GPER homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-10-06

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

NGL is a WebGL based 3D viewer powered by MMTF.

MAIN TEMPLATE

CCR5 (sequence similarity: 37%) PDB: 7O7F

TEMPLATES

7O7F (CCR5)
4MBS (CCR5)
4ZUD (AT1 receptor)
4YAY (AT1 receptor)
5XSZ (LPA6 receptor)
5C1M (μ receptor)
6LFL (CXCR2)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 81.8 9.8 8.4
Side-chains 22.6 59.9 17.5

Number of backbone templates: 7
Number of rotamer templates: 60

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 51 E - CCR5 7O7F CCR5 7O7F
N-term 52 H - CCR5 7O7F CCR5 7O7F
N-term 53 Q - CCR5 7O7F CCR5 7O7F
N-term 54 Q - CCR5 7O7F CCR5 7O7F
N-term 55 Y - CCR5 7O7F CCR5 7O7F
TM1 56 V 1.29x29 CCR5 7O7F - -
TM1 57 I 1.30x30 CCR5 7O7F CCR5 7O7F
TM1 58 G 1.31x31 CCR5 7O7F A2A receptor 5WF5
TM1 59 L 1.32x32 CCR5 7O7F ghrelin receptor 6KO5
TM1 60 F 1.33x33 CCR5 7O7F Y1 receptor 5ZBH
TM1 61 L 1.34x34 CCR5 7O7F CCR5 7O7F
TM1 62 S 1.35x35 CCR5 7O7F 5-HT2A receptor 6A94
TM1 63 C 1.36x36 CCR5 7O7F 5-HT1E receptor 7E33
TM1 64 L 1.37x37 CCR5 7O7F CCK1 receptor 7EZM
TM1 65 Y 1.38x38 CCR5 7O7F Rhodopsin 4X1H
TM1 66 T 1.39x39 CCR5 7O7F M1 receptor 6OIJ
TM1 67 I 1.40x40 CCR5 7O7F MT1 receptor 7DB6
TM1 68 F 1.41x41 CCR5 7O7F MT1 receptor 7DB6
TM1 69 L 1.42x42 CCR5 7O7F Rhodopsin 4X1H
TM1 70 F 1.43x43 CCR5 7O7F CCR5 7O7F
TM1 71 P 1.44x44 CCR5 7O7F - -
TM1 72 I 1.45x45 CCR5 7O7F AT2 receptor 5UNG
TM1 73 G 1.46x46 CCR5 7O7F CCR5 7O7F
TM1 74 F 1.47x47 CCR5 7O7F CCR5 7O7F
TM1 75 V 1.48x48 CCR5 7O7F CCR5 7O7F
TM1 76 G 1.49x49 CCR5 7O7F CCR5 7O7F
TM1 77 N 1.50x50 CCR5 7O7F CCR5 7O7F
TM1 78 I 1.51x51 CCR5 7O7F CCR6 6WWZ
TM1 79 L 1.52x52 CCR5 7O7F CCR5 7O7F
TM1 80 I 1.53x53 CCR5 7O7F DP2 receptor 7M8W
TM1 81 L 1.54x54 CCR5 7O7F H1 receptor 7DFL
TM1 82 V 1.55x55 CCR5 7O7F OX2 receptor 7L1V
TM1 83 V 1.56x56 CCR5 7O7F CXCR2 6LFO
TM1 84 N 1.57x57 CCR5 7O7F - -
TM1 85 I 1.58x58 CCR5 7O7F CCR5 7O7F
TM1 86 S 1.59x59 CCR5 7O7F H1 receptor 7DFL
TM1 87 F 1.60x60 CCR5 7O7F - -
ICL1 88 R 12.48x48 - - - -
