GPR141 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-09-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

CXCR2 (sequence similarity: 31%) PDB: 6LFO

TEMPLATES

6LFO (CXCR2)
5XSZ (LPA6 receptor)
4DJH (κ receptor)
3VW7 (PAR1)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 83.2 7.4 9.4
Side-chains 16.4 56.4 27.2

Number of backbone templates: 4
Number of rotamer templates: 48

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 8 R - CXCR2 6LFO CXCR2 6LFO
N-term 9 N - CXCR2 6LFO CXCR2 6LFO
N-term 10 S - CXCR2 6LFO CXCR2 6LFO
N-term 11 S - CXCR2 6LFO CXCR2 6LFO
N-term 12 C - CXCR2 6LFO CXCR2 6LFO
TM1 13 D 1.29x29 CXCR2 6LFO CysLT1 receptor 6RZ5
TM1 14 P 1.30x30 CXCR2 6LFO 5-HT1F receptor 7EXD
TM1 15 I 1.31x31 CXCR2 6LFO κ receptor 6B73
TM1 16 V 1.32x32 CXCR2 6LFO β2-adrenoceptor 3SN6
TM1 17 T 1.33x33 CXCR2 6LFO CB2 receptor 6PT0
TM1 18 P 1.34x34 CXCR2 6LFO H1 receptor 7DFL
TM1 19 H 1.35x35 CXCR2 6LFO - -
TM1 20 L 1.36x36 CXCR2 6LFO FPR2/ALX 6OMM
TM1 21 I 1.37x37 CXCR2 6LFO CXCR2 6LFO
TM1 22 S 1.38x38 CXCR2 6LFO 5-HT2C receptor 6BQG
TM1 23 L 1.39x39 CXCR2 6LFO H1 receptor 7DFL
TM1 24 Y 1.40x40 CXCR2 6LFO AT2 receptor 5UNG
TM1 25 F 1.41x41 CXCR2 6LFO α2B-adrenoceptor 6K42
TM1 26 I 1.42x42 CXCR2 6LFO H1 receptor 7DFL
TM1 27 V 1.43x43 CXCR2 6LFO β1-adrenoceptor 7BU7
TM1 28 L 1.44x44 CXCR2 6LFO CXCR2 6LFO
TM1 29 I 1.45x45 CXCR2 6LFO AT2 receptor 5UNG
TM1 30 G 1.46x46 CXCR2 6LFO κ receptor 6B73
TM1 31 G 1.47x47 CXCR2 6LFO - -
TM1 32 L 1.48x48 CXCR2 6LFO CXCR2 6LFO
TM1 33 V 1.49x49 CXCR2 6LFO AT2 receptor 5UNG
TM1 34 G 1.50x50 CXCR2 6LFO - -
TM1 35 V 1.51x51 CXCR2 6LFO δ receptor 6PT2
TM1 36 I 1.52x52 CXCR2 6LFO EP2 receptor 7CX2
TM1 37 S 1.53x53 CXCR2 6LFO CysLT2 receptor 6RZ6
TM1 38 I 1.54x54 CXCR2 6LFO CCK1 receptor 7MBX
TM1 39 L 1.55x55 CXCR2 6LFO CXCR2 6LFO
TM1 40 F 1.56x56 CXCR2 6LFO - -
TM1 41 L 1.57x57 CXCR2 6LFO CCK1 receptor 7MBX
TM1 42 L 1.58x58 CXCR2 6LFO CXCR2 6LFO
TM1 43 V 1.59x59 CXCR2 6LFO 5-HT1F receptor 7EXD
TM1 44 K 1.60x60 LPA6 receptor 5XSZ NTS1 receptor 6OSA
ICL1 45 M 12.48x48 - - - -
ICL1 46 N 12.49x49 κ receptor 4DJH MC4 receptor 7AUE
