GPR158 homology model

PROTEIN CLASS

Class C (Glutamate)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive

VERSION

2021-05-12

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

mGlu1 receptor (sequence similarity: 16%) PDB: 4OR2

TEMPLATES

4OR2 (mGlu1 receptor)
7C7Q (GABAB2)
4OO9 (mGlu5 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 78.6 1.8 19.6
Side-chains 21.0 11.4 67.6

Number of backbone templates: 3
Number of rotamer templates: 6

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 410 V - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
N-term 411 Q - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
N-term 412 E - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
N-term 413 D - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
N-term 414 K - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM1 415 Y 1.38x38 mGlu1 receptor 4OR2 - -
TM1 416 L 1.39x39 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM1 417 R 1.40x40 mGlu1 receptor 4OR2 - -
TM1 418 L 1.41x41 mGlu1 receptor 4OR2 - -
TM1 419 A 1.42x42 mGlu1 receptor 4OR2 mGlu5 receptor 6FFI
TM1 420 I 1.43x43 mGlu1 receptor 4OR2 - -
TM1 421 I 1.44x44 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM1 422 S 1.45x45 mGlu1 receptor 4OR2 - -
TM1 423 F 1.46x46 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM1 424 Q 1.47x47 mGlu1 receptor 4OR2 - -
TM1 425 A 1.48x48 mGlu1 receptor 4OR2 - -
TM1 426 L 1.49x49 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM1 427 C 1.50x50 mGlu1 receptor 4OR2 - -
TM1 428 M 1.51x51 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM1 429 L 1.52x52 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM1 430 L 1.53x53 mGlu1 receptor 4OR2 GABAB1 6W2Y
TM1 431 D 1.54x54 mGlu1 receptor 4OR2 - -
TM1 432 F 1.55x55 mGlu1 receptor 4OR2 - -
TM1 433 V 1.56x56 mGlu1 receptor 4OR2 GABAB1 6W2Y
TM1 434 S 1.57x57 mGlu1 receptor 4OR2 - -
TM1 435 M 1.58x58 mGlu1 receptor 4OR2 - -
TM1 436 L 1.59x59 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM1 437 V 1.60x60 mGlu1 receptor 4OR2 mGlu5 receptor 6FFI
TM1 438 V 1.61x61 mGlu1 receptor 4OR2 - -
TM1 439 Y 1.62x62 mGlu1 receptor 4OR2 - -
TM1 440 H 1.63x63 mGlu1 receptor 4OR2 - -
TM1 441 F 1.64x64 mGlu1 receptor 4OR2 - -
ICL1 442 R - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
ICL1 443 K - mGlu1 receptor 4OR2 - -
ICL1 444 A 12.47x47 mGlu1 receptor 4OR2 - -
ICL1 445 K 12.48x48 mGlu1 receptor 4OR2 GABAB2 7C7Q
ICL1 446 S 12.49x49 mGlu1 receptor 4OR2 - -
ICL1 447 I 12.50x50 mGlu1 receptor 4OR2 GABAB2 7C7Q
ICL1 448 R 12.51x51 mGlu1 receptor 4OR2 - -
ICL1 449 A 12.52x52 mGlu1 receptor 4OR2 - -
ICL1 450 S 12.53x53 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM2 451 G 2.35x35 mGlu1 receptor 4OR2 - -
TM2 452 L 2.36x36 mGlu1 receptor 4OR2 - -
TM2 453 I 2.37x37 mGlu1 receptor 4OR2 - -
TM2 454 L 2.38x38 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM2 455 L 2.39x39 mGlu1 receptor 4OR2 - -
TM2 456 E 2.40x40 mGlu1 receptor 4OR2 - -
TM2 457 T 2.41x41 mGlu1 receptor 4OR2 - -
TM2 458 I 2.42x42 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM2 459 L 2.43x43 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM2 460 F 2.44x44 mGlu1 receptor 4OR2 - -
TM2 461 G 2.45x45 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM2 462 S 2.46x46 mGlu1 receptor 4OR2 - -
TM2 463 L 2.47x47 mGlu1 receptor 4OR2 - -
