GPR20 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

GPR20

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-02-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

κ receptor (sequence similarity: 44%) PDB: 6B73
Align

TEMPLATES

4N6H (δ receptor)
6B73 (κ receptor)
6VI4 (κ receptor)
5XSZ (LPA6 receptor)
5UNG (AT2 receptor)
7BR3 (GnRH1 receptor)
5LWE (CCR9)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 74.0 13.4 12.6
Side-chains 20.9 57.4 21.7

Number of backbone templates: 7
Number of rotamer templates: 46

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 44 E - - - -
N-term 45 L - - - -
N-term 46 H - - - -
N-term 47 G - - - -
N-term 48 T - - - -
TM1 49 F 1.28x28 δ receptor 4N6H - -
TM1 50 P 1.29x29 δ receptor 4N6H Rhodopsin 4ZWJ
TM1 51 G 1.30x30 κ receptor 6B73 NOP receptor 5DHG
TM1 52 L 1.31x31 κ receptor 6B73 δ receptor 6PT2
TM1 53 W 1.32x32 κ receptor 6B73 - -
TM1 54 L 1.33x33 κ receptor 6B73 CCR6 6WWZ
TM1 55 A 1.34x34 κ receptor 6B73 δ receptor 6PT2
TM1 56 L 1.35x35 κ receptor 6B73 Rhodopsin 4ZWJ
TM1 57 M 1.36x36 κ receptor 6B73 μ receptor 5C1M
TM1 58 A 1.37x37 κ receptor 6B73 κ receptor 6B73
TM1 59 V 1.38x38 κ receptor 6B73 κ receptor 6B73
TM1 60 H 1.39x39 κ receptor 6B73 DP2 receptor 6D27
TM1 61 G 1.40x40 κ receptor 6B73 US28 5WB1
TM1 62 A 1.41x41 κ receptor 6B73 δ receptor 6PT2
TM1 63 I 1.42x42 κ receptor 6B73 AT2 receptor 6JOD
TM1 64 F 1.43x43 κ receptor 6B73 κ receptor 6B73
TM1 65 L 1.44x44 κ receptor 6B73 CXCR2 6LFO
TM1 66 A 1.45x45 κ receptor 6B73 β2-adrenoceptor 3SN6
TM1 67 G 1.46x46 κ receptor 6B73 κ receptor 6B73
TM1 68 L 1.47x47 κ receptor 6B73 κ receptor 6B73
TM1 69 V 1.48x48 κ receptor 6B73 κ receptor 6B73
TM1 70 L 1.49x49 κ receptor 6B73 PAR1 3VW7
TM1 71 N 1.50x50 κ receptor 6B73 κ receptor 6B73
TM1 72 G 1.51x51 κ receptor 6B73 FPR2/ALX 6LW5
TM1 73 L 1.52x52 κ receptor 6B73 κ receptor 6B73
TM1 74 A 1.53x53 κ receptor 6B73 EP3 receptor 6M9T
TM1 75 L 1.54x54 κ receptor 6B73 NTS1 receptor 4XES
TM1 76 Y 1.55x55 κ receptor 6B73 μ receptor 5C1M
TM1 77 V 1.56x56 κ receptor 6B73 κ receptor 6B73
TM1 78 F 1.57x57 κ receptor 6B73 AT2 receptor 6JOD
TM1 79 C 1.58x58 κ receptor 6B73 AT2 receptor 6JOD
TM1 80 C 1.59x59 κ receptor 6B73 AT2 receptor 5UNG
TM1 81 R 1.60x60 κ receptor 6B73 FPR2/ALX 6LW5
ICL1 82 T 12.48x48 - - - -
ICL1 83 R 12.49x49 κ receptor 6VI4 β2-adrenoceptor 4LDE
ICL1 84 A 12.50x50 κ receptor 6VI4 CCR6 6WWZ
ICL1 85 K 12.51x51 - - - -
TM2 86 T 2.37x37 κ receptor 6B73 κ receptor 6B73
TM2 87 P 2.38x38 κ receptor 6B73 Rhodopsin 4ZWJ
TM2 88 S 2.39x39 κ receptor 6B73 AT2 receptor 6JOD
TM2 89 V 2.40x40 κ receptor 6B73 PAR2 5NDD
