GPR62 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-06-10

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

D3 receptor (sequence similarity: 23%) PDB: 7CMV

TEMPLATES

7BVQ (β1-adrenoceptor)
7CMV (D3 receptor)
4PXZ (P2Y12 receptor)
6K42 (α2B-adrenoceptor)
6ME7 (MT2 receptor)
3SN6 (β2-adrenoceptor)
6LFL (CXCR2)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 77.3 7.4 15.4
Side-chains 19.4 50.8 29.8

Number of backbone templates: 7
Number of rotamer templates: 48

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 6 G - - - - -
N-term 7 L - - - - -
N-term 8 N - - - - -
N-term 9 A - - - - -
N-term 10 S - - - - -
TM1 11 E 1.29x29 β1-adrenoceptor 7BVQ CXCR2 6LFO
TM1 12 V 1.30x30 β1-adrenoceptor 7BVQ β2-adrenoceptor 3SN6
TM1 13 A 1.31x31 β1-adrenoceptor 7BVQ α2C-adrenoceptor 6KUW
TM1 14 G 1.32x32 β1-adrenoceptor 7BVQ D4 receptor 5WIV
TM1 15 S 1.33x33 β1-adrenoceptor 7BVQ A2A receptor 4UHR
TM1 16 L 1.34x34 β1-adrenoceptor 7BVQ 5-HT1B receptor 6G79
TM1 17 G 1.35x35 D3 receptor 7CMV - -
TM1 18 L 1.36x36 D3 receptor 7CMV V2 receptor 7KH0
TM1 19 I 1.37x37 D3 receptor 7CMV β2-adrenoceptor 3SN6
TM1 20 L 1.38x38 D3 receptor 7CMV CCK1 receptor 7MBX
TM1 21 A 1.39x39 D3 receptor 7CMV M2 receptor 4MQT
TM1 22 A 1.40x40 D3 receptor 7CMV β1-adrenoceptor 7BU7
TM1 23 V 1.41x41 D3 receptor 7CMV 5-HT1D receptor 7E32
TM1 24 V 1.42x42 D3 receptor 7CMV CXCR2 6LFO
TM1 25 E 1.43x43 D3 receptor 7CMV - -
TM1 26 V 1.44x44 D3 receptor 7CMV OX2 receptor 7L1V
TM1 27 G 1.45x45 D3 receptor 7CMV NOP receptor 5DHG
TM1 28 A 1.46x46 D3 receptor 7CMV OX2 receptor 7L1V
TM1 29 L 1.47x47 D3 receptor 7CMV CXCR2 6LFO
TM1 30 L 1.48x48 D3 receptor 7CMV CCK1 receptor 7MBX
TM1 31 G 1.49x49 D3 receptor 7CMV D3 receptor 7CMV
TM1 32 N 1.50x50 D3 receptor 7CMV D3 receptor 7CMV
TM1 33 G 1.51x51 D3 receptor 7CMV D3 receptor 7CMV
TM1 34 A 1.52x52 D3 receptor 7CMV 5-ht1E receptor 7E33
TM1 35 L 1.53x53 D3 receptor 7CMV GPBA receptor 7CFN
TM1 36 L 1.54x54 D3 receptor 7CMV 5-HT1D receptor 7E32
TM1 37 V 1.55x55 D3 receptor 7CMV β1-adrenoceptor 7BU7
TM1 38 V 1.56x56 D3 receptor 7CMV CCK1 receptor 7MBX
TM1 39 V 1.57x57 D3 receptor 7CMV D3 receptor 7CMV
TM1 40 L 1.58x58 D3 receptor 7CMV D3 receptor 7CMV
TM1 41 R 1.59x59 D3 receptor 7CMV CCK1 receptor 7MBX
TM1 42 T 1.60x60 D3 receptor 7CMV β1-adrenoceptor 7BU7
ICL1 43 P - - - - -
ICL1 44 G - - - - -
