GPR146 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

GPR146

SPECIES

Homo sapiens

STATE

Inactive

VERSION

2021-11-02

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

CXCR2 (sequence similarity: 27%) PDB: 6LFL
Align

TEMPLATES

6WWZ (CCR6)
6LFL (CXCR2)
7DDZ (Y2 receptor)
6RZ6 (CysLT2 receptor)
4N6H (δ receptor)
4ZUD (AT1 receptor)
3ODU (CXCR4)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 73.5 14.1 12.4
Side-chains 15.4 57.5 27.1

Number of backbone templates: 7
Number of rotamer templates: 60

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 15 E - CCR6 6WWZ CCR6 6WWZ
N-term 16 L - CCR6 6WWZ CCR6 6WWZ
N-term 17 P - CCR6 6WWZ CCR6 6WWZ
N-term 18 A - CCR6 6WWZ CCR6 6WWZ
N-term 19 C - CCR6 6WWZ CCR6 6WWZ
TM1 20 Q 1.25x25 CCR6 6WWZ CCR6 6WWZ
TM1 21 D 1.26x26 CCR6 6WWZ US28 5WB1
TM1 22 L 1.27x27 CCR6 6WWZ - -
TM1 23 Q 1.28x28 CCR6 6WWZ - -
TM1 24 L 1.29x29 CCR6 6WWZ δ receptor 4N6H
TM1 25 G 1.30x30 CXCR2 6LFL D4 receptor 5WIV
TM1 26 L 1.31x31 CXCR2 6LFL δ receptor 4N6H
TM1 27 S 1.32x32 CXCR2 6LFL CCR9 5LWE
TM1 28 L 1.33x33 CXCR2 6LFL BLT1 receptor 7K15
TM1 29 L 1.34x34 CXCR2 6LFL CCR5 4MBS
TM1 30 S 1.35x35 CXCR2 6LFL 5-HT2A receptor 6A94
TM1 31 L 1.36x36 CXCR2 6LFL D4 receptor 5WIV
TM1 32 L 1.37x37 CXCR2 6LFL Y2 receptor 7DDZ
TM1 33 G 1.38x38 CXCR2 6LFL OX2 receptor 5WQC
TM1 34 L 1.39x39 CXCR2 6LFL MT2 receptor 6ME7
TM1 35 V 1.40x40 CXCR2 6LFL D4 receptor 5WIV
TM1 36 V 1.41x41 CXCR2 6LFL MT2 receptor 6ME7
TM1 37 G 1.42x42 CXCR2 6LFL - -
TM1 38 V 1.43x43 CXCR2 6LFL β1-adrenoceptor 7BVQ
TM1 39 P 1.44x44 CXCR2 6LFL - -
TM1 40 V 1.45x45 CXCR2 6LFL AT1 receptor 4ZUD
TM1 41 G 1.46x46 CXCR2 6LFL AT1 receptor 4ZUD
TM1 42 L 1.47x47 CXCR2 6LFL CXCR2 6LFL
TM1 43 C 1.48x48 CXCR2 6LFL - -
TM1 44 Y 1.49x49 CXCR2 6LFL - -
TM1 45 N 1.50x50 CXCR2 6LFL CXCR2 6LFL
TM1 46 A 1.51x51 CXCR2 6LFL 5-HT1B receptor 4IAQ
TM1 47 L 1.52x52 CXCR2 6LFL CXCR2 6LFL
TM1 48 L 1.53x53 CXCR2 6LFL Y1 receptor 5ZBH
TM1 49 V 1.54x54 CXCR2 6LFL AT1 receptor 4ZUD
TM1 50 L 1.55x55 CXCR2 6LFL CXCR2 6LFL
TM1 51 A 1.56x56 CXCR2 6LFL 5-HT2A receptor 6A94
TM1 52 N 1.57x57 CXCR2 6LFL - -