TM2 90 I 2.41x41 κ receptor 6B73 κ receptor 6B73
TM2 91 Y 2.42x42 κ receptor 6B73 κ receptor 6B73
TM2 92 T 2.43x43 κ receptor 6B73 - -
TM2 93 I 2.44x44 κ receptor 6B73 US28 5WB1
TM2 94 N 2.45x45 κ receptor 6B73 κ receptor 6B73
TM2 95 L 2.46x46 κ receptor 6B73 κ receptor 6B73
TM2 96 V 2.47x47 κ receptor 6B73 LPA6 receptor 5XSZ
TM2 97 V 2.48x48 κ receptor 6B73 AT2 receptor 6JOD
TM2 98 T 2.49x49 κ receptor 6B73 5-HT1B receptor 6G79
TM2 99 D 2.50x50 κ receptor 6B73 κ receptor 6B73
TM2 100 L 2.51x51 κ receptor 6B73 AT2 receptor 6JOD
TM2 101 L 2.52x52 κ receptor 6B73 κ receptor 6B73
TM2 102 V 2.53x53 κ receptor 6B73 κ receptor 6B73
TM2 103 G 2.54x54 κ receptor 6B73 β2-adrenoceptor 3SN6
TM2 104 L 2.55x55 κ receptor 6B73 CCR6 6WWZ
TM2 105 S 2.56x56 κ receptor 6B73 M1 receptor 6OIJ
TM2 106 L 2.57x57 κ receptor 6B73 μ receptor 5C1M
TM2 107 P 2.58x58 κ receptor 6B73 κ receptor 6B73
TM2 108 T 2.59x59 κ receptor 6B73 Rhodopsin 5DYS
TM2 109 R 2.60x60 κ receptor 6B73 LPA6 receptor 5XSZ
TM2 110 F 2.61x61 κ receptor 6B73 CB1 receptor 6N4B
TM2 111 A 2.62x62 κ receptor 6B73 δ receptor 6PT2
TM2 112 V 2.63x63 κ receptor 6B73 κ receptor 6B73
ECL1 113 Y - - - -
ECL1 114 Y - - - -
ECL1 115 G - - - -
ECL1 116 A - - - -
ECL1 117 R - - - -
ECL1 118 G - - - -
ECL1 119 C - - - -
ECL1 120 L - - - -
ECL1 121 R - - - -
TM3 122 C 3.24x24 κ receptor 6B73 D3 receptor 3PBL
TM3 123 A 3.25x25 κ receptor 6B73 - -
TM3 124 F 3.26x26 κ receptor 6B73 S1P1 receptor 3V2Y
TM3 125 P 3.27x27 κ receptor 6B73 - -
TM3 126 H 3.28x28 κ receptor 6B73 DP2 receptor 6D27
TM3 127 V 3.29x29 κ receptor 6B73 D2 receptor 6VMS
TM3 128 L 3.30x30 κ receptor 6B73 CXCR2 6LFO
TM3 129 G 3.31x31 κ receptor 6B73 CB1 receptor 6N4B
TM3 130 Y 3.32x32 κ receptor 6B73 CCR6 6WWZ
TM3 131 F 3.33x33 κ receptor 6B73 apelin receptor 5VBL
TM3 132 L 3.34x34 κ receptor 6B73 AT2 receptor 6JOD
TM3 133 N 3.35x35 κ receptor 6B73 κ receptor 6B73
TM3 134 M 3.36x36 κ receptor 6B73 κ receptor 6B73
TM3 135 H 3.37x37 κ receptor 6B73 - -
TM3 136 C 3.38x38 κ receptor 6B73 CCR6 6WWZ
TM3 137 S 3.39x39 κ receptor 6B73 κ receptor 6B73
TM3 138 I 3.40x40 κ receptor 6B73 κ receptor 6B73
TM3 139 L 3.41x41 κ receptor 6B73 CCR6 6WWZ
TM3 140 F 3.42x42 κ receptor 6B73 AT2 receptor 6JOD
TM3 141 L 3.43x43 κ receptor 6B73 κ receptor 6B73
TM3 142 T 3.44x44 κ receptor 6B73 κ receptor 6B73
TM3 143 C 3.45x45 κ receptor 6B73 AT2 receptor 6JOD
TM3 144 I 3.46x46 κ receptor 6B73 CCR6 6WWZ
TM3 145 C 3.47x47 κ receptor 6B73 δ receptor 6PT2
TM3 146 V 3.48x48 κ receptor 6B73 κ receptor 6B73
TM3 147 D 3.49x49 κ receptor 6B73 κ receptor 6B73
TM3 148 R 3.50x50 κ receptor 6B73 κ receptor 6B73
