mGlu6 receptor homology model

PROTEIN CLASS

Class C (Glutamate)

RECEPTOR

mGlu6 receptor

SPECIES

Homo sapiens

STATE

Inactive

VERSION

2021-01-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

mGlu5 receptor (sequence similarity: 66%) PDB: 4OO9
Align

TEMPLATES

4OO9 (mGlu5 receptor)
6FFI (mGlu5 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 77.5 1.1 21.4
Side-chains 38.6 9.1 52.3

Number of backbone templates: 2
Number of rotamer templates: 5

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 579 L mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
N-term 580 S mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
N-term 581 W mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
N-term 582 S mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
N-term 583 S mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 584 P 1.38x38 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 585 W 1.39x39 mGlu5 receptor 4OO9 - -
TM1 586 A 1.40x40 mGlu5 receptor 4OO9 - -
TM1 587 A 1.41x41 mGlu5 receptor 4OO9 - -
TM1 588 P 1.42x42 mGlu5 receptor 4OO9 - -
TM1 589 P 1.43x43 mGlu5 receptor 4OO9 - -
TM1 590 L 1.44x44 mGlu5 receptor 4OO9 - -
TM1 591 L 1.45x45 mGlu5 receptor 4OO9 - -
TM1 592 L 1.46x46 mGlu5 receptor 4OO9 GABAB2 7C7S
TM1 593 A 1.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 594 V 1.48x48 mGlu5 receptor 4OO9 - -
TM1 595 L 1.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 596 G 1.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 597 I 1.51x51 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM1 598 V 1.52x52 mGlu5 receptor 4OO9 GABAB1 6W2Y
TM1 599 A 1.53x53 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 600 T 1.54x54 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 601 T 1.55x55 mGlu5 receptor 4OO9 - -
TM1 602 T 1.56x56 mGlu5 receptor 4OO9 - -
TM1 603 V 1.57x57 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 604 V 1.58x58 mGlu5 receptor 4OO9 - -
TM1 605 A 1.59x59 mGlu5 receptor 4OO9 - -
TM1 606 T 1.60x60 mGlu5 receptor 4OO9 - -
TM1 607 F 1.61x61 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 608 V 1.62x62 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM1 609 R 1.63x63 mGlu5 receptor 4OO9 - -
TM1 610 Y 1.64x64 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL1 611 N mGlu5 receptor 4OO9 - -
ICL1 612 N mGlu5 receptor 4OO9 - -
ICL1 613 T 12.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL1 614 P 12.48x48 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL1 615 I 12.49x49 mGlu5 receptor 4OO9 - -
ICL1 616 V 12.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL1 617 R 12.51x51 mGlu5 receptor 4OO9 - -
ICL1 618 A 12.52x52 mGlu5 receptor 4OO9 - -
ICL1 619 S 12.53x53 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 620 G 2.35x35 mGlu5 receptor 4OO9 - -
TM2 621 R 2.36x36 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 622 E 2.37x37 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 623 L 2.38x38 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 624 S 2.39x39 mGlu5 receptor 4OO9 - -
TM2 625 Y 2.40x40 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 626 V 2.41x41 mGlu5 receptor 4OO9 - -
TM2 627 L 2.42x42 mGlu5 receptor 4OO9 - -
TM2 628 L 2.43x43 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 629 T 2.44x44 mGlu5 receptor 4OO9 - -
TM2 630 G 2.45x45 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 631 I 2.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 632 F 2.47x47 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM2 633 L 2.48x48 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 634 I 2.49x49 mGlu5 receptor 4OO9 - -
TM2 635 Y 2.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 636 A 2.51x51 mGlu5 receptor 4OO9 GABAB2 7C7S
TM2 637 I 2.52x52 mGlu5 receptor 4OO9 - -
TM2 638 T 2.53x53 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 639 F 2.54x54 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 640 L 2.55x55 mGlu5 receptor 4OO9 GABAB2 7C7S
TM2 641 M 2.56x56 mGlu5 receptor 4OO9 - -
TM2 642 V 2.57x57 mGlu5 receptor 4OO9 - -
ECL1 643 A - - - -
ECL1 644 E mGlu5 receptor 6FFI - -
ECL1 645 P - - - -
TM3 646 G 3.25x25 mGlu5 receptor 6FFI - -
TM3 647 A 3.26x26 mGlu5 receptor 4OO9 - -
TM3 648 A 3.27x27 mGlu5 receptor 4OO9 - -
TM3 649 V 3.28x28 mGlu5 receptor 4OO9 GABAB1 6W2Y
TM3 650 C 3.29x29 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 651 A 3.30x30 mGlu5 receptor 4OO9 - -
TM3 652 A 3.31x31 mGlu5 receptor 4OO9 GABAB1 6W2Y
TM3 653 R 3.32x32 mGlu5 receptor 4OO9 GABAB2 7C7S
TM3 654 R 3.33x33 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 655 L 3.34x34 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM3 656 F 3.35x35 mGlu5 receptor 4OO9 - -
TM3 657 L 3.36x36 mGlu5 receptor 4OO9 GABAB2 7C7S
