GPR142 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive

VERSION

2021-11-02

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

D4 receptor (sequence similarity: 20%) PDB: 6IQL

TEMPLATES

6A94 (5-HT2A receptor)
6IQL (D4 receptor)
5TGZ (CB1 receptor)
4N6H (δ receptor)
7JVR (D2 receptor)
4PXZ (P2Y12 receptor)
3PBL (D3 receptor)
6ME2 (MT1 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 66.7 18.4 14.9
Side-chains 13.9 61.5 24.7

Number of backbone templates: 8
Number of rotamer templates: 59

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 148 A - - - - -
N-term 149 E - - - - -
N-term 150 R - - - - -
N-term 151 S - - - - -
N-term 152 P - - - - -
TM1 153 C 1.29x29 5-HT2A receptor 6A94 - -
TM1 154 V 1.30x30 5-HT2A receptor 6A94 β2-adrenoceptor 4GBR
TM1 155 A 1.31x31 5-HT2A receptor 6A94 α2C-adrenoceptor 6KUW
TM1 156 G 1.32x32 5-HT2A receptor 6A94 D4 receptor 5WIV
TM1 157 V 1.33x33 D4 receptor 6IQL β2-adrenoceptor 4GBR
TM1 158 I 1.34x34 D4 receptor 6IQL κ receptor 4DJH
TM1 159 P 1.35x35 D4 receptor 6IQL EP4 receptor 5YWY
TM1 160 V 1.36x36 D4 receptor 6IQL M2 receptor 5YC8
TM1 161 I 1.37x37 D4 receptor 6IQL β2-adrenoceptor 4GBR
TM1 162 Y 1.38x38 D4 receptor 6IQL Rhodopsin 1U19
TM1 163 Y 1.39x39 D4 receptor 6IQL D3 receptor 3PBL
TM1 164 S 1.40x40 D4 receptor 6IQL H1 receptor 3RZE
TM1 165 V 1.41x41 D4 receptor 6IQL 5-HT2A receptor 6A94
TM1 166 L 1.42x42 D4 receptor 6IQL D4 receptor 6IQL
TM1 167 L 1.43x43 D4 receptor 6IQL BLT1 receptor 7K15
TM1 168 G 1.44x44 D4 receptor 6IQL D4 receptor 6IQL
TM1 169 L 1.45x45 D4 receptor 6IQL D4 receptor 6IQL
TM1 170 G 1.46x46 D4 receptor 6IQL δ receptor 4N6H
TM1 171 L 1.47x47 D4 receptor 6IQL D4 receptor 6IQL
TM1 172 P 1.48x48 D4 receptor 6IQL BLT1 receptor 7K15
TM1 173 V 1.49x49 D4 receptor 6IQL AT2 receptor 5UNG
TM1 174 S 1.50x50 D4 receptor 6IQL - -
TM1 175 L 1.51x51 D4 receptor 6IQL H1 receptor 3RZE
TM1 176 L 1.52x52 D4 receptor 6IQL D4 receptor 6IQL
TM1 177 T 1.53x53 D4 receptor 6IQL NTS1 receptor 4BUO
TM1 178 A 1.54x54 D4 receptor 6IQL NTS1 receptor 6UP7
TM1 179 V 1.55x55 D4 receptor 6IQL D4 receptor 6IQL
TM1 180 A 1.56x56 D4 receptor 6IQL 5-HT2A receptor 6A94
TM1 181 L 1.57x57 D4 receptor 6IQL NTS1 receptor 4BUO
TM1 182 A 1.58x58 D4 receptor 6IQL D4 receptor 6IQL
TM1 183 R 1.59x59 D4 receptor 6IQL D2 receptor 6CM4