TM2 45 L 2.37x37 D3 receptor 7CMV - -
TM2 46 R 2.38x38 D3 receptor 7CMV OT receptor 6TPK
TM2 47 D 2.39x39 D3 receptor 7CMV - -
TM2 48 A 2.40x40 D3 receptor 7CMV BLT1 receptor 7K15
TM2 49 L 2.41x41 D3 receptor 7CMV α2B-adrenoceptor 6K42
TM2 50 Y 2.42x42 D3 receptor 7CMV CXCR2 6LFO
TM2 51 L 2.43x43 D3 receptor 7CMV CCK1 receptor 7MBX
TM2 52 A 2.44x44 D3 receptor 7CMV 5-HT1B receptor 6G79
TM2 53 H 2.45x45 D3 receptor 7CMV V2 receptor 7KH0
TM2 54 L 2.46x46 D3 receptor 7CMV D3 receptor 7CMV
TM2 55 C 2.47x47 D3 receptor 7CMV V2 receptor 7KH0
TM2 56 V 2.48x48 D3 receptor 7CMV D3 receptor 7CMV
TM2 57 V 2.49x49 D3 receptor 7CMV - -
TM2 58 D 2.50x50 D3 receptor 7CMV D3 receptor 7CMV
TM2 59 L 2.51x51 D3 receptor 7CMV D3 receptor 7CMV
TM2 60 L 2.52x52 D3 receptor 7CMV D3 receptor 7CMV
TM2 61 A 2.53x53 D3 receptor 7CMV δ receptor 6PT2
TM2 62 A 2.54x54 D3 receptor 7CMV D3 receptor 7CMV
TM2 63 A 2.55x55 D3 receptor 7CMV H1 receptor 7DFL
TM2 64 S 2.56x551 D3 receptor 7CMV - -
TM2 65 I 2.57x56 D3 receptor 7CMV α2B-adrenoceptor 6K42
TM2 66 M 2.58x57 D3 receptor 7CMV D3 receptor 7CMV
TM2 67 P 2.59x58 D3 receptor 7CMV D3 receptor 7CMV
TM2 68 L 2.60x59 D3 receptor 7CMV 5-ht1E receptor 7E33
TM2 69 G 2.61x60 D3 receptor 7CMV β1-adrenoceptor 7BU7
TM2 70 L 2.62x61 D3 receptor 7CMV CCK1 receptor 7MBX
TM2 71 L 2.63x62 D3 receptor 7CMV 5-HT1A receptor 7E2X
TM2 72 A 2.64x63 D3 receptor 7CMV 5-HT2C receptor 6BQG
TM2 73 A 2.65x64 D3 receptor 7CMV CXCR4 3ODU
TM2 74 P 2.66x65 D3 receptor 7CMV - -
ECL1 75 P - - - - -
ECL1 76 P - - - - -
ECL1 77 G - - - - -
ECL1 78 L - - - - -
ECL1 79 G - - - - -
ECL1 80 R - - - - -
TM3 81 V 3.18x18 P2Y12 receptor 4PXZ - -
TM3 82 R 3.19x19 P2Y12 receptor 4PXZ - -
TM3 83 L 3.20x20 P2Y12 receptor 4PXZ P2Y12 receptor 4PXZ
TM3 84 G 3.21x21 D3 receptor 7CMV CCK1 receptor 7MBX
TM3 85 P 3.22x22 D3 receptor 7CMV AT2 receptor 5UNG
TM3 86 A 3.23x23 D3 receptor 7CMV CCK1 receptor 7MBX
TM3 87 P 3.24x24 D3 receptor 7CMV US28 5WB1
TM3 88 C 3.25x25 D3 receptor 7CMV D3 receptor 7CMV
TM3 89 R 3.26x26 D3 receptor 7CMV V2 receptor 7KH0
TM3 90 A 3.27x27 D3 receptor 7CMV V2 receptor 7KH0
TM3 91 A 3.28x28 D3 receptor 7CMV AT1 receptor 6DO1
TM3 92 R 3.29x29 D3 receptor 7CMV succinate receptor 6RNK
TM3 93 F 3.30x30 D3 receptor 7CMV 5-HT2B receptor 5TUD
TM3 94 L 3.31x31 D3 receptor 7CMV D3 receptor 7CMV
TM3 95 S 3.32x32 D3 receptor 7CMV ghrelin receptor 6KO5
