mGlu8 receptor homology model

PROTEIN CLASS

Class C (Glutamate)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active

VERSION

2020-10-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

NGL is a WebGL based 3D viewer powered by MMTF.

MAIN TEMPLATE

mGlu5 receptor (sequence similarity: 69%) PDB: 4OO9

TEMPLATES

4OO9 (mGlu5 receptor)
6FFI (mGlu5 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 77.5 1.1 21.4
Side-chains 41.1 8.8 50.2

Number of backbone templates: 2
Number of rotamer templates: 4

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 577 L mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
N-term 578 E mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
N-term 579 W mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
N-term 580 H mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
N-term 581 S mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 582 P 1.38x38 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 583 W 1.39x39 mGlu5 receptor 4OO9 - -
TM1 584 A 1.40x40 mGlu5 receptor 4OO9 - -
TM1 585 V 1.41x41 mGlu5 receptor 4OO9 - -
TM1 586 V 1.42x42 mGlu5 receptor 4OO9 - -
TM1 587 P 1.43x43 mGlu5 receptor 4OO9 - -
TM1 588 V 1.44x44 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 589 F 1.45x45 mGlu5 receptor 4OO9 - -
TM1 590 V 1.46x46 mGlu5 receptor 4OO9 - -
TM1 591 A 1.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 592 I 1.48x48 mGlu5 receptor 4OO9 GABAB2 7C7S
TM1 593 L 1.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 594 G 1.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 595 I 1.51x51 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM1 596 I 1.52x52 mGlu5 receptor 4OO9 GABAB2 7C7S
TM1 597 A 1.53x53 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 598 T 1.54x54 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 599 T 1.55x55 mGlu5 receptor 4OO9 - -
TM1 600 F 1.56x56 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 601 V 1.57x57 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 602 I 1.58x58 mGlu5 receptor 4OO9 - -
TM1 603 V 1.59x59 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 604 T 1.60x60 mGlu5 receptor 4OO9 - -
TM1 605 F 1.61x61 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM1 606 V 1.62x62 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM1 607 R 1.63x63 mGlu5 receptor 4OO9 - -
TM1 608 Y 1.64x64 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL1 609 N mGlu5 receptor 4OO9 - -
ICL1 610 D mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL1 611 T 12.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL1 612 P 12.48x48 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL1 613 I 12.49x49 mGlu5 receptor 4OO9 - -
ICL1 614 V 12.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL1 615 R 12.51x51 mGlu5 receptor 4OO9 - -
ICL1 616 A 12.52x52 mGlu5 receptor 4OO9 - -
ICL1 617 S 12.53x53 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 618 G 2.35x35 mGlu5 receptor 4OO9 - -
TM2 619 R 2.36x36 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 620 E 2.37x37 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 621 L 2.38x38 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 622 S 2.39x39 mGlu5 receptor 4OO9 - -
TM2 623 Y 2.40x40 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 624 V 2.41x41 mGlu5 receptor 4OO9 - -
TM2 625 L 2.42x42 mGlu5 receptor 4OO9 - -
TM2 626 L 2.43x43 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 627 T 2.44x44 mGlu5 receptor 4OO9 - -
TM2 628 G 2.45x45 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 629 I 2.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 630 F 2.47x47 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM2 631 L 2.48x48 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 632 C 2.49x49 mGlu5 receptor 4OO9 - -
TM2 633 Y 2.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 634 S 2.51x51 mGlu5 receptor 4OO9 - -
TM2 635 I 2.52x52 mGlu5 receptor 4OO9 - -
TM2 636 T 2.53x53 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 637 F 2.54x54 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM2 638 L 2.55x55 mGlu5 receptor 4OO9 GABAB2 7C7S
TM2 639 M 2.56x56 mGlu5 receptor 4OO9 - -
TM2 640 I 2.57x57 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ECL1 641 A - - - -
ECL1 642 A mGlu5 receptor 6FFI - -
ECL1 643 P - - - -
TM3 644 D 3.25x25 mGlu5 receptor 6FFI - -
TM3 645 T 3.26x26 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM3 646 I 3.27x27 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 647 I 3.28x28 mGlu5 receptor 4OO9 - -
TM3 648 C 3.29x29 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 649 S 3.30x30 mGlu5 receptor 4OO9 - -
TM3 650 F 3.31x31 mGlu5 receptor 4OO9 - -
TM3 651 R 3.32x32 mGlu5 receptor 4OO9 GABAB2 7C7S
TM3 652 R 3.33x33 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 653 V 3.34x34 mGlu5 receptor 4OO9 - -