TM2 464 L 2.48x48 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM2 465 L 2.49x49 mGlu1 receptor 4OR2 - -
TM2 466 Y 2.50x50 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM2 467 F 2.51x51 mGlu1 receptor 4OR2 - -
TM2 468 P 2.52x52 mGlu1 receptor 4OR2 - -
TM2 469 V 2.53x53 mGlu1 receptor 4OR2 GABAB1 6W2Y
TM2 470 V 2.54x54 mGlu1 receptor 4OR2 - -
TM2 471 I 2.55x55 mGlu1 receptor 4OR2 - -
TM2 472 L 2.56x56 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM2 473 Y 2.57x57 mGlu1 receptor 4OR2 - -
ECL1 474 F - mGlu1 receptor 4OR2 - -
ECL1 475 E - mGlu1 receptor 4OR2 - -
ECL1 476 P - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
ECL1 477 S - mGlu1 receptor 4OR2 - -
TM3 478 T 3.26x26 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM3 479 F 3.27x27 mGlu1 receptor 4OR2 - -
TM3 480 R 3.28x28 mGlu1 receptor 4OR2 - -
TM3 481 C 3.29x29 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM3 482 I 3.30x30 mGlu1 receptor 4OR2 - -
TM3 483 L 3.31x31 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM3 484 L 3.32x32 mGlu1 receptor 4OR2 - -
TM3 485 R 3.33x33 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM3 486 W 3.34x34 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM3 487 A 3.35x35 mGlu1 receptor 4OR2 - -
TM3 488 R 3.36x36 mGlu1 receptor 4OR2 - -
TM3 489 L 3.37x37 mGlu1 receptor 4OR2 - -
TM3 490 L 3.38x38 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM3 491 G 3.39x39 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM3 492 F 3.40x40 mGlu1 receptor 4OR2 GABAB1 6W2Y
TM3 493 A 3.41x41 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM3 494 T 3.42x42 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM3 495 V 3.43x43 mGlu1 receptor 4OR2 - -
TM3 496 Y 3.44x44 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM3 497 G 3.45x45 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM3 498 T 3.46x46 mGlu1 receptor 4OR2 - -
TM3 499 V 3.47x47 mGlu1 receptor 4OR2 - -
TM3 500 T 3.48x48 mGlu1 receptor 4OR2 - -
TM3 501 L 3.49x49 mGlu1 receptor 4OR2 - -
TM3 502 K 3.50x50 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM3 503 L 3.51x51 mGlu1 receptor 4OR2 - -
TM3 504 H 3.52x52 mGlu1 receptor 4OR2 - -
TM3 505 R 3.53x53 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM3 506 V 3.54x54 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM3 507 L 3.55x55 mGlu1 receptor 4OR2 - -
TM3 508 K 3.56x56 mGlu1 receptor 4OR2 - -
TM3 509 V 3.57x57 mGlu1 receptor 4OR2 - -
TM3 510 F 3.58x58 mGlu1 receptor 4OR2 GABAB2 6UO8
ICL2 511 L - - - - -
TM4 512 S 4.28x28 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM4 513 R 4.29x29 mGlu1 receptor 4OR2 - -
TM4 514 T 4.30x30 mGlu1 receptor 4OR2 - -
TM4 515 A 4.31x31 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM4 516 Q 4.32x32 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM4 517 R 4.33x33 mGlu1 receptor 4OR2 - -
TM4 518 I 4.34x34 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM4 519 P 4.35x35 mGlu1 receptor 4OR2 - -
TM4 520 Y 4.36x36 mGlu1 receptor 4OR2 - -
TM4 521 M 4.37x37 mGlu1 receptor 4OR2 - -
TM4 522 T 4.38x38 mGlu1 receptor 4OR2 - -
TM4 523 G 4.39x39 mGlu1 receptor 4OR2 - -
TM4 524 G 4.40x40 mGlu1 receptor 4OR2 - -
TM4 525 R 4.41x41 mGlu1 receptor 4OR2 - -
TM4 526 V 4.42x42 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM4 527 M 4.43x43 mGlu1 receptor 4OR2 - -
TM4 528 R 4.44x44 mGlu1 receptor 4OR2 - -
