GPR4 homology model
PROTEIN CLASS
Class A (Rhodopsin)
RECEPTOR
SPECIES
Homo sapiens
STATE
Inactive
VERSION
2021-01-08
MODEL
TEMPLATES
5T1A (CCR2)
6RNK (succinate receptor)
6IBB (succinate receptor)
5ZKQ (PAF receptor)
4XNW (P2Y1 receptor)
6JOD (AT2 receptor)
5XSZ (LPA6 receptor)
None
6RNK (succinate receptor)
6IBB (succinate receptor)
5ZKQ (PAF receptor)
4XNW (P2Y1 receptor)
6JOD (AT2 receptor)
5XSZ (LPA6 receptor)
None
| Main template (%) | Additional templates (%) | No template - freely modelled (%) | |
|---|---|---|---|
| Backbone | 73.8 | 16.7 | 9.5 |
| Side-chains | 19.7 | 60.3 | 20.0 |
Number of backbone templates: 7
Number of rotamer templates: 54
| Segment | Seq.num. | AA | GPCRdb# | Backbone | PDB | Rotamer | PDB |
|---|---|---|---|---|---|---|---|
| N-term | 7 | E | - | - | - | - | |
| N-term | 8 | G | - | - | - | - | |
| N-term | 9 | C | - | - | - | - | |
| N-term | 10 | H | - | - | - | - | |
| N-term | 11 | V | - | - | - | - | |
| TM1 | 12 | D | 1.27x27 | CCR2 | 5T1A | - | - |
| TM1 | 13 | S | 1.28x28 | CCR2 | 5T1A | δ receptor | 4N6H |
| TM1 | 14 | R | 1.29x29 | CCR2 | 5T1A | - | - |
| TM1 | 15 | V | 1.30x30 | CCR2 | 5T1A | μ receptor | 4DKL |
| TM1 | 16 | D | 1.31x31 | CCR2 | 5T1A | - | - |
| TM1 | 17 | H | 1.32x32 | CCR2 | 5T1A | Rhodopsin | 6I9K |
| TM1 | 18 | L | 1.33x33 | CCR2 | 5T1A | BLT1 receptor | 5X33 |
| TM1 | 19 | F | 1.34x34 | CCR2 | 5T1A | CCR7 | 6QZH |
| TM1 | 20 | P | 1.35x35 | CCR2 | 5T1A | EP4 receptor | 5YWY |
| TM1 | 21 | P | 1.36x36 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM1 | 22 | S | 1.37x37 | CCR2 | 5T1A | PAR1 | 3VW7 |
| TM1 | 23 | L | 1.38x38 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM1 | 24 | Y | 1.39x39 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM1 | 25 | I | 1.40x40 | CCR2 | 5T1A | OX2 receptor | 5WS3 |
| TM1 | 26 | F | 1.41x41 | CCR2 | 5T1A | MT1 receptor | 6ME2 |
| TM1 | 27 | V | 1.42x42 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM1 | 28 | I | 1.43x43 | CCR2 | 5T1A | MT1 receptor | 6ME2 |
| TM1 | 29 | G | 1.44x44 | CCR2 | 5T1A | D4 receptor | 5WIV |
| TM1 | 30 | V | 1.45x45 | CCR2 | 5T1A | AT1 receptor | 4ZUD |
| TM1 | 31 | G | 1.46x46 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM1 | 32 | L | 1.47x47 | CCR2 | 5T1A | CCR7 | 6QZH |
| TM1 | 33 | P | 1.48x48 | CCR2 | 5T1A | BLT1 receptor | 5X33 |
| TM1 | 34 | T | 1.49x49 | CCR2 | 5T1A | LPA6 receptor | 5XSZ |
| TM1 | 35 | N | 1.50x50 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM1 | 36 | C | 1.51x51 | CCR2 | 5T1A | NOP receptor | 5DHG |
| TM1 | 37 | L | 1.52x52 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM1 | 38 | A | 1.53x53 | CCR2 | 5T1A | EP4 receptor | 5YWY |
| TM1 | 39 | L | 1.54x54 | CCR2 | 5T1A | apelin receptor | 5VBL |
| TM1 | 40 | W | 1.55x55 | CCR2 | 5T1A | apelin receptor | 5VBL |
