GPR55 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive

VERSION

2020-09-02

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

κ receptor (sequence similarity: 41%) PDB: 6VI4

TEMPLATES

6B73 (κ receptor)
6VI4 (κ receptor)
5XSZ (LPA6 receptor)
6JOD (AT2 receptor)
5UNG (AT2 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 77.4 9.8 12.8
Side-chains 20.5 55.2 24.2

Number of backbone templates: 5
Number of rotamer templates: 52

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 13 D - - - -
N-term 14 G - - - -
N-term 15 V - - - -
N-term 16 N - - - -
N-term 17 E - - - -
TM1 18 L 1.30x30 κ receptor 6B73 succinate receptor 6RNK
TM1 19 M 1.31x31 κ receptor 6B73 Y1 receptor 5ZBH
TM1 20 K 1.32x32 κ receptor 6B73 NOP receptor 5DHG
TM1 21 T 1.33x33 κ receptor 6B73 CB2 receptor 5ZTY
TM1 22 L 1.34x34 κ receptor 6B73 CCR5 5UIW
TM1 23 Q 1.35x35 κ receptor 6B73 - -
TM1 24 F 1.36x36 κ receptor 6VI4 FFA1 receptor 5TZY
TM1 25 A 1.37x37 κ receptor 6VI4 κ receptor 6VI4
TM1 26 V 1.38x38 κ receptor 6VI4 κ receptor 6VI4
TM1 27 H 1.39x39 κ receptor 6VI4 DP2 receptor 6D27
TM1 28 I 1.40x40 κ receptor 6VI4 OX2 receptor 5WS3
TM1 29 P 1.41x41 κ receptor 6VI4 - -
TM1 30 T 1.42x42 κ receptor 6VI4 MT1 receptor 6ME2
TM1 31 F 1.43x43 κ receptor 6VI4 κ receptor 6VI4
TM1 32 V 1.44x44 κ receptor 6VI4 κ receptor 6VI4
TM1 33 L 1.45x45 κ receptor 6VI4 ETB receptor 5X93
TM1 34 G 1.46x46 κ receptor 6VI4 κ receptor 6VI4
TM1 35 L 1.47x47 κ receptor 6VI4 κ receptor 6VI4
TM1 36 L 1.48x48 κ receptor 6VI4 NOP receptor 5DHG
TM1 37 L 1.49x49 κ receptor 6VI4 H1 receptor 3RZE
TM1 38 N 1.50x50 κ receptor 6VI4 κ receptor 6VI4
TM1 39 L 1.51x51 κ receptor 6VI4 ghrelin receptor 6KO5
TM1 40 L 1.52x52 κ receptor 6VI4 κ receptor 6VI4
TM1 41 A 1.53x53 κ receptor 6VI4 EP4 receptor 5YWY
TM1 42 I 1.54x54 κ receptor 6VI4 CCR5 5UIW
TM1 43 H 1.55x55 κ receptor 6VI4 - -
TM1 44 G 1.56x56 κ receptor 6VI4 δ receptor 4N6H
TM1 45 F 1.57x57 κ receptor 6VI4 M5 receptor 6OL9
TM1 46 S 1.58x58 κ receptor 6VI4 ghrelin receptor 6KO5
TM1 47 T 1.59x59 κ receptor 6VI4 α2C-adrenoceptor 6KUW
TM1 48 F 1.60x60 κ receptor 6VI4 β2-adrenoceptor 5JQH
ICL1 49 L - - - -
ICL1 50 K - - - -
ICL1 51 N - - - -
ICL1 52 R - - - -
ICL1 53 W - - - -
ICL1 54 P - - - -
ICL1 55 D - - - -
ICL1 56 Y - - - -
TM2 57 A 2.37x37 κ receptor 6VI4 α2C-adrenoceptor 6KUW
