mGlu3 receptor homology model

PROTEIN CLASS

Class C (Glutamate)

RECEPTOR

mGlu3 receptor

SPECIES

Homo sapiens

STATE

Inactive

VERSION

2021-02-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

mGlu5 receptor (sequence similarity: 67%) PDB: 4OO9
Align

TEMPLATES

4OO9 (mGlu5 receptor)
6FFI (mGlu5 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 79.8 1.1 19.1
Side-chains 41.9 8.7 49.5

Number of backbone templates: 2
Number of rotamer templates: 6

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 570 I mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
N-term 571 R mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
N-term 572 W mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
N-term 573 E mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
N-term 574 D mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 575 A 1.38x38 mGlu5 receptor 4OO9 - -
TM1 576 W 1.39x39 mGlu5 receptor 4OO9 - -
TM1 577 A 1.40x40 mGlu5 receptor 4OO9 - -
TM1 578 I 1.41x41 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 579 G 1.42x42 mGlu5 receptor 4OO9 - -
TM1 580 P 1.43x43 mGlu5 receptor 4OO9 - -
TM1 581 V 1.44x44 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 582 T 1.45x45 mGlu5 receptor 4OO9 - -
TM1 583 I 1.46x46 mGlu5 receptor 4OO9 - -
TM1 584 A 1.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 585 C 1.48x48 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 586 L 1.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 587 G 1.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 588 F 1.51x51 mGlu5 receptor 4OO9 - -
TM1 589 M 1.52x52 mGlu5 receptor 4OO9 - -
TM1 590 C 1.53x53 mGlu5 receptor 4OO9 - -
TM1 591 T 1.54x54 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 592 C 1.55x55 mGlu5 receptor 4OO9 - -
TM1 593 M 1.56x56 mGlu5 receptor 4OO9 - -
TM1 594 V 1.57x57 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 595 V 1.58x58 mGlu5 receptor 4OO9 - -
TM1 596 T 1.59x59 mGlu5 receptor 4OO9 - -
TM1 597 V 1.60x60 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 598 F 1.61x61 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 599 I 1.62x62 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 600 K 1.63x63 mGlu5 receptor 4OO9 GABAB2 7C7S
TM1 601 H 1.64x64 mGlu5 receptor 4OO9 - -
ICL1 602 N mGlu5 receptor 4OO9 - -
ICL1 603 N mGlu5 receptor 4OO9 - -
ICL1 604 T 12.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL1 605 P 12.48x48 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL1 606 L 12.49x49 mGlu5 receptor 4OO9 GABAB2 7C7S
ICL1 607 V 12.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL1 608 K 12.51x51 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL1 609 A 12.52x52 mGlu5 receptor 4OO9 - -
ICL1 610 S 12.53x53 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 611 G 2.35x35 mGlu5 receptor 4OO9 - -
TM2 612 R 2.36x36 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 613 E 2.37x37 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 614 L 2.38x38 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 615 C 2.39x39 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 616 Y 2.40x40 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 617 I 2.41x41 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 618 L 2.42x42 mGlu5 receptor 4OO9 - -
TM2 619 L 2.43x43 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 620 F 2.44x44 mGlu5 receptor 4OO9 - -
TM2 621 G 2.45x45 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 622 V 2.46x46 mGlu5 receptor 4OO9 - -
TM2 623 G 2.47x47 mGlu5 receptor 4OO9 - -
TM2 624 L 2.48x48 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 625 S 2.49x49 mGlu5 receptor 4OO9 GABAB2 7C7S
TM2 626 Y 2.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 627 C 2.51x51 mGlu5 receptor 4OO9 - -
TM2 628 M 2.52x52 mGlu5 receptor 4OO9 - -
TM2 629 T 2.53x53 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 630 F 2.54x54 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 631 F 2.55x55 mGlu5 receptor 4OO9 - -
TM2 632 F 2.56x56 mGlu5 receptor 4OO9 GABAB2 7C7S
TM2 633 I 2.57x57 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ECL1 634 A - - - -
ECL1 635 K mGlu5 receptor 6FFI mGlu5 receptor 6FFI
ECL1 636 P - - - -
TM3 637 S 3.25x25 mGlu5 receptor 6FFI - -
TM3 638 P 3.26x26 mGlu5 receptor 4OO9 GABAB1 6W2Y
TM3 639 V 3.27x27 mGlu5 receptor 4OO9 - -
TM3 640 I 3.28x28 mGlu5 receptor 4OO9 - -
TM3 641 C 3.29x29 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 642 A 3.30x30 mGlu5 receptor 4OO9 - -
TM3 643 L 3.31x31 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 644 R 3.32x32 mGlu5 receptor 4OO9 GABAB1 6W2Y
TM3 645 R 3.33x33 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 646 L 3.34x34 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM3 647 G 3.35x35 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 648 L 3.36x36 mGlu5 receptor 4OO9 GABAB1 6W2Y