ICL1 89 E 12.49x49 AT1 receptor 4ZUD ghrelin receptor 6KO5
ICL1 90 K 12.50x50 AT1 receptor 4ZUD - -
ICL1 91 M 12.51x51 - - - -
TM2 92 T 2.37x37 CCR5 7O7F AT1 receptor 6DO1
TM2 93 I 2.38x38 CCR5 7O7F C5a1 receptor 6C1Q
TM2 94 P 2.39x39 CCR5 7O7F ETB receptor 5X93
TM2 95 D 2.40x40 CCR5 7O7F CCR5 7O7F
TM2 96 L 2.41x41 CCR5 7O7F H1 receptor 7DFL
TM2 97 Y 2.42x42 CCR5 7O7F CCR5 7O7F
TM2 98 F 2.43x43 CCR5 7O7F US28 5WB1
TM2 99 I 2.44x44 CCR5 7O7F US28 5WB1
TM2 100 N 2.45x45 CCR5 7O7F CCR5 7O7F
TM2 101 L 2.46x46 CCR5 7O7F CCR5 7O7F
TM2 102 A 2.47x47 CCR5 7O7F CCR5 7O7F
TM2 103 V 2.48x48 CCR5 7O7F AT2 receptor 5UNG
TM2 104 A 2.49x49 CCR5 7O7F CXCR2 6LFO
TM2 105 D 2.50x50 CCR5 7O7F CCR5 7O7F
TM2 106 L 2.51x51 CCR5 7O7F CCR5 7O7F
TM2 107 I 2.52x52 CCR5 7O7F H1 receptor 7DFL
TM2 108 L 2.53x53 CCR5 7O7F AT2 receptor 5UNG
TM2 109 V 2.54x54 CCR5 7O7F CCR6 6WWZ
TM2 110 A 2.55x55 CCR5 7O7F AT2 receptor 5UNG
TM2 111 D 2.56x56 CCR5 7O7F ETB receptor 6K1Q
TM2 112 S 2.57x57 CCR5 7O7F EP4 receptor 7D7M
TM2 113 L 2.58x58 CCR5 7O7F V2 receptor 7KH0
TM2 114 I 2.59x59 CCR5 7O7F CXCR2 6LFO
TM2 115 E 2.60x60 CCR5 7O7F NTS1 receptor 4XES
TM2 116 V 2.61x61 CCR5 7O7F D3 receptor 7CMV
TM2 117 F 2.62x62 CCR5 7O7F LPA6 receptor 5XSZ
TM2 118 N 2.63x63 CCR5 7O7F μ receptor 5C1M
TM2 119 L 2.64x64 CCR5 7O7F US28 5WB1
TM2 120 H 2.65x65 CCR5 7O7F - -
TM2 121 E 2.66x66 CCR5 4MBS - -
ECL1 122 R - - - - -
ECL1 123 Y 23.49x49 CCR5 4MBS Rhodopsin 4X1H
ECL1 124 Y 23.50x50 CCR5 4MBS - -
ECL1 125 D 23.51x51 CCR5 4MBS CCR5 4MBS
ECL1 126 I 23.52x52 - - - -
TM3 127 A 3.22x22 CCR5 7O7F β3-adrenoceptor 7DH5
TM3 128 V 3.23x23 CCR5 7O7F κ receptor 6B73
TM3 129 L 3.24x24 CCR5 7O7F CXCR2 6LFO
TM3 130 C 3.25x25 CCR5 7O7F CCR5 7O7F
TM3 131 T 3.26x26 CCR5 7O7F US28 5WB1
TM3 132 F 3.27x27 CCR5 7O7F H1 receptor 7DFL
TM3 133 M 3.28x28 CCR5 7O7F CysLT2 receptor 6RZ6
TM3 134 S 3.29x29 CCR5 7O7F CXCR2 6LFO
TM3 135 L 3.30x30 CCR5 7O7F CXCR2 6LFO
TM3 136 F 3.31x31 CCR5 7O7F AT2 receptor 5UNG
TM3 137 L 3.32x32 CCR5 7O7F AT2 receptor 5UNG
TM3 138 Q 3.33x33 CCR5 7O7F - -
TM3 139 V 3.34x34 CCR5 7O7F CXCR2 6LFO
