GPR42 homology model
PROTEIN CLASS
Class A (Rhodopsin)
RECEPTOR
SPECIES
Homo sapiens
STATE
Inactive
VERSION
2021-06-10
MODEL
TEMPLATES
5NDD (PAR2)
6QZH (CCR7)
5VBL (apelin receptor)
5TZY (FFA1 receptor)
7MBX (CCK1 receptor)
6RZ6 (CysLT2 receptor)
6LFO (CXCR2)
5LWE (CCR9)
None
6QZH (CCR7)
5VBL (apelin receptor)
5TZY (FFA1 receptor)
7MBX (CCK1 receptor)
6RZ6 (CysLT2 receptor)
6LFO (CXCR2)
5LWE (CCR9)
None
| Main template (%) | Additional templates (%) | No template - freely modelled (%) | |
|---|---|---|---|
| Backbone | 70.7 | 22.1 | 7.1 |
| Side-chains | 20.1 | 63.6 | 16.3 |
Number of backbone templates: 8
Number of rotamer templates: 56
| Segment | Seq.num. | AA | GPCRdb# | Backbone | PDB | Rotamer | PDB |
|---|---|---|---|---|---|---|---|
| N-term | 6 | D | - | PAR2 | 5NDD | PAR2 | 5NDD |
| N-term | 7 | Q | - | PAR2 | 5NDD | PAR2 | 5NDD |
| N-term | 8 | S | - | PAR2 | 5NDD | PAR2 | 5NDD |
| N-term | 9 | Y | - | PAR2 | 5NDD | PAR2 | 5NDD |
| N-term | 10 | F | - | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 11 | S | 1.29x29 | PAR2 | 5NDD | MT1 receptor | 6ME3 |
| TM1 | 12 | G | 1.30x30 | CCR7 | 6QZH | NOP receptor | 5DHG |
| TM1 | 13 | N | 1.31x31 | CCR7 | 6QZH | CXCR2 | 6LFL |
| TM1 | 14 | H | 1.32x32 | CCR7 | 6QZH | Rhodopsin | 6I9K |
| TM1 | 15 | W | 1.33x33 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM1 | 16 | F | 1.34x34 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM1 | 17 | V | 1.35x35 | CCR7 | 6QZH | CXCR2 | 6LFL |
| TM1 | 18 | F | 1.36x36 | CCR7 | 6QZH | FFA1 receptor | 5TZY |
| TM1 | 19 | S | 1.37x37 | CCR7 | 6QZH | PAR1 | 3VW7 |
| TM1 | 20 | V | 1.38x38 | CCR7 | 6QZH | κ receptor | 4DJH |
| TM1 | 21 | Y | 1.39x39 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM1 | 22 | L | 1.40x40 | CCR7 | 6QZH | NOP receptor | 5DHG |
| TM1 | 23 | L | 1.41x41 | CCR7 | 6QZH | CCR9 | 5LWE |
| TM1 | 24 | T | 1.42x42 | CCR7 | 6QZH | MT1 receptor | 6ME2 |
| TM1 | 25 | F | 1.43x43 | CCR7 | 6QZH | CCR9 | 5LWE |
| TM1 | 26 | L | 1.44x44 | CCR7 | 6QZH | CXCR2 | 6LFL |
| TM1 | 27 | V | 1.45x45 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM1 | 28 | G | 1.46x46 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM1 | 29 | L | 1.47x47 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM1 | 30 | P | 1.48x48 | CCR7 | 6QZH | Rhodopsin | 1U19 |
| TM1 | 31 | L | 1.49x49 | CCR7 | 6QZH | H1 receptor | 3RZE |
| TM1 | 32 | N | 1.50x50 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM1 | 33 | L | 1.51x51 | CCR7 | 6QZH | MT1 receptor | 6ME2 |
| TM1 | 34 | L | 1.52x52 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM1 | 35 | A | 1.53x53 | CCR7 | 6QZH | EP4 receptor | 5YWY |
| TM1 | 36 | L | 1.54x54 | CCR7 | 6QZH | DP2 receptor | 6D27 |