ICL1 47 T 12.50x50 κ receptor 4DJH - -
ICL1 48 R 12.51x51 - - - -
TM2 49 S 2.37x37 LPA6 receptor 5XSZ CXCR2 6LFM
TM2 50 V 2.38x38 CXCR2 6LFO CXCR2 6LFO
TM2 51 T 2.39x39 CXCR2 6LFO CXCR2 6LFO
TM2 52 T 2.40x40 CXCR2 6LFO FPR2/ALX 6OMM
TM2 53 M 2.41x41 CXCR2 6LFO CCR9 5LWE
TM2 54 A 2.42x42 CXCR2 6LFO - -
TM2 55 V 2.43x43 CXCR2 6LFO β3-adrenoceptor 7DH5
TM2 56 I 2.44x44 CXCR2 6LFO US28 5WB1
TM2 57 N 2.45x45 CXCR2 6LFO CXCR2 6LFO
TM2 58 L 2.46x46 CXCR2 6LFO CXCR2 6LFO
TM2 59 V 2.47x47 CXCR2 6LFO EP2 receptor 7CX2
TM2 60 V 2.48x48 CXCR2 6LFO H1 receptor 7DFL
TM2 61 V 2.49x49 CXCR2 6LFO - -
TM2 62 H 2.50x50 CXCR2 6LFO - -
TM2 63 S 2.51x51 CXCR2 6LFO - -
TM2 64 V 2.52x52 CXCR2 6LFO β1-adrenoceptor 7BU7
TM2 65 F 2.53x53 CXCR2 6LFO CXCR2 6LFO
TM2 66 L 2.54x54 CXCR2 6LFO AT1 receptor 6DO1
TM2 67 L 2.55x55 CXCR2 6LFO CXCR2 6LFO
TM2 68 T 2.56x56 CXCR2 6LFO CXCR2 6LFO
TM2 69 V 2.57x57 CXCR2 6LFO β1-adrenoceptor 7BU7
TM2 70 P 2.58x58 CXCR2 6LFO CXCR2 6LFO
TM2 71 F 2.59x59 CXCR2 6LFO κ receptor 6B73
TM2 72 R 2.60x60 CXCR2 6LFO LPA6 receptor 5XSZ
TM2 73 L 2.61x61 CXCR2 6LFO CCK1 receptor 7MBX
TM2 74 T 2.62x62 CXCR2 6LFO κ receptor 6B73
TM2 75 Y 2.63x63 CXCR2 6LFO H1 receptor 7DFL
TM2 76 L 2.64x64 CXCR2 6LFO H1 receptor 7DFL
TM2 77 I 2.65x65 CXCR2 6LFO OX2 receptor 7L1V
TM2 78 K 2.66x66 CXCR2 6LFO M4 receptor 6KP6
ECL1 79 K - - - - -
ECL1 80 T 23.49x49 LPA6 receptor 5XSZ μ receptor 5C1M
ECL1 81 W 23.50x50 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
ECL1 82 M 23.51x51 LPA6 receptor 5XSZ - -
ECL1 83 F 23.52x52 - - - -
TM3 84 G 3.21x21 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM3 85 L 3.22x22 CXCR2 6LFO 5-HT2B receptor 5TUD
TM3 86 P 3.23x23 CXCR2 6LFO H1 receptor 7DFL
TM3 87 F 3.24x24 CXCR2 6LFO β1-adrenoceptor 7BU7
TM3 88 C 3.25x25 CXCR2 6LFO CXCR2 6LFO
TM3 89 K 3.26x26 CXCR2 6LFO κ receptor 6B73
TM3 90 F 3.27x27 CXCR2 6LFO H1 receptor 7DFL
TM3 91 V 3.28x28 CXCR2 6LFO CXCR2 6LFO
TM3 92 S 3.29x29 CXCR2 6LFO CXCR2 6LFO
TM3 93 A 3.30x30 CXCR2 6LFO AT1 receptor 6DO1
TM3 94 M 3.31x31 CXCR2 6LFO H1 receptor 7DFL
TM3 95 L 3.32x32 CXCR2 6LFO AT2 receptor 5UNG
