GPRC5B homology model

PROTEIN CLASS

Class C (Glutamate)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-11-02

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

NGL is a WebGL based 3D viewer powered by MMTF.

MAIN TEMPLATE

mGlu2 receptor (sequence similarity: 13%) PDB: 7MTS

TEMPLATES

7EPA (mGlu2 receptor)
7MTS (mGlu2 receptor)
7EPE (mGlu2 receptor)
7EPB (mGlu2 receptor)
7E9G (mGlu2 receptor)
4OO9 (mGlu5 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 74.4 7.0 18.5
Side-chains 19.3 17.0 63.7

Number of backbone templates: 6
Number of rotamer templates: 9

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 47 S - mGlu2 receptor 7EPA mGlu2 receptor 7EPA
N-term 48 L - mGlu2 receptor 7EPA mGlu2 receptor 7EPA
N-term 49 C - mGlu2 receptor 7EPA mGlu2 receptor 7EPA
N-term 50 D - mGlu2 receptor 7EPA mGlu2 receptor 7EPA
N-term 51 L - mGlu2 receptor 7EPA mGlu2 receptor 7EPA
TM1 52 D 1.36x36 mGlu2 receptor 7EPA - -
TM1 53 A 1.37x37 mGlu2 receptor 7MTS - -
TM1 54 I 1.38x38 mGlu2 receptor 7MTS mGlu1 receptor 4OR2
TM1 55 W 1.39x39 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM1 56 G 1.40x40 mGlu2 receptor 7MTS CaS receptor 7DD6
TM1 57 I 1.41x41 mGlu2 receptor 7MTS CaS receptor 7DD6
TM1 58 V 1.42x42 mGlu2 receptor 7MTS - -
TM1 59 V 1.43x43 mGlu2 receptor 7MTS GABAB1 6W2Y
TM1 60 E 1.44x44 mGlu2 receptor 7MTS - -
TM1 61 A 1.45x45 mGlu2 receptor 7MTS GABAB2 7C7Q
TM1 62 V 1.46x46 mGlu2 receptor 7MTS - -
TM1 63 A 1.47x47 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM1 64 G 1.48x48 mGlu2 receptor 7MTS - -
TM1 65 A 1.49x49 mGlu2 receptor 7MTS - -
TM1 66 G 1.50x50 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM1 67 A 1.51x51 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM1 68 L 1.52x52 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM1 69 I 1.53x53 mGlu2 receptor 7MTS - -
TM1 70 T 1.54x54 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM1 71 L 1.55x55 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM1 72 L 1.56x56 mGlu2 receptor 7MTS - -
TM1 73 L 1.57x57 mGlu2 receptor 7MTS - -
TM1 74 M 1.58x58 mGlu2 receptor 7MTS - -
TM1 75 L 1.59x59 mGlu2 receptor 7MTS mGlu1 receptor 4OR2
TM1 76 I 1.60x60 mGlu2 receptor 7MTS mGlu1 receptor 4OR2
TM1 77 L 1.61x61 mGlu2 receptor 7MTS - -
TM1 78 L 1.62x62 mGlu2 receptor 7MTS - -
TM1 79 V 1.63x63 mGlu2 receptor 7MTS - -
TM1 80 R 1.64x64 mGlu2 receptor 7MTS - -
ICL1 81 L 12.47x47 - - - -
ICL1 82 P 12.48x48 - - - -
ICL1 83 F 12.49x49 - - - -
ICL1 84 I 12.50x50 - - - -
ICL1 85 K 12.51x51 - - - -
ICL1 86 E 12.52x52 - - - -
ICL1 87 K 12.53x53 - - - -
TM2 88 E 2.31x31 - - - -
TM2 89 K 2.32x32 - - - -
TM2 90 K 2.33x33 - - - -
TM2 91 S 2.34x34 - - - -
TM2 92 P 2.35x35 mGlu2 receptor 7MTS - -
TM2 93 V 2.36x36 mGlu2 receptor 7MTS - -
TM2 94 G 2.37x37 mGlu2 receptor 7MTS - -
TM2 95 L 2.38x38 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM2 96 H 2.39x39 mGlu2 receptor 7MTS - -
TM2 97 F 2.40x40 mGlu2 receptor 7MTS - -
TM2 98 L 2.41x41 mGlu2 receptor 7MTS CaS receptor 7DD6
TM2 99 F 2.42x42 mGlu2 receptor 7MTS - -
TM2 100 L 2.43x43 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM2 101 L 2.44x44 mGlu2 receptor 7MTS GABAB2 7C7Q
TM2 102 G 2.45x45 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM2 103 T 2.46x46 mGlu2 receptor 7MTS - -
