GPR6 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

GPR6

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-04-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

D2 receptor (sequence similarity: 24%) PDB: 7JVR
Align

TEMPLATES

7JVR (D2 receptor)
6W25 (MC4 receptor)
4Z35 (LPA1 receptor)
5NM4 (A2A receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 77.7 9.9 12.4
Side-chains 23.7 55.5 20.8

Number of backbone templates: 4
Number of rotamer templates: 51

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 70 P - - - - -
N-term 71 A - - - - -
N-term 72 V - - - - -
N-term 73 N - - - - -
N-term 74 P - - - - -
TM1 75 W 1.35x35 D2 receptor 7JVR 5-HT2B receptor 5TVN
TM1 76 D 1.36x36 D2 receptor 7JVR - -
TM1 77 V 1.37x37 D2 receptor 7JVR H1 receptor 7DFL
TM1 78 L 1.38x38 D2 receptor 7JVR D2 receptor 7JVR
TM1 79 L 1.39x39 D2 receptor 7JVR D2 receptor 7JVR
TM1 80 C 1.40x40 D2 receptor 7JVR D3 receptor 7CMV
TM1 81 V 1.41x41 D2 receptor 7JVR κ receptor 6B73
TM1 82 S 1.42x42 D2 receptor 7JVR BLT1 receptor 5X33
TM1 83 G 1.43x43 D2 receptor 7JVR CB1 receptor 6N4B
TM1 84 T 1.44x44 D2 receptor 7JVR CB1 receptor 6N4B
TM1 85 V 1.45x45 D2 receptor 7JVR D2 receptor 7JVR
TM1 86 I 1.46x46 D2 receptor 7JVR D2 receptor 7JVR
TM1 87 A 1.47x47 D2 receptor 7JVR CB2 receptor 6PT0
TM1 88 G 1.48x48 D2 receptor 7JVR H1 receptor 7DFL
TM1 89 E 1.49x49 D2 receptor 7JVR CB1 receptor 5XRA
TM1 90 N 1.50x50 D2 receptor 7JVR D2 receptor 7JVR
TM1 91 A 1.51x51 D2 receptor 7JVR α2B-adrenoceptor 6K42
TM1 92 L 1.52x52 D2 receptor 7JVR D2 receptor 7JVR
TM1 93 V 1.53x53 D2 receptor 7JVR D2 receptor 7JVR
TM1 94 V 1.54x54 D2 receptor 7JVR AT1 receptor 6DO1
TM1 95 A 1.55x55 D2 receptor 7JVR 5-HT1B receptor 6G79
TM1 96 L 1.56x56 D2 receptor 7JVR CB2 receptor 6PT0
TM1 97 I 1.57x57 D2 receptor 7JVR CB1 receptor 5XRA
TM1 98 A 1.58x58 D2 receptor 7JVR β2-adrenoceptor 3SN6
TM1 99 S 1.59x59 D2 receptor 7JVR H1 receptor 7DFL
TM1 100 T 1.60x60 D2 receptor 7JVR 5-HT1B receptor 6G79
ICL1 101 P 12.48x48 - - - -
ICL1 102 A 12.49x49 MC4 receptor 6W25 D2 receptor 7JVR
ICL1 103 L 12.50x50 MC4 receptor 6W25 MC4 receptor 6W25
ICL1 104 R 12.51x51 - - - -
TM2 105 T 2.37x37 D2 receptor 7JVR D2 receptor 7JVR
TM2 106 P 2.38x38 D2 receptor 7JVR α2B-adrenoceptor 6K41
TM2 107 M 2.39x39 D2 receptor 7JVR MC4 receptor 6W25
