GPR149 homology model
PROTEIN CLASS
Class A (Rhodopsin)
RECEPTOR
SPECIES
Homo sapiens
STATE
Active
VERSION
2022-06-19
MODEL
MAIN TEMPLATE
TEMPLATES
3V2Y (S1P1 receptor)
7TD4 (S1P1 receptor)
5TGZ (CB1 receptor)
6KPG (CB1 receptor)
6BQH (5-HT2C receptor)
None
7TD4 (S1P1 receptor)
5TGZ (CB1 receptor)
6KPG (CB1 receptor)
6BQH (5-HT2C receptor)
None
| Main template (%) | Additional templates (%) | No template - freely modelled (%) | |
|---|---|---|---|
| Backbone | 65.3 | 13.2 | 21.5 |
| Side-chains | 8.0 | 45.1 | 46.9 |
Number of backbone templates: 5
Number of rotamer templates: 55
| Segment | Seq.num. | AA | GPCRdb# | Backbone | PDB | Rotamer | PDB |
|---|---|---|---|---|---|---|---|
| N-term | 7 | N | - | S1P1 receptor | 3V2Y | S1P1 receptor | 3V2Y |
| N-term | 8 | L | - | S1P1 receptor | 3V2Y | S1P1 receptor | 3V2Y |
| N-term | 9 | S | - | S1P1 receptor | 3V2Y | S1P1 receptor | 3V2Y |
| N-term | 10 | T | - | S1P1 receptor | 3V2Y | S1P1 receptor | 3V2Y |
| N-term | 11 | N | - | S1P1 receptor | 3V2Y | S1P1 receptor | 3V2Y |
| TM1 | 12 | D | 1.29x29 | S1P1 receptor | 3V2Y | CysLT1 receptor | 6RZ5 |
| TM1 | 13 | S | 1.30x30 | S1P1 receptor | 3V2Y | CB1 receptor | 5TGZ |
| TM1 | 14 | S | 1.31x31 | S1P1 receptor | 3V2Y | GnRH1 receptor | 7BR3 |
| TM1 | 15 | L | 1.32x32 | S1P1 receptor | 3V2Y | ghrelin receptor | 7F83 |
| TM1 | 16 | W | 1.33x33 | S1P1 receptor | 3V2Y | 5-HT2C receptor | 6BQH |
| TM1 | 17 | K | 1.34x34 | S1P1 receptor | 3V2Y | - | - |
| TM1 | 18 | E | 1.35x35 | S1P1 receptor | 7TD4 | GPR52 | 6LI1 |
| TM1 | 19 | N | 1.36x36 | S1P1 receptor | 7TD4 | - | - |
| TM1 | 20 | H | 1.37x37 | S1P1 receptor | 7TD4 | - | - |
| TM1 | 21 | N | 1.38x38 | S1P1 receptor | 7TD4 | - | - |
| TM1 | 22 | S | 1.39x39 | S1P1 receptor | 7TD4 | CB1 receptor | 5TGZ |
| TM1 | 23 | T | 1.40x40 | S1P1 receptor | 7TD4 | NK1 receptor | 6HLP |
| TM1 | 24 | D | 1.41x41 | S1P1 receptor | 7TD4 | - | - |
| TM1 | 25 | L | 1.42x42 | S1P1 receptor | 7TD4 | CB1 receptor | 5TGZ |
| TM1 | 26 | L | 1.43x43 | S1P1 receptor | 7TD4 | BLT1 receptor | 7K15 |
| TM1 | 27 | N | 1.44x44 | S1P1 receptor | 7TD4 | - | - |
| TM1 | 28 | P | 1.45x45 | S1P1 receptor | 7TD4 | 5-HT2B receptor | 5TVN |
| TM1 | 29 | P | 1.46x46 | S1P1 receptor | 7TD4 | - | - |
| TM1 | 30 | G | 1.47x47 | S1P1 receptor | 7TD4 | - | - |
| TM1 | 31 | T | 1.48x48 | S1P1 receptor | 7TD4 | M1 receptor | 6ZFZ |
| TM1 | 32 | L | 1.49x49 | S1P1 receptor | 7TD4 | H1 receptor | 3RZE |
| TM1 | 33 | N | 1.50x50 | S1P1 receptor | 7TD4 | S1P1 receptor | 7TD4 |
| TM1 | 34 | I | 1.51x51 | S1P1 receptor | 7TD4 | S1P1 receptor | 7TD4 |