TM2 58 A 2.38x38 κ receptor 6VI4 κ receptor 6VI4
TM2 59 T 2.39x39 κ receptor 6VI4 κ receptor 6VI4
TM2 60 S 2.40x40 κ receptor 6VI4 AT1 receptor 4ZUD
TM2 61 I 2.41x41 κ receptor 6VI4 κ receptor 6VI4
TM2 62 Y 2.42x42 κ receptor 6VI4 κ receptor 6VI4
TM2 63 M 2.43x43 κ receptor 6VI4 LPA1 receptor 4Z35
TM2 64 I 2.44x44 κ receptor 6VI4 US28 5WB1
TM2 65 N 2.45x45 κ receptor 6VI4 κ receptor 6VI4
TM2 66 L 2.46x46 κ receptor 6VI4 κ receptor 6VI4
TM2 67 A 2.47x47 κ receptor 6VI4 κ receptor 6VI4
TM2 68 V 2.48x48 κ receptor 6VI4 CXCR4 3ODU
TM2 69 F 2.49x49 κ receptor 6VI4 - -
TM2 70 D 2.50x50 κ receptor 6VI4 κ receptor 6VI4
TM2 71 L 2.51x51 κ receptor 6VI4 CCR5 5UIW
TM2 72 L 2.52x52 κ receptor 6VI4 κ receptor 6VI4
TM2 73 L 2.53x53 κ receptor 6VI4 5-HT2A receptor 6A94
TM2 74 V 2.54x54 κ receptor 6VI4 CXCR4 3ODU
TM2 75 L 2.55x55 κ receptor 6VI4 NOP receptor 5DHG
TM2 76 S 2.56x56 κ receptor 6VI4 DP2 receptor 6D27
TM2 77 L 2.57x57 κ receptor 6VI4 μ receptor 4DKL
TM2 78 P 2.58x58 κ receptor 6VI4 κ receptor 6VI4
TM2 79 F 2.59x59 κ receptor 6VI4 κ receptor 6VI4
TM2 80 K 2.60x60 κ receptor 6VI4 PAR1 3VW7
TM2 81 M 2.61x61 κ receptor 6VI4 5-HT2A receptor 6A94
TM2 82 V 2.62x62 κ receptor 6VI4 μ receptor 4DKL
TM2 83 L 2.63x63 κ receptor 6VI4 D2 receptor 6CM4
TM2 84 S 2.64x64 κ receptor 6VI4 A2A receptor 3VG9
TM2 85 Q 2.65x65 κ receptor 6VI4 PAF receptor 5ZKQ
TM2 86 V 2.66x66 κ receptor 6VI4 DP2 receptor 6D27
ECL1 87 Q - - - -
ECL1 88 S - - - -
ECL1 89 P - - - -
ECL1 90 F - - - -
ECL1 91 P - - - -
ECL1 92 S - - - -
TM3 93 L 3.24x24 κ receptor 6VI4 κ receptor 6VI4
TM3 94 C 3.25x25 κ receptor 6VI4 κ receptor 6VI4
TM3 95 T 3.26x26 κ receptor 6VI4 US28 5WB1
TM3 96 L 3.27x27 κ receptor 6VI4 CCR5 5UIW
TM3 97 V 3.28x28 κ receptor 6VI4 κ receptor 6VI4
TM3 98 E 3.29x29 κ receptor 6VI4 S1P1 receptor 3V2Y
TM3 99 C 3.30x30 κ receptor 6VI4 A1 receptor 5UEN
TM3 100 L 3.31x31 κ receptor 6VI4 CCR5 5UIW
TM3 101 Y 3.32x32 κ receptor 6VI4 CCR5 5UIW
TM3 102 F 3.33x33 κ receptor 6VI4 CCR5 5UIW
TM3 103 V 3.34x34 κ receptor 6VI4 CXCR4 3ODU
TM3 104 S 3.35x35 κ receptor 6VI4 CCR7 6QZH
TM3 105 M 3.36x36 κ receptor 6VI4 κ receptor 6VI4
TM3 106 Y 3.37x37 κ receptor 6VI4 CXCR4 3ODU
TM3 107 G 3.38x38 κ receptor 6VI4 CCR2 5T1A
TM3 108 S 3.39x39 κ receptor 6VI4 κ receptor 6VI4
TM3 109 V 3.40x40 κ receptor 6VI4 CXCR4 3ODU