TM3 96 A 3.33x33 D3 receptor 7CMV CCR6 6WWZ
TM3 97 A 3.34x34 D3 receptor 7CMV CB1 receptor 6N4B
TM3 98 L 3.35x35 D3 receptor 7CMV A2A receptor 4UHR
TM3 99 L 3.36x36 D3 receptor 7CMV MC4 receptor 7AUE
TM3 100 P 3.37x37 D3 receptor 7CMV - -
TM3 101 A 3.38x38 D3 receptor 7CMV D3 receptor 7CMV
TM3 102 C 3.39x39 D3 receptor 7CMV CCR9 5LWE
TM3 103 T 3.40x40 D3 receptor 7CMV CCK1 receptor 7MBX
TM3 104 L 3.41x41 D3 receptor 7CMV D3 receptor 7CMV
TM3 105 G 3.42x42 D3 receptor 7CMV - -
TM3 106 V 3.43x43 D3 receptor 7CMV H1 receptor 7DFL
TM3 107 A 3.44x44 D3 receptor 7CMV CXCR2 6LFO
TM3 108 A 3.45x45 D3 receptor 7CMV D3 receptor 7CMV
TM3 109 L 3.46x46 D3 receptor 7CMV H1 receptor 7DFL
TM3 110 G 3.47x47 D3 receptor 7CMV - -
TM3 111 L 3.48x48 D3 receptor 7CMV CCK1 receptor 7MBX
TM3 112 A 3.49x49 D3 receptor 7CMV NTS1 receptor 4XES
TM3 113 R 3.50x50 D3 receptor 7CMV D3 receptor 7CMV
TM3 114 Y 3.51x51 D3 receptor 7CMV D3 receptor 7CMV
TM3 115 R 3.52x52 D3 receptor 7CMV V2 receptor 7KH0
TM3 116 L 3.53x53 D3 receptor 7CMV Y1 receptor 5ZBH
TM3 117 I 3.54x54 D3 receptor 7CMV CCK1 receptor 7MBX
TM3 118 V 3.55x55 D3 receptor 7CMV D3 receptor 7CMV
TM3 119 H 3.56x56 D3 receptor 7CMV CXCR2 6LFO
ICL2 120 P - - - - -
ICL2 121 L - - - - -
ICL2 122 R - - - - -
ICL2 123 P - - - - -
ICL2 124 G - - - - -
ICL2 125 S - - - - -
ICL2 126 R - - - - -
ICL2 127 P - - - - -
TM4 128 P 4.41x41 D3 receptor 7CMV - -
TM4 129 P 4.42x42 D3 receptor 7CMV - -
TM4 130 V 4.43x43 D3 receptor 7CMV CB1 receptor 6N4B
TM4 131 L 4.44x44 D3 receptor 7CMV D3 receptor 7CMV
TM4 132 V 4.45x45 D3 receptor 7CMV CCK1 receptor 7MBX
TM4 133 L 4.46x46 D3 receptor 7CMV EP4 receptor 7D7M
TM4 134 T 4.47x47 D3 receptor 7CMV D3 receptor 7CMV
TM4 135 A 4.48x48 D3 receptor 7CMV D3 receptor 7CMV
TM4 136 V 4.49x49 D3 receptor 7CMV D3 receptor 7CMV
TM4 137 W 4.50x50 D3 receptor 7CMV D3 receptor 7CMV
TM4 138 A 4.51x51 D3 receptor 7CMV β1-adrenoceptor 7BU7
TM4 139 A 4.52x52 D3 receptor 7CMV MC4 receptor 7AUE
TM4 140 A 4.53x53 D3 receptor 7CMV D3 receptor 7CMV
TM4 141 G 4.54x54 D3 receptor 7CMV β2-adrenoceptor 3SN6
TM4 142 L 4.55x55 D3 receptor 7CMV β1-adrenoceptor 7BU7
TM4 143 L 4.56x56 D3 receptor 7CMV CXCR2 6LFO
TM4 144 G 4.57x57 α2B-adrenoceptor 6K42 A2A receptor 4UHR
TM4 145 A 4.58x58 α2B-adrenoceptor 6K42 EP4 receptor 7D7M
TM4 146 L 4.59x59 α2B-adrenoceptor 6K42 β1-adrenoceptor 7BU7