| TM1 | 37 | V | 1.55x55 | CCR7 | 6QZH | OX2 receptor | 5WQC |
| TM1 | 38 | V | 1.56x56 | CCR7 | 6QZH | μ receptor | 4DKL |
| TM1 | 39 | F | 1.57x57 | CCR7 | 6QZH | M5 receptor | 6OL9 |
| TM1 | 40 | V | 1.58x58 | CCR7 | 6QZH | μ receptor | 4DKL |
| TM1 | 41 | G | 1.59x59 | CCR7 | 6QZH | TP receptor | 6IIU |
| TM1 | 42 | K | 1.60x60 | PAR2 | 5NDD | PAR1 | 3VW7 |
| ICL1 | 43 | L | - | - | - | - | - |
| ICL1 | 44 | R | - | apelin receptor | 5VBL | apelin receptor | 5VBL |
| ICL1 | 45 | C | - | apelin receptor | 5VBL | - | - |
| ICL1 | 46 | R | - | apelin receptor | 5VBL | - | - |
| ICL1 | 47 | P | - | - | - | - | - |
| TM2 | 48 | V | 2.37x37 | CCR7 | 6QZH | - | - |
| TM2 | 49 | A | 2.38x38 | CCR7 | 6QZH | μ receptor | 4DKL |
| TM2 | 50 | V | 2.39x39 | CCR7 | 6QZH | DP2 receptor | 6D27 |
| TM2 | 51 | D | 2.40x40 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM2 | 52 | V | 2.41x41 | CCR7 | 6QZH | AT1 receptor | 4ZUD |
| TM2 | 53 | L | 2.42x42 | CCR7 | 6QZH | D3 receptor | 3PBL |
| TM2 | 54 | L | 2.43x43 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM2 | 55 | L | 2.44x44 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM2 | 56 | N | 2.45x45 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM2 | 57 | L | 2.46x46 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM2 | 58 | T | 2.47x47 | CCR7 | 6QZH | GnRH1 receptor | 7BR3 |
| TM2 | 59 | A | 2.48x48 | CCR7 | 6QZH | D4 receptor | 5WIV |
| TM2 | 60 | S | 2.49x49 | CCR7 | 6QZH | DP2 receptor | 6D27 |
| TM2 | 61 | D | 2.50x50 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM2 | 62 | L | 2.51x51 | CCR7 | 6QZH | CCR9 | 5LWE |
| TM2 | 63 | L | 2.52x52 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM2 | 64 | L | 2.53x53 | CCR7 | 6QZH | D4 receptor | 5WIV |
| TM2 | 65 | L | 2.54x54 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM2 | 66 | L | 2.55x55 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM2 | 67 | F | 2.56x56 | CCR7 | 6QZH | Rhodopsin | 6I9K |
| TM2 | 68 | L | 2.57x57 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM2 | 69 | P | 2.58x58 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM2 | 70 | F | 2.59x59 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM2 | 71 | R | 2.60x60 | CCR7 | 6QZH | CysLT2 receptor | 6RZ6 |
| TM2 | 72 | M | 2.61x61 | CCR7 | 6QZH | 5-HT2A receptor | 6A94 |
| TM2 | 73 | V | 2.62x62 | CCR7 | 6QZH | μ receptor | 4DKL |
| TM2 | 74 | E | 2.63x63 | CCR7 | 6QZH | FFA1 receptor | 5TZY |
| TM2 | 75 | A | 2.64x64 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM2 | 76 | A | 2.65x65 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM2 | 77 | N | 2.66x66 | CCR7 | 6QZH | CXCR2 | 6LFL |
| ECL1 | 78 | G | - | - | - | - | - |
| ECL1 | 79 | M | - | PAR2 | 5NDD | - | - |