TM2 108 F 2.40x40 D2 receptor 7JVR A1 receptor 6D9H
TM2 109 V 2.41x41 D2 receptor 7JVR CXCR2 6LFO
TM2 110 L 2.42x42 D2 receptor 7JVR D2 receptor 7JVR
TM2 111 V 2.43x43 D2 receptor 7JVR D3 receptor 7CMV
TM2 112 G 2.44x44 D2 receptor 7JVR CB1 receptor 6N4B
TM2 113 S 2.45x45 D2 receptor 7JVR D2 receptor 7JVR
TM2 114 L 2.46x46 D2 receptor 7JVR D2 receptor 7JVR
TM2 115 A 2.47x47 D2 receptor 7JVR D2 receptor 7JVR
TM2 116 T 2.48x48 D2 receptor 7JVR PAR1 3VW7
TM2 117 A 2.49x49 D2 receptor 7JVR D2 receptor 7JVR
TM2 118 D 2.50x50 D2 receptor 7JVR D2 receptor 7JVR
TM2 119 L 2.51x51 D2 receptor 7JVR D2 receptor 7JVR
TM2 120 L 2.52x52 D2 receptor 7JVR D2 receptor 7JVR
TM2 121 A 2.53x53 D2 receptor 7JVR CB2 receptor 6PT0
TM2 122 G 2.54x54 D2 receptor 7JVR H1 receptor 7DFL
TM2 123 C 2.55x55 MC4 receptor 6W25 US28 5WB1
TM2 124 G 2.56x56 MC4 receptor 6W25 Rhodopsin 4X1H
TM2 125 L 2.57x57 D2 receptor 7JVR CXCR2 6LFO
TM2 126 I 2.58x58 D2 receptor 7JVR - -
TM2 127 L 2.59x59 D2 receptor 7JVR 5-HT2C receptor 6BQG
TM2 128 H 2.60x60 D2 receptor 7JVR - -
TM2 129 F 2.61x61 D2 receptor 7JVR CB1 receptor 6N4B
TM2 130 V 2.62x62 D2 receptor 7JVR D1 receptor 7JVQ
ECL1 131 F - - - - -
ECL1 132 Q 23.49x49 LPA1 receptor 4Z35 - -
ECL1 133 Y 23.50x50 LPA1 receptor 4Z35 - -
ECL1 134 L 23.51x51 LPA1 receptor 4Z35 AT2 receptor 5UNG
ECL1 135 V 23.52x52 LPA1 receptor 4Z35 LPA1 receptor 4Z35
TM3 136 P 3.20x20 MC4 receptor 6W25 - -
TM3 137 S 3.21x21 D2 receptor 7JVR D2 receptor 7JVR
TM3 138 E 3.22x22 D2 receptor 7JVR δ receptor 6PT2
TM3 139 T 3.23x23 D2 receptor 7JVR Rhodopsin 4X1H
TM3 140 V 3.24x24 D2 receptor 7JVR CB1 receptor 6N4B
TM3 141 S 3.25x25 D2 receptor 7JVR - -
TM3 142 L 3.26x26 D2 receptor 7JVR CB1 receptor 6N4B
TM3 143 L 3.27x27 D2 receptor 7JVR CB2 receptor 6PT0
TM3 144 T 3.28x28 D2 receptor 7JVR P2Y12 receptor 4NTJ
TM3 145 V 3.29x29 D2 receptor 7JVR D2 receptor 7JVR
TM3 146 G 3.30x30 D2 receptor 7JVR CB1 receptor 6N4B
TM3 147 F 3.31x31 D2 receptor 7JVR D1 receptor 7JVQ
TM3 148 L 3.32x32 D2 receptor 7JVR EP4 receptor 7D7M
TM3 149 V 3.33x33 D2 receptor 7JVR D2 receptor 7JVR
TM3 150 A 3.34x34 D2 receptor 7JVR CB1 receptor 6N4B
TM3 151 S 3.35x35 D2 receptor 7JVR CB1 receptor 6N4B
TM3 152 F 3.36x36 D2 receptor 7JVR CB1 receptor 6N4B
TM3 153 A 3.37x37 D2 receptor 7JVR A2A receptor 4UHR
TM3 154 A 3.38x38 D2 receptor 7JVR D2 receptor 7JVR