TM3 140 N 3.35x35 CCR5 7O7F CXCR2 6LFO
TM3 141 M 3.36x36 CCR5 7O7F μ receptor 5C1M
TM3 142 Y 3.37x37 CCR5 7O7F CXCR2 6LFO
TM3 143 S 3.38x38 CCR5 7O7F CCR5 7O7F
TM3 144 S 3.39x39 CCR5 7O7F AT1 receptor 6DO1
TM3 145 V 3.40x40 CCR5 7O7F AT1 receptor 6DO1
TM3 146 F 3.41x41 CCR5 7O7F CCR5 7O7F
TM3 147 F 3.42x42 CCR5 7O7F CCR5 7O7F
TM3 148 L 3.43x43 CCR5 7O7F CXCR2 6LFO
TM3 149 T 3.44x44 CCR5 7O7F AT1 receptor 6DO1
TM3 150 W 3.45x45 CCR5 7O7F - -
TM3 151 M 3.46x46 CCR5 7O7F μ receptor 5C1M
TM3 152 S 3.47x47 CCR5 7O7F CXCR2 6LFO
TM3 153 F 3.48x48 CCR5 7O7F M1 receptor 6OIJ
TM3 154 D 3.49x49 CCR5 7O7F CCR5 7O7F
TM3 155 R 3.50x50 CCR5 7O7F CCR5 7O7F
TM3 156 Y 3.51x51 CCR5 7O7F CCR5 7O7F
TM3 157 I 3.52x52 CCR5 7O7F μ receptor 5C1M
TM3 158 A 3.53x53 CCR5 7O7F CCR5 7O7F
TM3 159 L 3.54x54 CCR5 7O7F BILF1 7JHJ
TM3 160 A 3.55x55 CCR5 7O7F D2 receptor 7JVR
TM3 161 R 3.56x56 CCR5 7O7F M1 receptor 6OIJ
ICL2 162 A 34.50x50 - - - -
ICL2 163 M 34.51x51 CCR5 4MBS AT1 receptor 6DO1
ICL2 164 R 34.52x52 CCR5 4MBS CXCR2 6LFO
ICL2 165 C 34.53x53 CCR5 4MBS C5a1 receptor 5O9H
ICL2 166 S 34.54x54 CCR5 4MBS 5-HT2A receptor 6WHA
ICL2 167 L 34.55x55 CCR5 4MBS AT1 receptor 6DO1
ICL2 168 F 34.56x56 CCR5 4MBS μ receptor 5C1M
ICL2 169 R 34.57x57 CCR5 4MBS CCR5 4MBS
ICL2 170 T - - - - -
ICL2 171 K - - - - -
ICL2 172 H - - - - -
TM4 173 H 4.41x41 CCR5 7O7F CCK1 receptor 7EZM
TM4 174 A 4.42x42 CCR5 7O7F AT1 receptor 6DO1
TM4 175 R 4.43x43 CCR5 7O7F OX2 receptor 7L1V
TM4 176 L 4.44x44 CCR5 7O7F US28 5WB1
TM4 177 S 4.45x45 CCR5 7O7F OX2 receptor 7L1V
TM4 178 C 4.46x46 CCR5 7O7F CXCR2 6LFO
TM4 179 G 4.47x47 CCR5 7O7F M1 receptor 6OIJ
TM4 180 L 4.48x48 CCR5 7O7F AT2 receptor 5UNG
TM4 181 I 4.49x49 CCR5 7O7F CXCR2 6LFO
TM4 182 W 4.50x50 CCR5 7O7F CCR5 7O7F
TM4 183 M 4.51x51 CCR5 7O7F - -
TM4 184 A 4.52x52 CCR5 7O7F NTS1 receptor 4XES
TM4 185 S 4.53x53 CCR5 7O7F CXCR2 6LFO
TM4 186 V 4.54x54 CCR5 7O7F CCR5 7O7F
TM4 187 S 4.55x55 CCR5 7O7F 5-HT1B receptor 6G79
TM4 188 A 4.56x56 CCR5 7O7F CCR5 7O7F
TM4 189 T 4.57x57 LPA6 receptor 5XSZ FPR2/ALX 6OMM
