mGlu7 receptor homology model

PROTEIN CLASS

Class C (Glutamate)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active

VERSION

2020-10-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

NGL is a WebGL based 3D viewer powered by MMTF.

MAIN TEMPLATE

mGlu5 receptor (sequence similarity: 68%) PDB: 4OO9

TEMPLATES

4OO9 (mGlu5 receptor)
6FFI (mGlu5 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 77.5 1.1 21.4
Side-chains 40.0 9.5 50.5

Number of backbone templates: 2
Number of rotamer templates: 6

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 584 L mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
N-term 585 E mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
N-term 586 W mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
N-term 587 H mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
N-term 588 S mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 589 P 1.38x38 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 590 W 1.39x39 mGlu5 receptor 4OO9 - -
TM1 591 A 1.40x40 mGlu5 receptor 4OO9 - -
TM1 592 V 1.41x41 mGlu5 receptor 4OO9 - -
TM1 593 I 1.42x42 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM1 594 P 1.43x43 mGlu5 receptor 4OO9 - -
TM1 595 V 1.44x44 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 596 F 1.45x45 mGlu5 receptor 4OO9 - -
TM1 597 L 1.46x46 mGlu5 receptor 4OO9 GABAB2 7C7S
TM1 598 A 1.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 599 M 1.48x48 mGlu5 receptor 4OO9 - -
TM1 600 L 1.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 601 G 1.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 602 I 1.51x51 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM1 603 I 1.52x52 mGlu5 receptor 4OO9 GABAB2 7C7S
TM1 604 A 1.53x53 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 605 T 1.54x54 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 606 I 1.55x55 mGlu5 receptor 4OO9 - -
TM1 607 F 1.56x56 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 608 V 1.57x57 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 609 M 1.58x58 mGlu5 receptor 4OO9 - -
TM1 610 A 1.59x59 mGlu5 receptor 4OO9 - -
TM1 611 T 1.60x60 mGlu5 receptor 4OO9 - -
TM1 612 F 1.61x61 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 613 I 1.62x62 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 614 R 1.63x63 mGlu5 receptor 4OO9 - -
TM1 615 Y 1.64x64 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL1 616 N mGlu5 receptor 4OO9 - -
ICL1 617 D mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL1 618 T 12.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL1 619 P 12.48x48 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL1 620 I 12.49x49 mGlu5 receptor 4OO9 - -
ICL1 621 V 12.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL1 622 R 12.51x51 mGlu5 receptor 4OO9 - -
ICL1 623 A 12.52x52 mGlu5 receptor 4OO9 - -
ICL1 624 S 12.53x53 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 625 G 2.35x35 mGlu5 receptor 4OO9 - -
TM2 626 R 2.36x36 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 627 E 2.37x37 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 628 L 2.38x38 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 629 S 2.39x39 mGlu5 receptor 4OO9 - -
TM2 630 Y 2.40x40 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 631 V 2.41x41 mGlu5 receptor 4OO9 - -
TM2 632 L 2.42x42 mGlu5 receptor 4OO9 - -
TM2 633 L 2.43x43 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 634 T 2.44x44 mGlu5 receptor 4OO9 - -
TM2 635 G 2.45x45 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 636 I 2.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 637 F 2.47x47 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM2 638 L 2.48x48 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 639 C 2.49x49 mGlu5 receptor 4OO9 - -
TM2 640 Y 2.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 641 I 2.51x51 mGlu5 receptor 4OO9 - -
TM2 642 I 2.52x52 mGlu5 receptor 4OO9 - -
TM2 643 T 2.53x53 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 644 F 2.54x54 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 645 L 2.55x55 mGlu5 receptor 4OO9 GABAB2 7C7S
TM2 646 M 2.56x56 mGlu5 receptor 4OO9 - -
TM2 647 I 2.57x57 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ECL1 648 A - - - -
ECL1 649 K mGlu5 receptor 6FFI mGlu5 receptor 6FFI
ECL1 650 P - - - -
TM3 651 D 3.25x25 mGlu5 receptor 6FFI - -
TM3 652 V 3.26x26 mGlu5 receptor 4OO9 - -
TM3 653 A 3.27x27 mGlu5 receptor 4OO9 - -
TM3 654 V 3.28x28 mGlu5 receptor 4OO9 GABAB1 6W2Y
TM3 655 C 3.29x29 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 656 S 3.30x30 mGlu5 receptor 4OO9 - -
TM3 657 F 3.31x31 mGlu5 receptor 4OO9 - -
TM3 658 R 3.32x32 mGlu5 receptor 4OO9 GABAB2 7C7S
TM3 659 R 3.33x33 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 660 V 3.34x34 mGlu5 receptor 4OO9 - -