TM1 53 L 1.58x58 CXCR2 6LFL CXCR2 6LFL
TM1 54 H 1.59x59 CXCR2 6LFL CB1 receptor 5TGZ
TM1 55 S 1.60x60 CCR6 6WWZ apelin receptor 5VBL
ICL1 56 K - - - - -
ICL1 57 A - - - - -
ICL1 58 S - - - - -
ICL1 59 M - - - - -
ICL1 60 T - - - - -
ICL1 61 M - - - - -
ICL1 62 P - - - - -
ICL1 63 D - - - - -
ICL1 64 V - - - - -
TM2 65 Y 2.37x37 CXCR2 6LFL 5-HT2B receptor 5TVN
TM2 66 F 2.38x38 CXCR2 6LFL - -
TM2 67 V 2.39x39 CXCR2 6LFL DP2 receptor 7M8W
TM2 68 N 2.40x40 CXCR2 6LFL δ receptor 4N6H
TM2 69 M 2.41x41 CXCR2 6LFL CCR9 5LWE
TM2 70 A 2.42x42 CXCR2 6LFL - -
TM2 71 V 2.43x43 CXCR2 6LFL BLT1 receptor 7K15
TM2 72 A 2.44x44 CXCR2 6LFL Y2 receptor 7DDZ
TM2 73 G 2.45x45 CXCR2 6LFL EP4 receptor 5YWY
TM2 74 L 2.46x46 CXCR2 6LFL CXCR2 6LFL
TM2 75 V 2.47x47 CXCR2 6LFL LPA6 receptor 5XSZ
TM2 76 L 2.48x48 CXCR2 6LFL CXCR2 6LFL
TM2 77 S 2.49x49 CXCR2 6LFL CCR5 4MBS
TM2 78 A 2.50x50 CXCR2 6LFL OX2 receptor 6TPN
TM2 79 L 2.51x51 CXCR2 6LFL CXCR2 6LFL
TM2 80 A 2.52x52 CXCR2 6LFL BLT1 receptor 7K15
TM2 81 P 2.53x53 CXCR2 6LFL - -
TM2 82 V 2.54x54 CXCR2 6LFL CXCR4 3ODU
TM2 83 H 2.55x55 Y2 receptor 7DDZ - -
TM2 84 L 2.56x551 Y2 receptor 7DDZ Y2 receptor 7DDZ
TM2 85 L 2.57x56 Y2 receptor 7DDZ - -
TM2 86 G 2.58x57 CXCR2 6LFL TP receptor 6IIV
TM2 87 P 2.59x58 CXCR2 6LFL CXCR2 6LFL
TM2 88 P 2.60x59 CXCR2 6LFL OT receptor 6TPK
TM2 89 S 2.61x60 CXCR2 6LFL 5-HT2A receptor 6A94
TM2 90 S 2.62x61 CXCR2 6LFL δ receptor 4N6H
TM2 91 R 2.63x62 CXCR2 6LFL succinate receptor 6RNK
ECL1 92 W - - - - -
ECL1 93 A - - - - -
ECL1 94 L 23.49x49 CCR6 6WWZ - -
ECL1 95 W 23.50x50 CCR6 6WWZ CCR6 6WWZ
ECL1 96 S 23.51x51 CCR6 6WWZ BLT1 receptor 7K15
ECL1 97 V 23.52x52 - - - -
TM3 98 G 3.21x21 CXCR2 6LFL CXCR2 6LFL
TM3 99 G 3.22x22 CXCR2 6LFL C5a1 receptor 6C1Q
TM3 100 E 3.23x23 CXCR2 6LFL MT2 receptor 6ME6
TM3 101 V 3.24x24 CXCR2 6LFL 5-HT1B receptor 4IAQ
TM3 102 H 3.25x25 CXCR2 6LFL - -
TM3 103 V 3.26x26 CXCR2 6LFL - -
TM3 104 A 3.27x27 CXCR2 6LFL δ receptor 4N6H
TM3 105 L 3.28x28 CXCR2 6LFL CCR5 4MBS
TM3 106 Q 3.29x29 CXCR2 6LFL LPA1 receptor 4Z35
TM3 107 I 3.30x30 CXCR2 6LFL FPR2/ALX 6OMM
TM3 108 P 3.31x31 CXCR2 6LFL A1 receptor 5UEN