TM4 190 L 4.58x58 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM4 191 V 4.59x59 LPA6 receptor 5XSZ 5-HT2C receptor 6BQG
TM4 192 P 4.60x60 CCR5 7O7F CCR5 7O7F
TM4 193 F 4.61x61 CCR5 7O7F CysLT1 receptor 6RZ4
TM4 194 T 4.62x62 CCR5 7O7F - -
TM4 195 A 4.63x63 CCR5 7O7F OX1 receptor 6TO7
TM4 196 V 4.64x64 CCR5 7O7F OX2 receptor 7L1V
ECL2 197 H - - - - -
ECL2 198 L - AT1 receptor 4YAY - -
ECL2 199 Q - AT1 receptor 4YAY - -
ECL2 200 H - AT1 receptor 4YAY - -
ECL2 201 T - AT1 receptor 4YAY - -
ECL2 202 D - - - - -
ECL2 203 E - - - - -
ECL2 204 A - - - - -
ECL2 205 C 45.50x50 CCR5 7O7F CCR5 7O7F
ECL2 206 F 45.51x51 CCR5 7O7F EP4 receptor 7D7M
ECL2 207 C 45.52x52 CCR5 7O7F - -
ECL2 208 F - - - - -
ECL2 209 A - - - - -
TM5 210 D 5.34x35 CCR5 7O7F PAR2 5NDD
TM5 211 V 5.35x36 CCR5 7O7F NTS1 receptor 4XES
TM5 212 R 5.36x37 CCR5 7O7F D1 receptor 7JVQ
TM5 213 E 5.37x38 CCR5 7O7F A1 receptor 6D9H
TM5 214 V 5.38x39 CCR5 7O7F M2 receptor 4MQT
TM5 215 Q 5.39x40 CCR5 7O7F BILF1 7JHJ
TM5 216 W 5.40x41 CCR5 7O7F ghrelin receptor 6KO5
TM5 217 L 5.41x42 CCR5 7O7F CXCR2 6LFO
TM5 218 E 5.42x43 CCR5 7O7F CCR6 6WWZ
TM5 219 V 5.43x44 CCR5 7O7F CCR5 7O7F
TM5 220 T 5.44x45 CCR5 7O7F MC4 receptor 7AUE
TM5 221 L 5.45x46 CCR5 7O7F CCR5 7O7F
TM5 222 G 5.46x461 CCR5 7O7F CCR5 7O7F
TM5 223 F 5.47x47 CCR5 7O7F CXCR2 6LFO
TM5 224 I 5.48x48 CCR5 7O7F CXCR2 6LFO
TM5 225 V 5.49x49 CCR5 7O7F CXCR2 6LFO
TM5 226 P 5.50x50 CCR5 7O7F CCR5 7O7F
TM5 227 F 5.51x51 CCR5 7O7F AT1 receptor 6DO1
TM5 228 A 5.52x52 CCR5 7O7F 5-HT2B receptor 5TUD
TM5 229 I 5.53x53 CCR5 7O7F CXCR2 6LFO
TM5 230 I 5.54x54 CCR5 7O7F AT1 receptor 6DO1
TM5 231 G 5.55x55 CCR5 7O7F NK1 receptor 6HLP
TM5 232 L 5.56x56 CCR5 7O7F OX2 receptor 7L1V
TM5 233 C 5.57x57 CCR5 7O7F CCR5 7O7F
TM5 234 Y 5.58x58 CCR5 7O7F CCR5 7O7F
TM5 235 S 5.59x59 CCR5 7O7F CCR5 7O7F
TM5 236 L 5.60x60 CCR5 7O7F AT1 receptor 6DO1
TM5 237 I 5.61x61 CCR5 7O7F CCR5 7O7F
TM5 238 V 5.62x62 CCR5 7O7F CCR6 6WWZ
TM5 239 R 5.63x63 CCR5 7O7F CXCR2 6LFO
TM5 240 V 5.64x64 CCR5 7O7F 5-HT2C receptor 6BQG
TM5 241 L 5.65x65 CCR5 7O7F CCR5 7O7F