TM2 104 L 2.47x47 mGlu2 receptor 7MTS CaS receptor 7DD6
TM2 105 G 2.48x48 mGlu2 receptor 7MTS - -
TM2 106 L 2.49x49 mGlu2 receptor 7MTS - -
TM2 107 F 2.50x50 mGlu2 receptor 7MTS CaS receptor 7DD6
TM2 108 G 2.51x51 mGlu2 receptor 7MTS - -
TM2 109 L 2.52x52 mGlu2 receptor 7MTS - -
TM2 110 T 2.53x53 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM2 111 F 2.54x54 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM2 112 A 2.55x55 mGlu2 receptor 7MTS - -
TM2 113 F 2.56x56 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM2 114 I 2.57x57 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM2 115 I 2.58x58 mGlu2 receptor 7MTS - -
ECL1 116 Q - - - - -
ECL1 117 E - - - - -
TM3 118 D 3.25x25 mGlu2 receptor 7EPE - -
TM3 119 E 3.26x26 mGlu2 receptor 7EPE GABAB2 7C7Q
TM3 120 T 3.27x27 mGlu2 receptor 7MTS GABAB2 7C7Q
TM3 121 I 3.28x28 mGlu2 receptor 7MTS - -
TM3 122 C 3.29x29 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM3 123 S 3.30x30 mGlu2 receptor 7MTS mGlu4 receptor 7E9H
TM3 124 V 3.31x31 mGlu2 receptor 7MTS GABAB2 7C7Q
TM3 125 R 3.32x32 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM3 126 R 3.33x33 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM3 127 F 3.34x34 mGlu2 receptor 7MTS - -
TM3 128 L 3.35x35 mGlu2 receptor 7MTS mGlu1 receptor 4OR2
TM3 129 W 3.36x36 mGlu2 receptor 7MTS - -
TM3 130 G 3.37x37 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM3 131 V 3.38x38 mGlu2 receptor 7MTS GABAB2 7C7Q
TM3 132 L 3.39x39 mGlu2 receptor 7MTS - -
TM3 133 F 3.40x40 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM3 134 A 3.41x41 mGlu2 receptor 7MTS mGlu1 receptor 4OR2
TM3 135 L 3.42x42 mGlu2 receptor 7MTS CaS receptor 7DD6
TM3 136 C 3.43x43 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM3 137 F 3.44x44 mGlu2 receptor 7MTS GABAB2 7C7Q
TM3 138 S 3.45x45 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM3 139 C 3.46x46 mGlu2 receptor 7MTS CaS receptor 7DD6
TM3 140 L 3.47x47 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM3 141 L 3.48x48 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM3 142 S 3.49x49 mGlu2 receptor 7MTS - -
TM3 143 Q 3.50x50 mGlu2 receptor 7MTS - -
TM3 144 A 3.51x51 mGlu2 receptor 7MTS - -
TM3 145 W 3.52x52 mGlu2 receptor 7MTS GABAB2 7C7Q
TM3 146 R 3.53x53 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM3 147 V 3.54x54 mGlu2 receptor 7MTS GABAB2 7C7Q
TM3 148 R 3.55x55 mGlu2 receptor 7MTS - -
TM3 149 R 3.56x56 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM3 150 L 3.57x57 mGlu2 receptor 7MTS - -
TM3 151 V 3.58x58 mGlu2 receptor 7MTS - -
TM3 152 R 3.59x59 mGlu2 receptor 7MTS - -
TM3 153 H 3.60x60 mGlu2 receptor 7MTS - -
ICL2 154 G - - - - -
ICL2 155 T - - - - -
ICL2 156 G - - - - -
ICL2 157 P - - - - -
TM4 158 A 4.28x28 mGlu2 receptor 7MTS - -
TM4 159 G 4.29x29 mGlu2 receptor 7MTS - -
TM4 160 W 4.30x30 mGlu2 receptor 7MTS mGlu1 receptor 4OR2
TM4 161 Q 4.31x31 mGlu2 receptor 7MTS - -
TM4 162 L 4.32x32 mGlu2 receptor 7MTS GABAB2 7C7Q
TM4 163 V 4.33x33 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM4 164 G 4.34x34 mGlu2 receptor 7MTS - -
TM4 165 L 4.35x35 mGlu2 receptor 7MTS CaS receptor 7DD6
TM4 166 A 4.36x36 mGlu2 receptor 7MTS mGlu1 receptor 4OR2