| ECL1 | 80 | H | 23.49x49 | PAR2 | 5NDD | Y1 receptor | 5ZBH |
| ECL1 | 81 | W | 23.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| ECL1 | 82 | P | 23.51x51 | PAR2 | 5NDD | μ receptor | 4DKL |
| ECL1 | 83 | L | 23.52x52 | - | - | - | - |
| TM3 | 84 | P | 3.21x21 | CCR7 | 6QZH | 5-HT2C receptor | 6BQH |
| TM3 | 85 | F | 3.22x22 | CCR7 | 6QZH | A1 receptor | 5UEN |
| TM3 | 86 | I | 3.23x23 | CCR7 | 6QZH | μ receptor | 4DKL |
| TM3 | 87 | L | 3.24x24 | CCR7 | 6QZH | μ receptor | 4DKL |
| TM3 | 88 | C | 3.25x25 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM3 | 89 | P | 3.26x26 | CCR7 | 6QZH | 5-HT2C receptor | 6BQH |
| TM3 | 90 | L | 3.27x27 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM3 | 91 | S | 3.28x28 | CCR7 | 6QZH | apelin receptor | 5VBL |
| TM3 | 92 | G | 3.29x29 | CCR7 | 6QZH | Rhodopsin | 1U19 |
| TM3 | 93 | F | 3.30x30 | CCR7 | 6QZH | MT1 receptor | 6ME2 |
| TM3 | 94 | I | 3.31x31 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM3 | 95 | F | 3.32x32 | CCR7 | 6QZH | DP2 receptor | 6D27 |
| TM3 | 96 | F | 3.33x33 | CCR7 | 6QZH | DP2 receptor | 6D27 |
| TM3 | 97 | T | 3.34x34 | CCR7 | 6QZH | 5-HT1B receptor | 4IAQ |
| TM3 | 98 | T | 3.35x35 | CCR7 | 6QZH | CB2 receptor | 5ZTY |
| TM3 | 99 | I | 3.36x36 | CCR7 | 6QZH | Y1 receptor | 5ZBH |
| TM3 | 100 | Y | 3.37x37 | CCR7 | 6QZH | CCR9 | 5LWE |
| TM3 | 101 | L | 3.38x38 | CCR7 | 6QZH | - | - |
| TM3 | 102 | T | 3.39x39 | CCR7 | 6QZH | NTS1 receptor | 4BUO |
| TM3 | 103 | A | 3.40x40 | CCR7 | 6QZH | apelin receptor | 5VBL |
| TM3 | 104 | L | 3.41x41 | CCR7 | 6QZH | CCR9 | 5LWE |
| TM3 | 105 | F | 3.42x42 | CCR7 | 6QZH | CCR2 | 5T1A |
| TM3 | 106 | L | 3.43x43 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM3 | 107 | A | 3.44x44 | CCR7 | 6QZH | CXCR2 | 6LFL |
| TM3 | 108 | A | 3.45x45 | CCR7 | 6QZH | NOP receptor | 5DHG |
| TM3 | 109 | V | 3.46x46 | CCR7 | 6QZH | NK1 receptor | 6HLP |
| TM3 | 110 | S | 3.47x47 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM3 | 111 | I | 3.48x48 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM3 | 112 | E | 3.49x49 | CCR7 | 6QZH | ghrelin receptor | 6KO5 |
| TM3 | 113 | R | 3.50x50 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM3 | 114 | F | 3.51x51 | CCR7 | 6QZH | D4 receptor | 5WIV |
| TM3 | 115 | L | 3.52x52 | CCR7 | 6QZH | AT1 receptor | 4ZUD |
| TM3 | 116 | S | 3.53x53 | CCR7 | 6QZH | H1 receptor | 3RZE |
| TM3 | 117 | V | 3.54x54 | CCR7 | 6QZH | κ receptor | 4DJH |
| TM3 | 118 | A | 3.55x55 | CCR7 | 6QZH | ETB receptor | 6LRY |
| TM3 | 119 | H | 3.56x56 | PAR2 | 5NDD | μ receptor | 4DKL |
| ICL2 | 120 | P | 34.50x50 | - | - | - | - |
| ICL2 | 121 | L | 34.51x51 | FFA1 receptor | 5TZY | FFA1 receptor | 5TZY |
| ICL2 | 122 | W | 34.52x52 | FFA1 receptor | 5TZY | DP2 receptor | 6D27 |