TM5 242 V 5.66x66 CCR5 7O7F CCR6 6WWZ
TM5 243 R 5.67x67 CCR5 7O7F CCR5 7O7F
TM5 244 A 5.68x68 CCR5 7O7F CXCR2 6LFO
ICL3 245 H - CCR5 7O7F - -
ICL3 246 R - CCR5 7O7F - -
ICL3 247 H - CCR5 7O7F - -
TM6 248 R 6.24x24 μ receptor 5C1M α2B-adrenoceptor 6K42
TM6 249 G 6.25x25 μ receptor 5C1M NTS1 receptor 5T04
TM6 250 L 6.26x26 μ receptor 5C1M FFA1 receptor 5TZR
TM6 251 R 6.27x27 μ receptor 5C1M AT2 receptor 5UNG
TM6 252 P 6.28x28 CCR5 7O7F - -
TM6 253 R 6.29x29 CCR5 7O7F H1 receptor 7DFL
TM6 254 R 6.30x30 CCR5 7O7F CCR5 7O7F
TM6 255 Q 6.31x31 CCR5 7O7F 5-HT2B receptor 5TUD
TM6 256 K 6.32x32 CCR5 7O7F CCR6 6WWZ
TM6 257 A 6.33x33 CCR5 7O7F CCR5 7O7F
TM6 258 L 6.34x34 CCR5 7O7F AT2 receptor 5UNG
TM6 259 R 6.35x35 CCR5 7O7F CCR5 7O7F
TM6 260 M 6.36x36 CCR5 7O7F μ receptor 5C1M
TM6 261 I 6.37x37 CCR5 7O7F CCR5 7O7F
TM6 262 L 6.38x38 CCR5 7O7F μ receptor 5C1M
TM6 263 A 6.39x39 CCR5 7O7F CXCR2 6LFO
TM6 264 V 6.40x40 CCR5 7O7F CXCR2 6LFO
TM6 265 V 6.41x41 CCR5 7O7F CXCR2 6LFO
TM6 266 L 6.42x42 CCR5 7O7F CXCR2 6LFO
TM6 267 V 6.43x43 CCR5 7O7F CCR5 7O7F
TM6 268 F 6.44x44 CCR5 7O7F CXCR2 6LFO
TM6 269 F 6.45x45 CCR5 7O7F CCR5 7O7F
TM6 270 V 6.46x46 CCR5 7O7F μ receptor 5C1M
TM6 271 C 6.47x47 CCR5 7O7F CXCR2 6LFO
TM6 272 W 6.48x48 CCR5 7O7F CCR5 7O7F
TM6 273 L 6.49x49 CCR5 7O7F CXCR2 6LFO
TM6 274 P 6.50x50 CCR5 7O7F CCR5 7O7F
TM6 275 E 6.51x51 CCR5 7O7F - -
TM6 276 N 6.52x52 CCR5 7O7F CCR5 7O7F
TM6 277 V 6.53x53 CCR5 7O7F AT2 receptor 5UNG
TM6 278 F 6.54x54 CCR5 7O7F AT1 receptor 6DO1
TM6 279 I 6.55x55 CCR5 7O7F κ receptor 6B73
TM6 280 S 6.56x56 CCR5 7O7F α2B-adrenoceptor 6K42
TM6 281 V 6.57x57 CCR5 7O7F κ receptor 6B73
TM6 282 H 6.58x58 CCR5 7O7F β2-adrenoceptor 3SN6
TM6 283 L 6.59x59 CCR5 7O7F A1 receptor 6D9H
TM6 284 L 6.60x60 CCR5 7O7F CXCR2 6LFO
TM6 285 Q 6.61x61 CCR5 7O7F CCR5 7O7F
TM6 286 R 6.62x62 CCR5 4MBS CXCR2 6LFO
TM6 287 T 6.63x63 CCR5 4MBS CXCR2 6LFM
TM6 288 Q 6.64x64 CCR5 4MBS GPBA receptor 7CFN
ECL3 289 P - - - - -
ECL3 290 G - - - - -
ECL3 291 A - - - - -
ECL3 292 A - - - - -
ECL3 293 P - - - - -
ECL3 294 C - - - - -
TM7 295 K 7.24x23 CCR5 7O7F - -
