mGlu4 receptor homology model

PROTEIN CLASS

Class C (Glutamate)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active

VERSION

2020-10-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

NGL is a WebGL based 3D viewer powered by MMTF.

MAIN TEMPLATE

mGlu5 receptor (sequence similarity: 70%) PDB: 4OO9

TEMPLATES

4OO9 (mGlu5 receptor)
6FFI (mGlu5 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 77.5 1.1 21.4
Side-chains 41.8 8.1 50.2

Number of backbone templates: 2
Number of rotamer templates: 5

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 581 L mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
N-term 582 E mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
N-term 583 W mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
N-term 584 G mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
N-term 585 S mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 586 P 1.38x38 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 587 W 1.39x39 mGlu5 receptor 4OO9 - -
TM1 588 A 1.40x40 mGlu5 receptor 4OO9 - -
TM1 589 V 1.41x41 mGlu5 receptor 4OO9 - -
TM1 590 L 1.42x42 mGlu5 receptor 4OO9 - -
TM1 591 P 1.43x43 mGlu5 receptor 4OO9 - -
TM1 592 L 1.44x44 mGlu5 receptor 4OO9 - -
TM1 593 F 1.45x45 mGlu5 receptor 4OO9 - -
TM1 594 L 1.46x46 mGlu5 receptor 4OO9 GABAB2 7C7S
TM1 595 A 1.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 596 V 1.48x48 mGlu5 receptor 4OO9 - -
TM1 597 V 1.49x49 mGlu5 receptor 4OO9 - -
TM1 598 G 1.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 599 I 1.51x51 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM1 600 A 1.52x52 mGlu5 receptor 4OO9 - -
TM1 601 A 1.53x53 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 602 T 1.54x54 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 603 L 1.55x55 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 604 F 1.56x56 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 605 V 1.57x57 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 606 V 1.58x58 mGlu5 receptor 4OO9 - -
TM1 607 I 1.59x59 mGlu5 receptor 4OO9 - -
TM1 608 T 1.60x60 mGlu5 receptor 4OO9 - -
TM1 609 F 1.61x61 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 610 V 1.62x62 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM1 611 R 1.63x63 mGlu5 receptor 4OO9 - -
TM1 612 Y 1.64x64 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL1 613 N mGlu5 receptor 4OO9 - -
ICL1 614 D mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL1 615 T 12.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL1 616 P 12.48x48 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL1 617 I 12.49x49 mGlu5 receptor 4OO9 - -
ICL1 618 V 12.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL1 619 K 12.51x51 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL1 620 A 12.52x52 mGlu5 receptor 4OO9 - -
ICL1 621 S 12.53x53 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 622 G 2.35x35 mGlu5 receptor 4OO9 - -
TM2 623 R 2.36x36 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 624 E 2.37x37 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 625 L 2.38x38 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 626 S 2.39x39 mGlu5 receptor 4OO9 - -
TM2 627 Y 2.40x40 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 628 V 2.41x41 mGlu5 receptor 4OO9 - -
TM2 629 L 2.42x42 mGlu5 receptor 4OO9 - -
TM2 630 L 2.43x43 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 631 A 2.44x44 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 632 G 2.45x45 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 633 I 2.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 634 F 2.47x47 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM2 635 L 2.48x48 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 636 C 2.49x49 mGlu5 receptor 4OO9 - -
TM2 637 Y 2.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 638 A 2.51x51 mGlu5 receptor 4OO9 GABAB2 7C7S
TM2 639 T 2.52x52 mGlu5 receptor 4OO9 - -
TM2 640 T 2.53x53 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 641 F 2.54x54 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 642 L 2.55x55 mGlu5 receptor 4OO9 GABAB2 7C7S
TM2 643 M 2.56x56 mGlu5 receptor 4OO9 - -
TM2 644 I 2.57x57 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ECL1 645 A - - - -
ECL1 646 E mGlu5 receptor 6FFI - -
ECL1 647 P - - - -
TM3 648 D 3.25x25 mGlu5 receptor 6FFI - -
TM3 649 L 3.26x26 mGlu5 receptor 4OO9 - -
TM3 650 G 3.27x27 mGlu5 receptor 4OO9 - -
TM3 651 T 3.28x28 mGlu5 receptor 4OO9 - -
TM3 652 C 3.29x29 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 653 S 3.30x30 mGlu5 receptor 4OO9 - -
TM3 654 L 3.31x31 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 655 R 3.32x32 mGlu5 receptor 4OO9 GABAB2 7C7S
TM3 656 R 3.33x33 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 657 I 3.34x34 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 658 F 3.35x35 mGlu5 receptor 4OO9 - -