TM4 167 L 4.37x37 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM4 168 C 4.38x38 mGlu2 receptor 7MTS - -
TM4 169 L 4.39x39 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM4 170 M 4.40x40 mGlu2 receptor 7MTS - -
TM4 171 L 4.41x41 mGlu2 receptor 7MTS GABAB2 7C7Q
TM4 172 V 4.42x42 mGlu2 receptor 7MTS CaS receptor 7DD6
TM4 173 Q 4.43x43 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM4 174 V 4.44x44 mGlu2 receptor 7MTS - -
TM4 175 I 4.45x45 mGlu2 receptor 7MTS - -
TM4 176 I 4.46x46 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM4 177 A 4.47x47 mGlu2 receptor 7MTS - -
TM4 178 V 4.48x48 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM4 179 E 4.49x49 mGlu2 receptor 7MTS - -
TM4 180 W 4.50x50 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM4 181 L 4.51x51 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM4 182 V 4.52x52 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM4 183 L 4.53x53 mGlu2 receptor 7MTS - -
TM4 184 T 4.54x54 mGlu2 receptor 7MTS - -
ECL2 185 V - - - - -
ECL2 186 L - - - - -
ECL2 187 R - - - - -
ECL2 188 D - - - - -
ECL2 189 T - - - - -
ECL2 190 R - - - - -
ECL2 191 P - - - - -
ECL2 192 A - - - - -
ECL2 193 C 45.50x50 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
ECL2 194 A 45.51x51 mGlu2 receptor 7MTS - -
ECL2 195 Y 45.52x52 mGlu2 receptor 7MTS - -
ECL2 196 E - - - - -
TM5 197 P 5.37x37 mGlu2 receptor 7EPB - -
TM5 198 M 5.38x38 mGlu2 receptor 7EPB CaS receptor 7DD6
TM5 199 D 5.39x39 mGlu2 receptor 7MTS - -
TM5 200 F 5.40x40 mGlu2 receptor 7MTS - -
TM5 201 V 5.41x41 mGlu2 receptor 7MTS mGlu1 receptor 4OR2
TM5 202 M 5.42x42 mGlu2 receptor 7MTS - -
TM5 203 A 5.43x43 mGlu2 receptor 7MTS - -
TM5 204 L 5.44x44 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM5 205 I 5.45x45 mGlu2 receptor 7MTS - -
TM5 206 Y 5.46x46 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM5 207 D 5.47x47 mGlu2 receptor 7MTS - -
TM5 208 M 5.48x48 mGlu2 receptor 7MTS - -
TM5 209 V 5.49x49 mGlu2 receptor 7MTS - -
TM5 210 L 5.50x50 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM5 211 L 5.51x51 mGlu2 receptor 7MTS GABAB1 6W2Y
TM5 212 V 5.52x52 mGlu2 receptor 7MTS - -
TM5 213 V 5.53x53 mGlu2 receptor 7MTS - -
TM5 214 T 5.54x54 mGlu2 receptor 7MTS - -
TM5 215 L 5.55x55 mGlu2 receptor 7MTS - -
TM5 216 G 5.56x56 mGlu2 receptor 7MTS - -
TM5 217 L 5.57x57 mGlu2 receptor 7MTS GABAB2 7C7Q
TM5 218 A 5.58x58 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM5 219 L 5.59x59 mGlu2 receptor 7MTS - -
TM5 220 F 5.60x60 mGlu2 receptor 7MTS - -
TM5 221 T 5.61x61 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM5 222 L 5.62x62 mGlu2 receptor 7MTS - -
TM5 223 C 5.63x63 mGlu2 receptor 7E9G - -
TM5 224 G 5.64x64 mGlu2 receptor 7E9G - -
ICL3 225 K - - - - -
ICL3 226 F - - - - -
ICL3 227 K - - - - -
ICL3 228 R - - - - -
ICL3 229 W - - - - -
TM6 230 K 6.33x33 mGlu2 receptor 7EPB - -
TM6 231 L 6.34x34 mGlu2 receptor 7EPB - -
TM6 232 N 6.35x35 mGlu2 receptor 7MTS - -
TM6 233 G 6.36x36 mGlu2 receptor 7MTS - -
TM6 234 A 6.37x37 mGlu2 receptor 7MTS - -
TM6 235 F 6.38x38 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM6 236 L 6.39x39 mGlu2 receptor 7MTS - -
TM6 237 L 6.40x40 mGlu2 receptor 7MTS - -
TM6 238 I 6.41x41 mGlu2 receptor 7MTS - -
TM6 239 T 6.42x42 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM6 240 A 6.43x43 mGlu2 receptor 7MTS - -