| TM1 | 35 | Y | 1.52x52 | S1P1 receptor | 7TD4 | PAF receptor | 5ZKQ |
| TM1 | 36 | L | 1.53x53 | S1P1 receptor | 7TD4 | Y1 receptor | 5ZBH |
| TM1 | 37 | F | 1.54x54 | S1P1 receptor | 7TD4 | - | - |
| TM1 | 38 | C | 1.55x55 | S1P1 receptor | 7TD4 | CB1 receptor | 5TGZ |
| TM1 | 39 | L | 1.56x56 | S1P1 receptor | 7TD4 | CB2 receptor | 5ZTY |
| TM1 | 40 | T | 1.57x57 | S1P1 receptor | 7TD4 | C5a1 receptor | 6C1Q |
| TM1 | 41 | C | 1.58x58 | S1P1 receptor | 7TD4 | EP4 receptor | 5YWY |
| TM1 | 42 | L | 1.59x59 | S1P1 receptor | 7TD4 | 5-HT2B receptor | 5TVN |
| TM1 | 43 | M | 1.60x60 | S1P1 receptor | 3V2Y | - | - |
| ICL1 | 44 | T | - | - | - | - | - |
| ICL1 | 45 | F | - | CB1 receptor | 5TGZ | - | - |
| ICL1 | 46 | A | - | CB1 receptor | 5TGZ | - | - |
| ICL1 | 47 | A | - | CB1 receptor | 5TGZ | - | - |
| ICL1 | 48 | L | - | - | - | - | - |
| TM2 | 49 | V | 2.37x37 | S1P1 receptor | 7TD4 | - | - |
| TM2 | 50 | G | 2.38x38 | S1P1 receptor | 7TD4 | ETB receptor | 5X93 |
| TM2 | 51 | S | 2.39x39 | S1P1 receptor | 7TD4 | CB1 receptor | 5TGZ |
| TM2 | 52 | I | 2.40x40 | S1P1 receptor | 7TD4 | P2Y12 receptor | 4NTJ |
| TM2 | 53 | Y | 2.41x41 | S1P1 receptor | 7TD4 | S1P1 receptor | 7TD4 |
| TM2 | 54 | S | 2.42x42 | S1P1 receptor | 7TD4 | - | - |
| TM2 | 55 | L | 2.43x43 | S1P1 receptor | 7TD4 | 5-HT2C receptor | 6BQH |
| TM2 | 56 | I | 2.44x44 | S1P1 receptor | 7TD4 | CysLT1 receptor | 6RZ4 |
| TM2 | 57 | S | 2.45x45 | S1P1 receptor | 7TD4 | 5-HT2C receptor | 6BQH |
| TM2 | 58 | L | 2.46x46 | S1P1 receptor | 7TD4 | S1P1 receptor | 7TD4 |
| TM2 | 59 | L | 2.47x47 | S1P1 receptor | 7TD4 | EP4 receptor | 5YWY |
| TM2 | 60 | K | 2.48x48 | S1P1 receptor | 7TD4 | - | - |
| TM2 | 61 | M | 2.49x49 | S1P1 receptor | 7TD4 | - | - |
| TM2 | 62 | Q | 2.50x50 | S1P1 receptor | 7TD4 | - | - |
| TM2 | 63 | N | 2.51x51 | S1P1 receptor | 7TD4 | - | - |
| TM2 | 64 | R | 2.52x52 | S1P1 receptor | 7TD4 | - | - |
| TM2 | 65 | T | 2.53x53 | S1P1 receptor | 7TD4 | - | - |
| TM2 | 66 | V | 2.54x54 | S1P1 receptor | 7TD4 | apelin receptor | 5VBL |
| TM2 | 67 | V | 2.55x55 | S1P1 receptor | 7TD4 | S1P1 receptor | 7TD4 |
| TM2 | 68 | S | 2.56x56 | S1P1 receptor | 7TD4 | M5 receptor | 6OL9 |
| TM2 | 69 | M | 2.57x57 | S1P1 receptor | 7TD4 | 5-HT2C receptor | 6BQH |
| TM2 | 70 | L | 2.58x58 | S1P1 receptor | 7TD4 | GPR52 | 6LI1 |
| TM2 | 71 | V | 2.59x59 | S1P1 receptor | 7TD4 | 5-HT2A receptor | 6A94 |
| TM2 | 72 | A | 2.60x60 | S1P1 receptor | 7TD4 | 5-HT2B receptor | 5TVN |
| TM2 | 73 | S | 2.61x61 | S1P1 receptor | 7TD4 | κ receptor | 4DJH |
| TM2 | 74 | W | 2.62x62 | S1P1 receptor | 7TD4 | - | - |