TM3 96 H 3.33x33 CXCR2 6LFO P2Y1 receptor 4XNW
TM3 97 I 3.34x34 CXCR2 6LFO CCR5 7O7F
TM3 98 H 3.35x35 CXCR2 6LFO - -
TM3 99 M 3.36x36 CXCR2 6LFO κ receptor 6B73
TM3 100 Y 3.37x37 CXCR2 6LFO CXCR2 6LFO
TM3 101 L 3.38x38 CXCR2 6LFO - -
TM3 102 T 3.39x39 CXCR2 6LFO NTS1 receptor 4XES
TM3 103 F 3.40x40 CXCR2 6LFO - -
TM3 104 L 3.41x41 CXCR2 6LFO CXCR2 6LFO
TM3 105 F 3.42x42 CXCR2 6LFO CCR5 7O7F
TM3 106 Y 3.43x43 CXCR2 6LFO - -
TM3 107 V 3.44x44 CXCR2 6LFO CCK1 receptor 7MBX
TM3 108 V 3.45x45 CXCR2 6LFO β1-adrenoceptor 7BU7
TM3 109 I 3.46x46 CXCR2 6LFO CXCR2 6LFO
TM3 110 L 3.47x47 CXCR2 6LFO - -
TM3 111 V 3.48x48 CXCR2 6LFO CXCR2 6LFO
TM3 112 T 3.49x49 CXCR2 6LFO - -
TM3 113 R 3.50x50 CXCR2 6LFO CXCR2 6LFO
TM3 114 Y 3.51x51 CXCR2 6LFO CXCR2 6LFO
TM3 115 L 3.52x52 CXCR2 6LFO CXCR2 6LFO
TM3 116 I 3.53x53 CXCR2 6LFO - -
TM3 117 F 3.54x54 CXCR2 6LFO - -
TM3 118 F 3.55x55 CXCR2 6LFO MC4 receptor 7AUE
TM3 119 K 3.56x56 CXCR2 6LFO CCK1 receptor 7MBX
ICL2 120 C 34.50x50 - - - -
ICL2 121 K 34.51x51 LPA6 receptor 5XSZ - -
ICL2 122 D 34.52x52 LPA6 receptor 5XSZ 5-HT1A receptor 7E2X
ICL2 123 K 34.53x53 LPA6 receptor 5XSZ - -
ICL2 124 V 34.54x54 LPA6 receptor 5XSZ 5-HT1A receptor 7E2X
ICL2 125 E 34.55x55 LPA6 receptor 5XSZ - -
ICL2 126 F 34.56x56 LPA6 receptor 5XSZ κ receptor 6B73
ICL2 127 Y 34.57x57 - - - -
TM4 128 R 4.38x38 LPA6 receptor 5XSZ OT receptor 6TPK
TM4 129 K 4.39x39 LPA6 receptor 5XSZ H1 receptor 7DFL
TM4 130 L 4.40x40 LPA6 receptor 5XSZ κ receptor 6B73
TM4 131 H 4.41x41 CXCR2 6LFO CCK1 receptor 7MBX
TM4 132 A 4.42x42 CXCR2 6LFO κ receptor 6B73
TM4 133 V 4.43x43 CXCR2 6LFO CCR5 7O7F
TM4 134 A 4.44x44 CXCR2 6LFO H1 receptor 7DFL
TM4 135 A 4.45x45 CXCR2 6LFO OT receptor 6TPK
TM4 136 S 4.46x46 CXCR2 6LFO CCR5 7O7F
TM4 137 A 4.47x47 CXCR2 6LFO CCK1 receptor 7MBX
TM4 138 G 4.48x48 CXCR2 6LFO H1 receptor 7DFL
TM4 139 M 4.49x49 CXCR2 6LFO CB1 receptor 5XRA
TM4 140 W 4.50x50 CXCR2 6LFO CXCR2 6LFO
TM4 141 T 4.51x51 CXCR2 6LFO D1 receptor 7JVQ
TM4 142 L 4.52x52 CXCR2 6LFO CXCR2 6LFO
TM4 143 V 4.53x53 CXCR2 6LFO EP3 receptor 6M9T
TM4 144 I 4.54x54 CXCR2 6LFO 5-HT2C receptor 6BQG