TM4 147 S 4.60x60 D3 receptor 7CMV CCR6 6WWZ
TM4 148 L 4.61x61 D3 receptor 7CMV D3 receptor 7CMV
TM4 149 L 4.62x62 D3 receptor 7CMV D3 receptor 7CMV
TM4 150 G 4.63x63 D3 receptor 7CMV 5-HT1A receptor 7E2X
TM4 151 T 4.64x64 D3 receptor 7CMV NTS1 receptor 4XES
ECL2 152 P - D3 receptor 7CMV - -
ECL2 153 P - D3 receptor 7CMV - -
ECL2 154 A - D3 receptor 7CMV - -
ECL2 155 P - D3 receptor 7CMV - -
ECL2 156 P - D3 receptor 7CMV - -
ECL2 157 P - D3 receptor 7CMV - -
ECL2 158 A - D3 receptor 7CMV - -
ECL2 159 P - D3 receptor 7CMV - -
ECL2 160 A - D3 receptor 7CMV - -
ECL2 161 R - - - - -
ECL2 162 C 45.50x50 D3 receptor 7CMV D3 receptor 7CMV
ECL2 163 S 45.51x51 D3 receptor 7CMV D3 receptor 7CMV
ECL2 164 V 45.52x52 D3 receptor 7CMV 5-HT1D receptor 7E32
ECL2 165 L - - - - -
ECL2 166 A - MT2 receptor 6ME7 - -
ECL2 167 G - MT2 receptor 6ME7 MT2 receptor 6ME7
ECL2 168 G - - - - -
TM5 169 L 5.35x36 D3 receptor 7CMV - -
TM5 170 G 5.36x37 D3 receptor 7CMV 5-HT2B receptor 5TUD
TM5 171 P 5.37x38 D3 receptor 7CMV GPBA receptor 7CFN
TM5 172 F 5.38x39 D3 receptor 7CMV D3 receptor 7CMV
TM5 173 R 5.39x40 D3 receptor 7CMV CXCR2 6LFO
TM5 174 P 5.40x41 D3 receptor 7CMV - -
TM5 175 L 5.41x42 D3 receptor 7CMV CXCR2 6LFO
TM5 176 W 5.42x43 D3 receptor 7CMV CB1 receptor 6N4B
TM5 177 A 5.43x44 D3 receptor 7CMV V2 receptor 7KH0
TM5 178 L 5.44x45 D3 receptor 7CMV CCK1 receptor 7MBX
TM5 179 L 5.45x46 D3 receptor 7CMV AT2 receptor 5UNG
TM5 180 A 5.46x461 D3 receptor 7CMV 5-HT1D receptor 7E32
TM5 181 F 5.47x47 D3 receptor 7CMV D3 receptor 7CMV
TM5 182 A 5.48x48 D3 receptor 7CMV CB2 receptor 6PT0
TM5 183 L 5.49x49 D3 receptor 7CMV D3 receptor 7CMV
TM5 184 P 5.50x50 D3 receptor 7CMV D3 receptor 7CMV
TM5 185 A 5.51x51 D3 receptor 7CMV GPR52 6LI3
TM5 186 L 5.52x52 D3 receptor 7CMV α2B-adrenoceptor 6K42
TM5 187 L 5.53x53 D3 receptor 7CMV 5-HT1D receptor 7E32
TM5 188 L 5.54x54 D3 receptor 7CMV 5-HT1D receptor 7E32
TM5 189 L 5.55x55 D3 receptor 7CMV D2 receptor 7JVR
TM5 190 G 5.56x56 D3 receptor 7CMV A2A receptor 4UHR
TM5 191 A 5.57x57 D3 receptor 7CMV CCK1 receptor 7MBX
TM5 192 Y 5.58x58 D3 receptor 7CMV D3 receptor 7CMV
TM5 193 G 5.59x59 D3 receptor 7CMV CCK1 receptor 7MBX
TM5 194 G 5.60x60 D3 receptor 7CMV AT2 receptor 5UNG
TM5 195 I 5.61x61 D3 receptor 7CMV D3 receptor 7CMV
TM5 196 F 5.62x62 D3 receptor 7CMV β1-adrenoceptor 7BU7
TM5 197 V 5.63x63 D3 receptor 7CMV D3 receptor 7CMV