| TM2 | 75 | S | 2.63x63 | S1P1 receptor | 7TD4 | CXCR2 | 6LFL |
| TM2 | 76 | V | 2.64x64 | 5-HT2C receptor | 6BQH | β1-adrenoceptor | 7BVQ |
| TM2 | 77 | D | 2.65x65 | 5-HT2C receptor | 6BQH | - | - |
| TM2 | 78 | D | 2.66x66 | 5-HT2C receptor | 6BQH | - | - |
| TM2 | 79 | L | 2.67x67 | 5-HT2C receptor | 6BQH | MC4 receptor | 6W25 |
| ECL1 | 80 | M | - | - | - | - | - |
| ECL1 | 81 | S | - | - | - | - | - |
| ECL1 | 82 | V | - | - | - | - | - |
| ECL1 | 83 | L | - | - | - | - | - |
| ECL1 | 84 | S | - | - | - | - | - |
| ECL1 | 85 | V | - | - | - | - | - |
| ECL1 | 86 | T | - | - | - | - | - |
| ECL1 | 87 | I | 23.49x49 | - | - | - | - |
| ECL1 | 88 | F | 23.50x50 | - | - | - | - |
| ECL1 | 89 | M | 23.51x51 | - | - | - | - |
| ECL1 | 90 | F | 23.52x52 | - | - | - | - |
| TM3 | 91 | L | 3.10x10 | - | - | - | - |
| TM3 | 92 | Q | 3.11x11 | - | - | - | - |
| TM3 | 93 | W | 3.12x12 | - | - | - | - |
| TM3 | 94 | P | 3.13x13 | - | - | - | - |
| TM3 | 95 | N | 3.14x14 | - | - | - | - |
| TM3 | 96 | E | 3.15x15 | - | - | - | - |
| TM3 | 97 | V | 3.16x16 | - | - | - | - |
| TM3 | 98 | P | 3.17x17 | - | - | - | - |
| TM3 | 99 | G | 3.18x18 | - | - | - | - |
| TM3 | 100 | Y | 3.19x19 | - | - | - | - |
| TM3 | 101 | F | 3.20x20 | - | - | - | - |
| TM3 | 102 | Q | 3.21x21 | S1P1 receptor | 7TD4 | - | - |
| TM3 | 103 | F | 3.22x22 | S1P1 receptor | 7TD4 | A1 receptor | 5UEN |
| TM3 | 104 | L | 3.23x23 | S1P1 receptor | 7TD4 | M5 receptor | 6OL9 |
| TM3 | 105 | C | 3.24x24 | S1P1 receptor | 7TD4 | D3 receptor | 3PBL |
| TM3 | 106 | T | 3.25x25 | S1P1 receptor | 7TD4 | - | - |
| TM3 | 107 | T | 3.26x26 | S1P1 receptor | 7TD4 | - | - |
| TM3 | 108 | S | 3.27x27 | S1P1 receptor | 7TD4 | succinate receptor | 6RNK |
| TM3 | 109 | A | 3.28x28 | S1P1 receptor | 7TD4 | M1 receptor | 6ZFZ |
| TM3 | 110 | L | 3.29x29 | S1P1 receptor | 7TD4 | CB1 receptor | 5TGZ |
| TM3 | 111 | M | 3.30x30 | S1P1 receptor | 7TD4 | Rhodopsin | 6I9K |
| TM3 | 112 | Y | 3.31x31 | S1P1 receptor | 7TD4 | - | - |
| TM3 | 113 | L | 3.32x32 | S1P1 receptor | 7TD4 | succinate receptor | 6RNK |
| TM3 | 114 | C | 3.33x33 | S1P1 receptor | 7TD4 | Y1 receptor | 5ZBH |
| TM3 | 115 | Q | 3.34x34 | S1P1 receptor | 7TD4 | - | - |
| TM3 | 116 | G | 3.35x35 | S1P1 receptor | 7TD4 | CCR2 | 5T1A |
| TM3 | 117 | L | 3.36x36 | S1P1 receptor | 7TD4 | S1P1 receptor | 7TD4 |
| TM3 | 118 | S | 3.37x37 | S1P1 receptor | 7TD4 | S1P1 receptor | 7TD4 |
| TM3 | 119 | S | 3.38x38 | S1P1 receptor | 7TD4 | CXCR2 | 6LFL |
| TM3 | 120 | N | 3.39x39 | S1P1 receptor | 7TD4 | - | - |
| TM3 | 121 | L | 3.40x40 | S1P1 receptor | 7TD4 | Rhodopsin | 1U19 |