| TM1 | 41 | A | 1.56x56 | CCR2 | 5T1A | OX1 receptor | 6TO7 |
| TM1 | 42 | A | 1.57x57 | CCR2 | 5T1A | FPR2/ALX | 6LW5 |
| TM1 | 43 | Y | 1.58x58 | CCR2 | 5T1A | AT1 receptor | 4YAY |
| TM1 | 44 | R | 1.59x59 | CCR2 | 5T1A | apelin receptor | 5VBL |
| TM1 | 45 | Q | 1.60x60 | CCR2 | 5T1A | CXCR4 | 3ODU |
| TM1 | 46 | V | 1.61x61 | succinate receptor | 6RNK | - | - |
| ICL1 | 47 | Q | - | - | - | - | |
| ICL1 | 48 | Q | succinate receptor | 6RNK | - | - | |
| ICL1 | 49 | R | - | - | - | - | |
| TM2 | 50 | N | 2.37x37 | CCR2 | 5T1A | MT1 receptor | 6ME2 |
| TM2 | 51 | E | 2.38x38 | CCR2 | 5T1A | PAF receptor | 5ZKQ |
| TM2 | 52 | L | 2.39x39 | CCR2 | 5T1A | Rhodopsin | 1GZM |
| TM2 | 53 | G | 2.40x40 | CCR2 | 5T1A | GPBA receptor | 7CFN |
| TM2 | 54 | V | 2.41x41 | CCR2 | 5T1A | AT1 receptor | 4ZUD |
| TM2 | 55 | Y | 2.42x42 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM2 | 56 | L | 2.43x43 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM2 | 57 | M | 2.44x44 | CCR2 | 5T1A | 5-HT2A receptor | 6A94 |
| TM2 | 58 | N | 2.45x45 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM2 | 59 | L | 2.46x46 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM2 | 60 | S | 2.47x47 | CCR2 | 5T1A | CXCR4 | 3ODU |
| TM2 | 61 | I | 2.48x48 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM2 | 62 | A | 2.49x49 | CCR2 | 5T1A | AT1 receptor | 4ZUD |
| TM2 | 63 | D | 2.50x50 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM2 | 64 | L | 2.51x51 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM2 | 65 | L | 2.52x52 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM2 | 66 | Y | 2.53x53 | CCR2 | 5T1A | P2Y1 receptor | 4XNW |
| TM2 | 67 | I | 2.54x54 | CCR2 | 5T1A | ETB receptor | 5X93 |
| TM2 | 68 | C | 2.55x55 | CCR2 | 5T1A | succinate receptor | 6RNK |
| TM2 | 69 | T | 2.56x56 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM2 | 70 | L | 2.57x57 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM2 | 71 | P | 2.58x58 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM2 | 72 | L | 2.59x59 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM2 | 73 | W | 2.60x60 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM2 | 74 | V | 2.61x61 | CCR2 | 5T1A | D2 receptor | 6CM4 |
| TM2 | 75 | D | 2.62x62 | CCR2 | 5T1A | CysLT2 receptor | 6RZ6 |
| TM2 | 76 | Y | 2.63x63 | CCR2 | 5T1A | CCR5 | 5UIW |
| TM2 | 77 | F | 2.64x64 | CCR2 | 5T1A | NTS1 receptor | 4BUO |
| TM2 | 78 | L | 2.65x65 | CCR2 | 5T1A | μ receptor | 4DKL |
| TM2 | 79 | H | 2.66x66 | CCR2 | 5T1A | Rhodopsin | 5TE5 |
| TM2 | 80 | H | 2.67x67 | PAF receptor | 5ZKQ | C5a1 receptor | 5O9H |
| ECL1 | 81 | D | - | - | - | - | |
| ECL1 | 82 | N | 23.49x49 | PAF receptor | 5ZKQ | PAF receptor | 5ZKQ |
| ECL1 | 83 | W | 23.50x50 | PAF receptor | 5ZKQ | PAF receptor | 5ZKQ |
| ECL1 | 84 | I | 23.51x51 | PAF receptor | 5ZKQ | PAF receptor | 5ZKQ |