TM3 109 F 3.32x32 CXCR2 6LFL DP2 receptor 7M8W
TM3 110 N 3.33x33 CXCR2 6LFL GPBA receptor 7CFN
TM3 111 V 3.34x34 CXCR2 6LFL CXCR2 6LFL
TM3 112 S 3.35x35 CXCR2 6LFL CCR7 6QZH
TM3 113 S 3.36x36 CXCR2 6LFL 5-HT2A receptor 6A94
TM3 114 L 3.37x37 CXCR2 6LFL EP4 receptor 5YWY
TM3 115 V 3.38x38 CXCR2 6LFL Y2 receptor 7DDZ
TM3 116 A 3.39x39 CXCR2 6LFL OX1 receptor 6TO7
TM3 117 M 3.40x40 CXCR2 6LFL CCR7 6QZH
TM3 118 Y 3.41x41 CXCR2 6LFL NK1 receptor 6HLP
TM3 119 S 3.42x42 CXCR2 6LFL Y1 receptor 5ZBH
TM3 120 T 3.43x43 CXCR2 6LFL - -
TM3 121 A 3.44x44 CXCR2 6LFL CXCR2 6LFL
TM3 122 L 3.45x45 CXCR2 6LFL CCR5 4MBS
TM3 123 L 3.46x46 CXCR2 6LFL AT1 receptor 4ZUD
TM3 124 S 3.47x47 CXCR2 6LFL CXCR2 6LFL
TM3 125 L 3.48x48 CXCR2 6LFL Y2 receptor 7DDZ
TM3 126 D 3.49x49 CXCR2 6LFL CXCR2 6LFL
TM3 127 H 3.50x50 CXCR2 6LFL - -
TM3 128 Y 3.51x51 CXCR2 6LFL CXCR2 6LFL
TM3 129 I 3.52x52 CXCR2 6LFL δ receptor 4N6H
TM3 130 E 3.53x53 CXCR2 6LFL PAR2 5NDD
TM3 131 R 3.54x54 CXCR2 6LFL - -
TM3 132 A 3.55x55 CXCR2 6LFL CCR9 5LWE
TM3 133 L 3.56x56 CXCR2 6LFL - -
ICL2 134 P - - - - -
ICL2 135 R - Y2 receptor 7DDZ - -
ICL2 136 T - Y2 receptor 7DDZ - -
ICL2 137 Y - Y2 receptor 7DDZ - -
ICL2 138 M - Y2 receptor 7DDZ - -
ICL2 139 A - - - - -
TM4 140 S 4.38x38 CysLT2 receptor 6RZ6 CysLT2 receptor 6RZ6
TM4 141 V 4.39x39 CysLT2 receptor 6RZ6 CCR5 4MBS
TM4 142 Y 4.40x40 CysLT2 receptor 6RZ6 CXCR2 6LFL
TM4 143 N 4.41x41 CXCR2 6LFL μ receptor 4DKL
TM4 144 T 4.42x42 CXCR2 6LFL MT2 receptor 6ME7
TM4 145 R 4.43x43 CXCR2 6LFL BLT1 receptor 7K15
TM4 146 H 4.44x44 CXCR2 6LFL - -
TM4 147 V 4.45x45 CXCR2 6LFL CCR9 5LWE
TM4 148 C 4.46x46 CXCR2 6LFL CXCR2 6LFL
TM4 149 G 4.47x47 CXCR2 6LFL Y2 receptor 7DDZ
TM4 150 F 4.48x48 CXCR2 6LFL Rhodopsin 1U19
TM4 151 V 4.49x49 CXCR2 6LFL 5-HT2A receptor 6A94
TM4 152 W 4.50x50 CXCR2 6LFL CXCR2 6LFL
TM4 153 G 4.51x51 CXCR2 6LFL CXCR2 6LFL
TM4 154 G 4.52x52 CXCR2 6LFL OT receptor 6TPK
TM4 155 A 4.53x53 CXCR2 6LFL AT1 receptor 4ZUD
TM4 156 L 4.54x54 CXCR2 6LFL CXCR2 6LFL
TM4 157 L 4.55x55 CXCR2 6LFL CXCR2 6LFL
TM4 158 T 4.56x56 CXCR2 6LFL β2-adrenoceptor 4GBR
TM4 159 S 4.57x57 δ receptor 4N6H AT1 receptor 4ZUD