TM3 661 F 3.35x35 mGlu5 receptor 4OO9 - -
TM3 662 L 3.36x36 mGlu5 receptor 4OO9 GABAB2 7C7S
TM3 663 G 3.37x37 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 664 L 3.38x38 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 665 G 3.39x39 mGlu5 receptor 4OO9 GABAB2 7C7S
TM3 666 M 3.40x40 mGlu5 receptor 4OO9 - -
TM3 667 C 3.41x41 mGlu5 receptor 4OO9 - -
TM3 668 I 3.42x42 mGlu5 receptor 4OO9 - -
TM3 669 S 3.43x43 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 670 Y 3.44x44 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 671 A 3.45x45 mGlu5 receptor 4OO9 - -
TM3 672 A 3.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 673 L 3.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 674 L 3.48x48 mGlu5 receptor 4OO9 - -
TM3 675 T 3.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 676 K 3.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 677 T 3.51x51 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 678 N 3.52x52 mGlu5 receptor 4OO9 mGlu5 receptor 6N52
TM3 679 R 3.53x53 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 680 I 3.54x54 mGlu5 receptor 4OO9 mGlu5 receptor 6N52
TM3 681 Y 3.55x55 mGlu5 receptor 4OO9 - -
TM3 682 R 3.56x56 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 683 I 3.57x57 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 684 F 3.58x58 mGlu5 receptor 4OO9 GABAB2 7C7S
ICL2 685 E - - - -
ICL2 686 Q - - - -
ICL2 687 G - - - -
ICL2 688 K - - - -
ICL2 689 K - - - -
ICL2 690 S - - - -
ICL2 691 V - - - -
ICL2 692 T - - - -
ICL2 693 A - - - -
ICL2 694 P - - - -
ICL2 695 R - - - -
ICL2 696 L - - - -
ICL2 697 I - - - -
TM4 698 S 4.28x28 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 699 P 4.29x29 mGlu5 receptor 4OO9 - -
TM4 700 T 4.30x30 mGlu5 receptor 4OO9 - -
TM4 701 S 4.31x31 mGlu5 receptor 4OO9 - -
TM4 702 Q 4.32x32 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 703 L 4.33x33 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 704 A 4.34x34 mGlu5 receptor 4OO9 GABAB1 6W2Y
TM4 705 I 4.35x35 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 706 T 4.36x36 mGlu5 receptor 4OO9 - -
TM4 707 S 4.37x37 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM4 708 S 4.38x38 mGlu5 receptor 4OO9 - -
TM4 709 L 4.39x39 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 710 I 4.40x40 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 711 S 4.41x41 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM4 712 V 4.42x42 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM4 713 Q 4.43x43 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 714 L 4.44x44 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 715 L 4.45x45 mGlu5 receptor 4OO9 - -
TM4 716 G 4.46x46 mGlu5 receptor 4OO9 - -
TM4 717 V 4.47x47 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM4 718 F 4.48x48 mGlu5 receptor 4OO9 - -
TM4 719 I 4.49x49 mGlu5 receptor 4OO9 GABAB1 6W2Y
TM4 720 W 4.50x50 mGlu5 receptor 4OO9 GABAB2 7C7S
TM4 721 F 4.51x51 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 722 G 4.52x52 mGlu5 receptor 4OO9 - -
TM4 723 V 4.53x53 mGlu5 receptor 4OO9 GABAB2 7C7S
TM4 724 D 4.54x54 mGlu5 receptor 4OO9 GABAB2 7C7S
ECL2 725 P - - - -
ECL2 726 P - - - -
ECL2 727 N - - - -
ECL2 728 I - - - -
ECL2 729 I - - - -
ECL2 730 I - - - -
ECL2 731 D - - - -
ECL2 732 Y - - - -
ECL2 733 D - - - -
ECL2 734 E - - - -
ECL2 735 H - - - -
ECL2 736 K - - - -
ECL2 737 T - - - -
ECL2 738 M - - - -
ECL2 739 N - - - -
ECL2 740 P - - - -
ECL2 741 E - - - -
ECL2 742 Q - - - -
ECL2 743 A - - - -
ECL2 744 R - - - -
ECL2 745 G - - - -
ECL2 746 V - - - -
ECL2 747 L - - - -
ECL2 748 K - - - -
ECL2 749 C 45.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ECL2 750 D 45.51x51 mGlu5 receptor 4OO9 - -
ECL2 751 I 45.52x52 mGlu5 receptor 4OO9 - -
TM5 752 T 5.36x36 mGlu5 receptor 6FFI mGlu5 receptor 6FFI
TM5 753 D 5.37x37 mGlu5 receptor 4OO9 - -
TM5 754 L 5.38x38 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 755 Q 5.39x39 mGlu5 receptor 4OO9 - -
TM5 756 I 5.40x40 mGlu5 receptor 4OO9 - -
TM5 757 I 5.41x41 mGlu5 receptor 4OO9 - -
TM5 758 C 5.42x42 mGlu5 receptor 4OO9 - -
TM5 759 S 5.43x43 mGlu5 receptor 4OO9 - -
TM5 760 L 5.44x44 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 761 G 5.45x45 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 762 Y 5.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 763 S 5.47x47 mGlu5 receptor 4OO9 - -
TM5 764 I 5.48x48 mGlu5 receptor 4OO9 - -
TM5 765 L 5.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 766 L 5.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 767 M 5.51x51 mGlu5 receptor 4OO9 GABAB2 7C7S
TM5 768 V 5.52x52 mGlu5 receptor 4OO9 - -
TM5 769 T 5.53x53 mGlu5 receptor 4OO9 - -
TM5 770 C 5.54x54 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 771 T 5.55x55 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 772 V 5.56x56 mGlu5 receptor 4OO9 - -