| TM3 | 122 | K | 3.41x41 | S1P1 receptor | 7TD4 | - | - |
| TM3 | 123 | A | 3.42x42 | S1P1 receptor | 7TD4 | A1 receptor | 5UEN |
| TM3 | 124 | T | 3.43x43 | S1P1 receptor | 7TD4 | - | - |
| TM3 | 125 | L | 3.44x44 | S1P1 receptor | 7TD4 | S1P1 receptor | 7TD4 |
| TM3 | 126 | L | 3.45x45 | S1P1 receptor | 7TD4 | CB1 receptor | 5TGZ |
| TM3 | 127 | V | 3.46x46 | S1P1 receptor | 7TD4 | NK1 receptor | 6HLP |
| TM3 | 128 | S | 3.47x47 | S1P1 receptor | 7TD4 | 5-HT2C receptor | 6BQH |
| TM3 | 129 | Y | 3.48x48 | S1P1 receptor | 7TD4 | PAF receptor | 5ZKQ |
| TM3 | 130 | N | 3.49x49 | S1P1 receptor | 7TD4 | PAF receptor | 5ZKQ |
| TM3 | 131 | F | 3.50x50 | S1P1 receptor | 7TD4 | - | - |
| TM3 | 132 | Y | 3.51x51 | S1P1 receptor | 7TD4 | S1P1 receptor | 7TD4 |
| TM3 | 133 | T | 3.52x52 | S1P1 receptor | 7TD4 | D3 receptor | 3PBL |
| TM3 | 134 | M | 3.53x53 | S1P1 receptor | 7TD4 | - | - |
| TM3 | 135 | H | 3.54x54 | S1P1 receptor | 7TD4 | - | - |
| TM3 | 136 | R | 3.55x55 | S1P1 receptor | 7TD4 | CB2 receptor | 5ZTY |
| TM3 | 137 | G | 3.56x56 | S1P1 receptor | 7TD4 | - | - |
| ICL2 | 138 | V | - | - | - | - | - |
| ICL2 | 139 | G | - | CB1 receptor | 5TGZ | - | - |
| ICL2 | 140 | S | - | CB1 receptor | 5TGZ | - | - |
| ICL2 | 141 | Q | - | CB1 receptor | 5TGZ | - | - |
| ICL2 | 142 | T | - | CB1 receptor | 5TGZ | - | - |
| ICL2 | 143 | A | - | CB1 receptor | 5TGZ | - | - |
| ICL2 | 144 | S | - | CB1 receptor | 5TGZ | - | - |
| ICL2 | 145 | R | - | - | - | - | - |
| TM4 | 146 | R | 4.38x38 | S1P1 receptor | 7TD4 | GPR183 | 7TUY |
| TM4 | 147 | S | 4.39x39 | S1P1 receptor | 7TD4 | NOP receptor | 5DHG |
| TM4 | 148 | G | 4.40x40 | S1P1 receptor | 7TD4 | CB2 receptor | 5ZTY |
| TM4 | 149 | Q | 4.41x41 | S1P1 receptor | 7TD4 | - | - |
| TM4 | 150 | V | 4.42x42 | S1P1 receptor | 7TD4 | LPA1 receptor | 4Z35 |
| TM4 | 151 | L | 4.43x43 | S1P1 receptor | 7TD4 | M1 receptor | 6ZFZ |
| TM4 | 152 | G | 4.44x44 | S1P1 receptor | 7TD4 | PAR2 | 5NDD |
| TM4 | 153 | V | 4.45x45 | S1P1 receptor | 7TD4 | LPA1 receptor | 4Z35 |
| TM4 | 154 | V | 4.46x46 | S1P1 receptor | 7TD4 | β1-adrenoceptor | 7BVQ |
| TM4 | 155 | L | 4.47x47 | S1P1 receptor | 7TD4 | β2-adrenoceptor | 4GBR |
| TM4 | 156 | T | 4.48x48 | S1P1 receptor | 7TD4 | β1-adrenoceptor | 7BVQ |
| TM4 | 157 | V | 4.49x49 | S1P1 receptor | 7TD4 | 5-HT2C receptor | 6BQH |
| TM4 | 158 | W | 4.50x50 | S1P1 receptor | 7TD4 | S1P1 receptor | 7TD4 |
| TM4 | 159 | A | 4.51x51 | S1P1 receptor | 7TD4 | 5-HT2C receptor | 6BQH |
| TM4 | 160 | A | 4.52x52 | S1P1 receptor | 7TD4 | MC4 receptor | 6W25 |
| TM4 | 161 | S | 4.53x53 | S1P1 receptor | 7TD4 | S1P1 receptor | 7TD4 |
