58 κ receptor 6B73 - -
TM1 62 K 1.59x59 κ receptor 6B73 β2-adrenoceptor 3SN6
TM1 63 W 1.60x60 κ receptor 6B73 - -
ICL1 64 T - - - -
ICL1 65 Q - - - -
ICL1 66 K - - - -
ICL1 67 K - - - -
ICL1 68 E - - - -
ICL1 69 K - - - -
ICL1 70 G - - - -
ICL1 71 K 12.48x48 OX2 receptor 5WS3 Rhodopsin 4ZWJ
ICL1 72 K 12.49x49 OX2 receptor 5WS3 Rhodopsin 4ZWJ
ICL1 73 L 12.50x50 OX2 receptor 5WS3 5-HT1B receptor 6G79
ICL1 74 S 12.51x51 - - - -
TM2 75 R 2.38x38 κ receptor 6B73 OT receptor 6TPK
TM2 76 M 2.39x39 κ receptor 6B73 S1P1 receptor 3V2Y
TM2 77 K 2.40x40 κ receptor 6B73 PAF receptor 5ZKQ
TM2 78 L 2.41x41 κ receptor 6B73 α2B-adrenoceptor 6K41
TM2 79 L 2.42x42 κ receptor 6B73 5-HT1B receptor 6G79
TM2 80 L 2.43x43 κ receptor 6B73 NTS1 receptor 6OSA
TM2 81 K 2.44x44 κ receptor 6B73 OT receptor 6TPK
TM2 82 H 2.45x45 κ receptor 6B73 OT receptor 6TPK
TM2 83 L 2.46x46 κ receptor 6B73 κ receptor 6B73
TM2 84 T 2.47x47 κ receptor 6B73 PAF receptor 5ZKQ
TM2 85 L 2.48x48 κ receptor 6B73 κ receptor 6B73
TM2 86 A 2.49x49 κ receptor 6B73 κ receptor 6B73
TM2 87 N 2.50x50 κ receptor 6B73 A2A receptor 5WF5
TM2 88 L 2.51x51 κ receptor 6B73 5-HT1B receptor 6G79
TM2 89 L 2.52x52 κ receptor 6B73 κ receptor 6B73
TM2 90 E 2.53x53 κ receptor 6B73 - -
TM2 91 T 2.54x54 κ receptor 6B73 κ receptor 6B73
TM2 92 L 2.55x55 OT receptor 6TPK NTS1 receptor 6OSA
TM2 93 I 2.56x551 OT receptor 6TPK OX1 receptor 6TO7
TM2 94 V 2.57x56 OT receptor 6TPK 5-HT1B receptor 6G79
TM2 95 M 2.58x57 κ receptor 6B73 κ receptor 6B73
TM2 96 P 2.59x58 κ receptor 6B73 κ receptor 6B73
TM2 97 L 2.60x59 κ receptor 6B73 M2 receptor 4MQT
TM2 98 D 2.61x60 κ receptor 6B73 ghrelin receptor 6KO5
TM2 99 G 2.62x61 κ receptor 6B73 NOP receptor 5DHG
TM2 100 M 2.63x62 κ receptor 6B73 5-HT1B receptor 4IAQ
TM2 101 W 2.64x63 κ receptor 6B73 OT receptor 6TPK
TM2 102 N 2.65x64 κ receptor 6B73 A1 receptor 6D9H
TM2 103 I 2.66x65 κ receptor 6B73 NTS1 receptor 6OSA
ECL1 104 T - - - -
ECL1 105 V - - - -
ECL1 106 Q 23.49x49 OT receptor 6TPK CCR5 5UIW
ECL1 107 W 23.50x50 OT receptor 6TPK EP3 receptor 6M9T
ECL1 108 Y 23.51x51 OT receptor 6TPK OT receptor 6TPK
ECL1 109 A 23.52x52 - - - -
TM3 110 G 3.21x21 κ receptor 6B73 κ receptor 6B73
TM3 111 E 3.22x22 κ receptor 6B73 δ receptor 6PT2
TM3 112 L 3.23x23 κ receptor 6B73 δ receptor 6PT2
TM3 113 L 3.24x24 κ receptor 6B73 κ receptor 6B73
TM3 114 C 3.25x25 κ receptor 6B73 κ receptor 6B73
TM3 115 K 3.26x26 κ receptor 6B73 κ receptor 6B73