| ICL2 | 123 | Y | 34.53x53 | FFA1 receptor | 5TZY | FFA1 receptor | 5TZY |
| ICL2 | 124 | K | 34.54x54 | FFA1 receptor | 5TZY | ghrelin receptor | 6KO5 |
| ICL2 | 125 | T | 34.55x55 | FFA1 receptor | 5TZY | CCR9 | 5LWE |
| ICL2 | 126 | R | 34.56x56 | FFA1 receptor | 5TZY | M4 receptor | 6KP6 |
| ICL2 | 127 | P | 34.57x57 | - | - | - | - |
| TM4 | 128 | R | 4.38x38 | CCR7 | 6QZH | CCR9 | 5LWE |
| TM4 | 129 | L | 4.39x39 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM4 | 130 | G | 4.40x40 | CCR7 | 6QZH | ghrelin receptor | 6KO5 |
| TM4 | 131 | Q | 4.41x41 | CCR7 | 6QZH | AT2 receptor | 5UNG |
| TM4 | 132 | A | 4.42x42 | CCR7 | 6QZH | μ receptor | 4DKL |
| TM4 | 133 | G | 4.43x43 | CCR7 | 6QZH | M2 receptor | 5YC8 |
| TM4 | 134 | L | 4.44x44 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM4 | 135 | V | 4.45x45 | CCR7 | 6QZH | μ receptor | 4DKL |
| TM4 | 136 | S | 4.46x46 | CCR7 | 6QZH | CCR2 | 5T1A |
| TM4 | 137 | V | 4.47x47 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM4 | 138 | A | 4.48x48 | CCR7 | 6QZH | NOP receptor | 5DHG |
| TM4 | 139 | C | 4.49x49 | CCR7 | 6QZH | A1 receptor | 5UEN |
| TM4 | 140 | W | 4.50x50 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM4 | 141 | L | 4.51x51 | CCR7 | 6QZH | κ receptor | 4DJH |
| TM4 | 142 | L | 4.52x52 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM4 | 143 | A | 4.53x53 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM4 | 144 | S | 4.54x54 | CCR7 | 6QZH | μ receptor | 4DKL |
| TM4 | 145 | A | 4.55x55 | CCR7 | 6QZH | μ receptor | 4DKL |
| TM4 | 146 | H | 4.56x56 | CCR7 | 6QZH | FFA1 receptor | 5TZY |
| TM4 | 147 | C | 4.57x57 | FFA1 receptor | 5TZY | CCR9 | 5LWE |
| TM4 | 148 | S | 4.58x58 | FFA1 receptor | 5TZY | P2Y1 receptor | 4XNW |
| TM4 | 149 | V | 4.59x59 | FFA1 receptor | 5TZY | DP2 receptor | 6D27 |
| TM4 | 150 | V | 4.60x60 | CCR7 | 6QZH | μ receptor | 4DKL |
| TM4 | 151 | Y | 4.61x61 | CCR7 | 6QZH | DP2 receptor | 6D27 |
| TM4 | 152 | V | 4.62x62 | CCR7 | 6QZH | κ receptor | 4DJH |
| TM4 | 153 | I | 4.63x63 | CCR7 | 6QZH | AT1 receptor | 4ZUD |
| ECL2 | 154 | E | - | - | - | - | - |
| ECL2 | 155 | F | - | CCK1 receptor | 7MBX | - | - |
| ECL2 | 156 | S | - | CCK1 receptor | 7MBX | - | - |
| ECL2 | 157 | G | - | CCK1 receptor | 7MBX | - | - |
| ECL2 | 158 | D | - | CCK1 receptor | 7MBX | - | - |
| ECL2 | 159 | I | - | CCK1 receptor | 7MBX | - | - |
| ECL2 | 160 | S | - | CCK1 receptor | 7MBX | - | - |
| ECL2 | 161 | H | - | CCK1 receptor | 7MBX | - | - |
| ECL2 | 162 | S | - | CCK1 receptor | 7MBX | - | - |
| ECL2 | 163 | Q | - | CCK1 receptor | 7MBX | - | - |
| ECL2 | 164 | G | - | CCK1 receptor | 7MBX | - | - |
| ECL2 | 165 | T | - | CCK1 receptor | 7MBX | CCK1 receptor | 7MBX |