| TM4 | 162 | L | 4.54x54 | S1P1 receptor | 7TD4 | S1P1 receptor | 7TD4 |
| TM4 | 163 | L | 4.55x55 | S1P1 receptor | 7TD4 | β2-adrenoceptor | 4GBR |
| TM4 | 164 | L | 4.56x56 | S1P1 receptor | 7TD4 | S1P1 receptor | 7TD4 |
| TM4 | 165 | S | 4.57x57 | S1P1 receptor | 7TD4 | 5-HT2C receptor | 6BQH |
| TM4 | 166 | A | 4.58x58 | S1P1 receptor | 7TD4 | LPA1 receptor | 4Z35 |
| TM4 | 167 | L | 4.59x59 | S1P1 receptor | 7TD4 | S1P1 receptor | 7TD4 |
| TM4 | 168 | P | 4.60x60 | S1P1 receptor | 3V2Y | S1P1 receptor | 3V2Y |
| TM4 | 169 | L | 4.61x61 | S1P1 receptor | 3V2Y | CB1 receptor | 5TGZ |
| TM4 | 170 | C | 4.62x62 | S1P1 receptor | 3V2Y | - | - |
| TM4 | 171 | G | 4.63x63 | S1P1 receptor | 3V2Y | S1P1 receptor | 3V2Y |
| ECL2 | 172 | W | - | - | - | - | - |
| ECL2 | 173 | G | - | - | - | - | - |
| ECL2 | 174 | A | - | - | - | - | - |
| ECL2 | 175 | F | - | - | - | - | - |
| ECL2 | 176 | V | - | - | - | - | - |
| ECL2 | 177 | R | - | - | - | - | - |
| ECL2 | 178 | T | - | - | - | - | - |
| ECL2 | 179 | P | - | - | - | - | - |
| ECL2 | 180 | W | - | - | - | - | - |
| ECL2 | 181 | G | - | - | - | - | - |
| ECL2 | 182 | C | - | - | - | - | - |
| ECL2 | 183 | L | - | - | - | - | - |
| ECL2 | 184 | V | - | - | - | - | - |
| ECL2 | 185 | D | - | - | - | - | - |
| ECL2 | 186 | C | - | - | - | - | - |
| ECL2 | 187 | S | - | - | - | - | - |
| ECL2 | 188 | S | - | - | - | - | - |
| ECL2 | 189 | S | - | - | - | - | - |
| ECL2 | 190 | Y | - | - | - | - | - |
| ECL2 | 191 | V | - | - | - | - | - |
| ECL2 | 192 | L | - | - | - | - | - |
| ECL2 | 193 | F | - | - | - | - | - |
| ECL2 | 194 | L | - | - | - | - | - |
| ECL2 | 195 | S | - | - | - | - | - |
| ECL2 | 196 | I | - | - | - | - | - |
| TM5 | 197 | V | 5.36x37 | S1P1 receptor | 7TD4 | apelin receptor | 5VBL |
| TM5 | 198 | Y | 5.37x38 | S1P1 receptor | 7TD4 | PAR1 | 3VW7 |
| TM5 | 199 | A | 5.38x39 | S1P1 receptor | 7TD4 | FFA1 receptor | 5TZY |
| TM5 | 200 | L | 5.39x40 | S1P1 receptor | 7TD4 | CB1 receptor | 5TGZ |
| TM5 | 201 | A | 5.40x41 | S1P1 receptor | 7TD4 | PAR1 | 3VW7 |
| TM5 | 202 | F | 5.41x42 | S1P1 receptor | 7TD4 | S1P1 receptor | 7TD4 |
| TM5 | 203 | G | 5.42x43 | S1P1 receptor | 7TD4 | 5-HT2C receptor | 6BQH |
| TM5 | 204 | L | 5.43x44 | S1P1 receptor | 7TD4 | Y1 receptor | 5ZBH |
| TM5 | 205 | L | 5.44x45 | S1P1 receptor | 7TD4 | 5-HT2B receptor | 5TVN |
| TM5 | 206 | V | 5.45x46 | 5-HT2C receptor | 6BQH | 5-HT2C receptor | 6BQH |
| TM5 | 207 | G | 5.46x461 | 5-HT2C receptor | 6BQH | 5-HT2B receptor | 6DRZ |
| TM5 | 208 | L | 5.47x47 | 5-HT2C receptor | 6BQH | CXCR4 | 3ODU |