TM4 160 F 4.58x58 δ receptor 4N6H β1-adrenoceptor 7BVQ
TM4 161 S 4.59x59 δ receptor 4N6H Y2 receptor 7DDZ
TM4 162 S 4.60x60 CXCR2 6LFL CCR6 6WWZ
TM4 163 L 4.61x61 CXCR2 6LFL Y2 receptor 7DDZ
TM4 164 L 4.62x62 CXCR2 6LFL CXCR2 6LFL
TM4 165 F 4.63x63 CXCR2 6LFL MT2 receptor 6ME7
TM4 166 Y 4.64x64 CXCR2 6LFL CCR7 6QZH
ECL2 167 I - - - - -
ECL2 168 C - - - - -
ECL2 169 S - - - - -
ECL2 170 H - - - - -
ECL2 171 V - - - - -
ECL2 172 S - - - - -
ECL2 173 T - - - - -
ECL2 174 R - - - - -
ECL2 175 A - - - - -
ECL2 176 L - - - - -
ECL2 177 E - - - - -
ECL2 178 C - - - - -
ECL2 179 A - - - - -
TM5 180 K 5.31x32 CCR6 6WWZ CysLT2 receptor 6RZ6
TM5 181 M 5.32x33 CXCR2 6LFL - -
TM5 182 Q 5.33x34 CXCR2 6LFL AT2 receptor 5UNG
TM5 183 N 5.34x35 CXCR2 6LFL Rhodopsin 1U19
TM5 184 A 5.35x36 CXCR2 6LFL ETB receptor 5X93
TM5 185 E 5.36x37 CXCR2 6LFL Rhodopsin 1U19
TM5 186 A 5.37x38 CXCR2 6LFL MT1 receptor 6ME2
TM5 187 A 5.38x39 CXCR2 6LFL FFA1 receptor 5TZY
TM5 188 D 5.39x40 CXCR2 6LFL ETB receptor 5X93
TM5 189 A 5.40x41 CXCR2 6LFL MT2 receptor 6ME7
TM5 190 T 5.41x42 CXCR2 6LFL AT1 receptor 4ZUD
TM5 191 L 5.42x43 CXCR2 6LFL Y1 receptor 5ZBH
TM5 192 V 5.43x44 CXCR2 6LFL MT2 receptor 6ME7
TM5 193 F 5.44x45 CXCR2 6LFL 5-HT2A receptor 6A94
TM5 194 I 5.45x46 CXCR2 6LFL CCR7 6QZH
TM5 195 G 5.46x461 CXCR2 6LFL CXCR2 6LFL
TM5 196 Y 5.47x47 CXCR2 6LFL Y2 receptor 7DDZ
TM5 197 V 5.48x48 CXCR2 6LFL δ receptor 4N6H
TM5 198 V 5.49x49 CXCR2 6LFL CXCR2 6LFL
TM5 199 P 5.50x50 CXCR2 6LFL CXCR2 6LFL
TM5 200 A 5.51x51 CXCR2 6LFL 5-HT2A receptor 6WGT
TM5 201 L 5.52x52 CXCR2 6LFL CXCR2 6LFL
TM5 202 A 5.53x53 CXCR2 6LFL CCR7 6QZH
TM5 203 T 5.54x54 CXCR2 6LFL ETB receptor 5X93
TM5 204 L 5.55x55 CXCR2 6LFL CXCR2 6LFL
TM5 205 Y 5.56x56 CXCR2 6LFL NK1 receptor 6HLP
TM5 206 A 5.57x57 CXCR2 6LFL OX2 receptor 5WQC
TM5 207 L 5.58x58 CXCR2 6LFL - -
TM5 208 V 5.59x59 CXCR2 6LFL α2A-adrenoceptor 6KUX
TM5 209 L 5.60x60 CXCR2 6LFL AT1 receptor 4ZUD
TM5 210 L 5.61x61 CXCR2 6LFL Rhodopsin 1GZM
TM5 211 S 5.62x62 CXCR2 6LFL CCR2 5T1A
TM5 212 R 5.63x63 CXCR2 6LFL CXCR2 6LFL
TM5 213 V 5.64x64 CXCR2 6LFL 5-HT2C receptor 6BQH