TM1 184 L 1.60x60 D4 receptor 6IQL PAF receptor 5ZKQ
ICL1 185 A - - - - -
ICL1 186 T - CB1 receptor 5TGZ - -
ICL1 187 R - CB1 receptor 5TGZ - -
ICL1 188 T - CB1 receptor 5TGZ - -
ICL1 189 R - - - - -
TM2 190 R 2.37x37 D4 receptor 6IQL CB1 receptor 5TGZ
TM2 191 P 2.38x38 D4 receptor 6IQL D4 receptor 6IQL
TM2 192 S 2.39x39 D4 receptor 6IQL CB1 receptor 5TGZ
TM2 193 Y 2.40x40 D4 receptor 6IQL S1P1 receptor 3V2Y
TM2 194 Y 2.41x41 D4 receptor 6IQL D4 receptor 6IQL
TM2 195 Y 2.42x42 D4 receptor 6IQL H1 receptor 3RZE
TM2 196 L 2.43x43 D4 receptor 6IQL 5-HT2A receptor 6A94
TM2 197 L 2.44x44 D4 receptor 6IQL M5 receptor 6OL9
TM2 198 A 2.45x45 D4 receptor 6IQL BILF1 7JHJ
TM2 199 L 2.46x46 D4 receptor 6IQL D4 receptor 6IQL
TM2 200 T 2.47x47 D4 receptor 6IQL GnRH1 receptor 7BR3
TM2 201 A 2.48x48 D4 receptor 6IQL D4 receptor 6IQL
TM2 202 S 2.49x49 D4 receptor 6IQL NTS1 receptor 4BUO
TM2 203 D 2.50x50 D4 receptor 6IQL D4 receptor 6IQL
TM2 204 I 2.51x51 D4 receptor 6IQL α2A-adrenoceptor 6KUX
TM2 205 I 2.52x52 D4 receptor 6IQL H1 receptor 3RZE
TM2 206 I 2.53x53 D4 receptor 6IQL M2 receptor 5YC8
TM2 207 Q 2.54x54 D4 receptor 6IQL EP3 receptor 6AK3
TM2 208 V 2.55x55 δ receptor 4N6H D4 receptor 6IQL
TM2 209 V 2.56x56 δ receptor 4N6H D4 receptor 6IQL
TM2 210 I 2.57x57 D4 receptor 6IQL α2A-adrenoceptor 6KUX
TM2 211 V 2.58x58 D4 receptor 6IQL CB1 receptor 5TGZ
TM2 212 F 2.59x59 D4 receptor 6IQL β2-adrenoceptor 4GBR
TM2 213 A 2.60x60 D4 receptor 6IQL A1 receptor 5UEN
TM2 214 G 2.61x61 D4 receptor 6IQL NOP receptor 5DHH
TM2 215 F 2.62x62 D4 receptor 6IQL LPA1 receptor 4Z35
TM2 216 L 2.63x63 D4 receptor 6IQL D2 receptor 6LUQ
TM2 217 L 2.64x64 D4 receptor 6IQL H1 receptor 3RZE
TM2 218 Q 2.65x65 D4 receptor 6IQL PAF receptor 5ZKQ
TM2 219 G 2.66x66 D4 receptor 6IQL A2A receptor 5IU4
TM2 220 A 2.67x67 D2 receptor 7JVR α2C-adrenoceptor 6KUW
ECL1 221 V - - - - -
ECL1 222 L - - - - -
ECL1 223 A - - - - -
TM3 224 R 3.18x18 P2Y12 receptor 4PXZ - -
TM3 225 Q 3.19x19 P2Y12 receptor 4PXZ - -
TM3 226 V 3.20x20 P2Y12 receptor 4PXZ - -
TM3 227 P 3.21x21 P2Y12 receptor 4PXZ - -
TM3 228 Q 3.22x22 D4 receptor 6IQL OX2 receptor 5WQC
TM3 229 A 3.23x23 D4 receptor 6IQL α2A-adrenoceptor 6KUX
TM3 230 V 3.24x24 D4 receptor 6IQL M2 receptor 5YC8
TM3 231 V 3.25x25 D4 receptor 6IQL - -
TM3 232 R 3.26x26 D4 receptor 6IQL NTS1 receptor 4BUO
TM3 233 T 3.27x27 D4 receptor 6IQL D4 receptor 6IQL