| TM5 | 209 | S | 5.48x48 | S1P1 receptor | 7TD4 | CB1 receptor | 5TGZ |
| TM5 | 210 | V | 5.49x49 | S1P1 receptor | 7TD4 | CB1 receptor | 5TGZ |
| TM5 | 211 | P | 5.50x50 | S1P1 receptor | 7TD4 | 5-HT2C receptor | 6BQH |
| TM5 | 212 | L | 5.51x51 | S1P1 receptor | 7TD4 | S1P1 receptor | 7TD4 |
| TM5 | 213 | T | 5.52x52 | S1P1 receptor | 7TD4 | 5-HT2C receptor | 6BQH |
| TM5 | 214 | H | 5.53x53 | S1P1 receptor | 7TD4 | - | - |
| TM5 | 215 | R | 5.54x54 | S1P1 receptor | 7TD4 | - | - |
| TM5 | 216 | L | 5.55x55 | S1P1 receptor | 7TD4 | D2 receptor | 6LUQ |
| TM5 | 217 | L | 5.56x56 | S1P1 receptor | 7TD4 | D3 receptor | 3PBL |
| TM5 | 218 | C | 5.57x57 | S1P1 receptor | 7TD4 | Y1 receptor | 5ZBH |
| TM5 | 219 | S | 5.58x58 | S1P1 receptor | 7TD4 | LPA6 receptor | 5XSZ |
| TM5 | 220 | E | 5.59x59 | S1P1 receptor | 7TD4 | - | - |
| TM5 | 221 | E | 5.60x60 | S1P1 receptor | 7TD4 | A1 receptor | 5UEN |
| TM5 | 222 | P | 5.61x61 | S1P1 receptor | 7TD4 | - | - |
| TM5 | 223 | P | 5.62x62 | S1P1 receptor | 7TD4 | - | - |
| TM5 | 224 | R | 5.63x63 | S1P1 receptor | 7TD4 | M1 receptor | 6ZFZ |
| TM5 | 225 | L | 5.64x64 | S1P1 receptor | 7TD4 | S1P1 receptor | 7TD4 |
| TM5 | 226 | H | 5.65x65 | S1P1 receptor | 7TD4 | - | - |
| TM5 | 227 | S | 5.66x66 | S1P1 receptor | 7TD4 | CXCR4 | 3OE0 |
| TM5 | 228 | N | 5.67x67 | S1P1 receptor | 7TD4 | M1 receptor | 6ZFZ |
| TM5 | 229 | Y | 5.68x68 | S1P1 receptor | 7TD4 | - | - |
| TM5 | 230 | Q | 5.69x69 | S1P1 receptor | 7TD4 | - | - |
| TM5 | 231 | E | 5.70x70 | S1P1 receptor | 7TD4 | - | - |
| TM5 | 232 | I | 5.71x71 | S1P1 receptor | 7TD4 | - | - |
| TM5 | 233 | S | 5.72x72 | S1P1 receptor | 7TD4 | - | - |
| TM5 | 234 | R | 5.73x73 | CB1 receptor | 6KPG | Rhodopsin | 6I9K |
| TM5 | 235 | G | 5.74x74 | CB1 receptor | 6KPG | - | - |
| TM5 | 236 | A | 5.75x75 | CB1 receptor | 6KPG | - | - |
| TM5 | 237 | S | 5.76x76 | CB1 receptor | 6KPG | - | - |
| ICL3 | 238 | I | - | - | - | - | - |
| ICL3 | 239 | P | - | - | - | - | - |
| ICL3 | 240 | G | - | - | - | - | - |
| ICL3 | 241 | T | - | - | - | - | - |
| ICL3 | 242 | P | - | - | - | - | - |
| ICL3 | 294 | G | - | - | - | - | - |
| ICL3 | 295 | T | - | - | - | - | - |
| ICL3 | 296 | L | - | - | - | - | - |
| ICL3 | 297 | Y | - | - | - | - | - |
| ICL3 | 298 | G | - | - | - | - | - |
| TM6 | 299 | T | 6.24x24 | CB1 receptor | 5TGZ | - | - |
| TM6 | 300 | R | 6.25x25 | CB1 receptor | 5TGZ | LPA1 receptor | 4Z35 |
| TM6 | 301 | S | 6.26x26 | CB1 receptor | 5TGZ | 5-HT2A receptor | 6A94 |
| TM6 | 302 | F | 6.27x27 | S1P1 receptor | 7TD4 | - | - |
| TM6 | 303 | T | 6.28x28 | S1P1 receptor | 7TD4 | - | - |