TM4 145 V 4.55x55 CXCR2 6LFO FPR2/ALX 6OMM
TM4 146 I 4.56x56 CXCR2 6LFO μ receptor 5C1M
TM4 147 V 4.57x57 CXCR2 6LFO PAR1 3VW7
TM4 148 V 4.58x59 CXCR2 6LFO 5-HT2C receptor 6BQG
TM4 149 P 4.59x60 CXCR2 6LFO CXCR2 6LFO
TM4 150 L 4.60x61 CXCR2 6LFO Rhodopsin 4X1H
TM4 151 V 4.61x62 CXCR2 6LFO κ receptor 6B73
TM4 152 V 4.62x63 CXCR2 6LFO 5-HT2C receptor 6BQG
TM4 153 S 4.63x64 LPA6 receptor 5XSZ MC4 receptor 7AUE
TM4 154 R 4.64x65 LPA6 receptor 5XSZ AT1 receptor 6DO1
ECL2 155 Y - CXCR2 6LFO - -
ECL2 156 G - CXCR2 6LFO - -
ECL2 157 I - CXCR2 6LFO - -
ECL2 158 H - CXCR2 6LFO - -
ECL2 159 E - CXCR2 6LFO - -
ECL2 160 E - CXCR2 6LFO - -
ECL2 161 Y - CXCR2 6LFO - -
ECL2 162 N - CXCR2 6LFO - -
ECL2 163 E - CXCR2 6LFO - -
ECL2 164 E - CXCR2 6LFO - -
ECL2 165 H - CXCR2 6LFO - -
ECL2 166 C 45.50x50 CXCR2 6LFO CXCR2 6LFO
ECL2 167 F 45.51x51 CXCR2 6LFO EP4 receptor 7D7M
ECL2 168 K 45.52x52 CXCR2 6LFO - -
ECL2 169 F - - - - -
ECL2 170 H - - - - -
ECL2 171 K - - - - -
ECL2 172 E - - - - -
ECL2 173 L - - - - -
ECL2 174 A - - - - -
ECL2 175 Y - - - - -
ECL2 176 T - - - - -
ECL2 177 Y - - - - -
ECL2 178 V - - - - -
TM5 179 K 5.33x33 CXCR2 6LFO C5a1 receptor 6C1Q
TM5 180 I 5.34x34 CXCR2 6LFO OX2 receptor 7L1V
TM5 181 I 5.35x35 CXCR2 6LFO - -
TM5 182 N 5.36x36 CXCR2 6LFO Rhodopsin 4X1H
TM5 183 Y 5.37x37 CXCR2 6LFO EP2 receptor 7CX2
TM5 184 M 5.38x38 CXCR2 6LFO OX2 receptor 7L1V
TM5 185 I 5.39x39 CXCR2 6LFO AT2 receptor 5UNG
TM5 186 V 5.40x40 CXCR2 6LFO Rhodopsin 4X1H
TM5 187 I 5.41x41 CXCR2 6LFO CXCR2 6LFO
TM5 188 F 5.42x42 CXCR2 6LFO CCK1 receptor 7MBX
TM5 189 V 5.43x43 CXCR2 6LFO κ receptor 6B73
TM5 190 I 5.44x44 CXCR2 6LFO MC4 receptor 7AUE
TM5 191 A 5.45x45 CXCR2 6LFO - -
TM5 192 V 5.46x46 PAR1 3VW7 β1-adrenoceptor 7BU7
TM5 193 A 5.47x47 PAR1 3VW7 - -
TM5 194 V 5.48x48 CXCR2 6LFO κ receptor 6B73
TM5 195 I 5.49x49 CXCR2 6LFO κ receptor 6B73
TM5 196 L 5.50x50 CXCR2 6LFO CB1 receptor 6N4B
TM5 197 L 5.51x51 CXCR2 6LFO CXCR2 6LFO
TM5 198 V 5.52x52 CXCR2 6LFO β2-adrenoceptor 3SN6
TM5 199 F 5.53x53 CXCR2 6LFO AT2 receptor 5UNG
TM5 200 Q 5.54x54 CXCR2 6LFO - -