TM3 110 F 3.41x41 κ receptor 6VI4 κ receptor 6VI4
TM3 111 T 3.42x42 κ receptor 6VI4 κ receptor 6VI4
TM3 112 I 3.43x43 κ receptor 6VI4 CCR5 5UIW
TM3 113 C 3.44x44 κ receptor 6VI4 μ receptor 4DKL
TM3 114 F 3.45x45 κ receptor 6VI4 CXCR4 3ODU
TM3 115 I 3.46x46 κ receptor 6VI4 CXCR4 3ODU
TM3 116 S 3.47x47 κ receptor 6VI4 κ receptor 6VI4
TM3 117 M 3.48x48 κ receptor 6VI4 CCR6 6WWZ
TM3 118 D 3.49x49 κ receptor 6VI4 κ receptor 6VI4
TM3 119 R 3.50x50 κ receptor 6VI4 κ receptor 6VI4
TM3 120 F 3.51x51 κ receptor 6VI4 C5a1 receptor 5O9H
TM3 121 L 3.52x52 κ receptor 6VI4 CCR5 5UIW
TM3 122 A 3.53x53 κ receptor 6VI4 κ receptor 6VI4
TM3 123 I 3.54x54 κ receptor 6VI4 NOP receptor 5DHG
TM3 124 R 3.55x55 κ receptor 6VI4 A2A receptor 3VG9
TM3 125 Y 3.56x56 κ receptor 6VI4 CB2 receptor 5ZTY
ICL2 126 P 34.50x50 - - - -
ICL2 127 L 34.51x51 LPA6 receptor 5XSZ ghrelin receptor 6KO5
ICL2 128 L 34.52x52 LPA6 receptor 5XSZ OX1 receptor 6TO7
ICL2 129 V 34.53x53 LPA6 receptor 5XSZ - -
ICL2 130 S 34.54x54 LPA6 receptor 5XSZ 5-HT1B receptor 4IAQ
ICL2 131 H 34.55x55 LPA6 receptor 5XSZ D3 receptor 3PBL
ICL2 132 L 34.56x56 LPA6 receptor 5XSZ A2A receptor 3VG9
ICL2 133 R 34.57x57 - - - -
TM4 134 S 4.38x38 κ receptor 6VI4 NTS1 receptor 4BUO
TM4 135 P 4.39x39 κ receptor 6VI4 κ receptor 6VI4
TM4 136 R 4.40x40 κ receptor 6VI4 μ receptor 4DKL
TM4 137 K 4.41x41 κ receptor 6VI4 κ receptor 6VI4
TM4 138 I 4.42x42 κ receptor 6VI4 α2A-adrenoceptor 6KUX
TM4 139 F 4.43x43 κ receptor 6VI4 5-HT2A receptor 6A94
TM4 140 G 4.44x44 κ receptor 6VI4 OX1 receptor 6TO7
TM4 141 I 4.45x45 κ receptor 6VI4 κ receptor 6VI4
TM4 142 C 4.46x46 κ receptor 6VI4 AT1 receptor 4ZUD
TM4 143 C 4.47x47 κ receptor 6VI4 MT2 receptor 6ME6
TM4 144 T 4.48x48 κ receptor 6VI4 CCR9 5LWE
TM4 145 I 4.49x49 κ receptor 6VI4 κ receptor 6VI4
TM4 146 W 4.50x50 κ receptor 6VI4 κ receptor 6VI4
TM4 147 V 4.51x51 κ receptor 6VI4 CCR5 5UIW
TM4 148 L 4.52x52 κ receptor 6VI4 κ receptor 6VI4
TM4 149 V 4.53x53 κ receptor 6VI4 LPA6 receptor 5XSZ
TM4 150 W 4.54x54 κ receptor 6VI4 - -
TM4 151 T 4.55x55 κ receptor 6VI4 D2 receptor 6CM4
TM4 152 G 4.56x56 κ receptor 6VI4 LPA6 receptor 5XSZ
TM4 153 S 4.57x57 AT2 receptor 6JOD CCR5 5UIW
TM4 154 I 4.58x59 AT2 receptor 6JOD CXCR4 3ODU
TM4 155 P 4.59x60 κ receptor 6VI4 CCR5 5UIW
TM4 156 I 4.60x61 κ receptor 6VI4 κ receptor 6VI4