TM5 214 R 5.65x65 CXCR2 6LFL EP2 receptor 7CX2
TM5 215 R 5.66x66 CXCR2 6LFL δ receptor 4N6H
TM5 216 E 5.67x67 CXCR2 6LFL Rhodopsin 1GZM
TM5 217 D 5.68x68 CCR6 6WWZ - -
ICL3 218 T - - - - -
ICL3 219 P - - - - -
ICL3 220 L - - - - -
ICL3 221 D - - - - -
TM6 222 R 6.24x24 δ receptor 4N6H NOP receptor 5DHH
TM6 223 D 6.25x25 δ receptor 4N6H ETB receptor 5X93
TM6 224 T 6.26x26 δ receptor 4N6H A2A receptor 5IU4
TM6 225 G 6.27x27 δ receptor 4N6H CXCR4 3ODU
TM6 226 R 6.28x28 δ receptor 4N6H NOP receptor 5DHH
TM6 227 L 6.29x29 δ receptor 4N6H CB2 receptor 5ZTY
TM6 228 E 6.30x30 CXCR2 6LFL 5-HT2A receptor 6A94
TM6 229 P 6.31x31 CXCR2 6LFL BILF1 7JHJ
TM6 230 S 6.32x32 CXCR2 6LFL LPA1 receptor 4Z35
TM6 231 A 6.33x33 CXCR2 6LFL CCR9 5LWE
TM6 232 H 6.34x34 CXCR2 6LFL - -
TM6 233 R 6.35x35 CXCR2 6LFL CXCR2 6LFL
TM6 234 L 6.36x36 CXCR2 6LFL CCR5 4MBS
TM6 235 L 6.37x37 CXCR2 6LFL Y2 receptor 7DDZ
TM6 236 V 6.38x38 CXCR2 6LFL Y2 receptor 7DDZ
TM6 237 A 6.39x39 CXCR2 6LFL CXCR2 6LFL
TM6 238 T 6.40x40 CXCR2 6LFL Rhodopsin 6I9K
TM6 239 V 6.41x41 CXCR2 6LFL CXCR2 6LFL
TM6 240 C 6.42x42 CXCR2 6LFL NK1 receptor 6HLP
TM6 241 T 6.43x43 CXCR2 6LFL BLT1 receptor 7K15
TM6 242 Q 6.44x44 CXCR2 6LFL - -
TM6 243 F 6.45x45 CXCR2 6LFL AT1 receptor 4ZUD
TM6 244 G 6.46x46 CXCR2 6LFL NOP receptor 5DHH
TM6 245 L 6.47x47 CXCR2 6LFL succinate receptor 6RNK
TM6 246 W 6.48x48 CXCR2 6LFL CXCR2 6LFL
TM6 247 T 6.49x49 CXCR2 6LFL κ receptor 4DJH
TM6 248 P 6.50x50 CXCR2 6LFL CXCR2 6LFL
TM6 249 H 6.51x51 CXCR2 6LFL AT1 receptor 4ZUD
TM6 250 Y 6.52x52 CXCR2 6LFL CXCR4 3ODU
TM6 251 L 6.53x53 CXCR2 6LFL CXCR2 6LFL
TM6 252 I 6.54x54 CXCR2 6LFL MT2 receptor 6ME7
TM6 253 L 6.55x55 CXCR2 6LFL CXCR2 6LFL
TM6 254 L 6.56x56 CXCR2 6LFL CXCR2 6LFL
TM6 255 G 6.57x57 CXCR2 6LFL - -
TM6 256 H 6.58x58 CXCR2 6LFL β2-adrenoceptor 4GBR
TM6 257 T 6.59x59 CXCR2 6LFL CXCR2 6LFL
TM6 258 V 6.60x60 CXCR2 6LFL OX2 receptor 5WQC
TM6 259 I 6.61x61 CXCR2 6LFL AT1 receptor 4ZUD
TM6 260 I 6.62x62 CXCR2 6LFL PAR2 5NDD
TM6 261 S 6.63x63 CXCR2 6LFL - -
TM6 262 R 6.64x64 AT1 receptor 4ZUD - -
ECL3 263 G - - - - -
ECL3 264 K - CXCR4 3ODU - -
ECL3 265 P - CXCR4 3ODU - -
ECL3 266 V - - - - -