TM4 529 M 4.45x45 mGlu1 receptor 4OR2 - -
TM4 530 L 4.46x46 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM4 531 A 4.47x47 mGlu1 receptor 4OR2 - -
TM4 532 V 4.48x48 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM4 533 I 4.49x49 mGlu1 receptor 4OR2 GABAB1 6W2Y
TM4 534 L 4.50x50 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM4 535 L 4.51x51 mGlu1 receptor 4OR2 - -
TM4 536 V 4.52x52 mGlu1 receptor 4OR2 - -
TM4 537 V 4.53x53 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM4 538 F 4.54x54 mGlu1 receptor 4OR2 - -
ECL2 539 W - - - - -
ECL2 540 F - - - - -
ECL2 541 L - - - - -
ECL2 542 I - - - - -
ECL2 543 G - - - - -
ECL2 544 W - - - - -
ECL2 545 T - - - - -
ECL2 546 S - - - - -
ECL2 547 S - - - - -
ECL2 548 V - - - - -
ECL2 549 C - - - - -
ECL2 550 Q - - - - -
ECL2 551 N - - - - -
ECL2 552 L - - - - -
ECL2 553 E - - - - -
ECL2 554 K - - - - -
ECL2 555 Q - - - - -
ECL2 556 I - - - - -
ECL2 557 S - - - - -
ECL2 558 L - - - - -
ECL2 559 I - - - - -
ECL2 560 G - - - - -
ECL2 561 Q - - - - -
ECL2 562 G - - - - -
ECL2 563 K - - - - -
ECL2 564 T - - - - -
ECL2 565 S - - - - -
ECL2 566 D - - - - -
ECL2 567 H - - - - -
ECL2 568 L - - - - -
ECL2 569 I - - - - -
ECL2 570 F - - - - -
ECL2 571 N - - - - -
ECL2 572 M - - - - -
ECL2 573 C 45.50x50 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
ECL2 574 L 45.51x51 mGlu1 receptor 4OR2 - -
ECL2 575 I 45.52x52 mGlu1 receptor 4OR2 - -
TM5 576 D 5.37x37 mGlu1 receptor 4OR2 - -
TM5 577 R 5.38x38 mGlu1 receptor 4OR2 - -
TM5 578 W 5.39x39 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM5 579 D 5.40x40 mGlu1 receptor 4OR2 - -
TM5 580 Y 5.41x41 mGlu1 receptor 4OR2 - -
TM5 581 M 5.42x42 mGlu1 receptor 4OR2 - -
TM5 582 T 5.43x43 mGlu1 receptor 4OR2 - -
TM5 583 A 5.44x44 mGlu1 receptor 4OR2 - -
TM5 584 V 5.45x45 mGlu1 receptor 4OR2 - -
TM5 585 A 5.46x46 mGlu1 receptor 4OR2 - -
TM5 586 E 5.47x47 mGlu1 receptor 4OR2 - -
TM5 587 F 5.48x48 mGlu1 receptor 4OR2 - -
TM5 588 L 5.49x49 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM5 589 F 5.50x50 mGlu1 receptor 4OR2 - -
TM5 590 L 5.51x51 mGlu1 receptor 4OR2 GABAB1 6W2Y
TM5 591 L 5.52x52 mGlu1 receptor 4OR2 mGlu5 receptor 6FFI
TM5 592 W 5.53x53 mGlu1 receptor 4OR2 - -
TM5 593 G 5.54x54 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM5 594 V 5.55x55 mGlu1 receptor 4OR2 - -
TM5 595 Y 5.56x56 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM5 596 L 5.57x57 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM5 597 C 5.58x58 mGlu1 receptor 4OR2 - -
TM5 598 Y 5.59x59 mGlu1 receptor 4OR2 - -
TM5 599 A 5.60x60 mGlu1 receptor 4OR2 - -
TM5 600 V 5.61x61 mGlu1 receptor 4OR2 - -
ICL3 601 R - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
ICL3 602 T - mGlu1 receptor 4OR2 - -
ICL3 603 V - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
ICL3 604 P - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
ICL3 605 S - mGlu1 receptor 4OR2 - -
ICL3 606 A - mGlu1 receptor 4OR2 - -
ICL3 607 F - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
ICL3 608 H - mGlu1 receptor 4OR2 - -
TM6 609 E 6.35x35 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM6 610 P 6.36x36 mGlu1 receptor 4OR2 - -
TM6 611 R 6.37x37 mGlu1 receptor 4OR2 - -
TM6 612 Y 6.38x38 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM6 613 M 6.39x39 mGlu1 receptor 4OR2 - -