TM4 157 Y 4.61x62 κ receptor 6VI4 PAR2 5NDD
TM4 158 S 4.62x63 κ receptor 6VI4 - -
TM4 159 F 4.63x64 κ receptor 6VI4 - -
TM4 160 H 4.64x65 LPA6 receptor 5XSZ - -
ECL2 161 G - - - -
ECL2 162 K - - - -
ECL2 163 V - - - -
ECL2 164 E - - - -
ECL2 165 K - - - -
ECL2 166 Y - - - -
ECL2 167 M - - - -
ECL2 168 C 45.50x50 κ receptor 6VI4 κ receptor 6VI4
ECL2 169 F 45.51x51 κ receptor 6VI4 Y1 receptor 5ZBH
ECL2 170 H 45.52x52 κ receptor 6VI4 - -
ECL2 171 N - - - -
ECL2 172 M - - - -
TM5 173 S 5.30x31 AT2 receptor 6JOD apelin receptor 5VBL
TM5 174 D 5.31x32 κ receptor 6VI4 C5a1 receptor 5O9H
TM5 175 D 5.32x33 κ receptor 6VI4 NOP receptor 5DHG
TM5 176 T 5.33x34 κ receptor 6VI4 EP4 receptor 5YWY
TM5 177 W 5.34x35 κ receptor 6VI4 κ receptor 6VI4
TM5 178 S 5.35x36 κ receptor 6VI4 AT2 receptor 5UNG
TM5 179 A 5.36x37 κ receptor 6VI4 BLT1 receptor 5X33
TM5 180 K 5.37x38 κ receptor 6VI4 - -
TM5 181 V 5.38x39 κ receptor 6VI4 C5a1 receptor 5O9H
TM5 182 F 5.39x40 κ receptor 6VI4 GPR52 6LI1
TM5 183 F 5.40x41 κ receptor 6VI4 CXCR4 3ODU
TM5 184 P 5.41x42 κ receptor 6VI4 - -
TM5 185 L 5.42x43 κ receptor 6VI4 ETB receptor 5X93
TM5 186 E 5.43x44 κ receptor 6VI4 LPA6 receptor 5XSZ
TM5 187 V 5.44x45 κ receptor 6VI4 CCR7 6QZH
TM5 188 F 5.45x46 κ receptor 6VI4 κ receptor 6VI4
TM5 189 G 5.46x461 κ receptor 6VI4 CCR5 5UIW
TM5 190 F 5.47x47 κ receptor 6VI4 κ receptor 6VI4
TM5 191 L 5.48x48 κ receptor 6VI4 AT1 receptor 4ZUD
TM5 192 L 5.49x49 κ receptor 6VI4 CCR5 5UIW
TM5 193 P 5.50x50 κ receptor 6VI4 κ receptor 6VI4
TM5 194 M 5.51x51 κ receptor 6VI4 MT1 receptor 6ME2
TM5 195 G 5.52x52 κ receptor 6VI4 OX1 receptor 6TO7
TM5 196 I 5.53x53 κ receptor 6VI4 κ receptor 6VI4
TM5 197 M 5.54x54 κ receptor 6VI4 CCR5 5UIW
TM5 198 G 5.55x55 κ receptor 6VI4 α2C-adrenoceptor 6KUW
TM5 199 F 5.56x56 κ receptor 6VI4 CCR7 6QZH
TM5 200 C 5.57x57 κ receptor 6VI4 κ receptor 6VI4
TM5 201 C 5.58x58 κ receptor 6VI4 - -
TM5 202 S 5.59x59 κ receptor 6VI4 NOP receptor 5DHG
TM5 203 R 5.60x60 κ receptor 6VI4 A2A receptor 3VG9
TM5 204 S 5.61x61 κ receptor 6VI4 TP receptor 6IIV
TM5 205 I 5.62x62 κ receptor 6VI4 κ receptor 6VI4
TM5 206 H 5.63x63 κ receptor 6VI4 5-HT2B receptor 4IB4
TM5 207 I 5.64x64 κ receptor 6VI4 α2A-adrenoceptor 6KUX
TM5 208 L 5.65x65 κ receptor 6VI4 κ receptor 6VI4
TM5 209 L 5.66x66 κ receptor 6VI4 CCR5 5UIW