| ECL2 | 166 | N | - | CCK1 receptor | 7MBX | - | - |
| ECL2 | 167 | G | - | CCK1 receptor | 7MBX | - | - |
| ECL2 | 168 | T | - | - | - | - | - |
| ECL2 | 169 | C | 45.50x50 | CCR7 | 6QZH | CCR7 | 6QZH |
| ECL2 | 170 | Y | 45.51x51 | CCR7 | 6QZH | CXCR2 | 6LFL |
| ECL2 | 171 | L | 45.52x52 | CCR7 | 6QZH | CCR7 | 6QZH |
| ECL2 | 172 | E | - | - | - | - | - |
| ECL2 | 173 | F | - | PAR2 | 5NDD | - | - |
| ECL2 | 174 | W | - | PAR2 | 5NDD | - | - |
| ECL2 | 175 | K | - | PAR2 | 5NDD | - | - |
| ECL2 | 176 | D | - | PAR2 | 5NDD | - | - |
| ECL2 | 177 | Q | - | - | - | - | - |
| TM5 | 178 | L | 5.32x33 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM5 | 179 | A | 5.33x34 | PAR2 | 5NDD | apelin receptor | 5VBL |
| TM5 | 180 | I | 5.34x35 | PAR2 | 5NDD | - | - |
| TM5 | 181 | L | 5.35x36 | CCR7 | 6QZH | ghrelin receptor | 6KO5 |
| TM5 | 182 | L | 5.36x37 | CCR7 | 6QZH | κ receptor | 4DJH |
| TM5 | 183 | P | 5.37x38 | CCR7 | 6QZH | FFA1 receptor | 5TZY |
| TM5 | 184 | V | 5.38x39 | CCR7 | 6QZH | NTS1 receptor | 4BUO |
| TM5 | 185 | R | 5.39x40 | CCR7 | 6QZH | FFA1 receptor | 5TZY |
| TM5 | 186 | L | 5.40x41 | CCR7 | 6QZH | AT1 receptor | 4ZUD |
| TM5 | 187 | E | 5.41x42 | CCR7 | 6QZH | US28 | 5WB1 |
| TM5 | 188 | M | 5.42x43 | CCR7 | 6QZH | Rhodopsin | 1U19 |
| TM5 | 189 | A | 5.43x44 | CCR7 | 6QZH | H1 receptor | 3RZE |
| TM5 | 190 | V | 5.44x45 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM5 | 191 | V | 5.45x46 | CCR7 | 6QZH | CXCR4 | 3ODU |
| TM5 | 192 | L | 5.46x461 | CCR7 | 6QZH | Y2 receptor | 7DDZ |
| TM5 | 193 | F | 5.47x47 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM5 | 194 | V | 5.48x48 | CCR7 | 6QZH | κ receptor | 4DJH |
| TM5 | 195 | V | 5.49x49 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM5 | 196 | P | 5.50x50 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM5 | 197 | L | 5.51x51 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM5 | 198 | I | 5.52x52 | CCR7 | 6QZH | CXCR4 | 3ODU |
| TM5 | 199 | I | 5.53x53 | CCR7 | 6QZH | μ receptor | 4DKL |
| TM5 | 200 | T | 5.54x54 | CCR7 | 6QZH | D3 receptor | 3PBL |
| TM5 | 201 | S | 5.55x55 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM5 | 202 | Y | 5.56x56 | CCR7 | 6QZH | Rhodopsin | 6I9K |
| TM5 | 203 | C | 5.57x57 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM5 | 204 | Y | 5.58x58 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM5 | 205 | S | 5.59x59 | CCR7 | 6QZH | NOP receptor | 5DHG |
| TM5 | 206 | R | 5.60x60 | CCR7 | 6QZH | MT1 receptor | 6ME2 |
| TM5 | 207 | L | 5.61x61 | CCR7 | 6QZH | Rhodopsin | 1GZM |
| TM5 | 208 | V | 5.62x62 | CCR7 | 6QZH | Rhodopsin | 1GZM |
| TM5 | 209 | W | 5.63x63 | CCR7 | 6QZH | CB1 receptor | 5TGZ |
| TM5 | 210 | I | 5.64x64 | CCR7 | 6QZH | α2A-adrenoceptor | 6KUX |