TM6 614 A 6.40x40 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM6 615 V 6.41x41 mGlu1 receptor 4OR2 - -
TM6 616 A 6.42x42 mGlu1 receptor 4OR2 GABAB1 6W2Y
TM6 617 V 6.43x43 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM6 618 H 6.44x44 mGlu1 receptor 4OR2 - -
TM6 619 N 6.45x45 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM6 620 E 6.46x46 mGlu1 receptor 4OR2 - -
TM6 621 L 6.47x47 mGlu1 receptor 4OR2 - -
TM6 622 I 6.48x48 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM6 623 I 6.49x49 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM6 624 S 6.50x50 mGlu1 receptor 4OR2 - -
TM6 625 A 6.51x51 mGlu1 receptor 4OR2 - -
TM6 626 I 6.52x52 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM6 627 F 6.53x53 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM6 628 H 6.54x54 mGlu1 receptor 4OR2 - -
TM6 629 T 6.55x55 mGlu1 receptor 4OR2 - -
TM6 630 I 6.56x56 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM6 631 R 6.57x57 mGlu1 receptor 4OR2 - -
TM6 632 F 6.58x58 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM6 633 V 6.59x59 mGlu1 receptor 4OR2 - -
TM6 634 L 6.60x60 GABAB2 7C7Q GABAB1 6W2Y
ECL3 635 A - - - - -
ECL3 636 S - - - - -
ECL3 637 R - - - - -
ECL3 638 L - - - - -
ECL3 639 Q - - - - -
ECL3 640 S - - - - -
ECL3 641 D - - - - -
TM7 642 W 7.27x28 mGlu1 receptor 4OR2 - -
TM7 643 M 7.28x29 mGlu1 receptor 4OR2 - -
TM7 644 L 7.29x30 mGlu1 receptor 4OR2 - -
TM7 645 M 7.30x31 mGlu1 receptor 4OR2 - -
TM7 646 L 7.31x32 mGlu1 receptor 4OR2 - -
TM7 647 Y 7.32x33 mGlu1 receptor 4OR2 - -
TM7 648 F 7.33x34 mGlu1 receptor 4OR2 - -
TM7 649 A 7.34x35 mGlu1 receptor 4OR2 - -
TM7 650 H 7.35x36 mGlu1 receptor 4OR2 - -
TM7 651 T 7.36x37 mGlu1 receptor 4OR2 - -
TM7 652 H 7.37x38 mGlu1 receptor 4OR2 - -
TM7 653 L 7.38x39 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM7 654 T 7.39x40 mGlu1 receptor 4OR2 - -
TM7 655 V 7.40x41 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM7 656 T 7.41x42 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM7 657 V 7.42x43 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM7 658 T 7.43x44 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM7 659 I 7.44x45 mGlu1 receptor 4OR2 - -
TM7 660 G 7.45x46 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM7 661 L 7.46x47 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM7 662 L 7.47x471 mGlu1 receptor 4OR2 GABAB1 6W2Y
TM7 663 L 7.48x48 mGlu1 receptor 4OR2 - -
TM7 664 I 7.49x49 mGlu1 receptor 4OR2 - -
TM7 665 P 7.50x50 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM7 666 K 7.51x51 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM7 667 F 7.52x52 mGlu1 receptor 4OR2 - -
TM7 668 S 7.53x53 mGlu1 receptor 4OR2 - -
TM7 669 H 7.54x54 mGlu1 receptor 4OR2 - -
TM7 670 S 7.55x55 mGlu1 receptor 4OR2 - -
TM7 671 S 7.56x56 mGlu1 receptor 4OR2 - -
TM7 672 N 7.57x57 mGlu1 receptor 4OR2 - -
TM7 673 N 7.58x58 mGlu1 receptor 4OR2 - -
H8 674 P 8.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 675 R 8.47x47 mGlu5 receptor 4OO9 - -
H8 676 D 8.48x48 mGlu5 receptor 4OO9 - -
H8 677 D 8.49x49 mGlu5 receptor 4OO9 - -
H8 678 I 8.50x50 - - - -
H8 679 A 8.51x51 - - - -
H8 680 T 8.52x52 - - - -
H8 681 E 8.53x53 - - - -
H8 682 A 8.54x54 - - - -
H8 683 Y 8.55x55 - - - -
H8 684 E 8.56x56 - - - -
H8 685 D 8.57x57 - - - -
C-term 686 E - - - - -
C-term 687 L - - - - -
C-term 688 D - - - - -
C-term 689 M - - - - -
C-term 690 G - - - - -