TM3 155 S 3.39x39 D2 receptor 7JVR D2 receptor 7JVR
TM3 156 V 3.40x40 D2 receptor 7JVR CB1 receptor 6N4B
TM3 157 S 3.41x41 D2 receptor 7JVR EP4 receptor 7D7M
TM3 158 S 3.42x42 D2 receptor 7JVR CB1 receptor 6N4B
TM3 159 L 3.43x43 D2 receptor 7JVR D2 receptor 7JVR
TM3 160 L 3.44x44 D2 receptor 7JVR CB2 receptor 6PT0
TM3 161 A 3.45x45 D2 receptor 7JVR D2 receptor 7JVR
TM3 162 I 3.46x46 D2 receptor 7JVR D2 receptor 7JVR
TM3 163 T 3.47x47 D2 receptor 7JVR Rhodopsin 6I9K
TM3 164 V 3.48x48 D2 receptor 7JVR D1 receptor 7JVQ
TM3 165 D 3.49x49 D2 receptor 7JVR D2 receptor 7JVR
TM3 166 R 3.50x50 D2 receptor 7JVR D2 receptor 7JVR
TM3 167 Y 3.51x51 D2 receptor 7JVR D2 receptor 7JVR
TM3 168 L 3.52x52 D2 receptor 7JVR CB2 receptor 6PT0
TM3 169 S 3.53x53 D2 receptor 7JVR CB1 receptor 6N4B
TM3 170 L 3.54x54 D2 receptor 7JVR CB2 receptor 6PT0
TM3 171 Y 3.55x55 D2 receptor 7JVR - -
TM3 172 N 3.56x56 D2 receptor 7JVR 5-HT2C receptor 6BQG
ICL2 173 A 34.50x50 - - - -
ICL2 174 L 34.51x51 MC4 receptor 6W25 MC4 receptor 6W25
ICL2 175 T 34.52x52 MC4 receptor 6W25 M2 receptor 4MQT
ICL2 176 Y 34.53x53 MC4 receptor 6W25 MC4 receptor 6W25
ICL2 177 Y 34.54x54 MC4 receptor 6W25 - -
ICL2 178 S 34.55x55 MC4 receptor 6W25 α2B-adrenoceptor 6K42
ICL2 179 R 34.56x56 MC4 receptor 6W25 AT1 receptor 6DO1
ICL2 180 R 34.57x57 - - - -
TM4 181 T 4.38x38 D2 receptor 7JVR κ receptor 4DJH
TM4 182 L 4.39x39 D2 receptor 7JVR CCR6 6WWZ
TM4 183 L 4.40x40 D2 receptor 7JVR AT1 receptor 6DO1
TM4 184 G 4.41x41 D2 receptor 7JVR Rhodopsin 6I9K
TM4 185 V 4.42x42 D2 receptor 7JVR D2 receptor 7JVR
TM4 186 H 4.43x43 D2 receptor 7JVR DP2 receptor 6D27
TM4 187 L 4.44x44 D2 receptor 7JVR D3 receptor 7CMV
TM4 188 L 4.45x45 D2 receptor 7JVR D1 receptor 7JVQ
TM4 189 L 4.46x46 D2 receptor 7JVR CB2 receptor 6PT0
TM4 190 A 4.47x47 D2 receptor 7JVR 5-HT1B receptor 6G79
TM4 191 A 4.48x48 D2 receptor 7JVR D3 receptor 7CMV
TM4 192 T 4.49x49 D2 receptor 7JVR Rhodopsin 4X1H
TM4 193 W 4.50x50 D2 receptor 7JVR D2 receptor 7JVR
TM4 194 T 4.51x51 D2 receptor 7JVR CB1 receptor 5XRA
TM4 195 V 4.52x52 D2 receptor 7JVR M1 receptor 6OIJ
TM4 196 S 4.53x53 D2 receptor 7JVR D2 receptor 7JVR
TM4 197 L 4.54x54 D2 receptor 7JVR CXCR2 6LFO
TM4 198 G 4.55x55 D2 receptor 7JVR 5-HT2C receptor 6BQG
TM4 199 L 4.56x56 D2 receptor 7JVR M1 receptor 6OIJ
TM4 200 G 4.57x57 MC4 receptor 6W25 MC4 receptor 6W25