| ECL1 | 85 | H | 23.52x52 | - | - | - | - |
| TM3 | 86 | G | 3.21x21 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM3 | 87 | P | 3.22x22 | CCR2 | 5T1A | D4 receptor | 5WIV |
| TM3 | 88 | G | 3.23x23 | CCR2 | 5T1A | - | - |
| TM3 | 89 | S | 3.24x24 | CCR2 | 5T1A | GPBA receptor | 7CFN |
| TM3 | 90 | C | 3.25x25 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM3 | 91 | K | 3.26x26 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM3 | 92 | L | 3.27x27 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM3 | 93 | F | 3.28x28 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM3 | 94 | G | 3.29x29 | CCR2 | 5T1A | Rhodopsin | 1GZM |
| TM3 | 95 | F | 3.30x30 | CCR2 | 5T1A | MT1 receptor | 6ME2 |
| TM3 | 96 | I | 3.31x31 | CCR2 | 5T1A | CCR7 | 6QZH |
| TM3 | 97 | F | 3.32x32 | CCR2 | 5T1A | DP2 receptor | 6D27 |
| TM3 | 98 | Y | 3.33x33 | CCR2 | 5T1A | μ receptor | 4DKL |
| TM3 | 99 | T | 3.34x34 | CCR2 | 5T1A | 5-HT1B receptor | 4IAQ |
| TM3 | 100 | N | 3.35x35 | CCR2 | 5T1A | AT1 receptor | 4ZUD |
| TM3 | 101 | I | 3.36x36 | CCR2 | 5T1A | NK1 receptor | 6HLP |
| TM3 | 102 | Y | 3.37x37 | CCR2 | 5T1A | AT1 receptor | 4ZUD |
| TM3 | 103 | I | 3.38x38 | CCR2 | 5T1A | Rhodopsin | 1GZM |
| TM3 | 104 | S | 3.39x39 | CCR2 | 5T1A | AT1 receptor | 4ZUD |
| TM3 | 105 | I | 3.40x40 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM3 | 106 | A | 3.41x41 | CCR2 | 5T1A | LPA1 receptor | 4Z35 |
| TM3 | 107 | F | 3.42x42 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM3 | 108 | L | 3.43x43 | CCR2 | 5T1A | AT1 receptor | 4ZUD |
| TM3 | 109 | C | 3.44x44 | CCR2 | 5T1A | μ receptor | 4DKL |
| TM3 | 110 | C | 3.45x45 | CCR2 | 5T1A | AT1 receptor | 4ZUD |
| TM3 | 111 | I | 3.46x46 | CCR2 | 5T1A | CCR7 | 6QZH |
| TM3 | 112 | S | 3.47x47 | CCR2 | 5T1A | AT1 receptor | 4ZUD |
| TM3 | 113 | V | 3.48x48 | CCR2 | 5T1A | μ receptor | 4DKL |
| TM3 | 114 | D | 3.49x49 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM3 | 115 | R | 3.50x50 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM3 | 116 | Y | 3.51x51 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM3 | 117 | L | 3.52x52 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM3 | 118 | A | 3.53x53 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM3 | 119 | V | 3.54x54 | CCR2 | 5T1A | CCR5 | 5UIW |
| TM3 | 120 | A | 3.55x55 | CCR2 | 5T1A | CCR9 | 5LWE |
| TM3 | 121 | H | 3.56x56 | CCR2 | 5T1A | CCR2 | 5T1A |
| ICL2 | 122 | P | 34.50x50 | - | - | - | - |
| ICL2 | 123 | L | 34.51x51 | P2Y1 receptor | 4XNW | P2Y1 receptor | 4XNW |
| ICL2 | 124 | R | 34.52x52 | P2Y1 receptor | 4XNW | CCR9 | 5LWE |
| ICL2 | 125 | F | 34.53x53 | P2Y1 receptor | 4XNW | - | - |
| ICL2 | 126 | A | 34.54x54 | P2Y1 receptor | 4XNW | EP3 receptor | 6M9T |
| ICL2 | 127 | R | 34.55x55 | P2Y1 receptor | 4XNW | C5a1 receptor | 5O9H |