TM3 116 V 3.27x27 κ receptor 6B73 α2B-adrenoceptor 6K41
TM3 117 L 3.28x28 κ receptor 6B73 CCR6 6WWZ
TM3 118 S 3.29x29 κ receptor 6B73 AT1 receptor 6OS2
TM3 119 Y 3.30x30 κ receptor 6B73 GPR52 6LI3
TM3 120 L 3.31x31 κ receptor 6B73 NTS1 receptor 6OSA
TM3 121 K 3.32x32 κ receptor 6B73 - -
TM3 122 L 3.33x33 κ receptor 6B73 A2A receptor 4UHR
TM3 123 F 3.34x34 κ receptor 6B73 AT1 receptor 6OS2
TM3 124 S 3.35x35 κ receptor 6B73 δ receptor 6PT2
TM3 125 M 3.36x36 κ receptor 6B73 κ receptor 6B73
TM3 126 Y 3.37x37 κ receptor 6B73 NTS1 receptor 6OSA
TM3 127 A 3.38x38 κ receptor 6B73 5-HT1B receptor 6G79
TM3 128 P 3.39x39 κ receptor 6B73 TP receptor 6IIV
TM3 129 A 3.40x40 κ receptor 6B73 NTS1 receptor 6OSA
TM3 130 F 3.41x41 κ receptor 6B73 κ receptor 6B73
TM3 131 M 3.42x42 κ receptor 6B73 - -
TM3 132 M 3.43x43 κ receptor 6B73 NK1 receptor 6HLP
TM3 133 V 3.44x44 κ receptor 6B73 Rhodopsin 4ZWJ
TM3 134 V 3.45x45 κ receptor 6B73 5-HT1B receptor 6G79
TM3 135 I 3.46x46 κ receptor 6B73 5-HT1B receptor 6G79
TM3 136 S 3.47x47 κ receptor 6B73 κ receptor 6B73
TM3 137 L 3.48x48 κ receptor 6B73 5-HT1B receptor 6G79
TM3 138 D 3.49x49 κ receptor 6B73 κ receptor 6B73
TM3 139 R 3.50x50 κ receptor 6B73 κ receptor 6B73
TM3 140 S 3.51x51 κ receptor 6B73 BLT1 receptor 5X33
TM3 141 L 3.52x52 κ receptor 6B73 NTS1 receptor 6OSA
TM3 142 A 3.53x53 κ receptor 6B73 κ receptor 6B73
TM3 143 I 3.54x54 κ receptor 6B73 5-HT1B receptor 6G79
TM3 144 T 3.55x55 κ receptor 6B73 5-HT1B receptor 6G79
TM3 145 R 3.56x56 κ receptor 6B73 α2B-adrenoceptor 6K41
ICL2 146 P 34.50x50 - - - -
ICL2 147 L 34.51x51 OX1 receptor 6TO7 OX1 receptor 6TO7
ICL2 148 A 34.52x52 OX1 receptor 6TO7 CB1 receptor 6N4B
ICL2 149 L 34.53x53 OX1 receptor 6TO7 - -
ICL2 150 K OX1 receptor 6TO7 OX1 receptor 6TO7
ICL2 151 S - - - -
TM4 152 N 4.38x38 κ receptor 6B73 AT2 receptor 6JOD
TM4 153 S 4.39x39 κ receptor 6B73 NOP receptor 5DHG
TM4 154 K 4.40x40 κ receptor 6B73 5-HT1B receptor 6G79
TM4 155 V 4.41x41 κ receptor 6B73 AT1 receptor 6OS2
TM4 156 G 4.42x42 κ receptor 6B73 apelin receptor 5VBL
TM4 157 Q 4.43x43 κ receptor 6B73 NOP receptor 5DHG
TM4 158 S 4.44x44 κ receptor 6B73 PAF receptor 5ZKQ
TM4 159 M 4.45x45 κ receptor 6B73 5-HT1B receptor 6G79
TM4 160 V 4.46x46 κ receptor 6B73 Rhodopsin 4ZWJ
TM4 161 G 4.47x47 κ receptor 6B73 M1 receptor 6OIJ
TM4 162 L 4.48x48 κ receptor 6B73 5-HT1B receptor 6G79
TM4 163 A 4.49x49 κ receptor 6B73 M2 receptor 4MQT
TM4 164 W 4.50x50 κ receptor 6B73 κ receptor 6B73
