GPRC5D homology model

PROTEIN CLASS

Class C (Glutamate)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive

VERSION

2021-06-10

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

NGL is a WebGL based 3D viewer powered by MMTF.

MAIN TEMPLATE

mGlu1 receptor (sequence similarity: 9%) PDB: 4OR2

TEMPLATES

4OR2 (mGlu1 receptor)
4OO9 (mGlu5 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 75.3 1.8 22.9
Side-chains 16.6 13.7 69.7

Number of backbone templates: 2
Number of rotamer templates: 7

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 16 C - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
N-term 17 D - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
N-term 18 A - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
N-term 19 E - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
N-term 20 G - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM1 21 P 1.38x38 mGlu1 receptor 4OR2 mGlu5 receptor 6FFI
TM1 22 W 1.39x39 mGlu1 receptor 4OR2 - -
TM1 23 G 1.40x40 mGlu1 receptor 4OR2 CaS receptor 7DTU
TM1 24 I 1.41x41 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM1 25 I 1.42x42 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM1 26 L 1.43x43 mGlu1 receptor 4OR2 CaS receptor 7DTV
TM1 27 E 1.44x44 mGlu1 receptor 4OR2 - -
TM1 28 S 1.45x45 mGlu1 receptor 4OR2 - -
TM1 29 L 1.46x46 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM1 30 A 1.47x47 mGlu1 receptor 4OR2 mGlu5 receptor 6FFI
TM1 31 I 1.48x48 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM1 32 L 1.49x49 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM1 33 G 1.50x50 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM1 34 I 1.51x51 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM1 35 V 1.52x52 mGlu1 receptor 4OR2 GABAB1 6W2Y
TM1 36 V 1.53x53 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM1 37 T 1.54x54 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM1 38 I 1.55x55 mGlu1 receptor 4OR2 - -
TM1 39 L 1.56x56 mGlu1 receptor 4OR2 - -
TM1 40 L 1.57x57 mGlu1 receptor 4OR2 - -
TM1 41 L 1.58x58 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM1 42 L 1.59x59 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM1 43 A 1.60x60 mGlu1 receptor 4OR2 - -
TM1 44 F 1.61x61 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM1 45 L 1.62x62 mGlu1 receptor 4OR2 - -
TM1 46 F 1.63x63 mGlu1 receptor 4OR2 - -
TM1 47 L 1.64x64 mGlu1 receptor 4OR2 - -
ICL1 48 M 12.47x47 - - - -
ICL1 49 R 12.48x48 - - - -
ICL1 50 K 12.49x49 - - - -
ICL1 51 I 12.50x50 - - - -
ICL1 52 Q 12.51x51 - - - -
ICL1 53 D 12.52x52 - - - -
ICL1 54 C 12.53x53 - - - -
TM2 55 S 2.31x31 - - - -
TM2 56 Q 2.32x32 - - - -
TM2 57 W 2.33x33 - - - -
TM2 58 N 2.34x34 - - - -
TM2 59 V 2.35x35 mGlu1 receptor 4OR2 - -
TM2 60 L 2.36x36 mGlu1 receptor 4OR2 - -
TM2 61 P 2.37x37 mGlu1 receptor 4OR2 - -
TM2 62 T 2.38x38 mGlu1 receptor 4OR2 - -
TM2 63 Q 2.39x39 mGlu1 receptor 4OR2 - -
TM2 64 L 2.40x40 mGlu1 receptor 4OR2 - -
TM2 65 L 2.41x41 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM2 66 F 2.42x42 mGlu1 receptor 4OR2 - -
TM2 67 L 2.43x43 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM2 68 L 2.44x44 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM2 69 S 2.45x45 mGlu1 receptor 4OR2 - -