TM3 654 F 3.35x35 mGlu5 receptor 4OO9 - -
TM3 655 L 3.36x36 mGlu5 receptor 4OO9 GABAB2 7C7S
TM3 656 G 3.37x37 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 657 L 3.38x38 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 658 G 3.39x39 mGlu5 receptor 4OO9 GABAB2 7C7S
TM3 659 M 3.40x40 mGlu5 receptor 4OO9 - -
TM3 660 C 3.41x41 mGlu5 receptor 4OO9 - -
TM3 661 F 3.42x42 mGlu5 receptor 4OO9 - -
TM3 662 S 3.43x43 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 663 Y 3.44x44 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 664 A 3.45x45 mGlu5 receptor 4OO9 - -
TM3 665 A 3.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 666 L 3.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 667 L 3.48x48 mGlu5 receptor 4OO9 - -
TM3 668 T 3.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 669 K 3.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 670 T 3.51x51 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 671 N 3.52x52 mGlu5 receptor 4OO9 mGlu5 receptor 6N52
TM3 672 R 3.53x53 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 673 I 3.54x54 mGlu5 receptor 4OO9 mGlu5 receptor 6N52
TM3 674 H 3.55x55 mGlu5 receptor 4OO9 GABAB2 7C7S
TM3 675 R 3.56x56 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 676 I 3.57x57 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM3 677 F 3.58x58 mGlu5 receptor 4OO9 GABAB2 7C7S
ICL2 678 E - - - -
ICL2 679 Q - - - -
ICL2 680 G - - - -
ICL2 681 K - - - -
ICL2 682 K - - - -
ICL2 683 S - - - -
ICL2 684 V - - - -
ICL2 685 T - - - -
ICL2 686 A - - - -
ICL2 687 P - - - -
ICL2 688 K - - - -
ICL2 689 F - - - -
ICL2 690 I - - - -
TM4 691 S 4.28x28 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 692 P 4.29x29 mGlu5 receptor 4OO9 - -
TM4 693 A 4.30x30 mGlu5 receptor 4OO9 - -
TM4 694 S 4.31x31 mGlu5 receptor 4OO9 - -
TM4 695 Q 4.32x32 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 696 L 4.33x33 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 697 V 4.34x34 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 698 I 4.35x35 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 699 T 4.36x36 mGlu5 receptor 4OO9 - -
TM4 700 F 4.37x37 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 701 S 4.38x38 mGlu5 receptor 4OO9 - -
TM4 702 L 4.39x39 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 703 I 4.40x40 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 704 S 4.41x41 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM4 705 V 4.42x42 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM4 706 Q 4.43x43 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 707 L 4.44x44 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 708 L 4.45x45 mGlu5 receptor 4OO9 - -
TM4 709 G 4.46x46 mGlu5 receptor 4OO9 - -
TM4 710 V 4.47x47 mGlu5 receptor 4OO9 mGlu1 receptor 4OR2
TM4 711 F 4.48x48 mGlu5 receptor 4OO9 - -
TM4 712 V 4.49x49 mGlu5 receptor 4OO9 - -
TM4 713 W 4.50x50 mGlu5 receptor 4OO9 GABAB2 7C7S
TM4 714 F 4.51x51 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM4 715 V 4.52x52 mGlu5 receptor 4OO9 - -
TM4 716 V 4.53x53 mGlu5 receptor 4OO9 GABAB2 7C7S
TM4 717 D 4.54x54 mGlu5 receptor 4OO9 GABAB2 7C7S
ECL2 718 P - - - -
ECL2 719 P - - - -
ECL2 720 H - - - -
ECL2 721 I - - - -
ECL2 722 I - - - -
ECL2 723 I - - - -
ECL2 724 D - - - -
ECL2 725 Y - - - -
ECL2 726 G - - - -
ECL2 727 E - - - -
ECL2 728 Q - - - -
ECL2 729 R - - - -
ECL2 730 T - - - -
ECL2 731 L - - - -
ECL2 732 D - - - -
ECL2 733 P - - - -
ECL2 734 E - - - -
ECL2 735 K - - - -
ECL2 736 A - - - -
ECL2 737 R - - - -
ECL2 738 G - - - -
ECL2 739 V - - - -
ECL2 740 L - - - -
ECL2 741 K - - - -
ECL2 742 C 45.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ECL2 743 D 45.51x51 mGlu5 receptor 4OO9 - -
ECL2 744 I 45.52x52 mGlu5 receptor 4OO9 - -
TM5 745 S 5.36x36 mGlu5 receptor 6FFI mGlu1 receptor 4OR2
TM5 746 D 5.37x37 mGlu5 receptor 4OO9 - -
TM5 747 L 5.38x38 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 748 S 5.39x39 mGlu5 receptor 4OO9 - -
TM5 749 L 5.40x40 mGlu5 receptor 4OO9 GABAB2 7C7S
TM5 750 I 5.41x41 mGlu5 receptor 4OO9 - -
TM5 751 C 5.42x42 mGlu5 receptor 4OO9 - -
TM5 752 S 5.43x43 mGlu5 receptor 4OO9 - -
TM5 753 L 5.44x44 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 754 G 5.45x45 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 755 Y 5.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 756 S 5.47x47 mGlu5 receptor 4OO9 - -
TM5 757 I 5.48x48 mGlu5 receptor 4OO9 - -
TM5 758 L 5.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 759 L 5.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 760 M 5.51x51 mGlu5 receptor 4OO9 GABAB2 7C7S
TM5 761 V 5.52x52 mGlu5 receptor 4OO9 - -
TM5 762 T 5.53x53 mGlu5 receptor 4OO9 - -
TM5 763 C 5.54x54 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 764 T 5.55x55 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 765 V 5.56x56 mGlu5 receptor 4OO9 - -