| ICL2 | 128 | L | 34.56x56 | P2Y1 receptor | 4XNW | A2A receptor | 3VG9 |
| ICL2 | 129 | R | 34.57x57 | - | - | - | - |
| TM4 | 130 | R | 4.38x38 | CCR2 | 5T1A | OT receptor | 6TPK |
| TM4 | 131 | V | 4.39x39 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM4 | 132 | K | 4.40x40 | CCR2 | 5T1A | OX2 receptor | 5WS3 |
| TM4 | 133 | T | 4.41x41 | CCR2 | 5T1A | OT receptor | 6TPK |
| TM4 | 134 | A | 4.42x42 | CCR2 | 5T1A | AT1 receptor | 4ZUD |
| TM4 | 135 | V | 4.43x43 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM4 | 136 | A | 4.44x44 | CCR2 | 5T1A | NOP receptor | 5DHG |
| TM4 | 137 | V | 4.45x45 | CCR2 | 5T1A | CXCR4 | 3ODU |
| TM4 | 138 | S | 4.46x46 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM4 | 139 | S | 4.47x47 | CCR2 | 5T1A | NTS1 receptor | 4BUO |
| TM4 | 140 | V | 4.48x48 | CCR2 | 5T1A | apelin receptor | 5VBL |
| TM4 | 141 | V | 4.49x49 | CCR2 | 5T1A | CXCR4 | 3ODU |
| TM4 | 142 | W | 4.50x50 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM4 | 143 | A | 4.51x51 | CCR2 | 5T1A | DP2 receptor | 6D27 |
| TM4 | 144 | T | 4.52x52 | CCR2 | 5T1A | - | - |
| TM4 | 145 | E | 4.53x53 | CCR2 | 5T1A | - | - |
| TM4 | 146 | L | 4.54x54 | CCR2 | 5T1A | CXCR4 | 3ODU |
| TM4 | 147 | G | 4.55x55 | CCR2 | 5T1A | δ receptor | 4N6H |
| TM4 | 148 | A | 4.56x56 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM4 | 149 | N | 4.57x57 | PAF receptor | 5ZKQ | - | - |
| TM4 | 150 | S | 4.58x58 | PAF receptor | 5ZKQ | PAF receptor | 5ZKQ |
| TM4 | 151 | A | 4.59x59 | PAF receptor | 5ZKQ | D4 receptor | 5WIV |
| TM4 | 152 | P | 4.60x60 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM4 | 153 | L | 4.61x61 | CCR2 | 5T1A | D2 receptor | 6CM4 |
| TM4 | 154 | F | 4.62x62 | CCR2 | 5T1A | CXCR4 | 3ODU |
| TM4 | 155 | H | 4.63x63 | CCR2 | 5T1A | OT receptor | 6TPK |
| ECL2 | 156 | D | - | - | - | - | |
| ECL2 | 157 | E | AT2 receptor | 6JOD | - | - | |
| ECL2 | 158 | L | AT2 receptor | 6JOD | - | - | |
| ECL2 | 159 | F | AT2 receptor | 6JOD | - | - | |
| ECL2 | 160 | R | AT2 receptor | 6JOD | - | - | |
| ECL2 | 161 | D | AT2 receptor | 6JOD | - | - | |
| ECL2 | 162 | R | AT2 receptor | 6JOD | - | - | |
| ECL2 | 163 | Y | AT2 receptor | 6JOD | - | - | |
| ECL2 | 164 | N | AT2 receptor | 6JOD | - | - | |
| ECL2 | 165 | H | AT2 receptor | 6JOD | - | - | |
| ECL2 | 166 | T | AT2 receptor | 6JOD | - | - | |
| ECL2 | 167 | F | - | - | - | - | |
| ECL2 | 168 | C | 45.50x50 | CCR2 | 5T1A | CCR2 | 5T1A |
| ECL2 | 169 | F | 45.51x51 | CCR2 | 5T1A | M3 receptor | 5ZHP |
| ECL2 | 170 | E | 45.52x52 | CCR2 | 5T1A | CXCR2 | 6LFL |
| ECL2 | 171 | K | - | - | - | - | |
| ECL2 | 172 | F | AT2 receptor | 6JOD | AT2 receptor | 6JOD | |
| ECL2 | 173 | P | AT2 receptor | 6JOD | AT2 receptor | 6JOD | |
| ECL2 | 174 | M | AT2 receptor | 6JOD | - | - | |