TM3 234 A 3.28x28 D4 receptor 6IQL AT1 receptor 4ZUD
TM3 235 N 3.29x29 D4 receptor 6IQL CCR9 5LWE
TM3 236 I 3.30x30 D4 receptor 6IQL FPR2/ALX 6OMM
TM3 237 L 3.31x31 D4 receptor 6IQL 5-HT2A receptor 6A94
TM3 238 E 3.32x32 D4 receptor 6IQL - -
TM3 239 F 3.33x33 D4 receptor 6IQL CCR5 4MBS
TM3 240 A 3.34x34 D4 receptor 6IQL NTS1 receptor 4BUO
TM3 241 A 3.35x35 D4 receptor 6IQL H1 receptor 3RZE
TM3 242 N 3.36x36 D4 receptor 6IQL - -
TM3 243 H 3.37x37 D4 receptor 6IQL - -
TM3 244 A 3.38x38 D4 receptor 6IQL D4 receptor 6IQL
TM3 245 S 3.39x39 D4 receptor 6IQL D4 receptor 6IQL
TM3 246 V 3.40x40 D4 receptor 6IQL OX2 receptor 5WQC
TM3 247 W 3.41x41 D4 receptor 6IQL D4 receptor 6IQL
TM3 248 I 3.42x42 D4 receptor 6IQL CXCR4 3ODU
TM3 249 A 3.43x43 D4 receptor 6IQL EP3 receptor 6AK3
TM3 250 I 3.44x44 D4 receptor 6IQL CCR5 4MBS
TM3 251 L 3.45x45 D4 receptor 6IQL CCR5 4MBS
TM3 252 L 3.46x46 D4 receptor 6IQL H1 receptor 3RZE
TM3 253 T 3.47x47 D4 receptor 6IQL CCR5 4MBS
TM3 254 V 3.48x48 D4 receptor 6IQL D4 receptor 6IQL
TM3 255 D 3.49x49 D4 receptor 6IQL D4 receptor 6IQL
TM3 256 R 3.50x50 D4 receptor 6IQL D4 receptor 6IQL
TM3 257 Y 3.51x51 D2 receptor 7JVR D2 receptor 7JVR
TM3 258 T 3.52x52 D2 receptor 7JVR D2 receptor 7JVR
TM3 259 A 3.53x53 D2 receptor 7JVR D2 receptor 7JVR
TM3 260 L 3.54x54 D2 receptor 7JVR CB2 receptor 5ZTY
TM3 261 C 3.55x55 D2 receptor 7JVR δ receptor 4N6H
TM3 262 H 3.56x56 D2 receptor 7JVR δ receptor 4N6H
ICL2 263 P 34.50x50 - - - -
ICL2 264 L 34.51x51 D3 receptor 3PBL M2 receptor 5YC8
ICL2 265 H 34.52x52 D3 receptor 3PBL D3 receptor 3PBL
ICL2 266 H 34.53x53 D3 receptor 3PBL 5-HT2A receptor 6WHA
ICL2 267 R 34.54x54 D3 receptor 3PBL M5 receptor 6OL9
ICL2 268 A 34.55x55 D3 receptor 3PBL M5 receptor 6OL9
ICL2 269 A 34.56x56 - - - -
TM4 270 S 4.38x38 D2 receptor 7JVR D2 receptor 7JVR
TM4 271 S 4.39x39 D2 receptor 7JVR NOP receptor 5DHH
TM4 272 P 4.40x40 D2 receptor 7JVR CB1 receptor 5TGZ
TM4 273 G 4.41x41 D2 receptor 7JVR Rhodopsin 6I9K
TM4 274 R 4.42x42 D4 receptor 6IQL - -
TM4 275 T 4.43x43 D4 receptor 6IQL D2 receptor 6LUQ
TM4 276 R 4.44x44 D4 receptor 6IQL BLT1 receptor 7K15
TM4 277 R 4.45x45 D4 receptor 6IQL Rhodopsin 6I9K
TM4 278 A 4.46x46 D4 receptor 6IQL S1P5 receptor 7EW1
TM4 279 I 4.47x47 D4 receptor 6IQL 5-HT2A receptor 6A94
TM4 280 A 4.48x48 D4 receptor 6IQL D4 receptor 6IQL