TM5 201 V 5.55x55 CXCR2 6LFO OX2 receptor 7L1V
TM5 202 F 5.56x56 CXCR2 6LFO CXCR2 6LFO
TM5 203 I 5.57x57 CXCR2 6LFO A1 receptor 6D9H
TM5 204 I 5.58x58 CXCR2 6LFO - -
TM5 205 M 5.59x59 CXCR2 6LFO CB1 receptor 6N4B
TM5 206 L 5.60x60 CXCR2 6LFO κ receptor 6B73
TM5 207 M 5.61x61 CXCR2 6LFO κ receptor 6B73
TM5 208 V 5.62x62 CXCR2 6LFO Rhodopsin 4X1H
TM5 209 Q 5.63x63 CXCR2 6LFO β2-adrenoceptor 3SN6
TM5 210 K 5.64x64 CXCR2 6LFO OX2 receptor 7L1V
TM5 211 L 5.65x65 CXCR2 6LFO CXCR2 6LFO
TM5 212 R 5.66x66 CXCR2 6LFO δ receptor 6PT2
TM5 213 H 5.67x67 CXCR2 6LFO EP2 receptor 7CX2
TM5 214 S 5.68x68 CXCR2 6LFO US28 5WB1
ICL3 215 L - CXCR2 6LFO - -
ICL3 216 L - CXCR2 6LFO - -
ICL3 217 S - CXCR2 6LFO - -
TM6 218 H 6.28x28 PAR1 3VW7 CXCR4 3ODU
TM6 219 Q 6.29x29 CXCR2 6LFO CXCR2 6LFO
TM6 220 E 6.30x30 CXCR2 6LFO H1 receptor 7DFL
TM6 221 F 6.31x31 CXCR2 6LFO MT1 receptor 6PS8
TM6 222 W 6.32x32 CXCR2 6LFO - -
TM6 223 A 6.33x33 CXCR2 6LFO CXCR2 6LFO
TM6 224 Q 6.34x34 CXCR2 6LFO - -
TM6 225 L 6.35x35 CXCR2 6LFO NTS1 receptor 4XES
TM6 226 K 6.36x36 CXCR2 6LFO PAR2 5NDD
TM6 227 N 6.37x37 CXCR2 6LFO - -
TM6 228 L 6.38x38 CXCR2 6LFO κ receptor 6B73
TM6 229 F 6.39x39 CXCR2 6LFO H1 receptor 7DFL
TM6 230 F 6.40x40 CXCR2 6LFO GnRH1 receptor 7BR3
TM6 231 I 6.41x41 CXCR2 6LFO MC4 receptor 7AUE
TM6 232 G 6.42x42 CXCR2 6LFO β1-adrenoceptor 7BU7
TM6 233 V 6.43x43 CXCR2 6LFO κ receptor 6B73
TM6 234 I 6.44x44 CXCR2 6LFO PAR1 3VW7
TM6 235 L 6.45x45 CXCR2 6LFO CXCR2 6LFO
TM6 236 V 6.46x46 CXCR2 6LFO κ receptor 6B73
TM6 237 C 6.47x47 CXCR2 6LFO CXCR2 6LFO
TM6 238 F 6.48x48 CXCR2 6LFO LPA6 receptor 5XSZ
TM6 239 L 6.49x49 CXCR2 6LFO CXCR2 6LFO
TM6 240 P 6.50x50 CXCR2 6LFO CXCR2 6LFO
TM6 241 Y 6.51x51 CXCR2 6LFO CXCR2 6LFO
TM6 242 Q 6.52x52 CXCR2 6LFO AT1 receptor 6DO1
TM6 243 F 6.53x53 CXCR2 6LFO OT receptor 6TPK
TM6 244 F 6.54x54 CXCR2 6LFO κ receptor 6B73
TM6 245 R 6.55x55 CXCR2 6LFO NTS1 receptor 4XES
TM6 246 I 6.56x56 CXCR2 6LFO μ receptor 5C1M
TM6 247 Y 6.57x57 CXCR2 6LFO Rhodopsin 4X1H
TM6 248 Y 6.58x58 CXCR2 6LFO MC4 receptor 7AUE
TM6 249 L 6.59x59 CXCR2 6LFO A1 receptor 6D9H
TM6 250 N 6.60x60 CXCR2 6LFO - -