TM3 649 G 3.37x37 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 650 S 3.38x38 mGlu5 receptor 4OO9 - -
TM3 651 S 3.39x39 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 652 F 3.40x40 mGlu5 receptor 4OO9 GABAB1 6W2Y
TM3 653 A 3.41x41 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 654 I 3.42x42 mGlu5 receptor 4OO9 - -
TM3 655 C 3.43x43 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM3 656 Y 3.44x44 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 657 S 3.45x45 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 658 A 3.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 659 L 3.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 660 L 3.48x48 mGlu5 receptor 4OO9 - -
TM3 661 T 3.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 662 K 3.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 663 T 3.51x51 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 664 N 3.52x52 mGlu5 receptor 4OO9 mGlu5 receptor 6N52
TM3 665 C 3.53x53 mGlu5 receptor 4OO9 - -
TM3 666 I 3.54x54 mGlu5 receptor 4OO9 mGlu5 receptor 6N52
TM3 667 A 3.55x55 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 668 R 3.56x56 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 669 I 3.57x57 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 670 F 3.58x58 mGlu5 receptor 4OO9 GABAB2 7C7S
ICL2 671 D - - - -
ICL2 672 G - - - -
ICL2 673 V - - - -
ICL2 674 K - - - -
ICL2 675 N - - - -
ICL2 676 G - - - -
ICL2 677 A - - - -
ICL2 678 Q - - - -
ICL2 679 R - - - -
ICL2 680 P - - - -
ICL2 681 K - - - -
ICL2 682 F - - - -
ICL2 683 I - - - -
TM4 684 S 4.28x28 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 685 P 4.29x29 mGlu5 receptor 4OO9 - -
TM4 686 S 4.30x30 mGlu5 receptor 4OO9 - -
TM4 687 S 4.31x31 mGlu5 receptor 4OO9 - -
TM4 688 Q 4.32x32 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 689 V 4.33x33 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM4 690 F 4.34x34 mGlu5 receptor 4OO9 - -
TM4 691 I 4.35x35 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 692 C 4.36x36 mGlu5 receptor 4OO9 - -
TM4 693 L 4.37x37 mGlu5 receptor 4OO9 - -
TM4 694 G 4.38x38 mGlu5 receptor 4OO9 GABAB2 7C7S
TM4 695 L 4.39x39 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 696 I 4.40x40 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 697 L 4.41x41 mGlu5 receptor 4OO9 GABAB2 7C7S
TM4 698 V 4.42x42 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM4 699 Q 4.43x43 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 700 I 4.44x44 mGlu5 receptor 4OO9 - -
TM4 701 V 4.45x45 mGlu5 receptor 4OO9 - -
TM4 702 M 4.46x46 mGlu5 receptor 4OO9 - -
TM4 703 V 4.47x47 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM4 704 S 4.48x48 mGlu5 receptor 4OO9 - -
TM4 705 V 4.49x49 mGlu5 receptor 4OO9 - -
TM4 706 W 4.50x50 mGlu5 receptor 4OO9 GABAB1 6W2Y
TM4 707 L 4.51x51 mGlu5 receptor 4OO9 - -
TM4 708 I 4.52x52 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 709 L 4.53x53 mGlu5 receptor 4OO9 - -
TM4 710 E 4.54x54 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ECL2 711 A - - - -
ECL2 712 P - - - -
ECL2 713 G - - - -
ECL2 714 T - - - -
ECL2 715 R - - - -
ECL2 716 R - - - -
ECL2 717 Y - - - -
ECL2 718 T - - - -
ECL2 719 L - - - -
ECL2 720 A - - - -
ECL2 721 E - - - -
ECL2 722 K - - - -
ECL2 723 R - - - -
ECL2 724 E - - - -
ECL2 725 T - - - -
ECL2 726 V - - - -
ECL2 727 I - - - -
ECL2 728 L - - - -
ECL2 729 K - - - -
ECL2 730 C 45.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ECL2 731 N 45.51x51 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ECL2 732 V 45.52x52 mGlu5 receptor 4OO9 - -
TM5 733 K 5.36x36 mGlu5 receptor 6FFI - -
TM5 734 D 5.37x37 mGlu5 receptor 4OO9 - -
TM5 735 S 5.38x38 mGlu5 receptor 4OO9 - -
TM5 736 S 5.39x39 mGlu5 receptor 4OO9 - -
TM5 737 M 5.40x40 mGlu5 receptor 4OO9 - -
TM5 738 L 5.41x41 mGlu5 receptor 4OO9 - -
TM5 739 I 5.42x42 mGlu5 receptor 4OO9 GABAB1 6W2Y
TM5 740 S 5.43x43 mGlu5 receptor 4OO9 - -
TM5 741 L 5.44x44 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 742 T 5.45x45 mGlu5 receptor 4OO9 - -
TM5 743 Y 5.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 744 D 5.47x47 mGlu5 receptor 4OO9 - -
TM5 745 V 5.48x48 mGlu5 receptor 4OO9 - -
TM5 746 I 5.49x49 mGlu5 receptor 4OO9 - -
TM5 747 L 5.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 748 V 5.51x51 mGlu5 receptor 4OO9 - -
TM5 749 I 5.52x52 mGlu5 receptor 4OO9 - -
TM5 750 L 5.53x53 mGlu5 receptor 4OO9 GABAB1 6W2Y
TM5 751 C 5.54x54 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 752 T 5.55x55 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 753 V 5.56x56 mGlu5 receptor 4OO9 - -