TM5 773 Y 5.57x57 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 774 A 5.58x58 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 775 I 5.59x59 mGlu5 receptor 4OO9 - -
TM5 776 K 5.60x60 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 777 T 5.61x61 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL3 778 R mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL3 779 G mGlu5 receptor 4OO9 - -
ICL3 780 V mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL3 781 P mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL3 782 E mGlu5 receptor 4OO9 - -
ICL3 783 N mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL3 784 F mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL3 785 N mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 786 E 6.35x35 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 787 A 6.36x36 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 788 K 6.37x37 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 789 P 6.38x38 mGlu5 receptor 4OO9 - -
TM6 790 I 6.39x39 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 791 G 6.40x40 mGlu5 receptor 4OO9 GABAB2 7C7S
TM6 792 F 6.41x41 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 793 T 6.42x42 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 794 M 6.43x43 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 795 Y 6.44x44 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 796 T 6.45x45 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 797 T 6.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 798 C 6.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 799 I 6.48x48 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 800 V 6.49x49 mGlu5 receptor 4OO9 - -
TM6 801 W 6.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 802 L 6.51x51 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 803 A 6.52x52 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 804 F 6.53x53 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 805 I 6.54x54 mGlu5 receptor 4OO9 - -
TM6 806 P 6.55x55 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 807 I 6.56x56 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 808 F 6.57x57 mGlu5 receptor 4OO9 - -
TM6 809 F 6.58x58 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 810 G 6.59x59 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ECL3 811 T - - - -
ECL3 812 A - - - -
ECL3 813 Q - - - -
ECL3 814 S - - - -
ECL3 815 A - - - -
ECL3 816 E - - - -
ECL3 817 K - - - -
ECL3 818 L - - - -
ECL3 819 Y - - - -
TM7 820 I 7.27x28 mGlu5 receptor 4OO9 - -
TM7 821 Q 7.28x29 mGlu5 receptor 4OO9 GABAB2 7C7S
TM7 822 T 7.29x30 mGlu5 receptor 4OO9 - -
TM7 823 T 7.30x31 mGlu5 receptor 4OO9 - -
TM7 824 T 7.31x32 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 825 L 7.32x33 mGlu5 receptor 4OO9 - -
TM7 826 T 7.33x34 mGlu5 receptor 4OO9 - -
TM7 827 I 7.34x35 mGlu5 receptor 4OO9 - -
TM7 828 S 7.35x36 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 829 M 7.36x37 mGlu5 receptor 4OO9 - -
TM7 830 N 7.37x38 mGlu5 receptor 4OO9 - -
TM7 831 L 7.38x39 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 832 S 7.39x40 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 833 A 7.40x41 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 834 S 7.41x42 mGlu5 receptor 4OO9 - -
TM7 835 V 7.42x43 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 836 A 7.43x44 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 837 L 7.44x45 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 838 G 7.45x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 839 M 7.46x47 mGlu5 receptor 4OO9 - -
TM7 840 L 7.47x471 mGlu5 receptor 4OO9 - -
TM7 841 Y 7.48x48 mGlu5 receptor 4OO9 - -
TM7 842 M 7.49x49 mGlu5 receptor 4OO9 - -
TM7 843 P 7.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 844 K 7.51x51 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 845 V 7.52x52 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 846 Y 7.53x53 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 847 I 7.54x54 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 848 I 7.55x55 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 849 I 7.56x56 mGlu5 receptor 4OO9 - -
TM7 850 F 7.57x57 mGlu5 receptor 4OO9 - -
TM7 851 H 7.58x58 mGlu5 receptor 4OO9 - -
H8 852 P 8.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 853 E 8.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 854 L 8.48x48 mGlu5 receptor 4OO9 - -
H8 855 N 8.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 856 V 8.50x50 - - - -
H8 857 Q 8.51x51 - - - -
H8 858 K 8.52x52 - - - -
H8 859 R 8.53x53 - - - -
H8 860 K 8.54x54 - - - -
H8 861 R 8.55x55 - - - -
H8 862 S 8.56x56 - - - -
H8 863 F 8.57x57 - - - -
C-term 864 K - - - -
C-term 865 A - - - -
C-term 866 V - - - -
C-term 867 V - - - -
C-term 868 T - - - -