TM5 210 G 5.67x67 κ receptor 6VI4 - -
TM5 211 R 5.68x68 κ receptor 6VI4 C5a1 receptor 6C1R
ICL3 212 R - - - -
ICL3 213 D AT2 receptor 5UNG - -
ICL3 214 H - - - -
TM6 215 T 6.24x24 κ receptor 6VI4 - -
TM6 216 Q 6.25x25 κ receptor 6VI4 5-HT2A receptor 6A94
TM6 217 D 6.26x26 κ receptor 6VI4 - -
TM6 218 W 6.27x27 κ receptor 6VI4 - -
TM6 219 V 6.28x28 κ receptor 6VI4 M5 receptor 6OL9
TM6 220 Q 6.29x29 κ receptor 6VI4 CXCR4 3ODU
TM6 221 Q 6.30x30 κ receptor 6VI4 - -
TM6 222 K 6.31x31 κ receptor 6VI4 ghrelin receptor 6KO5
TM6 223 A 6.32x32 κ receptor 6VI4 S1P1 receptor 3V2Y
TM6 224 C 6.33x33 κ receptor 6VI4 - -
TM6 225 I 6.34x34 κ receptor 6VI4 CCR6 6WWZ
TM6 226 Y 6.35x35 κ receptor 6VI4 - -
TM6 227 S 6.36x36 κ receptor 6VI4 A2A receptor 3VG9
TM6 228 I 6.37x37 κ receptor 6VI4 CCR5 5UIW
TM6 229 A 6.38x38 κ receptor 6VI4 ghrelin receptor 6KO5
TM6 230 A 6.39x39 κ receptor 6VI4 AT1 receptor 4ZUD
TM6 231 S 6.40x40 κ receptor 6VI4 - -
TM6 232 L 6.41x41 κ receptor 6VI4 OX2 receptor 5WS3
TM6 233 A 6.42x42 κ receptor 6VI4 κ receptor 6VI4
TM6 234 V 6.43x43 κ receptor 6VI4 κ receptor 6VI4
TM6 235 F 6.44x44 κ receptor 6VI4 κ receptor 6VI4
TM6 236 V 6.45x45 κ receptor 6VI4 κ receptor 6VI4
TM6 237 V 6.46x46 κ receptor 6VI4 κ receptor 6VI4
TM6 238 S 6.47x47 κ receptor 6VI4 AT1 receptor 4ZUD
TM6 239 F 6.48x48 κ receptor 6VI4 MT1 receptor 6ME2
TM6 240 L 6.49x49 κ receptor 6VI4 CXCR4 3ODU
TM6 241 P 6.50x50 κ receptor 6VI4 κ receptor 6VI4
TM6 242 V 6.51x51 κ receptor 6VI4 NOP receptor 5DHG
TM6 243 H 6.52x52 κ receptor 6VI4 κ receptor 6VI4
TM6 244 L 6.53x53 κ receptor 6VI4 ETB receptor 5X93
TM6 245 G 6.54x54 κ receptor 6VI4 CXCR4 3ODU
TM6 246 F 6.55x55 κ receptor 6VI4 H1 receptor 3RZE
TM6 247 F 6.56x56 κ receptor 6VI4 AT1 receptor 4ZUD
TM6 248 L 6.57x57 κ receptor 6VI4 CCR5 5UIW
TM6 249 Q 6.58x58 κ receptor 6VI4 NOP receptor 5DHG
TM6 250 F 6.59x59 κ receptor 6VI4 A2A receptor 3VG9
TM6 251 L 6.60x60 κ receptor 6VI4 κ receptor 6VI4
TM6 252 V 6.61x61 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM6 253 R 6.62x62 LPA6 receptor 5XSZ α2C-adrenoceptor 6KUW
TM6 254 N 6.63x63 LPA6 receptor 5XSZ - -
TM6 255 S 6.64x64 LPA6 receptor 5XSZ - -
ECL3 256 F - - - -
ECL3 257 I LPA6 receptor 5XSZ - -
ECL3 258 V - - - -
TM7 259 E 7.24x23 LPA6 receptor 5XSZ - -