TM4 165 I 4.51x51 κ receptor 6B73 μ receptor 5C1M
TM4 166 L 4.52x52 κ receptor 6B73 κ receptor 6B73
TM4 167 S 4.53x53 κ receptor 6B73 κ receptor 6B73
TM4 168 S 4.54x54 κ receptor 6B73 κ receptor 6B73
TM4 169 V 4.55x55 κ receptor 6B73 α2B-adrenoceptor 6K41
TM4 170 F 4.56x56 κ receptor 6B73 EP3 receptor 6M9T
TM4 171 A 4.57x57 OT receptor 6TPK NTS1 receptor 6OSA
TM4 172 G 4.58x59 OT receptor 6TPK ghrelin receptor 6KO5
TM4 173 P 4.59x60 κ receptor 6B73 NTS1 receptor 6OSA
TM4 174 Q 4.60x61 κ receptor 6B73 OT receptor 6TPK
TM4 175 L 4.61x62 κ receptor 6B73 NTS1 receptor 6OSA
TM4 176 Y 4.62x63 κ receptor 6B73 AT2 receptor 6JOD
TM4 177 I 4.63x64 κ receptor 6B73 - -
TM4 178 F 4.64x65 OT receptor 6TPK OT receptor 6TPK
ECL2 179 R - - - -
ECL2 180 M - - - -
ECL2 181 I - - - -
ECL2 182 H - - - -
ECL2 183 L - - - -
ECL2 184 A - - - -
ECL2 185 D - - - -
ECL2 186 S - - - -
ECL2 187 S - - - -
ECL2 188 G - - - -
ECL2 189 Q - - - -
ECL2 190 T - - - -
ECL2 191 K - - - -
ECL2 192 V - - - -
ECL2 193 F - - - -
ECL2 194 S - - - -
ECL2 195 Q - - - -
ECL2 196 C - - - -
ECL2 197 V - - - -
ECL2 198 T - - - -
ECL2 199 H - - - -
ECL2 200 C 45.50x50 κ receptor 6B73 κ receptor 6B73
ECL2 201 S 45.51x51 κ receptor 6B73 κ receptor 6B73
ECL2 202 F 45.52x52 κ receptor 6B73 AT1 receptor 6OS2
ECL2 203 S - - - -
ECL2 204 Q Y1 receptor 5ZBQ - -
ECL2 205 W - - - -
TM5 206 W 5.33x34 κ receptor 6B73 κ receptor 6B73
TM5 207 H 5.34x35 κ receptor 6B73 Y1 receptor 5ZBH
TM5 208 Q 5.35x36 κ receptor 6B73 DP2 receptor 6D27
TM5 209 A 5.36x37 κ receptor 6B73 M2 receptor 4MQT
TM5 210 F 5.37x38 κ receptor 6B73 κ receptor 6B73
TM5 211 Y 5.38x39 κ receptor 6B73 α2B-adrenoceptor 6K41
TM5 212 N 5.39x40 κ receptor 6B73 US28 5WB1
TM5 213 F 5.40x41 κ receptor 6B73 M2 receptor 4MQT
TM5 214 F 5.41x42 κ receptor 6B73 A2A receptor 4UHR
TM5 215 T 5.42x43 κ receptor 6B73 M2 receptor 4MQT
TM5 216 F 5.43x44 κ receptor 6B73 κ receptor 6B73
TM5 217 S 5.44x45 κ receptor 6B73 ETB receptor 5X93
TM5 218 C 5.45x46 κ receptor 6B73 GPR52 6LI3
TM5 219 L 5.46x461 κ receptor 6B73 GPR52 6LI3
TM5 220 F 5.47x47 κ receptor 6B73 κ receptor 6B73
TM5 221 I 5.48x48 κ receptor 6B73 μ receptor 5C1M
TM5 222 I 5.49x49 κ receptor 6B73 κ receptor 6B73
TM5 223 P 5.50x50 κ receptor 6B73 κ receptor 6B73
TM5 224 L 5.51x51 κ receptor 6B73 β2-adrenoceptor 3SN6
TM5 225 F 5.52x52 κ receptor 6B73 ghrelin receptor 6KO5
TM5 226 I 5.53x53 κ receptor 6B73 κ receptor 6B73