| TM6 | 304 | V | 6.29x29 | S1P1 receptor | 7TD4 | - | - |
| TM6 | 305 | S | 6.30x30 | S1P1 receptor | 7TD4 | S1P1 receptor | 7TD4 |
| TM6 | 306 | V | 6.31x31 | S1P1 receptor | 7TD4 | S1P1 receptor | 3V2Y |
| TM6 | 307 | A | 6.32x32 | S1P1 receptor | 7TD4 | S1P1 receptor | 7TD4 |
| TM6 | 308 | Q | 6.33x33 | S1P1 receptor | 7TD4 | - | - |
| TM6 | 309 | K | 6.34x34 | S1P1 receptor | 7TD4 | - | - |
| TM6 | 310 | R | 6.35x35 | S1P1 receptor | 7TD4 | M1 receptor | 6ZFZ |
| TM6 | 311 | F | 6.36x36 | S1P1 receptor | 7TD4 | PAR1 | 3VW7 |
| TM6 | 312 | A | 6.37x37 | S1P1 receptor | 7TD4 | D2 receptor | 6LUQ |
| TM6 | 313 | L | 6.38x38 | S1P1 receptor | 7TD4 | Y1 receptor | 5ZBH |
| TM6 | 314 | I | 6.39x39 | S1P1 receptor | 7TD4 | S1P1 receptor | 7TD4 |
| TM6 | 315 | L | 6.40x40 | S1P1 receptor | 7TD4 | apelin receptor | 5VBL |
| TM6 | 316 | A | 6.41x41 | S1P1 receptor | 7TD4 | D2 receptor | 6LUQ |
| TM6 | 317 | L | 6.42x42 | S1P1 receptor | 7TD4 | M5 receptor | 6OL9 |
| TM6 | 318 | T | 6.43x43 | S1P1 receptor | 7TD4 | β2-adrenoceptor | 4GBR |
| TM6 | 319 | K | 6.44x44 | S1P1 receptor | 7TD4 | - | - |
| TM6 | 320 | V | 6.45x45 | S1P1 receptor | 7TD4 | 5-HT2A receptor | 6A94 |
| TM6 | 321 | V | 6.46x46 | S1P1 receptor | 7TD4 | 5-HT2A receptor | 6A94 |
| TM6 | 322 | L | 6.47x47 | S1P1 receptor | 7TD4 | GPR52 | 6LI1 |
| TM6 | 323 | W | 6.48x48 | S1P1 receptor | 7TD4 | S1P1 receptor | 7TD4 |
| TM6 | 324 | L | 6.49x49 | S1P1 receptor | 7TD4 | Y1 receptor | 5ZBH |
| TM6 | 325 | P | 6.50x50 | S1P1 receptor | 7TD4 | S1P1 receptor | 7TD4 |
| TM6 | 326 | M | 6.51x51 | S1P1 receptor | 7TD4 | - | - |
| TM6 | 327 | M | 6.52x52 | S1P1 receptor | 7TD4 | - | - |
| TM6 | 328 | M | 6.53x53 | S1P1 receptor | 7TD4 | - | - |
| TM6 | 329 | H | 6.54x54 | S1P1 receptor | 7TD4 | MC4 receptor | 6W25 |
| TM6 | 330 | M | 6.55x55 | S1P1 receptor | 7TD4 | CB1 receptor | 5TGZ |
| TM6 | 331 | V | 6.56x56 | S1P1 receptor | 7TD4 | CB1 receptor | 5TGZ |
| TM6 | 332 | V | 6.57x57 | S1P1 receptor | 7TD4 | M5 receptor | 6OL9 |
| TM6 | 333 | Q | 6.58x58 | S1P1 receptor | 7TD4 | D4 receptor | 5WIV |
| TM6 | 334 | N | 6.59x59 | S1P1 receptor | 7TD4 | - | - |
| TM6 | 335 | V | 6.60x60 | S1P1 receptor | 7TD4 | OX2 receptor | 5WQC |
| TM6 | 336 | V | 6.61x61 | S1P1 receptor | 7TD4 | δ receptor | 4N6H |
| ECL3 | 337 | G | - | - | - | - | - |
| ECL3 | 338 | F | - | - | - | - | - |
| ECL3 | 339 | Q | - | - | - | - | - |
| ECL3 | 340 | S | - | - | - | - | - |
| TM7 | 341 | L | 7.32x31 | S1P1 receptor | 7TD4 | S1P1 receptor | 7TD4 |
| TM7 | 342 | P | 7.33x32 | S1P1 receptor | 7TD4 | α2C-adrenoceptor | 6KUW |