TM2 70 V 2.46x46 mGlu1 receptor 4OR2 - -
TM2 71 L 2.47x47 mGlu1 receptor 4OR2 - -
TM2 72 G 2.48x48 mGlu1 receptor 4OR2 - -
TM2 73 L 2.49x49 mGlu1 receptor 4OR2 - -
TM2 74 F 2.50x50 mGlu1 receptor 4OR2 - -
TM2 75 G 2.51x51 mGlu1 receptor 4OR2 - -
TM2 76 L 2.52x52 mGlu1 receptor 4OR2 - -
TM2 77 A 2.53x53 mGlu1 receptor 4OR2 - -
TM2 78 F 2.54x54 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM2 79 A 2.55x55 mGlu1 receptor 4OR2 - -
TM2 80 F 2.56x56 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM2 81 I 2.57x57 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
ECL1 82 I - mGlu1 receptor 4OR2 - -
ECL1 83 E - mGlu1 receptor 4OR2 - -
ECL1 84 L - mGlu1 receptor 4OR2 - -
ECL1 85 N - mGlu1 receptor 4OR2 - -
TM3 86 Q 3.26x26 mGlu1 receptor 4OR2 mGlu5 receptor 6FFI
TM3 87 Q 3.27x27 mGlu1 receptor 4OR2 - -
TM3 88 T 3.28x28 mGlu1 receptor 4OR2 - -
TM3 89 A 3.29x29 mGlu1 receptor 4OR2 - -
TM3 90 P 3.30x30 mGlu1 receptor 4OR2 - -
TM3 91 V 3.31x31 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM3 92 R 3.32x32 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM3 93 Y 3.33x33 mGlu1 receptor 4OR2 - -
TM3 94 F 3.34x34 mGlu1 receptor 4OR2 - -
TM3 95 L 3.35x35 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM3 96 F 3.36x36 mGlu1 receptor 4OR2 - -
TM3 97 G 3.37x37 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM3 98 V 3.38x38 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM3 99 L 3.39x39 mGlu1 receptor 4OR2 - -
TM3 100 F 3.40x40 mGlu1 receptor 4OR2 GABAB1 6W2Y
TM3 101 A 3.41x41 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM3 102 L 3.42x42 mGlu1 receptor 4OR2 GABAB1 6W2Y
TM3 103 C 3.43x43 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM3 104 F 3.44x44 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM3 105 S 3.45x45 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM3 106 C 3.46x46 mGlu1 receptor 4OR2 - -
TM3 107 L 3.47x47 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM3 108 L 3.48x48 mGlu1 receptor 4OR2 - -
TM3 109 A 3.49x49 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM3 110 H 3.50x50 mGlu1 receptor 4OR2 - -
TM3 111 A 3.51x51 mGlu1 receptor 4OR2 - -
TM3 112 S 3.52x52 mGlu1 receptor 4OR2 - -
TM3 113 N 3.53x53 mGlu1 receptor 4OR2 - -
TM3 114 L 3.54x54 mGlu1 receptor 4OR2 - -
TM3 115 V 3.55x55 mGlu1 receptor 4OR2 - -
TM3 116 K 3.56x56 mGlu1 receptor 4OR2 - -
TM3 117 L 3.57x57 mGlu1 receptor 4OR2 - -
TM3 118 V 3.58x58 mGlu1 receptor 4OR2 - -
ICL2 119 R - - - - -
ICL2 120 G - - - - -
ICL2 121 C - - - - -
ICL2 122 V - - - - -
ICL2 123 S - - - - -
ICL2 124 F - - - - -
TM4 125 S 4.28x28 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM4 126 W 4.29x29 mGlu1 receptor 4OR2 - -
TM4 127 T 4.30x30 mGlu1 receptor 4OR2 - -
TM4 128 T 4.31x31 mGlu1 receptor 4OR2 - -
TM4 129 I 4.32x32 mGlu1 receptor 4OR2 - -
TM4 130 L 4.33x33 mGlu1 receptor 4OR2 mGlu5 receptor 6FFI
TM4 131 C 4.34x34 mGlu1 receptor 4OR2 - -
TM4 132 I 4.35x35 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM4 133 A 4.36x36 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM4 134 I 4.37x37 mGlu1 receptor 4OR2 - -