TM5 227 M 5.54x54 κ receptor 6B73 M2 receptor 4MQT
TM5 228 L 5.55x55 κ receptor 6B73 AT1 receptor 6OS2
TM5 229 I 5.56x56 κ receptor 6B73 NTS1 receptor 4XES
TM5 230 C 5.57x57 κ receptor 6B73 κ receptor 6B73
TM5 231 N 5.58x58 κ receptor 6B73 NTS1 receptor 6OSA
TM5 232 A 5.59x59 κ receptor 6B73 H1 receptor 3RZE
TM5 233 K 5.60x60 κ receptor 6B73 D2 receptor 6VMS
TM5 234 I 5.61x61 κ receptor 6B73 5-HT1B receptor 6G79
TM5 235 I 5.62x62 κ receptor 6B73 κ receptor 6B73
TM5 236 F 5.63x63 κ receptor 6B73 Rhodopsin 4ZWJ
TM5 237 T 5.64x64 κ receptor 6B73 Rhodopsin 4ZWJ
TM5 238 L 5.65x65 κ receptor 6B73 κ receptor 6B73
TM5 239 T 5.66x66 κ receptor 6B73 NTS1 receptor 6OSA
TM5 240 R 5.67x67 κ receptor 6B73 α2B-adrenoceptor 6K41
TM5 241 V 5.68x68 NTS1 receptor 6OSA δ receptor 6PT2
TM5 242 L 5.69x69 NTS1 receptor 6OSA β2-adrenoceptor 3SN6
TM5 243 H 5.70x70 NTS1 receptor 6OSA NTS1 receptor 4BUO
TM5 244 Q 5.71x71 NTS1 receptor 6OSA NTS1 receptor 6OSA
TM5 245 D 5.72x72 NTS1 receptor 6OSA - -
TM5 246 P 5.73x73 NTS1 receptor 6OSA - -
TM5 247 H 5.74x74 NTS1 receptor 6OSA - -
ICL3 248 E κ receptor 6B73 - -
ICL3 249 L - - - -
ICL3 250 Q - - - -
ICL3 251 L - - - -
ICL3 252 N - - - -
TM6 253 Q 6.21x21 A2A receptor 4UHR - -
TM6 254 S 6.22x22 A2A receptor 4UHR - -
TM6 255 K 6.23x23 κ receptor 6B73 - -
TM6 256 N 6.24x24 κ receptor 6B73 - -
TM6 257 N 6.25x25 κ receptor 6B73 - -
TM6 258 I 6.26x26 κ receptor 6B73 D4 receptor 6IQL
TM6 259 P 6.27x27 κ receptor 6B73 - -
TM6 260 R 6.28x28 κ receptor 6B73 μ receptor 6DDF
TM6 261 A 6.29x29 κ receptor 6B73 NTS1 receptor 6OSA
TM6 262 R 6.30x30 κ receptor 6B73 AT2 receptor 6JOD
TM6 263 L 6.31x31 κ receptor 6B73 A1 receptor 6D9H
TM6 264 K 6.32x32 κ receptor 6B73 5-HT1B receptor 6G79
TM6 265 T 6.33x33 κ receptor 6B73 EP3 receptor 6M9T
TM6 266 L 6.34x34 κ receptor 6B73 β2-adrenoceptor 4LDE
TM6 267 K 6.35x35 κ receptor 6B73 5-HT1B receptor 6G79
TM6 268 M 6.36x36 κ receptor 6B73 μ receptor 5C1M
TM6 269 T 6.37x37 κ receptor 6B73 OT receptor 6TPK
TM6 270 V 6.38x38 κ receptor 6B73 CB1 receptor 6N4B
TM6 271 A 6.39x39 κ receptor 6B73 NTS1 receptor 6OSA
TM6 272 F 6.40x40 κ receptor 6B73 - -
TM6 273 A 6.41x41 κ receptor 6B73 D2 receptor 6CM4
TM6 274 T 6.42x42 κ receptor 6B73 CCR9 5LWE
TM6 275 S 6.43x43 κ receptor 6B73 FPR2/ALX 6LW5
TM6 276 F 6.44x44 κ receptor 6B73 κ receptor 6B73
TM6 277 T 6.45x45 κ receptor 6B73 β2-adrenoceptor 3SN6
TM6 278 V 6.46x46 κ receptor 6B73 κ receptor 6B73