TM5 766 Y 5.57x57 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 767 A 5.58x58 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 768 I 5.59x59 mGlu5 receptor 4OO9 - -
TM5 769 K 5.60x60 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM5 770 T 5.61x61 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL3 771 R mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL3 772 G mGlu5 receptor 4OO9 - -
ICL3 773 V mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL3 774 P mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL3 775 E mGlu5 receptor 4OO9 - -
ICL3 776 T mGlu5 receptor 4OO9 - -
ICL3 777 F mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ICL3 778 N mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 779 E 6.35x35 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 780 A 6.36x36 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 781 K 6.37x37 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 782 P 6.38x38 mGlu5 receptor 4OO9 - -
TM6 783 I 6.39x39 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 784 G 6.40x40 mGlu5 receptor 4OO9 GABAB2 7C7S
TM6 785 F 6.41x41 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 786 T 6.42x42 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 787 M 6.43x43 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 788 Y 6.44x44 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 789 T 6.45x45 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 790 T 6.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 791 C 6.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 792 I 6.48x48 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 793 I 6.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 794 W 6.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 795 L 6.51x51 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 796 A 6.52x52 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 797 F 6.53x53 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 798 I 6.54x54 mGlu5 receptor 4OO9 - -
TM6 799 P 6.55x55 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 800 I 6.56x56 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 801 F 6.57x57 mGlu5 receptor 4OO9 - -
TM6 802 F 6.58x58 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM6 803 G 6.59x59 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
ECL3 804 T - - - -
ECL3 805 A - - - -
ECL3 806 Q - - - -
ECL3 807 S - - - -
ECL3 808 A - - - -
ECL3 809 E - - - -
ECL3 810 K - - - -
ECL3 811 M - - - -
ECL3 812 Y - - - -
TM7 813 I 7.27x28 mGlu5 receptor 4OO9 - -
TM7 814 Q 7.28x29 mGlu5 receptor 4OO9 GABAB2 7C7S
TM7 815 T 7.29x30 mGlu5 receptor 4OO9 - -
TM7 816 T 7.30x31 mGlu5 receptor 4OO9 - -
TM7 817 T 7.31x32 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 818 L 7.32x33 mGlu5 receptor 4OO9 - -
TM7 819 T 7.33x34 mGlu5 receptor 4OO9 - -
TM7 820 V 7.34x35 mGlu5 receptor 4OO9 - -
TM7 821 S 7.35x36 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 822 M 7.36x37 mGlu5 receptor 4OO9 - -
TM7 823 S 7.37x38 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 824 L 7.38x39 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 825 S 7.39x40 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 826 A 7.40x41 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 827 S 7.41x42 mGlu5 receptor 4OO9 - -
TM7 828 V 7.42x43 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 829 S 7.43x44 mGlu5 receptor 4OO9 - -
TM7 830 L 7.44x45 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 831 G 7.45x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 832 M 7.46x47 mGlu5 receptor 4OO9 - -
TM7 833 L 7.47x471 mGlu5 receptor 4OO9 - -
TM7 834 Y 7.48x48 mGlu5 receptor 4OO9 - -
TM7 835 M 7.49x49 mGlu5 receptor 4OO9 - -
TM7 836 P 7.50x50 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 837 K 7.51x51 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 838 V 7.52x52 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 839 Y 7.53x53 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 840 I 7.54x54 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 841 I 7.55x55 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
TM7 842 I 7.56x56 mGlu5 receptor 4OO9 - -
TM7 843 F 7.57x57 mGlu5 receptor 4OO9 - -
TM7 844 H 7.58x58 mGlu5 receptor 4OO9 - -
H8 845 P 8.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 846 E 8.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 847 Q 8.48x48 mGlu5 receptor 4OO9 - -
H8 848 N 8.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 849 V 8.50x50 - - - -
H8 850 Q 8.51x51 - - - -
H8 851 K 8.52x52 - - - -
H8 852 R 8.53x53 - - - -
H8 853 K 8.54x54 - - - -
H8 854 R 8.55x55 - - - -
H8 855 S 8.56x56 - - - -
H8 856 F 8.57x57 - - - -
C-term 857 K - - - -
C-term 858 A - - - -
C-term 859 V - - - -
C-term 860 V - - - -
C-term 861 T - - - -