TM4 201 L 4.58x58 MC4 receptor 6W25 α2B-adrenoceptor 6K42
TM4 202 L 4.59x59 MC4 receptor 6W25 MC4 receptor 6W25
TM4 203 P 4.60x60 D2 receptor 7JVR D2 receptor 7JVR
TM4 204 V 4.61x61 D2 receptor 7JVR D1 receptor 7JVQ
TM4 205 L 4.62x62 D2 receptor 7JVR D2 receptor 7JVR
TM4 206 G 4.63x63 D2 receptor 7JVR CB1 receptor 5XRA
TM4 207 W 4.64x64 D2 receptor 7JVR M1 receptor 6OIJ
ECL2 208 N - - - - -
ECL2 209 C - - - - -
ECL2 210 L - - - - -
ECL2 211 A - - - - -
ECL2 212 E - - - - -
ECL2 213 R - - - - -
ECL2 214 A - - - - -
ECL2 215 A - - - - -
ECL2 216 C - - - - -
ECL2 217 S - - - - -
ECL2 218 V - - - - -
ECL2 219 V - - - - -
ECL2 220 R - - - - -
ECL2 221 P - - - - -
ECL2 222 L - - - - -
TM5 223 A 5.36x36 D2 receptor 7JVR - -
TM5 224 R 5.37x37 D2 receptor 7JVR D1 receptor 7JVQ
TM5 225 S 5.38x38 D2 receptor 7JVR Rhodopsin 4X1H
TM5 226 H 5.39x39 D2 receptor 7JVR CCR2 5T1A
TM5 227 V 5.40x40 D2 receptor 7JVR D2 receptor 7JVR
TM5 228 A 5.41x41 D2 receptor 7JVR MT2 receptor 6ME7
TM5 229 L 5.42x42 D2 receptor 7JVR CXCR2 6LFO
TM5 230 L 5.43x43 D2 receptor 7JVR US28 5WB1
TM5 231 S 5.44x44 D2 receptor 7JVR D2 receptor 7JVR
TM5 232 A 5.45x45 D2 receptor 7JVR - -
TM5 233 A 5.46x46 MC4 receptor 6W25 A2A receptor 4UHR
TM5 234 F 5.47x47 MC4 receptor 6W25 MC4 receptor 6W25
TM5 235 F 5.48x48 D2 receptor 7JVR α2B-adrenoceptor 6K42
TM5 236 M 5.49x49 D2 receptor 7JVR μ receptor 5C1M
TM5 237 V 5.50x50 D2 receptor 7JVR PAF receptor 5ZKQ
TM5 238 F 5.51x51 D2 receptor 7JVR D2 receptor 7JVR
TM5 239 G 5.52x52 D2 receptor 7JVR D3 receptor 7CMV
TM5 240 I 5.53x53 D2 receptor 7JVR α2B-adrenoceptor 6K42
TM5 241 M 5.54x54 D2 receptor 7JVR H1 receptor 7DFL
TM5 242 L 5.55x55 D2 receptor 7JVR D2 receptor 7JVR
TM5 243 H 5.56x56 D2 receptor 7JVR - -
TM5 244 L 5.57x57 D2 receptor 7JVR 5-HT1B receptor 6G79
TM5 245 Y 5.58x58 D2 receptor 7JVR D2 receptor 7JVR
TM5 246 V 5.59x59 D2 receptor 7JVR EP4 receptor 7D7M
TM5 247 R 5.60x60 D2 receptor 7JVR α2B-adrenoceptor 6K42
TM5 248 I 5.61x61 D2 receptor 7JVR D2 receptor 7JVR
TM5 249 C 5.62x62 D2 receptor 7JVR EP4 receptor 7D7M
TM5 250 Q 5.63x63 D2 receptor 7JVR β2-adrenoceptor 3SN6
TM5 251 V 5.64x64 D2 receptor 7JVR D2 receptor 7JVR
TM5 252 V 5.65x65 D2 receptor 7JVR H1 receptor 7DFL
TM5 253 W 5.66x66 D2 receptor 7JVR NK1 receptor 6J20
TM5 254 R 5.67x67 D2 receptor 7JVR D2 receptor 7JVR