TM6 279 C 6.47x47 κ receptor 6B73 κ receptor 6B73
TM6 280 W 6.48x48 κ receptor 6B73 κ receptor 6B73
TM6 281 T 6.49x49 κ receptor 6B73 κ receptor 6B73
TM6 282 P 6.50x50 κ receptor 6B73 κ receptor 6B73
TM6 283 Y 6.51x51 κ receptor 6B73 NTS1 receptor 6OSA
TM6 284 Y 6.52x52 κ receptor 6B73 CXCR4 3ODU
TM6 285 V 6.53x53 κ receptor 6B73 NTS1 receptor 6OSA
TM6 286 L 6.54x54 κ receptor 6B73 AT2 receptor 6JOD
TM6 287 G 6.55x55 κ receptor 6B73 C5a1 receptor 5O9H
TM6 288 I 6.56x56 κ receptor 6B73 μ receptor 5C1M
TM6 289 W 6.57x57 κ receptor 6B73 OT receptor 6TPK
TM6 290 Y 6.58x58 κ receptor 6B73 apelin receptor 5VBL
TM6 291 W 6.59x59 κ receptor 6B73 - -
TM6 292 F 6.60x60 κ receptor 6B73 M2 receptor 4MQT
TM6 293 D 6.61x61 κ receptor 6B73 MT1 receptor 6ME2
ECL3 294 P - - - -
TM7 295 E 7.25x24 apelin receptor 5VBL - -
TM7 296 M 7.26x25 apelin receptor 5VBL - -
TM7 297 L 7.27x26 apelin receptor 5VBL NTS1 receptor 6OSA
TM7 298 N 7.28x27 κ receptor 6B73 CB1 receptor 5XRA
TM7 299 R 7.29x28 κ receptor 6B73 US28 5WB1
TM7 300 L 7.30x29 κ receptor 6B73 δ receptor 6PT2
TM7 301 S 7.31x30 κ receptor 6B73 - -
TM7 302 D 7.32x31 κ receptor 6B73 AT1 receptor 6OS2
TM7 303 P 7.33x32 κ receptor 6B73 α2C-adrenoceptor 6KUW
TM7 304 V 7.34x33 κ receptor 6B73 M2 receptor 4MQT
TM7 305 N 7.35x34 κ receptor 6B73 ghrelin receptor 6KO5
TM7 306 H 7.36x35 κ receptor 6B73 μ receptor 5C1M
TM7 307 F 7.37x36 κ receptor 6B73 κ receptor 6B73
TM7 308 F 7.38x37 κ receptor 6B73 5-HT1B receptor 6G79
TM7 309 F 7.39x38 κ receptor 6B73 α2B-adrenoceptor 6K41
TM7 310 L 7.40x39 κ receptor 6B73 AT2 receptor 6JOD
TM7 311 F 7.41x40 κ receptor 6B73 Rhodopsin 4ZWJ
TM7 312 A 7.42x41 κ receptor 6B73 AT1 receptor 6OS2
TM7 313 F 7.43x42 κ receptor 6B73 AT2 receptor 6JOD
TM7 314 L 7.44x43 κ receptor 6B73 CCR6 6WWZ
TM7 315 N 7.45x45 κ receptor 6B73 κ receptor 6B73
TM7 316 P 7.46x46 κ receptor 6B73 EP4 receptor 5YWY
TM7 317 C 7.47x47 κ receptor 6B73 μ receptor 5C1M
TM7 318 F 7.48x48 κ receptor 6B73 β2-adrenoceptor 3SN6
TM7 319 D 7.49x49 κ receptor 6B73 EP3 receptor 6M9T
TM7 320 P 7.50x50 κ receptor 6B73 κ receptor 6B73
TM7 321 L 7.51x51 κ receptor 6B73 AT1 receptor 6OS2
TM7 322 I 7.52x52 OT receptor 6TPK OT receptor 6TPK
TM7 323 Y 7.53x53 OT receptor 6TPK OT receptor 6TPK
TM7 324 G 7.54x54 OT receptor 6TPK AT1 receptor 6OS2
TM7 325 Y 7.55x55 OT receptor 6TPK A2A receptor 4UHR
TM7 326 F 7.56x56 OT receptor 6TPK OT receptor 6TPK
C-term 327 S - - - -
C-term 328 L - - - -