TM3 659 L 3.36x36 mGlu5 receptor 4OO9 GABAB2 7C7S
TM3 660 G 3.37x37 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 661 L 3.38x38 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 662 G 3.39x39 mGlu5 receptor 4OO9 GABAB2 7C7S
TM3 663 M 3.40x40 mGlu5 receptor 4OO9 - -
TM3 664 S 3.41x41 mGlu5 receptor 4OO9 GABAB1 6W2Y
TM3 665 I 3.42x42 mGlu5 receptor 4OO9 - -
TM3 666 S 3.43x43 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 667 Y 3.44x44 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 668 A 3.45x45 mGlu5 receptor 4OO9 - -
TM3 669 A 3.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 670 L 3.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 671 L 3.48x48 mGlu5 receptor 4OO9 - -
TM3 672 T 3.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 673 K 3.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 674 T 3.51x51 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 675 N 3.52x52 mGlu5 receptor 4OO9 mGlu5 receptor 6N52
TM3 676 R 3.53x53 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 677 I 3.54x54 mGlu5 receptor 4OO9 mGlu5 receptor 6N52
TM3 678 Y 3.55x55 mGlu5 receptor 4OO9 - -
TM3 679 R 3.56x56 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 680 I 3.57x57 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 681 F 3.58x58 mGlu5 receptor 4OO9 GABAB2 7C7S
ICL2 682 E - - - -
ICL2 683 Q - - - -
ICL2 684 G - - - -
ICL2 685 K - - - -
ICL2 686 R - - - -
ICL2 687 S - - - -
ICL2 688 V - - - -
ICL2 689 S - - - -
ICL2 690 A - - - -
ICL2 691 P - - - -
ICL2 692 R - - - -
ICL2 693 F - - - -
ICL2 694 I - - - -
TM4 695 S 4.28x28 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 696 P 4.29x29 mGlu5 receptor 4OO9 - -
TM4 697 A 4.30x30 mGlu5 receptor 4OO9 - -
TM4 698 S 4.31x31 mGlu5 receptor 4OO9 - -
TM4 699 Q 4.32x32 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 700 L 4.33x33 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 701 A 4.34x34 mGlu5 receptor 4OO9 GABAB1 6W2Y
TM4 702 I 4.35x35 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 703 T 4.36x36 mGlu5 receptor 4OO9 - -
TM4 704 F 4.37x37 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 705 S 4.38x38 mGlu5 receptor 4OO9 - -
TM4 706 L 4.39x39 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 707 I 4.40x40 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 708 S 4.41x41 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM4 709 L 4.42x42 mGlu5 receptor 4OO9 - -
TM4 710 Q 4.43x43 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 711 L 4.44x44 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 712 L 4.45x45 mGlu5 receptor 4OO9 - -
TM4 713 G 4.46x46 mGlu5 receptor 4OO9 - -
TM4 714 I 4.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 715 C 4.48x48 mGlu5 receptor 4OO9 - -
TM4 716 V 4.49x49 mGlu5 receptor 4OO9 - -
TM4 717 W 4.50x50 mGlu5 receptor 4OO9 GABAB2 7C7S
TM4 718 F 4.51x51 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 719 V 4.52x52 mGlu5 receptor 4OO9 - -
TM4 720 V 4.53x53 mGlu5 receptor 4OO9 GABAB2 7C7S
TM4 721 D 4.54x54 mGlu5 receptor 4OO9 GABAB2 7C7S
ECL2 722 P - - - -
ECL2 723 S - - - -
ECL2 724 H - - - -
ECL2 725 S - - - -
ECL2 726 V - - - -
ECL2 727 V - - - -
ECL2 728 D - - - -
ECL2 729 F - - - -
ECL2 730 Q - - - -
ECL2 731 D - - - -
ECL2 732 Q - - - -
ECL2 733 R - - - -
ECL2 734 T - - - -
ECL2 735 L - - - -
ECL2 736 D - - - -
ECL2 737 P - - - -
ECL2 738 R - - - -
ECL2 739 F - - - -
ECL2 740 A - - - -
ECL2 741 R - - - -
ECL2 742 G - - - -
ECL2 743 V - - - -
ECL2 744 L - - - -
ECL2 745 K - - - -
ECL2 746 C 45.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ECL2 747 D 45.51x51 mGlu5 receptor 4OO9 - -
ECL2 748 I 45.52x52 mGlu5 receptor 4OO9 - -
TM5 749 S 5.36x36 mGlu5 receptor 6FFI mGlu1 receptor 4OR2
TM5 750 D 5.37x37 mGlu5 receptor 4OO9 - -
TM5 751 L 5.38x38 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 752 S 5.39x39 mGlu5 receptor 4OO9 - -
TM5 753 L 5.40x40 mGlu5 receptor 4OO9 GABAB2 7C7S
TM5 754 I 5.41x41 mGlu5 receptor 4OO9 - -
TM5 755 C 5.42x42 mGlu5 receptor 4OO9 - -
TM5 756 L 5.43x43 mGlu5 receptor 4OO9 - -
TM5 757 L 5.44x44 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 758 G 5.45x45 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 759 Y 5.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 760 S 5.47x47 mGlu5 receptor 4OO9 - -
TM5 761 M 5.48x48 mGlu5 receptor 4OO9 - -
TM5 762 L 5.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 763 L 5.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 764 M 5.51x51 mGlu5 receptor 4OO9 GABAB2 7C7S
TM5 765 V 5.52x52 mGlu5 receptor 4OO9 - -
TM5 766 T 5.53x53 mGlu5 receptor 4OO9 - -
TM5 767 C 5.54x54 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 768 T 5.55x55 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 769 V 5.56x56 mGlu5 receptor 4OO9 - -