TM3 149 Y 3.51x51 κ receptor 6B73 κ receptor 6B73
TM3 150 L 3.52x52 κ receptor 6B73 CXCR2 6LFO
TM3 151 A 3.53x53 κ receptor 6B73 κ receptor 6B73
TM3 152 I 3.54x54 κ receptor 6B73 CCR6 6WWZ
TM3 153 V 3.55x55 κ receptor 6B73 CCR6 6WWZ
TM3 154 R 3.56x56 κ receptor 6B73 α2B-adrenoceptor 6K41
ICL2 155 P 34.50x50 - - - -
ICL2 156 E 34.51x51 LPA6 receptor 5XSZ - -
ICL2 157 G 34.52x52 LPA6 receptor 5XSZ FFA1 receptor 5TZY
ICL2 158 S 34.53x53 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
ICL2 159 R 34.54x54 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
ICL2 160 R 34.55x55 LPA6 receptor 5XSZ CCR6 6WWZ
ICL2 161 C 34.56x56 LPA6 receptor 5XSZ - -
ICL2 162 R 34.57x57 - - - -
TM4 163 Q 4.38x38 κ receptor 6B73 - -
TM4 164 P 4.39x39 κ receptor 6B73 κ receptor 6B73
TM4 165 A 4.40x40 κ receptor 6B73 δ receptor 6PT2
TM4 166 C 4.41x41 κ receptor 6B73 - -
TM4 167 A 4.42x42 κ receptor 6B73 κ receptor 6B73
TM4 168 R 4.43x43 κ receptor 6B73 β2-adrenoceptor 3SN6
TM4 169 A 4.44x44 κ receptor 6B73 EP3 receptor 6M9T
TM4 170 V 4.45x45 κ receptor 6B73 μ receptor 5C1M
TM4 171 C 4.46x46 κ receptor 6B73 CCR6 6WWZ
TM4 172 A 4.47x47 κ receptor 6B73 Rhodopsin 4ZWJ
TM4 173 F 4.48x48 κ receptor 6B73 US28 5WB1
TM4 174 V 4.49x49 κ receptor 6B73 AT2 receptor 6JOD
TM4 175 W 4.50x50 κ receptor 6B73 κ receptor 6B73
TM4 176 L 4.51x51 κ receptor 6B73 κ receptor 6B73
TM4 177 A 4.52x52 κ receptor 6B73 NTS1 receptor 4XES
TM4 178 A 4.53x53 κ receptor 6B73 δ receptor 6PT2
TM4 179 G 4.54x54 κ receptor 6B73 AT1 receptor 6OS2
TM4 180 A 4.55x55 κ receptor 6B73 μ receptor 5C1M
TM4 181 V 4.56x56 κ receptor 6B73 κ receptor 6B73
TM4 182 T 4.57x57 κ receptor 6B73 FPR2/ALX 6LW5
TM4 183 L 4.58x58 κ receptor 6B73 μ receptor 5C1M
TM4 184 S 4.59x59 κ receptor 6B73 CCR6 6WWZ
TM4 185 V 4.60x60 κ receptor 6B73 μ receptor 5C1M
TM4 186 L 4.61x61 κ receptor 6B73 Rhodopsin 4ZWJ
TM4 187 G 4.62x62 κ receptor 6B73 FFA1 receptor 5TZY
ECL2 188 V - - - -
ECL2 189 T - - - -
ECL2 190 G - - - -
ECL2 191 S - - - -
ECL2 192 R - - - -
ECL2 193 P - - - -
ECL2 194 C - - - -
ECL2 195 C - - - -
TM5 196 R 5.38x39 κ receptor 6B73 FPR2/ALX 6LW5
TM5 197 V 5.39x40 κ receptor 6B73 Rhodopsin 4ZWJ
TM5 198 F 5.40x41 κ receptor 6B73 M1 receptor 6OIJ
TM5 199 A 5.41x42 κ receptor 6B73 β2-adrenoceptor 3SN6
TM5 200 L 5.42x43 κ receptor 6B73 US28 5WB1
TM5 201 T 5.43x44 κ receptor 6B73 NTS1 receptor 4XES
TM5 202 V 5.44x45 κ receptor 6B73 FPR2/ALX 6LW5
TM5 203 L 5.45x46 κ receptor 6B73 AT2 receptor 6JOD
TM5 204 E 5.46x461 κ receptor 6B73 - -
TM5 205 F 5.47x47 κ receptor 6B73 κ receptor 6B73
TM5 206 L 5.48x48 κ receptor 6B73 AT1 receptor 6OS2
TM5 207 L 5.49x49 κ receptor 6B73 FPR2/ALX 6LW5