| TM5 | 211 | L | 5.65x65 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM5 | 212 | G | 5.66x66 | CCR7 | 6QZH | - | - |
| TM5 | 213 | R | 5.67x67 | CysLT2 receptor | 6RZ6 | CCR5 | 4MBS |
| TM5 | 214 | G | 5.68x68 | CysLT2 receptor | 6RZ6 | CCK1 receptor | 7MBX |
| ICL3 | 215 | G | - | - | - | - | - |
| ICL3 | 216 | S | - | CXCR2 | 6LFO | - | - |
| ICL3 | 217 | H | - | - | - | - | - |
| TM6 | 218 | R | 6.28x29 | PAR2 | 5NDD | CCR2 | 5T1A |
| TM6 | 219 | R | 6.29x30 | PAR2 | 5NDD | CCR5 | 4MBS |
| TM6 | 220 | Q | 6.30x31 | PAR2 | 5NDD | 5-HT2A receptor | 6A94 |
| TM6 | 221 | R | 6.31x32 | PAR2 | 5NDD | μ receptor | 4DKL |
| TM6 | 222 | R | 6.32x33 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 223 | V | 6.33x34 | PAR2 | 5NDD | DP2 receptor | 6D27 |
| TM6 | 224 | A | 6.34x35 | CCR7 | 6QZH | FFA1 receptor | 5TZY |
| TM6 | 225 | G | 6.35x36 | CCR7 | 6QZH | CysLT1 receptor | 6RZ4 |
| TM6 | 226 | L | 6.36x37 | CCR7 | 6QZH | OX2 receptor | 5WQC |
| TM6 | 227 | V | 6.37x38 | CCR7 | 6QZH | CXCR4 | 3ODU |
| TM6 | 228 | A | 6.38x39 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM6 | 229 | A | 6.39x40 | CCR7 | 6QZH | PAR1 | 3VW7 |
| TM6 | 230 | T | 6.40x41 | CCR7 | 6QZH | CysLT2 receptor | 6RZ6 |
| TM6 | 231 | L | 6.41x42 | CCR7 | 6QZH | AT1 receptor | 4ZUD |
| TM6 | 232 | L | 6.42x43 | CCR7 | 6QZH | MT1 receptor | 6ME2 |
| TM6 | 233 | N | 6.43x44 | CCR7 | 6QZH | - | - |
| TM6 | 234 | F | 6.44x45 | CCR7 | 6QZH | AT1 receptor | 4ZUD |
| TM6 | 235 | L | 6.45x46 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 236 | V | 6.46x461 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM6 | 237 | C | 6.47x47 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 238 | F | 6.48x48 | CCR7 | 6QZH | MT1 receptor | 6ME2 |
| TM6 | 239 | G | 6.49x49 | CCR7 | 6QZH | DP2 receptor | 6D27 |
| TM6 | 240 | P | 6.50x50 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM6 | 241 | Y | 6.51x51 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM6 | 242 | N | 6.52x52 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM6 | 243 | V | 6.53x53 | CCR7 | 6QZH | NOP receptor | 5DHG |
| TM6 | 244 | S | 6.54x54 | CCR7 | 6QZH | α2C-adrenoceptor | 6KUW |
| TM6 | 245 | H | 6.55x55 | CCR7 | 6QZH | D3 receptor | 3PBL |
| TM6 | 246 | V | 6.56x56 | CCR7 | 6QZH | OX2 receptor | 5WQC |
| TM6 | 247 | V | 6.57x57 | CCR7 | 6QZH | CCR9 | 5LWE |
| TM6 | 248 | G | 6.58x58 | CCR7 | 6QZH | Rhodopsin | 6I9K |
| TM6 | 249 | Y | 6.59x59 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 250 | I | 6.60x60 | PAR2 | 5NDD | CCR9 | 5LWE |
| TM6 | 251 | C | 6.61x61 | PAR2 | 5NDD | D2 receptor | 6CM4 |
| ECL3 | 252 | G | - | - | - | - | - |
| ECL3 | 253 | E | - | - | - | - | - |