TM4 135 G 4.38x38 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM4 136 C 4.39x39 mGlu1 receptor 4OR2 - -
TM4 137 S 4.40x40 mGlu1 receptor 4OR2 - -
TM4 138 L 4.41x41 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM4 139 L 4.42x42 mGlu1 receptor 4OR2 - -
TM4 140 Q 4.43x43 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM4 141 I 4.44x44 mGlu1 receptor 4OR2 - -
TM4 142 I 4.45x45 mGlu1 receptor 4OR2 - -
TM4 143 I 4.46x46 mGlu1 receptor 4OR2 mGlu5 receptor 6FFI
TM4 144 A 4.47x47 mGlu1 receptor 4OR2 - -
TM4 145 T 4.48x48 mGlu1 receptor 4OR2 - -
TM4 146 E 4.49x49 mGlu1 receptor 4OR2 - -
TM4 147 Y 4.50x50 mGlu1 receptor 4OR2 - -
TM4 148 V 4.51x51 mGlu1 receptor 4OR2 - -
TM4 149 T 4.52x52 mGlu1 receptor 4OR2 - -
TM4 150 L 4.53x53 mGlu1 receptor 4OR2 - -
TM4 151 I 4.54x54 mGlu1 receptor 4OR2 - -
ECL2 152 M - - - - -
ECL2 153 T - - - - -
ECL2 154 R - - - - -
ECL2 155 G - - - - -
ECL2 156 M - - - - -
ECL2 157 M - - - - -
ECL2 158 F - - - - -
ECL2 159 V - - - - -
ECL2 160 N - - - - -
ECL2 161 M - - - - -
ECL2 162 T - - - - -
ECL2 163 P - - - - -
ECL2 164 C 45.50x50 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
ECL2 165 Q 45.51x51 mGlu1 receptor 4OR2 - -
ECL2 166 L 45.52x52 mGlu1 receptor 4OR2 - -
TM5 167 N 5.37x37 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM5 168 V 5.38x38 mGlu1 receptor 4OR2 - -
TM5 169 D 5.39x39 mGlu1 receptor 4OR2 - -
TM5 170 F 5.40x40 mGlu1 receptor 4OR2 - -
TM5 171 V 5.41x41 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM5 172 V 5.42x42 mGlu1 receptor 4OR2 - -
TM5 173 L 5.43x43 mGlu1 receptor 4OR2 - -
TM5 174 L 5.44x44 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM5 175 V 5.45x45 mGlu1 receptor 4OR2 - -
TM5 176 Y 5.46x46 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM5 177 V 5.47x47 mGlu1 receptor 4OR2 - -
TM5 178 L 5.48x48 mGlu1 receptor 4OR2 - -
TM5 179 F 5.49x49 mGlu1 receptor 4OR2 - -
TM5 180 L 5.50x50 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM5 181 M 5.51x51 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM5 182 A 5.52x52 mGlu1 receptor 4OR2 CaS receptor 7DTU
TM5 183 L 5.53x53 mGlu1 receptor 4OR2 GABAB1 6W2Y
TM5 184 T 5.54x54 mGlu1 receptor 4OR2 - -
TM5 185 F 5.55x55 mGlu1 receptor 4OR2 - -
TM5 186 F 5.56x56 mGlu1 receptor 4OR2 mGlu5 receptor 6FFI
TM5 187 V 5.57x57 mGlu1 receptor 4OR2 - -
TM5 188 S 5.58x58 mGlu1 receptor 4OR2 - -
TM5 189 K 5.59x59 mGlu1 receptor 4OR2 - -
TM5 190 A 5.60x60 mGlu1 receptor 4OR2 - -
TM5 191 T 5.61x61 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
ICL3 192 F - - - - -
ICL3 193 C - - - - -
ICL3 194 G - - - - -
ICL3 195 P - - - - -
ICL3 196 C - - - - -
ICL3 197 E - - - - -
ICL3 198 N - - - - -
ICL3 199 W - - - - -
ICL3 200 K - - - - -
ICL3 201 Q - - - - -
TM6 202 H 6.35x35 mGlu1 receptor 4OR2 - -
TM6 203 G 6.36x36 mGlu1 receptor 4OR2 - -
TM6 204 R 6.37x37 mGlu1 receptor 4OR2 - -
TM6 205 L 6.38x38 mGlu1 receptor 4OR2 - -
TM6 206 I 6.39x39 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM6 207 F 6.40x40 mGlu1 receptor 4OR2 - -
TM6 208 I 6.41x41 mGlu1 receptor 4OR2 - -
TM6 209 T 6.42x42 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM6 210 V 6.43x43 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM6 211 L 6.44x44 mGlu1 receptor 4OR2 - -