TM4 281 A 4.49x49 D4 receptor 6IQL H1 receptor 3RZE
TM4 282 V 4.50x50 D4 receptor 6IQL - -
TM4 283 L 4.51x51 D4 receptor 6IQL D4 receptor 6IQL
TM4 284 S 4.52x52 D4 receptor 6IQL - -
TM4 285 A 4.53x53 D4 receptor 6IQL D3 receptor 3PBL
TM4 286 A 4.54x54 D4 receptor 6IQL D4 receptor 6IQL
TM4 287 L 4.55x55 D4 receptor 6IQL H1 receptor 3RZE
TM4 288 L 4.56x56 D4 receptor 6IQL M2 receptor 5YC8
TM4 289 T 4.57x57 D4 receptor 6IQL CXCR4 3ODU
TM4 290 G 4.58x58 - - - -
TM4 291 I 4.59x59 D4 receptor 6IQL H1 receptor 3RZE
TM4 292 P 4.60x60 - - - -
TM4 293 F 4.61x61 - - - -
TM4 294 Y 4.62x62 - - - -
TM4 295 W 4.63x63 - - - -
ECL2 296 W - - - - -
ECL2 297 L - - - - -
ECL2 298 D - - - - -
ECL2 299 M - - - - -
ECL2 300 W - - - - -
ECL2 301 R - - - - -
ECL2 302 D - - - - -
ECL2 303 T - - - - -
ECL2 304 D - - - - -
ECL2 305 S - - - - -
ECL2 306 P - - - - -
ECL2 307 R - - - - -
ECL2 308 T - - - - -
ECL2 309 L - - - - -
TM5 310 D 5.35x36 D2 receptor 7JVR 5-HT2A receptor 6A94
TM5 311 E 5.36x37 D2 receptor 7JVR CB1 receptor 5U09
TM5 312 V 5.37x38 D2 receptor 7JVR δ receptor 4N6H
TM5 313 L 5.38x39 D4 receptor 6IQL μ receptor 4DKL
TM5 314 K 5.39x40 D4 receptor 6IQL H1 receptor 3RZE
TM5 315 W 5.40x41 D4 receptor 6IQL ghrelin receptor 6KO5
TM5 316 A 5.41x42 D4 receptor 6IQL β2-adrenoceptor 4GBR
TM5 317 H 5.42x43 D4 receptor 6IQL CXCR4 3ODU
TM5 318 C 5.43x44 D4 receptor 6IQL α2A-adrenoceptor 6KUX
TM5 319 L 5.44x45 D4 receptor 6IQL δ receptor 4N6H
TM5 320 T 5.45x46 D4 receptor 6IQL BLT1 receptor 7K15
TM5 321 V 5.46x461 D4 receptor 6IQL OT receptor 6TPK
TM5 322 Y 5.47x47 D4 receptor 6IQL OX2 receptor 5WQC
TM5 323 F 5.48x48 D4 receptor 6IQL D4 receptor 6IQL
TM5 324 I 5.49x49 D4 receptor 6IQL 5-HT2A receptor 6A94
TM5 325 P 5.50x50 D4 receptor 6IQL D4 receptor 6IQL
TM5 326 C 5.51x51 D4 receptor 6IQL D4 receptor 6IQL
TM5 327 G 5.52x52 D4 receptor 6IQL D3 receptor 3PBL
TM5 328 V 5.53x53 D4 receptor 6IQL D2 receptor 6LUQ
TM5 329 F 5.54x54 D4 receptor 6IQL - -
TM5 330 L 5.55x55 D4 receptor 6IQL D4 receptor 6IQL
TM5 331 V 5.56x56 D4 receptor 6IQL δ receptor 4N6H
TM5 332 T 5.57x57 D4 receptor 6IQL 5-HT2A receptor 6A94
TM5 333 N 5.58x58 D4 receptor 6IQL NTS1 receptor 4BUO
TM5 334 S 5.59x59 D4 receptor 6IQL β2-adrenoceptor 4GBR
TM5 335 A 5.60x60 D4 receptor 6IQL D4 receptor 6IQL
TM5 336 I 5.61x61 D4 receptor 6IQL D2 receptor 6LUQ