TM3 658 G 3.37x37 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 659 L 3.38x38 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 660 G 3.39x39 mGlu5 receptor 4OO9 GABAB2 7C7S
TM3 661 T 3.40x40 mGlu5 receptor 4OO9 - -
TM3 662 T 3.41x41 mGlu5 receptor 4OO9 GABAB2 7C7S
TM3 663 L 3.42x42 mGlu5 receptor 4OO9 GABAB1 6W2Y
TM3 664 S 3.43x43 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 665 Y 3.44x44 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 666 S 3.45x45 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 667 A 3.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 668 L 3.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 669 L 3.48x48 mGlu5 receptor 4OO9 - -
TM3 670 T 3.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 671 K 3.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 672 T 3.51x51 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 673 N 3.52x52 mGlu5 receptor 4OO9 mGlu5 receptor 6N52
TM3 674 R 3.53x53 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 675 I 3.54x54 mGlu5 receptor 4OO9 mGlu5 receptor 6N52
TM3 676 Y 3.55x55 mGlu5 receptor 4OO9 - -
TM3 677 R 3.56x56 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 678 I 3.57x57 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 679 F 3.58x58 mGlu5 receptor 4OO9 GABAB2 7C7S
ICL2 680 E - - - -
ICL2 681 Q - - - -
ICL2 682 G - - - -
ICL2 683 K - - - -
ICL2 684 R - - - -
ICL2 685 S - - - -
ICL2 686 V - - - -
ICL2 687 T - - - -
ICL2 688 P - - - -
ICL2 689 P - - - -
ICL2 690 P - - - -
ICL2 691 F - - - -
ICL2 692 I - - - -
TM4 693 S 4.28x28 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 694 P 4.29x29 mGlu5 receptor 4OO9 - -
TM4 695 T 4.30x30 mGlu5 receptor 4OO9 - -
TM4 696 S 4.31x31 mGlu5 receptor 4OO9 - -
TM4 697 Q 4.32x32 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 698 L 4.33x33 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 699 V 4.34x34 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 700 I 4.35x35 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 701 T 4.36x36 mGlu5 receptor 4OO9 - -
TM4 702 F 4.37x37 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 703 S 4.38x38 mGlu5 receptor 4OO9 - -
TM4 704 L 4.39x39 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 705 T 4.40x40 mGlu5 receptor 4OO9 - -
TM4 706 S 4.41x41 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM4 707 L 4.42x42 mGlu5 receptor 4OO9 - -
TM4 708 Q 4.43x43 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 709 V 4.44x44 mGlu5 receptor 4OO9 - -
TM4 710 V 4.45x45 mGlu5 receptor 4OO9 - -
TM4 711 G 4.46x46 mGlu5 receptor 4OO9 - -
TM4 712 M 4.47x47 mGlu5 receptor 4OO9 - -
TM4 713 I 4.48x48 mGlu5 receptor 4OO9 GABAB2 7C7S
TM4 714 A 4.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 715 W 4.50x50 mGlu5 receptor 4OO9 GABAB2 7C7S
TM4 716 L 4.51x51 mGlu5 receptor 4OO9 - -
TM4 717 G 4.52x52 mGlu5 receptor 4OO9 - -
TM4 718 A 4.53x53 mGlu5 receptor 4OO9 - -
TM4 719 R 4.54x54 mGlu5 receptor 4OO9 - -
ECL2 720 P - - - -
ECL2 721 P - - - -
ECL2 722 H - - - -
ECL2 723 S - - - -
ECL2 724 V - - - -
ECL2 725 I - - - -
ECL2 726 D - - - -
ECL2 727 Y - - - -
ECL2 728 E - - - -
ECL2 729 E - - - -
ECL2 730 Q - - - -
ECL2 731 R - - - -
ECL2 732 T - - - -
ECL2 733 V - - - -
ECL2 734 D - - - -
ECL2 735 P - - - -
ECL2 736 E - - - -
ECL2 737 Q - - - -
ECL2 738 A - - - -
ECL2 739 R - - - -
ECL2 740 G - - - -
ECL2 741 V - - - -
ECL2 742 L - - - -
ECL2 743 K - - - -
ECL2 744 C 45.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ECL2 745 D 45.51x51 mGlu5 receptor 4OO9 - -
ECL2 746 M 45.52x52 mGlu5 receptor 4OO9 - -
TM5 747 S 5.36x36 mGlu5 receptor 6FFI mGlu1 receptor 4OR2
TM5 748 D 5.37x37 mGlu5 receptor 4OO9 - -
TM5 749 L 5.38x38 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 750 S 5.39x39 mGlu5 receptor 4OO9 - -
TM5 751 L 5.40x40 mGlu5 receptor 4OO9 GABAB2 7C7S
TM5 752 I 5.41x41 mGlu5 receptor 4OO9 - -
TM5 753 G 5.42x42 mGlu5 receptor 4OO9 - -
TM5 754 C 5.43x43 mGlu5 receptor 4OO9 - -
TM5 755 L 5.44x44 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 756 G 5.45x45 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 757 Y 5.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 758 S 5.47x47 mGlu5 receptor 4OO9 - -
TM5 759 L 5.48x48 mGlu5 receptor 4OO9 - -
TM5 760 L 5.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 761 L 5.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 762 M 5.51x51 mGlu5 receptor 4OO9 GABAB2 7C7S
TM5 763 V 5.52x52 mGlu5 receptor 4OO9 - -
TM5 764 T 5.53x53 mGlu5 receptor 4OO9 - -
TM5 765 C 5.54x54 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 766 T 5.55x55 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 767 V 5.56x56 mGlu5 receptor 4OO9 - -