TM5 255 H 5.68x68 D2 receptor 7JVR CB1 receptor 6N4B
TM5 256 A 5.69x69 D2 receptor 7JVR CB1 receptor 6N4B
TM5 257 H 5.70x70 D2 receptor 7JVR NTS1 receptor 7L0P
TM5 258 Q 5.71x71 D2 receptor 7JVR A2A receptor 4UHR
TM5 259 I 5.72x72 D2 receptor 7JVR D1 receptor 7JVQ
TM5 260 A 5.73x73 D2 receptor 7JVR D1 receptor 7JVQ
ICL3 261 L - - - - -
ICL3 262 Q - - - - -
ICL3 263 Q - - - - -
ICL3 264 H - - - - -
ICL3 265 C - - - - -
TM6 266 L 6.22x22 A2A receptor 5NM4 - -
TM6 267 A 6.23x23 A2A receptor 5NM4 A2A receptor 5NM4
TM6 268 P 6.24x24 A2A receptor 5NM4 NTS1 receptor 5T04
TM6 269 P 6.25x25 A2A receptor 5NM4 - -
TM6 270 H 6.26x26 A2A receptor 5NM4 ETB receptor 5X93
TM6 271 L 6.27x27 D2 receptor 7JVR α2B-adrenoceptor 6K42
TM6 272 A 6.28x28 D2 receptor 7JVR 5-HT1B receptor 6G79
TM6 273 A 6.29x29 D2 receptor 7JVR Rhodopsin 4X1H
TM6 274 T 6.30x30 D2 receptor 7JVR GPBA receptor 7CFN
TM6 275 R 6.31x31 D2 receptor 7JVR H1 receptor 7DFL
TM6 276 K 6.32x32 D2 receptor 7JVR D2 receptor 7JVR
TM6 277 G 6.33x33 D2 receptor 7JVR NTS1 receptor 4XES
TM6 278 V 6.34x34 D2 receptor 7JVR NTS1 receptor 4XES
TM6 279 G 6.35x35 D2 receptor 7JVR - -
TM6 280 T 6.36x36 D2 receptor 7JVR CB1 receptor 6N4B
TM6 281 L 6.37x37 D2 receptor 7JVR D2 receptor 7JVR
TM6 282 A 6.38x38 D2 receptor 7JVR D2 receptor 7JVR
TM6 283 V 6.39x39 D2 receptor 7JVR α2B-adrenoceptor 6K42
TM6 284 V 6.40x40 D2 receptor 7JVR D2 receptor 7JVR
TM6 285 L 6.41x41 D2 receptor 7JVR D2 receptor 7JVR
TM6 286 G 6.42x42 D2 receptor 7JVR D2 receptor 7JVR
TM6 287 T 6.43x43 D2 receptor 7JVR β2-adrenoceptor 3SN6
TM6 288 F 6.44x44 D2 receptor 7JVR D2 receptor 7JVR
TM6 289 G 6.45x45 D2 receptor 7JVR GPBA receptor 7CFN
TM6 290 A 6.46x46 D2 receptor 7JVR CCR6 6WWZ
TM6 291 S 6.47x47 D2 receptor 7JVR A1 receptor 6D9H
TM6 292 W 6.48x48 D2 receptor 7JVR D2 receptor 7JVR
TM6 293 L 6.49x49 D2 receptor 7JVR D2 receptor 7JVR
TM6 294 P 6.50x50 D2 receptor 7JVR D2 receptor 7JVR
TM6 295 F 6.51x51 D2 receptor 7JVR D2 receptor 7JVR
TM6 296 A 6.52x52 D2 receptor 7JVR Rhodopsin 4X1H
TM6 297 I 6.53x53 D2 receptor 7JVR D2 receptor 7JVR
TM6 298 Y 6.54x54 D2 receptor 7JVR μ receptor 5C1M
TM6 299 C 6.55x55 D2 receptor 7JVR - -
TM6 300 V 6.56x56 D2 receptor 7JVR CB1 receptor 5XRA
TM6 301 V 6.57x57 D2 receptor 7JVR H1 receptor 7DFL
TM6 302 G 6.58x58 D2 receptor 7JVR α2B-adrenoceptor 6K42