TM5 337 I 5.62x62 D4 receptor 6IQL 5-HT2A receptor 6A94
TM5 338 H 5.63x63 D4 receptor 6IQL 5-HT2B receptor 5TVN
TM5 339 R 5.64x64 D4 receptor 6IQL δ receptor 4N6H
TM5 340 L 5.65x65 D4 receptor 6IQL D4 receptor 6IQL
TM5 341 R 5.66x66 D4 receptor 6IQL D4 receptor 6IQL
TM5 342 R 5.67x67 D4 receptor 6IQL D4 receptor 5WIV
ICL3 343 R - - - - -
ICL3 344 G - - - - -
ICL3 345 R - - - - -
ICL3 346 S - - - - -
ICL3 347 G - - - - -
TM6 348 L 6.26x26 D4 receptor 6IQL FFA1 receptor 5TZR
TM6 349 Q 6.27x27 D4 receptor 6IQL α2C-adrenoceptor 6KUW
TM6 350 P 6.28x28 D4 receptor 6IQL - -
TM6 351 R 6.29x29 D4 receptor 6IQL D4 receptor 6IQL
TM6 352 V 6.30x30 D4 receptor 6IQL V2 receptor 7KH0
TM6 353 G 6.31x31 D4 receptor 6IQL US28 5WB1
TM6 354 K 6.32x32 D4 receptor 6IQL 5-HT2A receptor 6A94
TM6 355 S 6.33x33 D4 receptor 6IQL - -
TM6 356 T 6.34x34 D4 receptor 6IQL D2 receptor 6LUQ
TM6 357 A 6.35x35 D4 receptor 6IQL FFA1 receptor 5TZY
TM6 358 I 6.36x36 D4 receptor 6IQL AT1 receptor 4ZUD
TM6 359 L 6.37x37 D4 receptor 6IQL D4 receptor 6IQL
TM6 360 L 6.38x38 D4 receptor 6IQL δ receptor 4N6H
TM6 361 G 6.39x39 D4 receptor 6IQL EP3 receptor 6AK3
TM6 362 I 6.40x40 D4 receptor 6IQL H1 receptor 3RZE
TM6 363 T 6.41x41 D4 receptor 6IQL CysLT2 receptor 6RZ6
TM6 364 T 6.42x42 D4 receptor 6IQL GnRH1 receptor 7BR3
TM6 365 L 6.43x43 D4 receptor 6IQL 5-HT2A receptor 6A94
TM6 366 F 6.44x44 D4 receptor 6IQL D4 receptor 6IQL
TM6 367 T 6.45x45 D4 receptor 6IQL β2-adrenoceptor 4GBR
TM6 368 L 6.46x46 D4 receptor 6IQL D4 receptor 5WIV
TM6 369 L 6.47x47 D4 receptor 6IQL GPR52 6LI1
TM6 370 W 6.48x48 D4 receptor 6IQL D4 receptor 6IQL
TM6 371 A 6.49x49 D4 receptor 6IQL δ receptor 4N6H
TM6 372 P 6.50x50 D4 receptor 6IQL D4 receptor 6IQL
TM6 373 R 6.51x51 D4 receptor 6IQL - -
TM6 374 V 6.52x52 D4 receptor 6IQL EP4 receptor 5YWY
TM6 375 F 6.53x53 D4 receptor 6IQL α2A-adrenoceptor 6KUX
TM6 376 V 6.54x54 D4 receptor 6IQL D4 receptor 6IQL
TM6 377 M 6.55x55 D4 receptor 6IQL CB1 receptor 5TGZ
TM6 378 L 6.56x56 D4 receptor 6IQL M2 receptor 5YC8
TM6 379 Y 6.57x57 D4 receptor 6IQL CB1 receptor 5TGZ
TM6 380 H 6.58x58 D4 receptor 6IQL β2-adrenoceptor 4GBR
TM6 381 M 6.59x59 D4 receptor 6IQL apelin receptor 5VBL
TM6 382 Y 6.60x60 D4 receptor 6IQL NTS1 receptor 4BUO
TM6 383 V 6.61x61 D4 receptor 6IQL δ receptor 4N6H
ECL3 384 A - - - - -