TM6 241 F 6.44x44 mGlu2 receptor 7MTS - -
TM6 242 L 6.45x45 mGlu2 receptor 7MTS - -
TM6 243 S 6.46x46 mGlu2 receptor 7MTS - -
TM6 244 V 6.47x47 mGlu2 receptor 7MTS - -
TM6 245 L 6.48x48 mGlu2 receptor 7MTS - -
TM6 246 I 6.49x49 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM6 247 W 6.50x50 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM6 248 V 6.51x51 mGlu2 receptor 7MTS - -
TM6 249 A 6.52x52 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM6 250 W 6.53x53 mGlu2 receptor 7MTS - -
TM6 251 M 6.54x54 mGlu2 receptor 7MTS - -
TM6 252 T 6.55x55 mGlu2 receptor 7MTS - -
TM6 253 M 6.56x56 mGlu2 receptor 7MTS - -
TM6 254 Y 6.57x57 mGlu2 receptor 7MTS CaS receptor 7DD6
TM6 255 L 6.58x58 mGlu2 receptor 7MTS - -
TM6 256 F 6.59x59 mGlu2 receptor 7MTS - -
TM6 257 G 6.60x60 mGlu2 receptor 7MTS - -
TM6 258 N 6.61x61 mGlu2 receptor 7EPE - -
ECL3 259 V - - - - -
ECL3 260 K - - - - -
ECL3 261 L - - - - -
ECL3 262 Q - - - - -
ECL3 263 Q - - - - -
TM7 264 G 7.24x25 mGlu2 receptor 7MTS - -
TM7 265 D 7.25x26 mGlu2 receptor 7MTS - -
TM7 266 A 7.26x27 mGlu2 receptor 7MTS - -
TM7 267 W 7.27x28 mGlu2 receptor 7MTS - -
TM7 268 N 7.28x29 mGlu2 receptor 7MTS - -
TM7 269 D 7.29x30 mGlu2 receptor 7MTS - -
TM7 270 P 7.30x31 mGlu2 receptor 7MTS - -
TM7 271 T 7.31x32 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM7 272 L 7.32x33 mGlu2 receptor 7MTS mGlu4 receptor 7E9H
TM7 273 A 7.33x34 mGlu2 receptor 7MTS GABAB2 7C7Q
TM7 274 I 7.34x35 mGlu2 receptor 7MTS CaS receptor 7DD6
TM7 275 T 7.35x36 mGlu2 receptor 7MTS - -
TM7 276 L 7.36x37 mGlu2 receptor 7MTS - -
TM7 277 A 7.37x38 mGlu2 receptor 7MTS - -
TM7 278 A 7.38x39 mGlu2 receptor 7MTS CaS receptor 7DD6
TM7 279 S 7.39x40 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM7 280 G 7.40x41 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM7 281 W 7.41x42 mGlu2 receptor 7MTS - -
TM7 282 V 7.42x43 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM7 283 F 7.43x44 mGlu2 receptor 7MTS - -
TM7 284 V 7.44x45 mGlu2 receptor 7MTS - -
TM7 285 I 7.45x46 mGlu2 receptor 7MTS - -
TM7 286 F 7.46x47 mGlu2 receptor 7MTS - -
TM7 287 H 7.47x471 mGlu2 receptor 7MTS - -
TM7 288 A 7.48x48 mGlu2 receptor 7MTS - -
TM7 289 I 7.49x49 mGlu2 receptor 7MTS - -
TM7 290 P 7.50x50 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM7 291 E 7.51x51 mGlu2 receptor 7MTS - -
TM7 292 I 7.52x52 mGlu2 receptor 7MTS CaS receptor 7M3G
TM7 293 H 7.53x53 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM7 294 C 7.54x54 mGlu2 receptor 7MTS - -
TM7 295 T 7.55x55 mGlu2 receptor 7MTS - -
TM7 296 L 7.56x56 mGlu2 receptor 7MTS mGlu2 receptor 7MTS
TM7 297 L 7.57x57 mGlu2 receptor 7MTS - -
TM7 298 P 7.58x58 mGlu2 receptor 7MTS - -
ICL4 299 A - - - - -
H8 300 L 8.46x46 mGlu5 receptor 4OO9 - -
H8 301 Q 8.47x47 mGlu5 receptor 4OO9 mGlu2 receptor 7EPE
H8 302 E 8.48x48 mGlu5 receptor 4OO9 - -
H8 303 N 8.49x49 mGlu5 receptor 4OO9 mGlu2 receptor 7EPE
H8 304 T 8.50x50 - - - -
H8 305 P 8.51x51 - - - -
H8 306 N 8.52x52 - - - -
H8 307 Y 8.53x53 - - - -
H8 308 F 8.54x54 - - - -
H8 309 D 8.55x55 - - - -
H8 310 T 8.56x56 - - - -
H8 311 S 8.57x57 - - - -
C-term 312 Q - - - - -
C-term 313 P - - - - -
C-term 314 R - - - - -
C-term 315 M - - - - -
C-term 316 R - - - - -