TM7 296 Q 7.25x24 CCR5 7O7F - -
TM7 297 S 7.26x25 CCR5 7O7F CCR5 7O7F
TM7 298 F 7.27x26 CCR5 7O7F US28 5WB1
TM7 299 R 7.28x27 CCR5 7O7F CXCR2 6LFO
TM7 300 H 7.29x28 CCR5 7O7F - -
TM7 301 A 7.30x29 CCR5 7O7F κ receptor 6B73
TM7 302 H 7.31x30 CCR5 7O7F Y1 receptor 5ZBH
TM7 303 P 7.32x31 CCR5 7O7F Rhodopsin 4X1H
TM7 304 L 7.33x32 CCR5 7O7F AT2 receptor 5UNG
TM7 305 T 7.34x33 CCR5 7O7F CCR6 6WWZ
TM7 306 G 7.35x34 CCR5 7O7F 5-HT1A receptor 7E2X
TM7 307 H 7.36x35 CCR5 7O7F μ receptor 5C1M
TM7 308 I 7.37x36 CCR5 7O7F AT1 receptor 6DO1
TM7 309 V 7.38x37 CCR5 7O7F D4 receptor 5WIV
TM7 310 N 7.39x38 CCR5 7O7F β3-adrenoceptor 7DH5
TM7 311 L 7.40x39 CCR5 7O7F AT2 receptor 5UNG
TM7 312 A 7.41x40 CCR5 7O7F - -
TM7 313 A 7.42x41 CCR5 7O7F AT1 receptor 6DO1
TM7 314 F 7.43x42 CCR5 7O7F CCR6 6WWZ
TM7 315 S 7.44x43 CCR5 7O7F Rhodopsin 5W0P
TM7 316 N 7.45x45 CCR5 7O7F AT1 receptor 6DO1
TM7 317 S 7.46x46 CCR5 7O7F CXCR2 6LFO
TM7 318 C 7.47x47 CCR5 7O7F CCR5 7O7F
TM7 319 L 7.48x48 CCR5 7O7F CXCR2 6LFO
TM7 320 N 7.49x49 CCR5 7O7F CCR5 7O7F
TM7 321 P 7.50x50 CCR5 7O7F CCR5 7O7F
TM7 322 L 7.51x51 CCR5 7O7F CXCR2 6LFO
TM7 323 I 7.52x52 CCR5 7O7F CCR5 7O7F
TM7 324 Y 7.53x53 CCR5 7O7F CCR5 7O7F
TM7 325 S 7.54x54 CCR5 7O7F GPR52 6LI3
TM7 326 F 7.55x55 CCR5 7O7F CCR5 7O7F
TM7 327 L 7.56x56 CCR5 7O7F AT1 receptor 6OS0
H8 328 G 8.47x47 CCR5 7O7F CCR5 7O7F
H8 329 E 8.48x48 CCR5 7O7F CCR5 7O7F
H8 330 T 8.49x49 CCR5 7O7F 5-HT2B receptor 5TUD
H8 331 F 8.50x50 CCR5 7O7F CCR5 7O7F
H8 332 R 8.51x51 CCR5 7O7F CCR5 7O7F
H8 333 D 8.52x52 CCR5 7O7F 5-HT2B receptor 5TUD
H8 334 K 8.53x53 CCR5 7O7F AT2 receptor 5UNG
H8 335 L 8.54x54 CCR5 7O7F CCR5 7O7F
H8 336 R 8.55x55 CCR5 7O7F AT2 receptor 6JOD
H8 337 L 8.56x56 CCR5 7O7F M1 receptor 6OIJ
H8 338 Y 8.57x57 CCR5 7O7F 5-HT2C receptor 6BQG
H8 339 I 8.58x58 CCR5 7O7F 5-HT2B receptor 5TUD
H8 340 E 8.59x59 CCR5 7O7F GPR52 6LI3
H8 341 Q 8.60x60 CXCR2 6LFL succinate receptor 6IBB
H8 342 K 8.61x61 CXCR2 6LFL - -
C-term 343 T - - - - -
C-term 344 N - - - - -
C-term 345 L - - - - -
C-term 346 P - - - - -
C-term 347 A - - - - -