TM5 754 Y 5.57x57 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 755 A 5.58x58 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 756 F 5.59x59 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 757 K 5.60x60 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 758 T 5.61x61 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL3 759 R mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL3 760 K mGlu5 receptor 4OO9 - -
ICL3 761 C mGlu5 receptor 4OO9 - -
ICL3 762 P mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL3 763 E mGlu5 receptor 4OO9 - -
ICL3 764 N mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL3 765 F mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL3 766 N mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 767 E 6.35x35 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 768 A 6.36x36 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 769 K 6.37x37 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 770 F 6.38x38 mGlu5 receptor 4OO9 - -
TM6 771 I 6.39x39 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 772 G 6.40x40 mGlu5 receptor 4OO9 GABAB1 6W2Y
TM6 773 F 6.41x41 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 774 T 6.42x42 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 775 M 6.43x43 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 776 Y 6.44x44 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 777 T 6.45x45 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 778 T 6.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 779 C 6.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 780 I 6.48x48 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 781 I 6.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 782 W 6.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 783 L 6.51x51 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 784 A 6.52x52 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 785 F 6.53x53 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 786 L 6.54x54 mGlu5 receptor 4OO9 - -
TM6 787 P 6.55x55 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 788 I 6.56x56 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 789 F 6.57x57 mGlu5 receptor 4OO9 - -
TM6 790 Y 6.58x58 mGlu5 receptor 4OO9 - -
TM6 791 V 6.59x59 mGlu5 receptor 4OO9 - -
ECL3 792 T - - - -
ECL3 793 S - - - -
ECL3 794 S - - - -
ECL3 795 D - - - -
ECL3 796 Y - - - -
ECL3 797 R - - - -
TM7 798 V 7.27x28 mGlu5 receptor 4OO9 - -
TM7 799 Q 7.28x29 mGlu5 receptor 4OO9 GABAB2 7C7S
TM7 800 T 7.29x30 mGlu5 receptor 4OO9 - -
TM7 801 T 7.30x31 mGlu5 receptor 4OO9 - -
TM7 802 T 7.31x32 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 803 M 7.32x33 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 804 C 7.33x34 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 805 I 7.34x35 mGlu5 receptor 4OO9 - -
TM7 806 S 7.35x36 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 807 V 7.36x37 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 808 S 7.37x38 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 809 L 7.38x39 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 810 S 7.39x40 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 811 G 7.40x41 mGlu5 receptor 4OO9 - -
TM7 812 F 7.41x42 mGlu5 receptor 4OO9 - -
TM7 813 V 7.42x43 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 814 V 7.43x44 mGlu5 receptor 4OO9 - -
TM7 815 L 7.44x45 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 816 G 7.45x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 817 C 7.46x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 818 L 7.47x471 mGlu5 receptor 4OO9 - -
TM7 819 F 7.48x48 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 820 A 7.49x49 mGlu5 receptor 4OO9 - -
TM7 821 P 7.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 822 K 7.51x51 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 823 V 7.52x52 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 824 H 7.53x53 mGlu5 receptor 4OO9 - -
TM7 825 I 7.54x54 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 826 I 7.55x55 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 827 L 7.56x56 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 828 F 7.57x57 mGlu5 receptor 4OO9 - -
TM7 829 Q 7.58x58 mGlu5 receptor 4OO9 - -
H8 830 P 8.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 831 Q 8.47x47 mGlu5 receptor 4OO9 - -
H8 832 K 8.48x48 mGlu5 receptor 4OO9 - -
H8 833 N 8.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 834 V 8.50x50 - - - -
H8 835 V 8.51x51 - - - -
H8 836 T 8.52x52 - - - -
H8 837 H 8.53x53 - - - -
H8 838 R 8.54x54 - - - -
H8 839 L 8.55x55 - - - -
H8 840 H 8.56x56 - - - -
H8 841 L 8.57x57 - - - -
C-term 842 N - - - -
C-term 843 R - - - -
C-term 844 F - - - -
C-term 845 S - - - -
C-term 846 V - - - -