TM5 198 V 5.64x64 D3 receptor 7CMV D3 receptor 7CMV
TM5 199 A 5.65x65 D3 receptor 7CMV α2B-adrenoceptor 6K42
TM5 200 R 5.66x66 D3 receptor 7CMV D2 receptor 7JVR
TM5 201 R 5.67x67 D3 receptor 7CMV α2B-adrenoceptor 6K42
TM5 202 A 5.68x68 D3 receptor 7CMV AT1 receptor 6DO1
TM5 203 A 5.69x69 D3 receptor 7CMV 5-HT2B receptor 5TUD
TM5 204 L 5.70x70 D3 receptor 7CMV 5-HT1D receptor 7E32
TM5 205 R 5.71x71 D3 receptor 7CMV D2 receptor 7JVR
TM5 206 P 5.72x72 D3 receptor 7CMV - -
TM5 207 P 5.73x73 D3 receptor 7CMV - -
TM5 208 R 5.74x74 β2-adrenoceptor 3SN6 GPBA receptor 7CFN
TM5 209 P 5.75x75 β2-adrenoceptor 3SN6 - -
TM5 210 A 5.76x76 β2-adrenoceptor 3SN6 - -
ICL3 211 R - - - - -
ICL3 212 G - - - - -
ICL3 213 S - - - - -
ICL3 214 R - - - - -
ICL3 215 L - - - - -
ICL3 225 S - - - - -
ICL3 226 I - - - - -
ICL3 227 L - - - - -
ICL3 228 P - - - - -
ICL3 229 P - - - - -
TM6 230 L 6.24x24 α2B-adrenoceptor 6K42 - -
TM6 231 R 6.25x25 α2B-adrenoceptor 6K42 LPA1 receptor 4Z35
TM6 232 P 6.26x26 α2B-adrenoceptor 6K42 - -
TM6 233 R 6.27x27 D3 receptor 7CMV - -
TM6 234 L 6.28x28 D3 receptor 7CMV D3 receptor 7CMV
TM6 235 P 6.29x29 D3 receptor 7CMV P2Y1 receptor 4XNW
TM6 236 G 6.30x30 D3 receptor 7CMV - -
TM6 237 G 6.31x31 D3 receptor 7CMV US28 5WB1
TM6 238 K 6.32x32 D3 receptor 7CMV D3 receptor 7CMV
TM6 239 A 6.33x33 D3 receptor 7CMV D3 receptor 7CMV
TM6 240 A 6.34x34 D3 receptor 7CMV OX2 receptor 7L1V
TM6 241 L 6.35x35 D3 receptor 7CMV NTS1 receptor 4XES
TM6 242 A 6.36x36 D3 receptor 7CMV GPBA receptor 7CFN
TM6 243 P 6.37x37 D3 receptor 7CMV - -
TM6 244 A 6.38x38 D3 receptor 7CMV D3 receptor 7CMV
TM6 245 L 6.39x39 D3 receptor 7CMV 5-ht1E receptor 7E33
TM6 246 A 6.40x40 D3 receptor 7CMV GPBA receptor 7CFN
TM6 247 V 6.41x41 D3 receptor 7CMV CCK1 receptor 7MBX
TM6 248 G 6.42x42 D3 receptor 7CMV D3 receptor 7CMV
TM6 249 Q 6.43x43 D3 receptor 7CMV - -
TM6 250 F 6.44x44 D3 receptor 7CMV D3 receptor 7CMV
TM6 251 A 6.45x45 D3 receptor 7CMV OX2 receptor 7L1V
TM6 252 A 6.46x46 D3 receptor 7CMV CCR6 6WWZ
TM6 253 C 6.47x47 D3 receptor 7CMV D3 receptor 7CMV
TM6 254 W 6.48x48 D3 receptor 7CMV D3 receptor 7CMV
TM6 255 L 6.49x49 D3 receptor 7CMV D3 receptor 7CMV
TM6 256 P 6.50x50 D3 receptor 7CMV D3 receptor 7CMV
TM6 257 Y 6.51x51 D3 receptor 7CMV CXCR2 6LFO
TM6 258 G 6.52x52 D3 receptor 7CMV - -
TM6 259 C 6.53x53 D3 receptor 7CMV MT2 receptor 6ME7