TM6 251 V 6.61x61 CXCR2 6LFO LPA6 receptor 5XSZ
ECL3 252 V - - - - -
ECL3 253 T - - - - -
ECL3 254 H - - - - -
ECL3 255 S - - - - -
ECL3 256 N - - - - -
ECL3 257 A - - - - -
TM7 258 C 7.28x27 CXCR2 6LFO - -
TM7 259 N 7.29x28 CXCR2 6LFO CXCR2 6LFO
TM7 260 S 7.30x29 CXCR2 6LFO US28 5WB1
TM7 261 K 7.31x30 CXCR2 6LFO - -
TM7 262 V 7.32x31 CXCR2 6LFO δ receptor 6PT2
TM7 263 A 7.33x32 CXCR2 6LFO δ receptor 6PT2
TM7 264 F 7.34x33 CXCR2 6LFO Rhodopsin 4X1H
TM7 265 Y 7.35x34 CXCR2 6LFO κ receptor 6B73
TM7 266 N 7.36x35 CXCR2 6LFO FPR2/ALX 6OMM
TM7 267 E 7.37x36 CXCR2 6LFO - -
TM7 268 I 7.38x37 CXCR2 6LFO CCK1 receptor 7MBX
TM7 269 F 7.39x38 CXCR2 6LFO α2B-adrenoceptor 6K42
TM7 270 L 7.40x39 CXCR2 6LFO CCK1 receptor 7MBX
TM7 271 S 7.41x40 CXCR2 6LFO - -
TM7 272 V 7.42x41 CXCR2 6LFO OX2 receptor 7L1V
TM7 273 T 7.43x42 CXCR2 6LFO PAR2 5NDD
TM7 274 A 7.44x43 CXCR2 6LFO β1-adrenoceptor 7BU7
TM7 275 I 7.45x45 CXCR2 6LFO - -
TM7 276 S 7.46x46 CXCR2 6LFO CXCR2 6LFO
TM7 277 C 7.47x47 CXCR2 6LFO CXCR2 6LFO
TM7 278 Y 7.48x48 CXCR2 6LFO Rhodopsin 4X1H
TM7 279 D 7.49x49 CXCR2 6LFO MC4 receptor 7AUE
TM7 280 L 7.50x50 CXCR2 6LFO - -
TM7 281 L 7.51x51 CXCR2 6LFO CXCR2 6LFO
TM7 282 L 7.52x52 CXCR2 6LFO δ receptor 6PT2
TM7 283 F 7.53x53 CXCR2 6LFO EP2 receptor 7CX2
TM7 284 V 7.54x54 CXCR2 6LFO FPR2/ALX 6OMM
TM7 285 F 7.55x55 CXCR2 6LFO CXCR2 6LFO
TM7 286 G 7.56x56 CXCR2 6LFO GPBA receptor 7CFN
ICL4 287 G - - - - -
H8 288 S 8.47x47 CXCR2 6LFO β1-adrenoceptor 7BU7
H8 289 H 8.48x48 CXCR2 6LFO PAR2 5NDD
H8 290 W 8.49x49 CXCR2 6LFO - -
H8 291 F 8.50x50 CXCR2 6LFO CXCR2 6LFO
H8 292 K 8.51x51 CXCR2 6LFO δ receptor 6PT2
H8 293 Q 8.52x52 CXCR2 6LFO AT2 receptor 5UNG
H8 294 K 8.53x53 CXCR2 6LFO AT2 receptor 5UNG
H8 295 I 8.54x54 CXCR2 6LFO - -
H8 296 I 8.55x55 CXCR2 6LFO FPR2/ALX 6OMM
H8 297 G 8.56x56 CXCR2 6LFO β1-adrenoceptor 7BU7
H8 298 L 8.57x57 CXCR2 6LFO AT1 receptor 6DO1
H8 299 W 8.58x58 CXCR2 6LFO A1 receptor 5UEN
H8 300 N 8.59x59 CXCR2 6LFO A1 receptor 5UEN
C-term 301 C - - - - -
C-term 302 V - - - - -
C-term 303 L - - - - -
C-term 304 C - - - - -
C-term 305 R - - - - -