TM5 208 P 5.50x50 κ receptor 6B73 κ receptor 6B73
TM5 209 L 5.51x51 κ receptor 6B73 AT2 receptor 6JOD
TM5 210 L 5.52x52 κ receptor 6B73 κ receptor 6B73
TM5 211 V 5.53x53 κ receptor 6B73 US28 5WB1
TM5 212 I 5.54x54 κ receptor 6B73 κ receptor 6B73
TM5 213 S 5.55x55 κ receptor 6B73 US28 5WB1
TM5 214 V 5.56x56 κ receptor 6B73 κ receptor 6B73
TM5 215 F 5.57x57 κ receptor 6B73 GPR52 6LI3
TM5 216 T 5.58x58 κ receptor 6B73 GPR52 6LI3
TM5 217 G 5.59x59 κ receptor 6B73 μ receptor 5C1M
TM5 218 R 5.60x60 κ receptor 6B73 US28 5WB1
TM5 219 I 5.61x61 κ receptor 6B73 AT2 receptor 6JOD
TM5 220 M 5.62x62 κ receptor 6B73 - -
TM5 221 C 5.63x63 κ receptor 6B73 ETB receptor 5X93
TM5 222 A 5.64x64 κ receptor 6B73 AT1 receptor 6OS2
TM5 223 L 5.65x65 κ receptor 6B73 κ receptor 6B73
TM5 224 S 5.66x66 κ receptor 6B73 PAR1 3VW7
TM5 225 R 5.67x67 κ receptor 6B73 β2-adrenoceptor 7DHI
TM5 226 P 5.68x68 κ receptor 6VI4 - -
ICL3 227 G - - - -
ICL3 228 L AT2 receptor 5UNG - -
ICL3 229 L - - - -
TM6 230 H 6.24x24 κ receptor 6B73 - -
TM6 231 Q 6.25x25 κ receptor 6B73 5-HT2B receptor 5TUD
TM6 232 G 6.26x26 κ receptor 6B73 - -
TM6 233 R 6.27x27 κ receptor 6B73 AT2 receptor 6JOD
TM6 234 Q 6.28x28 κ receptor 6B73 NTS1 receptor 4XEE
TM6 235 R 6.29x29 κ receptor 6B73 α2B-adrenoceptor 6K41
TM6 236 R 6.30x30 κ receptor 6B73 AT2 receptor 6JOD
TM6 237 V 6.31x31 κ receptor 6B73 A2A receptor 4UHR
TM6 238 R 6.32x32 κ receptor 6B73 μ receptor 5C1M
TM6 239 A 6.33x33 κ receptor 6B73 CCR6 6WWZ
TM6 240 M 6.34x34 κ receptor 6B73 CXCR2 6LFO
TM6 241 Q 6.35x35 κ receptor 6B73 D2 receptor 6VMS
TM6 242 L 6.36x36 κ receptor 6B73 κ receptor 6B73
TM6 243 L 6.37x37 κ receptor 6B73 US28 5WB1
TM6 244 L 6.38x38 κ receptor 6B73 κ receptor 6B73
TM6 245 T 6.39x39 κ receptor 6B73 CCR9 5LWE
TM6 246 V 6.40x40 κ receptor 6B73 κ receptor 6B73
TM6 247 L 6.41x41 κ receptor 6B73 M1 receptor 6OIJ
TM6 248 I 6.42x42 κ receptor 6B73 NTS1 receptor 4XES
TM6 249 I 6.43x43 κ receptor 6B73 CXCR2 6LFO
TM6 250 F 6.44x44 κ receptor 6B73 κ receptor 6B73
TM6 251 L 6.45x45 κ receptor 6B73 CCR6 6WWZ
TM6 252 V 6.46x46 κ receptor 6B73 κ receptor 6B73
TM6 253 C 6.47x47 κ receptor 6B73 κ receptor 6B73
TM6 254 F 6.48x48 κ receptor 6B73 LPA6 receptor 5XSZ
TM6 255 T 6.49x49 κ receptor 6B73 κ receptor 6B73
TM6 256 P 6.50x50 κ receptor 6B73 κ receptor 6B73
TM6 257 F 6.51x51 κ receptor 6B73 AT2 receptor 6JOD
TM6 258 H 6.52x52 κ receptor 6B73 κ receptor 6B73
TM6 259 A 6.53x53 κ receptor 6B73 CB1 receptor 6N4B
TM6 260 R 6.54x54 κ receptor 6B73 NTS1 receptor 4XES
TM6 261 Q 6.55x55 κ receptor 6B73 Y2 receptor 7DDZ
TM6 262 V 6.56x56 κ receptor 6B73 CB1 receptor 5XRA