| ECL2 | 175 | E | - | - | - | - | |
| TM5 | 176 | G | 5.33x34 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM5 | 177 | W | 5.34x35 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM5 | 178 | V | 5.35x36 | CCR2 | 5T1A | CXCR4 | 3ODU |
| TM5 | 179 | A | 5.36x37 | CCR2 | 5T1A | BLT1 receptor | 5X33 |
| TM5 | 180 | W | 5.37x38 | CCR2 | 5T1A | H1 receptor | 3RZE |
| TM5 | 181 | M | 5.38x39 | CCR2 | 5T1A | κ receptor | 6VI4 |
| TM5 | 182 | N | 5.39x40 | CCR2 | 5T1A | GnRH1 receptor | 7BR3 |
| TM5 | 183 | L | 5.40x41 | CCR2 | 5T1A | CCR5 | 5UIW |
| TM5 | 184 | Y | 5.41x42 | CCR2 | 5T1A | D2 receptor | 6CM4 |
| TM5 | 185 | R | 5.42x43 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM5 | 186 | V | 5.43x44 | CCR2 | 5T1A | CCR5 | 5UIW |
| TM5 | 187 | F | 5.44x45 | CCR2 | 5T1A | BLT1 receptor | 5X33 |
| TM5 | 188 | V | 5.45x46 | CCR2 | 5T1A | CXCR4 | 3ODU |
| TM5 | 189 | G | 5.46x461 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM5 | 190 | F | 5.47x47 | CCR2 | 5T1A | AT1 receptor | 4YAY |
| TM5 | 191 | L | 5.48x48 | CCR2 | 5T1A | AT1 receptor | 4ZUD |
| TM5 | 192 | F | 5.49x49 | CCR2 | 5T1A | NTS1 receptor | 4BUO |
| TM5 | 193 | P | 5.50x50 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM5 | 194 | W | 5.51x51 | CCR2 | 5T1A | - | - |
| TM5 | 195 | A | 5.52x52 | CCR2 | 5T1A | DP2 receptor | 6D27 |
| TM5 | 196 | L | 5.53x53 | CCR2 | 5T1A | OX1 receptor | 6TO7 |
| TM5 | 197 | M | 5.54x54 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM5 | 198 | L | 5.55x55 | CCR2 | 5T1A | AT1 receptor | 4ZUD |
| TM5 | 199 | L | 5.56x56 | CCR2 | 5T1A | OX2 receptor | 5WS3 |
| TM5 | 200 | S | 5.57x57 | CCR2 | 5T1A | AT1 receptor | 4ZUD |
| TM5 | 201 | Y | 5.58x58 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM5 | 202 | R | 5.59x59 | CCR2 | 5T1A | - | - |
| TM5 | 203 | G | 5.60x60 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM5 | 204 | I | 5.61x61 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM5 | 205 | L | 5.62x62 | PAF receptor | 5ZKQ | CCR5 | 5UIW |
| TM5 | 206 | R | 5.63x63 | PAF receptor | 5ZKQ | PAF receptor | 5ZKQ |
| TM5 | 207 | A | 5.64x64 | PAF receptor | 5ZKQ | AT1 receptor | 4ZUD |
| TM5 | 208 | V | 5.65x65 | PAF receptor | 5ZKQ | MT1 receptor | 6ME2 |
| TM5 | 209 | R | 5.66x66 | PAF receptor | 5ZKQ | δ receptor | 4N6H |
| TM5 | 210 | G | 5.67x67 | PAF receptor | 5ZKQ | OX1 receptor | 6TO7 |
| ICL3 | 211 | S | - | - | - | - | |
| ICL3 | 212 | V | - | - | - | - | |
| ICL3 | 213 | S | - | - | - | - | |
| ICL3 | 214 | T | - | - | - | - | |
| TM6 | 215 | E | 6.26x26 | AT2 receptor | 6JOD | - | - |
| TM6 | 216 | R | 6.27x27 | AT2 receptor | 6JOD | AT2 receptor | 6JOD |
| TM6 | 217 | Q | 6.28x28 | AT2 receptor | 6JOD | NTS1 receptor | 4BUO |
| TM6 | 218 | E | 6.29x29 | AT2 receptor | 6JOD | Y1 receptor | 5ZBH |