TM6 260 A 6.54x54 D3 receptor 7CMV CCK1 receptor 7MBX
TM6 261 C 6.55x55 D3 receptor 7CMV - -
TM6 262 L 6.56x56 D3 receptor 7CMV CXCR2 6LFO
TM6 263 A 6.57x57 D3 receptor 7CMV CXCR2 6LFO
TM6 264 P 6.58x58 D3 receptor 7CMV NK1 receptor 6HLP
ECL3 265 A - - - - -
ECL3 266 A - - - - -
ECL3 267 R - - - - -
ECL3 268 A - - - - -
ECL3 269 A - - - - -
ECL3 270 E - - - - -
ECL3 271 A - - - - -
TM7 272 E 7.35x34 D3 receptor 7CMV LPA1 receptor 4Z35
TM7 273 A 7.36x35 D3 receptor 7CMV 5-HT1A receptor 7E2X
TM7 274 A 7.37x36 D3 receptor 7CMV D3 receptor 7CMV
TM7 275 V 7.38x37 D3 receptor 7CMV D4 receptor 5WIV
TM7 276 T 7.39x38 D3 receptor 7CMV D3 receptor 7CMV
TM7 277 W 7.40x39 D3 receptor 7CMV D3 receptor 7CMV
TM7 278 V 7.41x40 D3 receptor 7CMV PAR1 3VW7
TM7 279 A 7.42x41 D3 receptor 7CMV V2 receptor 7KH0
TM7 280 Y 7.43x42 D3 receptor 7CMV D3 receptor 7CMV
TM7 281 S 7.44x43 D3 receptor 7CMV 5-HT1A receptor 7E2X
TM7 282 A 7.45x45 D3 receptor 7CMV Rhodopsin 5W0P
TM7 283 F 7.46x46 D3 receptor 7CMV - -
TM7 284 A 7.47x47 D3 receptor 7CMV D3 receptor 7CMV
TM7 285 A 7.48x48 D3 receptor 7CMV OX2 receptor 7L1V
TM7 286 H 7.49x49 D3 receptor 7CMV - -
TM7 287 P 7.50x50 D3 receptor 7CMV D3 receptor 7CMV
TM7 288 F 7.51x51 D3 receptor 7CMV A2A receptor 4UHR
TM7 289 L 7.52x52 D3 receptor 7CMV 5-ht1E receptor 7E33
TM7 290 Y 7.53x53 D3 receptor 7CMV D3 receptor 7CMV
TM7 291 G 7.54x54 D3 receptor 7CMV AT1 receptor 6DO1
TM7 292 L 7.55x55 D3 receptor 7CMV 5-HT2B receptor 5TUD
TM7 293 L 7.56x56 D3 receptor 7CMV OX2 receptor 7L1V
H8 294 Q 8.47x47 D3 receptor 7CMV - -
H8 295 R 8.48x48 D3 receptor 7CMV A2A receptor 4UHR
H8 296 P 8.49x49 D3 receptor 7CMV EP2 receptor 7CX2
H8 297 V 8.50x50 D3 receptor 7CMV V2 receptor 7KH0
H8 298 R 8.51x51 D3 receptor 7CMV D3 receptor 7CMV
H8 299 L 8.52x52 D3 receptor 7CMV CCK1 receptor 7MBX
H8 300 A 8.53x53 D3 receptor 7CMV D3 receptor 7CMV
H8 301 L 8.54x54 D3 receptor 7CMV CXCR2 6LFO
H8 302 G 8.55x55 D3 receptor 7CMV 5-HT2B receptor 5TUD
H8 303 R 8.56x56 D3 receptor 7CMV α2B-adrenoceptor 6K42
H8 304 L 8.57x57 D3 receptor 7CMV β1-adrenoceptor 7BU7
H8 305 S 8.58x58 D3 receptor 7CMV GPR52 6LI3
H8 306 R 8.59x59 D3 receptor 7CMV 5-HT2C receptor 6BQG
H8 307 R 8.60x60 CXCR2 6LFL - -
H8 308 A 8.61x61 CXCR2 6LFL - -
C-term 309 L - - - - -
C-term 310 P - - - - -
C-term 311 G - - - - -
C-term 312 P - - - - -
C-term 313 V - - - - -