ECL3 385 P - MT1 receptor 6ME2 - -
ECL3 386 V - MT1 receptor 6ME2 - -
ECL3 387 H - MT1 receptor 6ME2 - -
ECL3 388 R - MT1 receptor 6ME2 - -
ECL3 389 D - MT1 receptor 6ME2 - -
ECL3 390 W - MT1 receptor 6ME2 - -
ECL3 391 R - - - - -
TM7 392 V 7.31x30 D4 receptor 6IQL PAR2 5NDD
TM7 393 H 7.32x31 D4 receptor 6IQL NTS1 receptor 4BUO
TM7 394 L 7.33x32 D4 receptor 6IQL Y2 receptor 7DDZ
TM7 395 A 7.34x33 D4 receptor 6IQL δ receptor 4N6H
TM7 396 L 7.35x34 D4 receptor 6IQL 5-HT2A receptor 6A94
TM7 397 D 7.36x35 D4 receptor 6IQL CXCR2 6LFL
TM7 398 V 7.37x36 D4 receptor 6IQL 5-HT2A receptor 6A94
TM7 399 A 7.38x37 D4 receptor 6IQL A1 receptor 5UEN
TM7 400 N 7.39x38 D4 receptor 6IQL β2-adrenoceptor 4GBR
TM7 401 M 7.40x39 D4 receptor 6IQL CB1 receptor 5TGZ
TM7 402 V 7.41x40 D4 receptor 6IQL PAR1 3VW7
TM7 403 A 7.42x41 D4 receptor 6IQL CXCR2 6LFL
TM7 404 M 7.43x42 D4 receptor 6IQL CCR5 4MBS
TM7 405 L 7.44x43 D4 receptor 6IQL 5-HT2A receptor 6A94
TM7 406 H 7.45x45 D4 receptor 6IQL CXCR2 6LFL
TM7 407 T 7.46x46 D4 receptor 6IQL Y2 receptor 7DDZ
TM7 408 A 7.47x47 D4 receptor 6IQL D4 receptor 6IQL
TM7 409 A 7.48x48 D4 receptor 6IQL OX2 receptor 5WQC
TM7 410 N 7.49x49 D4 receptor 6IQL D4 receptor 6IQL
TM7 411 F 7.50x50 D4 receptor 6IQL - -
TM7 412 G 7.51x51 D4 receptor 6IQL - -
TM7 413 L 7.52x52 D4 receptor 6IQL δ receptor 4N6H
TM7 414 Y 7.53x53 D4 receptor 6IQL D4 receptor 6IQL
TM7 415 C 7.54x54 D4 receptor 6IQL β2-adrenoceptor 4GBR
TM7 416 F 7.55x55 D2 receptor 7JVR δ receptor 4N6H
TM7 417 V 7.56x56 D2 receptor 7JVR NTS1 receptor 4BUO
H8 418 S 8.47x47 D2 receptor 7JVR β2-adrenoceptor 4GBR
H8 419 K 8.48x48 D2 receptor 7JVR 5-HT2A receptor 6A94
H8 420 T 8.49x49 D2 receptor 7JVR 5-HT2A receptor 6A94
H8 421 F 8.50x50 D2 receptor 7JVR D2 receptor 7JVR
H8 422 R 8.51x51 D2 receptor 7JVR D2 receptor 7JVR
H8 423 A 8.52x52 D2 receptor 7JVR NOP receptor 5DHH
H8 424 T 8.53x53 D2 receptor 7JVR H1 receptor 3RZE
H8 425 V 8.54x54 D2 receptor 7JVR ghrelin receptor 6KO5
H8 426 R 8.55x55 D2 receptor 7JVR δ receptor 4RWD
H8 427 Q 8.56x56 D2 receptor 7JVR LPA1 receptor 4Z36
H8 428 V 8.57x57 D2 receptor 7JVR AT2 receptor 5UNG
H8 429 I 8.58x58 D2 receptor 7JVR 5-HT2A receptor 6A94
H8 430 H 8.59x59 5-HT2A receptor 6A94 H1 receptor 3RZE
C-term 431 D - - - - -
C-term 432 A - - - - -
C-term 433 Y - - - - -
C-term 434 L - - - - -
C-term 435 P - - - - -