| TM6 | 219 | K | 6.30x30 | AT2 receptor | 6JOD | CXCR4 | 3ODU |
| TM6 | 220 | A | 6.31x31 | AT2 receptor | 6JOD | - | - |
| TM6 | 221 | K | 6.32x32 | AT2 receptor | 6JOD | CXCR4 | 3ODU |
| TM6 | 222 | I | 6.33x33 | CCR2 | 5T1A | AT1 receptor | 4ZUD |
| TM6 | 223 | K | 6.34x34 | CCR2 | 5T1A | - | - |
| TM6 | 224 | R | 6.35x35 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM6 | 225 | L | 6.36x36 | CCR2 | 5T1A | CCR5 | 5UIW |
| TM6 | 226 | A | 6.37x37 | CCR2 | 5T1A | D2 receptor | 6CM4 |
| TM6 | 227 | L | 6.38x38 | CCR2 | 5T1A | μ receptor | 4DKL |
| TM6 | 228 | S | 6.39x39 | CCR2 | 5T1A | Y1 receptor | 5ZBH |
| TM6 | 229 | L | 6.40x40 | CCR2 | 5T1A | CXCR4 | 3ODU |
| TM6 | 230 | I | 6.41x41 | CCR2 | 5T1A | CXCR4 | 3ODU |
| TM6 | 231 | A | 6.42x42 | CCR2 | 5T1A | μ receptor | 4DKL |
| TM6 | 232 | I | 6.43x43 | CCR2 | 5T1A | CXCR2 | 6LFL |
| TM6 | 233 | V | 6.44x44 | CCR2 | 5T1A | EP4 receptor | 5YWY |
| TM6 | 234 | L | 6.45x45 | CCR2 | 5T1A | CXCR2 | 6LFL |
| TM6 | 235 | V | 6.46x46 | CCR2 | 5T1A | CCR7 | 6QZH |
| TM6 | 236 | C | 6.47x47 | CCR2 | 5T1A | CXCR4 | 3ODU |
| TM6 | 237 | F | 6.48x48 | CCR2 | 5T1A | MT1 receptor | 6ME2 |
| TM6 | 238 | A | 6.49x49 | CCR2 | 5T1A | CCR5 | 5UIW |
| TM6 | 239 | P | 6.50x50 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM6 | 240 | Y | 6.51x51 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM6 | 241 | H | 6.52x52 | CCR2 | 5T1A | apelin receptor | 5VBL |
| TM6 | 242 | V | 6.53x53 | CCR2 | 5T1A | BLT1 receptor | 5X33 |
| TM6 | 243 | L | 6.54x54 | CCR2 | 5T1A | OX1 receptor | 6TO7 |
| TM6 | 244 | L | 6.55x55 | CCR2 | 5T1A | CCR5 | 5UIW |
| TM6 | 245 | L | 6.56x56 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM6 | 246 | S | 6.57x57 | CCR2 | 5T1A | - | - |
| TM6 | 247 | R | 6.58x58 | CCR2 | 5T1A | succinate receptor | 6RNK |
| TM6 | 248 | S | 6.59x59 | CCR2 | 5T1A | CXCR4 | 3ODU |
| TM6 | 249 | A | 6.60x60 | CCR2 | 5T1A | CB2 receptor | 5ZTY |
| TM6 | 250 | I | 6.61x61 | CCR2 | 5T1A | AT1 receptor | 4ZUD |
| TM6 | 251 | Y | 6.62x62 | CCR2 | 5T1A | GPBA receptor | 7CFN |
| TM6 | 252 | L | 6.63x63 | CCR2 | 5T1A | AT1 receptor | 4YAY |
| TM6 | 253 | G | 6.64x64 | CCR2 | 5T1A | AT1 receptor | 4ZUD |
| ECL3 | 254 | R | - | - | - | - | |
| ECL3 | 255 | P | LPA6 receptor | 5XSZ | - | - | |
| ECL3 | 256 | W | - | - | - | - | |
| TM7 | 257 | D | 7.24x23 | PAF receptor | 5ZKQ | PAF receptor | 5ZKQ |
| TM7 | 258 | C | 7.25x24 | PAF receptor | 5ZKQ | CCR5 | 5UIW |
| TM7 | 259 | G | 7.26x25 | CCR2 | 5T1A | - | - |
| TM7 | 260 | F | 7.27x26 | CCR2 | 5T1A | CXCR4 | 3ODU |
| TM7 | 261 | E | 7.28x27 | CCR2 | 5T1A | CXCR4 | 3ODU |
| TM7 | 262 | E | 7.29x28 | CCR2 | 5T1A | NOP receptor | 5DHG |
| TM7 | 263 | R | 7.30x29 | CCR2 | 5T1A | CCR5 | 5UIW |
| TM7 | 264 | V | 7.31x30 | CCR2 | 5T1A | AT1 receptor | 4ZUD |
| TM7 | 265 | F | 7.32x31 | CCR2 | 5T1A | P2Y12 receptor | 4NTJ |