TM6 303 S 6.59x59 D2 receptor 7JVR GPR52 6LI3
TM6 304 H 6.60x60 D2 receptor 7JVR D2 receptor 7JVR
TM6 305 E 6.61x61 D2 receptor 7JVR - -
ECL3 306 D - D2 receptor 7JVR D2 receptor 7JVR
ECL3 307 P - D2 receptor 7JVR - -
ECL3 308 A - D2 receptor 7JVR - -
ECL3 309 V - D2 receptor 7JVR - -
TM7 310 Y 7.34x33 D2 receptor 7JVR M3 receptor 5ZHP
TM7 311 T 7.35x34 D2 receptor 7JVR A1 receptor 6D9H
TM7 312 Y 7.36x35 D2 receptor 7JVR A2A receptor 4UHR
TM7 313 A 7.37x36 D2 receptor 7JVR D2 receptor 7JVR
TM7 314 T 7.38x37 D2 receptor 7JVR H1 receptor 7DFL
TM7 315 L 7.39x38 D2 receptor 7JVR GPBA receptor 7CFN
TM7 316 L 7.40x39 D2 receptor 7JVR AT2 receptor 5UNG
TM7 317 P 7.41x40 D2 receptor 7JVR - -
TM7 318 A 7.42x41 D2 receptor 7JVR Rhodopsin 4X1H
TM7 319 T 7.43x42 D2 receptor 7JVR PAR2 5NDD
TM7 320 Y 7.44x43 D2 receptor 7JVR - -
TM7 321 N 7.45x45 D2 receptor 7JVR D2 receptor 7JVR
TM7 322 S 7.46x46 D2 receptor 7JVR D2 receptor 7JVR
TM7 323 M 7.47x47 D2 receptor 7JVR CB2 receptor 6PT0
TM7 324 I 7.48x48 D2 receptor 7JVR D2 receptor 6VMS
TM7 325 N 7.49x49 D2 receptor 7JVR D2 receptor 7JVR
TM7 326 P 7.50x50 D2 receptor 7JVR D2 receptor 7JVR
TM7 327 I 7.51x51 D2 receptor 7JVR D2 receptor 7JVR
TM7 328 I 7.52x52 D2 receptor 7JVR D2 receptor 7JVR
TM7 329 Y 7.53x53 D2 receptor 7JVR D2 receptor 7JVR
TM7 330 A 7.54x54 D2 receptor 7JVR CB1 receptor 6N4B
TM7 331 F 7.55x55 D2 receptor 7JVR D1 receptor 7JVQ
TM7 332 R 7.56x56 D2 receptor 7JVR CB1 receptor 6N4B
H8 333 N 8.47x47 D2 receptor 7JVR D2 receptor 7JVR
H8 334 Q 8.48x48 D2 receptor 7JVR α2B-adrenoceptor 6K42
H8 335 E 8.49x49 D2 receptor 7JVR D2 receptor 7JVR
H8 336 I 8.50x50 D2 receptor 7JVR CB2 receptor 6PT0
H8 337 Q 8.51x51 D2 receptor 7JVR AT2 receptor 5UNF
H8 338 R 8.52x52 D2 receptor 7JVR α2B-adrenoceptor 6K42
H8 339 A 8.53x53 D2 receptor 7JVR D2 receptor 7JVR
H8 340 L 8.54x54 D2 receptor 7JVR CXCR2 6LFO
H8 341 W 8.55x55 D2 receptor 7JVR - -
H8 342 L 8.56x56 D2 receptor 7JVR M1 receptor 6OIJ
H8 343 L 8.57x57 D2 receptor 7JVR 5-HT1B receptor 6G79
H8 344 L 8.58x58 D2 receptor 7JVR D2 receptor 7JVR
H8 345 C 8.59x59 MC4 receptor 6W25 MC4 receptor 6W25
H8 346 G 8.60x60 MC4 receptor 6W25 - -
H8 347 C 8.61x61 MC4 receptor 6W25 OX2 receptor 5WQC
C-term 348 F - - - - -
C-term 349 Q - - - - -
C-term 350 S - - - - -
C-term 351 K - - - - -
C-term 352 V - - - - -