TM5 770 Y 5.57x57 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 771 A 5.58x58 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 772 I 5.59x59 mGlu5 receptor 4OO9 - -
TM5 773 K 5.60x60 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 774 T 5.61x61 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL3 775 R mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL3 776 G mGlu5 receptor 4OO9 - -
ICL3 777 V mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL3 778 P mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL3 779 E mGlu5 receptor 4OO9 - -
ICL3 780 T mGlu5 receptor 4OO9 - -
ICL3 781 F mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL3 782 N mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 783 E 6.35x35 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 784 A 6.36x36 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 785 K 6.37x37 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 786 P 6.38x38 mGlu5 receptor 4OO9 - -
TM6 787 I 6.39x39 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 788 G 6.40x40 mGlu5 receptor 4OO9 GABAB2 7C7S
TM6 789 F 6.41x41 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 790 T 6.42x42 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 791 M 6.43x43 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 792 Y 6.44x44 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 793 T 6.45x45 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 794 T 6.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 795 C 6.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 796 I 6.48x48 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 797 V 6.49x49 mGlu5 receptor 4OO9 - -
TM6 798 W 6.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 799 L 6.51x51 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 800 A 6.52x52 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 801 F 6.53x53 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 802 I 6.54x54 mGlu5 receptor 4OO9 - -
TM6 803 P 6.55x55 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 804 I 6.56x56 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 805 F 6.57x57 mGlu5 receptor 4OO9 - -
TM6 806 F 6.58x58 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 807 G 6.59x59 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ECL3 808 T - - - -
ECL3 809 S - - - -
ECL3 810 Q - - - -
ECL3 811 S - - - -
ECL3 812 A - - - -
ECL3 813 D - - - -
ECL3 814 K - - - -
ECL3 815 L - - - -
ECL3 816 Y - - - -
TM7 817 I 7.27x28 mGlu5 receptor 4OO9 - -
TM7 818 Q 7.28x29 mGlu5 receptor 4OO9 GABAB2 7C7S
TM7 819 T 7.29x30 mGlu5 receptor 4OO9 - -
TM7 820 T 7.30x31 mGlu5 receptor 4OO9 - -
TM7 821 T 7.31x32 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 822 L 7.32x33 mGlu5 receptor 4OO9 - -
TM7 823 T 7.33x34 mGlu5 receptor 4OO9 - -
TM7 824 V 7.34x35 mGlu5 receptor 4OO9 - -
TM7 825 S 7.35x36 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 826 V 7.36x37 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 827 S 7.37x38 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 828 L 7.38x39 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 829 S 7.39x40 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 830 A 7.40x41 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 831 S 7.41x42 mGlu5 receptor 4OO9 - -
TM7 832 V 7.42x43 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 833 S 7.43x44 mGlu5 receptor 4OO9 - -
TM7 834 L 7.44x45 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 835 G 7.45x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 836 M 7.46x47 mGlu5 receptor 4OO9 - -
TM7 837 L 7.47x471 mGlu5 receptor 4OO9 - -
TM7 838 Y 7.48x48 mGlu5 receptor 4OO9 - -
TM7 839 M 7.49x49 mGlu5 receptor 4OO9 - -
TM7 840 P 7.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 841 K 7.51x51 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 842 V 7.52x52 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 843 Y 7.53x53 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 844 I 7.54x54 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 845 I 7.55x55 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 846 L 7.56x56 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 847 F 7.57x57 mGlu5 receptor 4OO9 - -
TM7 848 H 7.58x58 mGlu5 receptor 4OO9 - -
H8 849 P 8.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 850 E 8.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 851 Q 8.48x48 mGlu5 receptor 4OO9 - -
H8 852 N 8.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 853 V 8.50x50 - - - -
H8 854 P 8.51x51 - - - -
H8 855 K 8.52x52 - - - -
H8 856 R 8.53x53 - - - -
H8 857 K 8.54x54 - - - -
H8 858 R 8.55x55 - - - -
H8 859 S 8.56x56 - - - -
H8 860 L 8.57x57 - - - -
C-term 861 K - - - -
C-term 862 A - - - -
C-term 863 V - - - -
C-term 864 V - - - -
C-term 865 T - - - -