| TM7 | 266 | S | 7.33x32 | CCR2 | 5T1A | κ receptor | 4DJH |
| TM7 | 267 | A | 7.34x33 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM7 | 268 | Y | 7.35x34 | CCR2 | 5T1A | CCR7 | 6QZH |
| TM7 | 269 | H | 7.36x35 | CCR2 | 5T1A | μ receptor | 4DKL |
| TM7 | 270 | S | 7.37x36 | CCR2 | 5T1A | P2Y12 receptor | 4NTJ |
| TM7 | 271 | S | 7.38x37 | CCR2 | 5T1A | OX1 receptor | 6TO7 |
| TM7 | 272 | L | 7.39x38 | CCR2 | 5T1A | LPA1 receptor | 4Z35 |
| TM7 | 273 | A | 7.40x39 | CCR2 | 5T1A | CXCR4 | 3ODU |
| TM7 | 274 | F | 7.41x40 | CCR2 | 5T1A | C5a1 receptor | 5O9H |
| TM7 | 275 | T | 7.42x41 | CCR2 | 5T1A | A1 receptor | 5UEN |
| TM7 | 276 | S | 7.43x42 | CCR2 | 5T1A | ETB receptor | 5X93 |
| TM7 | 277 | L | 7.44x43 | CCR2 | 5T1A | CXCR2 | 6LFL |
| TM7 | 278 | N | 7.45x45 | CCR2 | 5T1A | AT1 receptor | 4ZUD |
| TM7 | 279 | C | 7.46x46 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM7 | 280 | V | 7.47x47 | CCR2 | 5T1A | DP2 receptor | 6D27 |
| TM7 | 281 | A | 7.48x48 | CCR2 | 5T1A | DP2 receptor | 6D27 |
| TM7 | 282 | D | 7.49x49 | CCR2 | 5T1A | EP4 receptor | 5YWY |
| TM7 | 283 | P | 7.50x50 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM7 | 284 | I | 7.51x51 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM7 | 285 | L | 7.52x52 | CCR2 | 5T1A | CCR7 | 6QZH |
| TM7 | 286 | Y | 7.53x53 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM7 | 287 | C | 7.54x54 | CCR2 | 5T1A | β2-adrenoceptor | 5JQH |
| TM7 | 288 | L | 7.55x55 | CCR2 | 5T1A | DP2 receptor | 6D27 |
| TM7 | 289 | V | 7.56x56 | CCR2 | 5T1A | CCR2 | 5T1A |
| TM7 | 290 | N | 7.57x57 | - | - | - | - |
| TM7 | 291 | E | 7.58x58 | - | - | - | - |
| TM7 | 292 | G | 7.59x59 | - | - | - | - |
| H8 | 293 | A | 8.50x50 | CCR2 | 5T1A | - | - |
| H8 | 294 | R | 8.51x51 | CCR2 | 5T1A | CCR2 | 5T1A |
| H8 | 295 | S | 8.52x52 | CCR2 | 5T1A | 5-HT2A receptor | 6A94 |
| H8 | 296 | D | 8.53x53 | CCR2 | 5T1A | CCR7 | 6QZH |
| H8 | 297 | V | 8.54x54 | CCR2 | 5T1A | ghrelin receptor | 6KO5 |
| H8 | 298 | A | 8.55x55 | CCR2 | 5T1A | - | - |
| H8 | 299 | K | 8.56x56 | CCR2 | 5T1A | CXCR2 | 6LFL |
| H8 | 300 | A | 8.57x57 | succinate receptor | 6IBB | OX1 receptor | 6TO7 |
| H8 | 301 | L | 8.58x58 | succinate receptor | 6IBB | succinate receptor | 6IBB |
| H8 | 302 | H | 8.59x59 | succinate receptor | 6IBB | H1 receptor | 3RZE |
| H8 | 303 | N | 8.60x60 | succinate receptor | 6IBB | CCR9 | 5LWE |
| H8 | 304 | L | 8.61x61 | succinate receptor | 6IBB | CCR9 | 5LWE |
| H8 | 305 | L | 8.62x62 | succinate receptor | 6IBB | DP2 receptor | 6D27 |
| H8 | 306 | R | 8.63x63 | succinate receptor | 6IBB | - | - |
| C-term | 307 | F | - | - | - | - | |
| C-term | 308 | L | - | - | - | - | |
| C-term | 309 | A | - | - | - | - | |
| C-term | 310 | S | - | - | - | - | |
| C-term | 311 | D | - | - | - | - |