TM5 768 Y 5.57x57 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 769 A 5.58x58 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 770 I 5.59x59 mGlu5 receptor 4OO9 - -
TM5 771 K 5.60x60 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 772 A 5.61x61 mGlu5 receptor 4OO9 - -
ICL3 773 R mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL3 774 G mGlu5 receptor 4OO9 - -
ICL3 775 V mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL3 776 P mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL3 777 E mGlu5 receptor 4OO9 - -
ICL3 778 T mGlu5 receptor 4OO9 - -
ICL3 779 F mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL3 780 N mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 781 E 6.35x35 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 782 A 6.36x36 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 783 K 6.37x37 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 784 P 6.38x38 mGlu5 receptor 4OO9 - -
TM6 785 I 6.39x39 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 786 G 6.40x40 mGlu5 receptor 4OO9 GABAB2 7C7S
TM6 787 F 6.41x41 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 788 T 6.42x42 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 789 M 6.43x43 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 790 Y 6.44x44 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 791 T 6.45x45 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 792 T 6.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 793 C 6.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 794 I 6.48x48 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 795 I 6.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 796 W 6.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 797 L 6.51x51 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 798 A 6.52x52 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 799 F 6.53x53 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 800 V 6.54x54 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 801 P 6.55x55 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 802 I 6.56x56 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 803 F 6.57x57 mGlu5 receptor 4OO9 - -
TM6 804 F 6.58x58 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 805 G 6.59x59 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ECL3 806 T - - - -
ECL3 807 A - - - -
ECL3 808 Q - - - -
ECL3 809 S - - - -
ECL3 810 A - - - -
ECL3 811 E - - - -
ECL3 812 K - - - -
ECL3 813 I - - - -
ECL3 814 Y - - - -
TM7 815 I 7.27x28 mGlu5 receptor 4OO9 - -
TM7 816 Q 7.28x29 mGlu5 receptor 4OO9 GABAB2 7C7S
TM7 817 T 7.29x30 mGlu5 receptor 4OO9 - -
TM7 818 T 7.30x31 mGlu5 receptor 4OO9 - -
TM7 819 T 7.31x32 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 820 L 7.32x33 mGlu5 receptor 4OO9 - -
TM7 821 T 7.33x34 mGlu5 receptor 4OO9 - -
TM7 822 V 7.34x35 mGlu5 receptor 4OO9 - -
TM7 823 S 7.35x36 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 824 L 7.36x37 mGlu5 receptor 4OO9 - -
TM7 825 S 7.37x38 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 826 L 7.38x39 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 827 S 7.39x40 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 828 A 7.40x41 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 829 S 7.41x42 mGlu5 receptor 4OO9 - -
TM7 830 V 7.42x43 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 831 S 7.43x44 mGlu5 receptor 4OO9 - -
TM7 832 L 7.44x45 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 833 G 7.45x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 834 M 7.46x47 mGlu5 receptor 4OO9 - -
TM7 835 L 7.47x471 mGlu5 receptor 4OO9 - -
TM7 836 Y 7.48x48 mGlu5 receptor 4OO9 - -
TM7 837 V 7.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 838 P 7.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 839 K 7.51x51 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 840 T 7.52x52 mGlu5 receptor 4OO9 - -
TM7 841 Y 7.53x53 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 842 V 7.54x54 mGlu5 receptor 4OO9 - -
TM7 843 I 7.55x55 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 844 L 7.56x56 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 845 F 7.57x57 mGlu5 receptor 4OO9 - -
TM7 846 H 7.58x58 mGlu5 receptor 4OO9 - -
H8 847 P 8.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 848 E 8.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 849 Q 8.48x48 mGlu5 receptor 4OO9 - -
H8 850 N 8.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 851 V 8.50x50 - - - -
H8 852 Q 8.51x51 - - - -
H8 853 K 8.52x52 - - - -
H8 854 R 8.53x53 - - - -
H8 855 K 8.54x54 - - - -
H8 856 R 8.55x55 - - - -
H8 857 S 8.56x56 - - - -
H8 858 L 8.57x57 - - - -
C-term 859 K - - - -
C-term 860 A - - - -
C-term 861 T - - - -
C-term 862 S - - - -
C-term 863 T - - - -