TM6 263 A 6.57x57 κ receptor 6B73 CXCR2 6LFO
TM6 264 V 6.58x58 κ receptor 6B73 Y2 receptor 7DDZ
TM6 265 A 6.59x59 κ receptor 6B73 κ receptor 6B73
TM6 266 L 6.60x60 κ receptor 6B73 κ receptor 6B73
TM6 267 W 6.61x61 κ receptor 6B73 FPR2/ALX 6LW5
ECL3 268 P - - - -
ECL3 269 D GnRH1 receptor 7BR3 - -
ECL3 270 M GnRH1 receptor 7BR3 GnRH1 receptor 7BR3
ECL3 271 P GnRH1 receptor 7BR3 - -
ECL3 272 H GnRH1 receptor 7BR3 - -
ECL3 273 H GnRH1 receptor 7BR3 - -
ECL3 274 T - - - -
TM7 275 S 7.31x30 κ receptor 6B73 - -
TM7 276 L 7.32x31 κ receptor 6B73 κ receptor 6B73
TM7 277 V 7.33x32 κ receptor 6B73 μ receptor 5C1M
TM7 278 V 7.34x33 κ receptor 6B73 β2-adrenoceptor 3SN6
TM7 279 Y 7.35x34 κ receptor 6B73 κ receptor 6B73
TM7 280 H 7.36x35 κ receptor 6B73 μ receptor 5C1M
TM7 281 V 7.37x36 κ receptor 6B73 CCR6 6WWZ
TM7 282 A 7.38x37 κ receptor 6B73 AT2 receptor 6JOD
TM7 283 V 7.39x38 κ receptor 6B73 5-HT2B receptor 5TUD
TM7 284 T 7.40x39 κ receptor 6B73 CCR5 5UIW
TM7 285 L 7.41x40 κ receptor 6B73 κ receptor 6B73
TM7 286 S 7.42x41 κ receptor 6B73 A2A receptor 4UHR
TM7 287 S 7.43x42 κ receptor 6B73 EP3 receptor 6M9T
TM7 288 L 7.44x43 κ receptor 6B73 CCR6 6WWZ
TM7 289 N 7.45x45 κ receptor 6B73 κ receptor 6B73
TM7 290 S 7.46x46 κ receptor 6B73 κ receptor 6B73
TM7 291 C 7.47x47 κ receptor 6B73 μ receptor 5C1M
TM7 292 M 7.48x48 κ receptor 6B73 A1 receptor 6D9H
TM7 293 D 7.49x49 κ receptor 6B73 EP3 receptor 6M9T
TM7 294 P 7.50x50 κ receptor 6B73 κ receptor 6B73
TM7 295 I 7.51x51 κ receptor 6B73 NTS1 receptor 4XES
TM7 296 V 7.52x52 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM7 297 Y 7.53x53 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM7 298 C 7.54x54 LPA6 receptor 5XSZ AT2 receptor 6JOD
TM7 299 F 7.55x55 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM7 300 V 7.56x56 LPA6 receptor 5XSZ AT2 receptor 6JOD
H8 301 T 8.47x47 κ receptor 6VI4 - -
H8 302 S 8.48x48 κ receptor 6VI4 Y2 receptor 7DDZ
H8 303 G 8.49x49 κ receptor 6VI4 - -
H8 304 F 8.50x50 κ receptor 6VI4 κ receptor 6VI4
H8 305 Q 8.51x51 κ receptor 6VI4 AT2 receptor 6JOD
H8 306 A 8.52x52 κ receptor 6VI4 GPBA receptor 7CFN
H8 307 T 8.53x53 κ receptor 6VI4 A2A receptor 4UHR
H8 308 V 8.54x54 κ receptor 6VI4 ghrelin receptor 6KO5
H8 309 R 8.55x55 κ receptor 6VI4 κ receptor 6VI4
H8 310 G 8.56x56 κ receptor 6VI4 - -
H8 311 L 8.57x57 κ receptor 6VI4 AT1 receptor 6OS2
H8 312 F 8.58x58 κ receptor 6VI4 AT2 receptor 6JOD
H8 313 G 8.59x59 κ receptor 6VI4 - -
H8 314 Q 8.60x60 CCR9 5LWE succinate receptor 6IBB
H8 315 H 8.61x61 CCR9 5LWE CXCR2 6LFO
C-term 316 G - - - -
C-term 317 E - - - -
C-term 318 R - - - -
C-term 319 E - - - -
C-term 320 P - - - -