| ECL3 | 254 | S | - | - | - | - | - |
| ECL3 | 255 | P | - | - | - | - | - |
| TM7 | 256 | V | 7.33x32 | CCR7 | 6QZH | μ receptor | 4DKL |
| TM7 | 257 | W | 7.34x33 | CCR7 | 6QZH | CXCR4 | 3ODU |
| TM7 | 258 | R | 7.35x34 | CCR7 | 6QZH | BLT1 receptor | 7K15 |
| TM7 | 259 | I | 7.36x35 | CCR7 | 6QZH | β2-adrenoceptor | 2RH1 |
| TM7 | 260 | Y | 7.37x36 | CCR7 | 6QZH | apelin receptor | 5VBL |
| TM7 | 261 | V | 7.38x37 | CCR7 | 6QZH | DP2 receptor | 6D27 |
| TM7 | 262 | T | 7.39x38 | CCR7 | 6QZH | NOP receptor | 5DHG |
| TM7 | 263 | L | 7.40x39 | CCR7 | 6QZH | MT2 receptor | 6ME7 |
| TM7 | 264 | L | 7.41x40 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM7 | 265 | S | 7.42x41 | CCR7 | 6QZH | apelin receptor | 5VBL |
| TM7 | 266 | T | 7.43x42 | CCR7 | 6QZH | PAR2 | 5NDD |
| TM7 | 267 | L | 7.44x43 | CCR7 | 6QZH | CXCR2 | 6LFL |
| TM7 | 268 | N | 7.45x45 | CCR7 | 6QZH | μ receptor | 4DKL |
| TM7 | 269 | S | 7.46x46 | CCR7 | 6QZH | μ receptor | 4DKL |
| TM7 | 270 | C | 7.47x47 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM7 | 271 | V | 7.48x48 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM7 | 272 | D | 7.49x49 | CCR7 | 6QZH | EP4 receptor | 5YWY |
| TM7 | 273 | P | 7.50x50 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM7 | 274 | F | 7.51x51 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM7 | 275 | V | 7.52x52 | CCR7 | 6QZH | 5-HT2C receptor | 6BQH |
| TM7 | 276 | Y | 7.53x53 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM7 | 277 | Y | 7.54x54 | CCR7 | 6QZH | ETB receptor | 5X93 |
| TM7 | 278 | F | 7.55x55 | CCR7 | 6QZH | CCR7 | 6QZH |
| TM7 | 279 | S | 7.56x56 | PAR2 | 5NDD | 5-HT1B receptor | 4IAQ |
| H8 | 280 | S | 8.47x47 | PAR2 | 5NDD | PAR2 | 5NDD |
| H8 | 281 | S | 8.48x48 | PAR2 | 5NDD | Y2 receptor | 7DDZ |
| H8 | 282 | G | 8.49x49 | CCR7 | 6QZH | - | - |
| H8 | 283 | F | 8.50x50 | CCR7 | 6QZH | CCR7 | 6QZH |
| H8 | 284 | Q | 8.51x51 | CCR7 | 6QZH | Y1 receptor | 5ZBH |
| H8 | 285 | A | 8.52x52 | CCR7 | 6QZH | NOP receptor | 5DHG |
| H8 | 286 | D | 8.53x53 | CCR7 | 6QZH | CCR7 | 6QZH |
| H8 | 287 | F | 8.54x54 | CCR7 | 6QZH | μ receptor | 4DKL |
| H8 | 288 | H | 8.55x55 | CCR7 | 6QZH | 5-HT1B receptor | 4IAQ |
| H8 | 289 | E | 8.56x56 | CCR7 | 6QZH | EP4 receptor | 5YWY |
| H8 | 290 | L | 8.57x57 | CCR7 | 6QZH | δ receptor | 4N6H |
| H8 | 291 | L | 8.58x58 | CCR7 | 6QZH | CCR9 | 5LWE |
| H8 | 292 | R | 8.59x59 | CCR9 | 5LWE | DP2 receptor | 6D27 |
| H8 | 293 | R | 8.60x60 | CCR9 | 5LWE | - | - |
| H8 | 294 | L | 8.61x61 | CCR9 | 5LWE | CCR9 | 5LWE |
| C-term | 295 | C | - | - | - | - | - |
| C-term | 296 | G | - | - | - | - | - |
| C-term | 297 | L | - | - | - | - | - |
| C-term | 298 | W | - | - | - | - | - |
| C-term | 299 | G | - | - | - | - | - |