| TM7 | 343 | L | 7.34x33 | S1P1 receptor | 7TD4 | 5-HT2B receptor | 5TVN |
| TM7 | 344 | E | 7.35x34 | S1P1 receptor | 7TD4 | LPA1 receptor | 4Z35 |
| TM7 | 345 | T | 7.36x35 | S1P1 receptor | 7TD4 | M2 receptor | 5YC8 |
| TM7 | 346 | F | 7.37x36 | S1P1 receptor | 7TD4 | CB1 receptor | 5TGZ |
| TM7 | 347 | S | 7.38x37 | S1P1 receptor | 7TD4 | OX2 receptor | 5WQC |
| TM7 | 348 | F | 7.39x38 | S1P1 receptor | 7TD4 | α2A-adrenoceptor | 6KUX |
| TM7 | 349 | L | 7.40x39 | S1P1 receptor | 7TD4 | LPA1 receptor | 4Z35 |
| TM7 | 350 | L | 7.41x40 | S1P1 receptor | 7TD4 | S1P1 receptor | 7TD4 |
| TM7 | 351 | T | 7.42x41 | S1P1 receptor | 7TD4 | A1 receptor | 5UEN |
| TM7 | 352 | L | 7.43x42 | S1P1 receptor | 7TD4 | CB1 receptor | 5TGZ |
| TM7 | 353 | L | 7.44x43 | S1P1 receptor | 7TD4 | S1P1 receptor | 7TD4 |
| TM7 | 354 | A | 7.45x45 | S1P1 receptor | 7TD4 | - | - |
| TM7 | 355 | T | 7.46x46 | S1P1 receptor | 7TD4 | Y1 receptor | 5ZBH |
| TM7 | 356 | T | 7.47x47 | S1P1 receptor | 7TD4 | CB1 receptor | 5TGZ |
| TM7 | 357 | V | 7.48x48 | S1P1 receptor | 7TD4 | CB1 receptor | 5TGZ |
| TM7 | 358 | T | 7.49x49 | S1P1 receptor | 7TD4 | - | - |
| TM7 | 359 | P | 7.50x50 | S1P1 receptor | 7TD4 | S1P1 receptor | 7TD4 |
| TM7 | 360 | V | 7.51x51 | S1P1 receptor | 7TD4 | M3 receptor | 5ZHP |
| TM7 | 361 | F | 7.52x52 | S1P1 receptor | 7TD4 | Y1 receptor | 5ZBH |
| TM7 | 362 | V | 7.53x53 | S1P1 receptor | 7TD4 | - | - |
| TM7 | 363 | L | 7.54x54 | S1P1 receptor | 7TD4 | - | - |
| TM7 | 364 | S | 7.55x55 | S1P1 receptor | 7TD4 | - | - |
| TM7 | 365 | K | 7.56x56 | S1P1 receptor | 7TD4 | - | - |
| H8 | 366 | R | 8.47x47 | S1P1 receptor | 7TD4 | - | - |
| H8 | 367 | W | 8.48x48 | S1P1 receptor | 7TD4 | - | - |
| H8 | 368 | T | 8.49x49 | S1P1 receptor | 7TD4 | M5 receptor | 6OL9 |
| H8 | 369 | H | 8.50x50 | S1P1 receptor | 7TD4 | - | - |
| H8 | 370 | L | 8.51x51 | S1P1 receptor | 7TD4 | EP4 receptor | 5YWY |
| H8 | 371 | P | 8.52x52 | S1P1 receptor | 7TD4 | - | - |
| H8 | 372 | C | 8.53x53 | S1P1 receptor | 7TD4 | κ receptor | 4DJH |
| H8 | 373 | G | 8.54x54 | S1P1 receptor | 7TD4 | - | - |
| H8 | 374 | C | 8.55x55 | S1P1 receptor | 7TD4 | - | - |
| H8 | 375 | I | 8.56x56 | 5-HT2C receptor | 6BQH | - | - |
| H8 | 376 | I | 8.57x57 | 5-HT2C receptor | 6BQH | LPA1 receptor | 4Z36 |
| H8 | 377 | N | 8.58x58 | 5-HT2C receptor | 6BQH | - | - |
| H8 | 378 | C | 8.59x59 | 5-HT2C receptor | 6BQH | β2-adrenoceptor | 5D5A |
| C-term | 379 | R | - | - | - | - | - |
| C-term | 380 | Q | - | - | - | - | - |
| C-term | 381 | N | - | - | - | - | - |
| C-term | 382 | A | - | - | - | - | - |
| C-term | 383 | Y | - | - | - | - | - |