TM7 267 D 7.24x23 CCR6 6WWZ AT1 receptor 4ZUD
TM7 268 A 7.25x24 CCR6 6WWZ - -
TM7 269 H 7.26x25 CCR6 6WWZ - -
TM7 270 Y 7.27x26 CCR6 6WWZ - -
TM7 271 L 7.28x27 CXCR2 6LFL - -
TM7 272 G 7.29x28 CXCR2 6LFL - -
TM7 273 L 7.30x29 CXCR2 6LFL δ receptor 4N6H
TM7 274 L 7.31x30 CXCR2 6LFL CCR7 6QZH
TM7 275 H 7.32x31 CXCR2 6LFL CXCR4 3ODU
TM7 276 F 7.33x32 CXCR2 6LFL S1P1 receptor 3V2Y
TM7 277 V 7.34x33 CXCR2 6LFL β2-adrenoceptor 4GBR
TM7 278 K 7.35x34 CXCR2 6LFL CCR6 6WWZ
TM7 279 D 7.36x35 CXCR2 6LFL CXCR2 6LFL
TM7 280 F 7.37x36 CXCR2 6LFL κ receptor 4DJH
TM7 281 S 7.38x37 CXCR2 6LFL MT2 receptor 6ME7
TM7 282 K 7.39x38 CXCR2 6LFL - -
TM7 283 L 7.40x39 CXCR2 6LFL MT2 receptor 6ME7
TM7 284 L 7.41x40 CXCR2 6LFL CXCR2 6LFL
TM7 285 A 7.42x41 CXCR2 6LFL CXCR2 6LFL
TM7 286 F 7.43x42 CXCR2 6LFL CCR9 5LWE
TM7 287 S 7.44x43 CXCR2 6LFL NK1 receptor 6HLP
TM7 288 S 7.45x45 CXCR2 6LFL Y2 receptor 7DDZ
TM7 289 S 7.46x46 CXCR2 6LFL CXCR2 6LFL
TM7 290 F 7.47x47 CXCR2 6LFL Y2 receptor 7DDZ
TM7 291 V 7.48x48 CXCR2 6LFL CCR7 6QZH
TM7 292 T 7.49x49 CXCR2 6LFL - -
TM7 293 P 7.50x50 CXCR2 6LFL CXCR2 6LFL
TM7 294 L 7.51x51 CXCR2 6LFL CXCR2 6LFL
TM7 295 L 7.52x52 CXCR2 6LFL δ receptor 4N6H
TM7 296 Y 7.53x53 CXCR2 6LFL CXCR2 6LFL
TM7 297 R 7.54x54 CXCR2 6LFL - -
TM7 298 Y 7.55x55 CXCR2 6LFL LPA1 receptor 4Z35
TM7 299 M 7.56x56 CXCR2 6LFL Y2 receptor 7DDZ
H8 300 N 8.47x47 CXCR2 6LFL Y2 receptor 7DDZ
H8 301 Q 8.48x48 CXCR2 6LFL CXCR2 6LFL
H8 302 S 8.49x49 CXCR2 6LFL P2Y12 receptor 4NTJ
H8 303 F 8.50x50 CXCR2 6LFL CXCR2 6LFL
H8 304 P 8.51x51 CXCR2 6LFL - -
H8 305 S 8.52x52 CXCR2 6LFL 5-HT2A receptor 6A94
H8 306 K 8.53x53 CXCR2 6LFL DP2 receptor 7M8W
H8 307 L 8.54x54 CXCR2 6LFL CXCR2 6LFL
H8 308 Q 8.55x55 CXCR2 6LFL Y1 receptor 5ZBH
H8 309 R 8.56x56 CXCR2 6LFL MT2 receptor 6ME7
H8 310 L 8.57x57 CXCR2 6LFL δ receptor 4N6H
H8 311 M 8.58x58 CXCR2 6LFL - -
H8 312 K 8.59x59 CXCR2 6LFL CCR9 5LWE
H8 313 K 8.60x60 CXCR2 6LFL CCR5 7O7F
H8 314 L 8.61x61 CXCR2 6LFL MT2 receptor 6ME7
H8 315 P 8.62x62 CCR6 6WWZ - -
C-term 316 C - - - - -
C-term 317 G - - - - -
C-term 318 D - - - - -
C-term 319 R - - - - -
C-term 320 H - - - - -