TM6 212 F 6.45x45 mGlu1 receptor 4OR2 - -
TM6 213 S 6.46x46 mGlu1 receptor 4OR2 - -
TM6 214 I 6.47x47 mGlu1 receptor 4OR2 - -
TM6 215 I 6.48x48 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM6 216 I 6.49x49 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM6 217 W 6.50x50 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM6 218 V 6.51x51 mGlu1 receptor 4OR2 - -
TM6 219 V 6.52x52 mGlu1 receptor 4OR2 - -
TM6 220 W 6.53x53 mGlu1 receptor 4OR2 - -
TM6 221 I 6.54x54 mGlu1 receptor 4OR2 - -
TM6 222 S 6.55x55 mGlu1 receptor 4OR2 - -
TM6 223 M 6.56x56 mGlu1 receptor 4OR2 - -
TM6 224 L 6.57x57 mGlu1 receptor 4OR2 - -
TM6 225 L 6.58x58 mGlu1 receptor 4OR2 - -
TM6 226 R 6.59x59 mGlu1 receptor 4OR2 - -
TM6 227 G 6.60x60 mGlu5 receptor 4OO9 - -
ECL3 228 N - - - - -
ECL3 229 P - - - - -
ECL3 230 Q - - - - -
ECL3 231 F - - - - -
ECL3 232 Q - - - - -
ECL3 233 R - - - - -
ECL3 234 Q - - - - -
ECL3 235 P - - - - -
ECL3 236 Q - - - - -
TM7 237 W 7.27x28 mGlu1 receptor 4OR2 - -
TM7 238 D 7.28x29 mGlu1 receptor 4OR2 - -
TM7 239 D 7.29x30 mGlu1 receptor 4OR2 - -
TM7 240 P 7.30x31 mGlu1 receptor 4OR2 - -
TM7 241 V 7.31x32 mGlu1 receptor 4OR2 CaS receptor 7DTV
TM7 242 V 7.32x33 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM7 243 C 7.33x34 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM7 244 I 7.34x35 mGlu1 receptor 4OR2 - -
TM7 245 A 7.35x36 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM7 246 L 7.36x37 mGlu1 receptor 4OR2 - -
TM7 247 V 7.37x38 mGlu1 receptor 4OR2 GABAB1 6W2Y
TM7 248 T 7.38x39 mGlu1 receptor 4OR2 - -
TM7 249 N 7.39x40 mGlu1 receptor 4OR2 - -
TM7 250 A 7.40x41 mGlu1 receptor 4OR2 mGlu5 receptor 6FFI
TM7 251 W 7.41x42 mGlu1 receptor 4OR2 - -
TM7 252 V 7.42x43 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM7 253 F 7.43x44 mGlu1 receptor 4OR2 - -
TM7 254 L 7.44x45 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM7 255 L 7.45x46 mGlu1 receptor 4OR2 - -
TM7 256 L 7.46x47 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM7 257 Y 7.47x471 mGlu1 receptor 4OR2 - -
TM7 258 I 7.48x48 mGlu1 receptor 4OR2 - -
TM7 259 V 7.49x49 mGlu1 receptor 4OR2 mGlu5 receptor 6FFI
TM7 260 P 7.50x50 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM7 261 E 7.51x51 mGlu1 receptor 4OR2 - -
TM7 262 L 7.52x52 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM7 263 C 7.53x53 mGlu1 receptor 4OR2 - -
TM7 264 I 7.54x54 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
TM7 265 L 7.55x55 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM7 266 Y 7.56x56 mGlu1 receptor 4OR2 - -
TM7 267 R 7.57x57 mGlu1 receptor 4OR2 - -
TM7 268 S 7.58x58 mGlu1 receptor 4OR2 - -
ICL4 269 C - - - - -
ICL4 270 R - - - - -
H8 271 Q 8.46x46 mGlu5 receptor 4OO9 - -
H8 272 E 8.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 273 C 8.48x48 mGlu5 receptor 4OO9 - -
H8 274 P 8.49x49 mGlu5 receptor 4OO9 - -
H8 275 L 8.50x50 - - - -
H8 276 Q 8.51x51 - - - -
H8 277 G 8.52x52 - - - -
H8 278 N 8.53x53 - - - -
H8 279 A 8.54x54 - - - -
H8 280 C 8.55x55 - - - -
H8 281 P 8.56x56 - - - -
C-term 282 V - - - - -
C-term 283 T - - - - -
C-term 284 A - - - - -
C-term 285 Y - - - - -
C-term 286 Q - - - - -