TM7 260 C 7.25x24 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM7 261 R 7.26x25 LPA6 receptor 5XSZ AT1 receptor 4ZUD
TM7 262 A 7.27x26 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM7 263 K 7.28x27 LPA6 receptor 5XSZ CysLT2 receptor 6RZ6
TM7 264 Q 7.29x28 LPA6 receptor 5XSZ PAF receptor 5ZKQ
TM7 265 S 7.30x29 LPA6 receptor 5XSZ US28 5WB1
TM7 266 I 7.31x30 κ receptor 6VI4 CCR9 5LWE
TM7 267 S 7.32x31 κ receptor 6VI4 A1 receptor 5UEN
TM7 268 F 7.33x32 κ receptor 6VI4 S1P1 receptor 3V2Y
TM7 269 F 7.34x33 κ receptor 6VI4 NTS1 receptor 4BUO
TM7 270 L 7.35x34 κ receptor 6VI4 NOP receptor 5DHG
TM7 271 Q 7.36x35 κ receptor 6VI4 CCR5 5UIW
TM7 272 L 7.37x36 κ receptor 6VI4 δ receptor 4N6H
TM7 273 S 7.38x37 κ receptor 6VI4 ghrelin receptor 6KO5
TM7 274 M 7.39x38 κ receptor 6VI4 NK1 receptor 6HLP
TM7 275 C 7.40x39 κ receptor 6VI4 AT1 receptor 4ZUD
TM7 276 F 7.41x40 κ receptor 6VI4 C5a1 receptor 5O9H
TM7 277 S 7.42x41 κ receptor 6VI4 apelin receptor 5VBL
TM7 278 N 7.43x42 κ receptor 6VI4 - -
TM7 279 V 7.44x43 κ receptor 6VI4 NOP receptor 5DHG
TM7 280 N 7.45x45 κ receptor 6VI4 κ receptor 6VI4
TM7 281 C 7.46x46 κ receptor 6VI4 CCR5 5UIW
TM7 282 C 7.47x47 κ receptor 6VI4 μ receptor 4DKL
TM7 283 L 7.48x48 κ receptor 6VI4 κ receptor 6VI4
TM7 284 D 7.49x49 κ receptor 6VI4 EP4 receptor 5YWY
TM7 285 V 7.50x50 κ receptor 6VI4 - -
TM7 286 F 7.51x51 κ receptor 6VI4 CCR7 6QZH
TM7 287 C 7.52x52 κ receptor 6VI4 M5 receptor 6OL9
TM7 288 Y 7.53x53 κ receptor 6VI4 κ receptor 6VI4
TM7 289 Y 7.54x54 κ receptor 6VI4 ETB receptor 5X93
TM7 290 F 7.55x55 κ receptor 6VI4 κ receptor 6VI4
TM7 291 V 7.56x56 κ receptor 6VI4 CCR5 5UIW
H8 292 I 8.47x47 κ receptor 6VI4 A2A receptor 3VG9
H8 293 K 8.48x48 κ receptor 6VI4 ghrelin receptor 6KO5
H8 294 E 8.49x49 κ receptor 6VI4 CCR5 5UIW
H8 295 F 8.50x50 κ receptor 6VI4 κ receptor 6VI4
H8 296 R 8.51x51 κ receptor 6VI4 CCR5 5UIW
H8 297 M 8.52x52 κ receptor 6VI4 - -
H8 298 N 8.53x53 κ receptor 6VI4 - -
H8 299 I 8.54x54 κ receptor 6VI4 - -
H8 300 R 8.55x55 κ receptor 6VI4 κ receptor 6VI4
H8 301 A 8.56x56 κ receptor 6VI4 OX1 receptor 6TO7
H8 302 H 8.57x57 κ receptor 6VI4 - -
H8 303 R 8.58x58 κ receptor 6VI4 - -
H8 304 P 8.59x59 κ receptor 6VI4 - -
C-term 305 S κ receptor 6VI4 κ receptor 6VI4
C-term 306 R - - - -
C-term 307 V - - - -
C-term 308 Q - - - -
C-term 309 L - - - -